PE47099A1 - Compuestos de 2-imidazolinilaminoindazol utiles como agonistas de alfa-2 adrenoreceptores - Google Patents
Compuestos de 2-imidazolinilaminoindazol utiles como agonistas de alfa-2 adrenoreceptoresInfo
- Publication number
- PE47099A1 PE47099A1 PE1997001067A PE00106797A PE47099A1 PE 47099 A1 PE47099 A1 PE 47099A1 PE 1997001067 A PE1997001067 A PE 1997001067A PE 00106797 A PE00106797 A PE 00106797A PE 47099 A1 PE47099 A1 PE 47099A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- formula
- compounds
- alpha
- imidazolinylaminindazol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Resins (AREA)
Abstract
SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: R1 ES H o ALQUILO; R2 ES H, ALQUILO o NULO; R3 ES H, ALQUILO C1-C3, AMINO, OH, MERCAPTO,CIANO, ALQUILTIO C1-C3, ALCOXI C1-C3, ALQUILAMINO C1-C3, DIALQUILAMINO C1-C3 o HALOGENO; R4, R5 Y R7 SON H, ALQUILO C1-C3, ALQUENILO C1-C3, ALQUINILO C1-C3, CICLOALQUILO, CICLOALQUENILO, ALQUILTIO C1-C3, ALCOXI C1-C3, OH, TIO, NITRO, CN, AMINO, ALQUILAMINO C1-C3, DIALQUILAMINO C1-C3 o HALOGENO; (a) PUEDE SER UN DOBLE ENLACE CON LA CONDICION DE QUE EL COMPUESTO DE FORMULA (I) NO ES 7-BROMO-6-(2-IMIDAZOLINILAMINO)INDAZOL; SIENDO COMPUESTOS (I) PREFERIDOS: 7-ETIL-6-(2-IMIDAZOLINILAMINO)INDAZOL Y 6-(2-IMIDAZOLINILAMINO)-7-METILINDAZOL. TAMBIEN SE REFIERE A UNA COMPOSICION, QUE COMPRENDE: UN COMPUESTO DE FORMULA (I) Y UNO O MAS PRINCIPIOS ACTIVOS SELECCIONADOS DE UN ANTIHISTAMINICO, UN ANTIINFLAMATORIO, ENTRE OTROS. LOS COMPUESTOS DE FORMULA (I) ACTUAN COMO AGONISTAS ALFA 2 ADRENORECEPTORES, SIENDO UTILES EN EL TRATAMIENTO DE LA CONGESTION NASAL, OTITIS MEDIA, SINUSITIS, ASMA, DOLOR, MIGRANA, ABUSO DE SUSTANCIAS Y ADICCION, TRASTORNOS GASTROINTESTINALES, ULCERA, HIPERACIDEZ ESTOMACAL, HIPERTROFIA PROSTATICA BENIGNA, ENTRE OTROS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3174096P | 1996-11-25 | 1996-11-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE47099A1 true PE47099A1 (es) | 1999-06-12 |
Family
ID=21861136
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1997001067A PE47099A1 (es) | 1996-11-25 | 1997-11-25 | Compuestos de 2-imidazolinilaminoindazol utiles como agonistas de alfa-2 adrenoreceptores |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0944620A1 (es) |
JP (1) | JP2001506599A (es) |
KR (1) | KR20000069104A (es) |
CN (1) | CN1244864A (es) |
AR (1) | AR010643A1 (es) |
AU (1) | AU5433998A (es) |
BR (1) | BR9713535A (es) |
CA (1) | CA2272644A1 (es) |
CO (1) | CO4910166A1 (es) |
CZ (1) | CZ183999A3 (es) |
HU (1) | HUP9904660A3 (es) |
ID (1) | ID22676A (es) |
IL (1) | IL130067A0 (es) |
NO (1) | NO992502L (es) |
NZ (1) | NZ335882A (es) |
PE (1) | PE47099A1 (es) |
SK (1) | SK69699A3 (es) |
TR (1) | TR199901542T2 (es) |
WO (1) | WO1998023609A1 (es) |
ZA (1) | ZA9710576B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9908175D0 (en) * | 1999-04-09 | 1999-06-02 | Lilly Co Eli | Method of treating neurological disorders |
