NZ335882A - 2-Imidazolinylaminoindazole compounds useful as alpha-2 adrenoceptor agonists - Google Patents
2-Imidazolinylaminoindazole compounds useful as alpha-2 adrenoceptor agonistsInfo
- Publication number
- NZ335882A NZ335882A NZ335882A NZ33588297A NZ335882A NZ 335882 A NZ335882 A NZ 335882A NZ 335882 A NZ335882 A NZ 335882A NZ 33588297 A NZ33588297 A NZ 33588297A NZ 335882 A NZ335882 A NZ 335882A
- Authority
- NZ
- New Zealand
- Prior art keywords
- alkanyl
- unsubstituted
- hydrogen
- alpha
- alkylthio
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Resins (AREA)
Abstract
A compound of formula I wherein: R1 is hydrogen or C1-3 alkanyl, R2 is hydrogen, C1-3 alkanyl or nil, R3 is selected from hydrogen, unsubstituted C1-3 alkanyl, amino, hydroxy, mercapto, C1-3 alkylthio or alkoxy, C1-3 alkylamino, C1-3 dialkylamino, cyano and halo, R4 and R5 are each independently selected from hydrogen, unsubstituted C1-3 alkanyl, alkenyl or alkynyl, cycloalkanyl, cycloalkenyl, unsubstituted C1-3 alkylthio or alkoxy, hydroxy, thio, nitro, cyano, amino, C1-3 alkylamino, C1-3 dialkylamino and halo, R7 is selected from unsubstituted C1-3 alkanyl or alkenyl, unsubstituted C1-3 alkylthio or alkoxy, hydroxy, thio and halo, and provided that when R2 is nil, bond (a) is a double bond and the compound is not 7-bromo-6-(2-imidazolinylamino)indazole, and enantiomers, optical isomers, stereoisomers, diastereomers, tautomers, addition salts and biohydrolyzable amides and esters thereof. These compounds are useful in the treatment of disorders that are modulated by alpha-2 adrenoceptors.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3174096P | 1996-11-25 | 1996-11-25 | |
| PCT/US1997/020551 WO1998023609A1 (en) | 1996-11-25 | 1997-11-21 | 2-imidazolinylaminoindazole compounds useful as alpha-2 adrenoceptor agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ335882A true NZ335882A (en) | 2000-12-22 |
Family
ID=21861136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ335882A NZ335882A (en) | 1996-11-25 | 1997-11-21 | 2-Imidazolinylaminoindazole compounds useful as alpha-2 adrenoceptor agonists |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0944620A1 (en) |
| JP (1) | JP2001506599A (en) |
| KR (1) | KR20000069104A (en) |
| CN (1) | CN1244864A (en) |
| AR (1) | AR010643A1 (en) |
| AU (1) | AU5433998A (en) |
| BR (1) | BR9713535A (en) |
| CA (1) | CA2272644A1 (en) |
| CO (1) | CO4910166A1 (en) |
| CZ (1) | CZ183999A3 (en) |
| HU (1) | HUP9904660A3 (en) |
| ID (1) | ID22676A (en) |
| IL (1) | IL130067A0 (en) |
| NO (1) | NO992502L (en) |
| NZ (1) | NZ335882A (en) |
| PE (1) | PE47099A1 (en) |
| SK (1) | SK69699A3 (en) |
| TR (1) | TR199901542T2 (en) |
| WO (1) | WO1998023609A1 (en) |
| ZA (1) | ZA9710576B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9908175D0 (en) * | 1999-04-09 | 1999-06-02 | Lilly Co Eli | Method of treating neurological disorders |
| US6433186B1 (en) | 2000-08-16 | 2002-08-13 | Astrazeneca Ab | Amidino derivatives and their use as thormbin inhibitors |
| US20100311965A1 (en) | 2007-12-28 | 2010-12-09 | Carna Biosciences Inc. | 2-aminoquinazoline derivative |
| WO2010074753A1 (en) | 2008-12-23 | 2010-07-01 | Map Pharmaceuticals, Inc. | Inhalation devices and related methods for administration of sedative hypnotic compounds |
| CN112538074A (en) * | 2020-12-24 | 2021-03-23 | 艾希尔（深圳）药物研发有限公司 | Preparation method of debrominated impurities of brimonidine |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH641782A5 (en) * | 1978-12-07 | 1984-03-15 | Siegfried Ag | 1H- and 2H-indazole derivatives |
| US4526898A (en) * | 1980-09-05 | 1985-07-02 | Siegfried Aktiengesselschaft | Antihypertensive 4-(2-imidazolin-2-yl-amino)-2-methyl-indazole |
| PT735877E (en) * | 1993-12-17 | 2000-12-29 | Procter & Gamble | COMPOUNDS OF 6- (2-IMIDAZOLINYLAMINO) UQUINAL QUINOXALINS AS AGONISTS OF ADRENERGIC ALPHA-2 RECEPTOR |
| US5478858A (en) * | 1993-12-17 | 1995-12-26 | The Procter & Gamble Company | 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists |
-
1997
- 1997-11-21 CN CN97181453A patent/CN1244864A/en active Pending
- 