US6433186B1 (en) | 2000-08-16 | 2002-08-13 | Astrazeneca Ab | Amidino derivatives and their use as thormbin inhibitors |
JPWO2009084695A1 (ja) | 2007-12-28 | 2011-05-19 | カルナバイオサイエンス株式会社 | 2−アミノキナゾリン誘導体 |
US8555875B2 (en) | 2008-12-23 | 2013-10-15 | Map Pharmaceuticals, Inc. | Inhalation devices and related methods for administration of sedative hypnotic compounds |
CN112538074A (zh) * | 2020-12-24 | 2021-03-23 | 艾希尔(深圳)药物研发有限公司 | 一种溴莫尼定脱溴杂质的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH641782A5 (en) * | 1978-12-07 | 1984-03-15 | Siegfried Ag | 1H- and 2H-indazole derivatives |
US4526898A (en) * | 1980-09-05 | 1985-07-02 | Siegfried Aktiengesselschaft | Antihypertensive 4-(2-imidazolin-2-yl-amino)-2-methyl-indazole |
BR9408342A (pt) * | 1993-12-17 | 1997-08-19 | Procter & Gamble | Compostos de 6-(2-imidazolinilamino) quinoxalina úteis como agonistas de adrenoceptores de alfa-2 |
US5478858A (en) * | 1993-12-17 | 1995-12-26 | The Procter & Gamble Company | 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists |
-
1997
- 1997-11-21 HU HU9904660A patent/HUP9904660A3/hu unknown
- 1997-11-21 TR TR1999/01542T patent/TR199901542T2/xx unknown
- 1997-11-21 WO PCT/US1997/020551 patent/WO1998023609A1/en not_active Application Discontinuation
- 1997-11-21 JP JP52468698A patent/JP2001506599A/ja active Pending
- 1997-11-21 IL IL13006797A patent/IL130067A0/xx unknown
- 1997-11-21 CZ CZ991839A patent/CZ183999A3/cs unknown
- 1997-11-21 KR KR1019997004569A patent/KR20000069104A/ko not_active Application Discontinuation
- 1997-11-21 CN CN97181453A patent/CN1244864A/zh active Pending
- 1997-11-21 BR BR9713535A patent/BR9713535A/pt unknown
- 1997-11-21 AU AU54339/98A patent/AU5433998A/en not_active Abandoned
- 1997-11-21 EP EP97948238A patent/EP0944620A1/en not_active Withdrawn
- 1997-11-21 CA CA002272644A patent/CA2272644A1/en not_active Abandoned
- 1997-11-21 ID IDW990412A patent/ID22676A/id unknown
- 1997-11-21 NZ NZ335882A patent/NZ335882A/xx unknown
- 1997-11-24 CO CO97068615A patent/CO4910166A1/es unknown
- 1997-11-25 ZA ZA9710576A patent/ZA9710576B/xx unknown
- 1997-11-25 PE PE1997001067A patent/PE47099A1/es not_active Application Discontinuation
- 1997-11-25 AR ARP970105524A patent/AR010643A1/es unknown
-
1999
- 1999-05-25 NO NO992502A patent/NO992502L/no not_active Application Discontinuation
- 1999-05-25 SK SK696-99A patent/SK69699A3/sk unknown
Also Published As
Publication number | Publication date |
---|---|
CN1244864A (zh) | 2000-02-16 |
SK69699A3 (en) | 2000-06-12 |
CO4910166A1 (es) | 2000-04-24 |
IL130067A0 (en) | 2000-02-29 |
ID22676A (id) | 1999-12-09 |
HUP9904660A3 (en) | 2002-02-28 |
CA2272644A1 (en) | 1998-06-04 |
AU5433998A (en) | 1998-06-22 |
WO1998023609A1 (en) | 1998-06-04 |
NO992502D0 (no) | 1999-05-25 |
BR9713535A (pt) | 2000-03-21 |
CZ183999A3 (cs) | 1999-11-17 |
NZ335882A (en) | 2000-12-22 |
HUP9904660A2 (hu) | 2000-06-28 |
ZA9710576B (en) | 1998-09-16 |
NO992502L (no) | 1999-07-26 |
KR20000069104A (ko) | 2000-11-25 |
TR199901542T2 (xx) | 2000-01-21 |
EP0944620A1 (en) | 1999-09-29 |
JP2001506599A (ja) | 2001-05-22 |
AR010643A1 (es) | 2000-06-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE16299A1 (es) | Compuestos de 2-imidazolinilaminoindol utiles como agonistas de alfa-2 adrenoreceptores | |
PE1998A1 (es) | DERIVADOS DE BENZO [g] QUINOLINA | |
ES2044878T3 (es) | Un proceso para la preparacion de derivados de benzimidazol. | |
PE20001600A1 (es) | Derivados de 1,4-diazabiciclo (3.3.2) nonan-4-carboxilatos y carboxamidas, su preparacion y su aplicacion en terapeutica | |
ATE216360T1 (de) | Sulfinsäurederivate und deren herstellung und verwendung | |
PE20040840A1 (es) | Derivados de 4-oxoquinolina como inhibidores de la integrasa del vih | |
AR029216A1 (es) | Compuestos inhibidores no peptidicos de la union celular dependiente de vla-4 utiles en el tratamiento de enfermedades inflamatorias, autoinmunes y respiratorias; composicion farmaceutica y procedimiento de tratamiento | |
PE16399A1 (es) | Compuestos heterociclicos de guanidinilo utiles como agonistas de alfa-2 adrenoreceptores | |
ECSP034815A (es) | "composiciones de timolol y de lipido hipotensivas y los metodos para utilizarlas" | |
PE20010685A1 (es) | Composicion que comprende un polipeptido antagonista del receptor de interleuquina 1 y una diarilsulfonilurea como inhibidor del procesamiento y la liberacion de il-1 | |
PT939627E (pt) | Pentafluorobenzenossulfonamidas e analogos | |
DK0775129T3 (da) | 3-Benzoylbenzofuranderivater som thyroidhormonantagonister | |
PE107999A1 (es) | Derivados 3-amidinoanilina, inhibidores del factor x de coagulacion de la sangre activado e intermediarios de los mismos | |
AR013477A1 (es) | Prostaglandinas de tetrahidro sustituido c16-20 aromatico utiles como agonistas de fp. | |
EA200400444A1 (ru) | Композиции для лечения простуды | |
PE20081781A1 (es) | Agonistas de adrenoreceptores alfa2c funcionalmente selectivos | |
PE20040698A1 (es) | Derivados de isoindolina | |
PE16599A1 (es) | Compuestos de (2-imidazolinilamino) benzoxazol utiles como agonistas de alfa-2 adrenoreceptores | |
PE106299A1 (es) | Derivados del 2-(4-aril o heteroaril-piperazin-1-ilmetil)-1h-indol | |
PE20020144A1 (es) | Derivados de pleuromutilinas como agentes antibacterianos | |
PE20010127A1 (es) | Suspension de ziprasidona | |
ES2135769T3 (es) | Derivados de isotiourea como inhibidores de no-sintasa. | |
AR016551A1 (es) | Derivados de 2-oxindol, composiciones farmaceuticas que los comprenden y el uso de los mismos para la manufactura de medicamentos | |
PE47099A1 (es) | Compuestos de 2-imidazolinilaminoindazol utiles como agonistas de alfa-2 adrenoreceptores | |
PT775118E (pt) | Derivados de benzimidazole com actividade dopaminergica |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FX | Voluntary withdrawal |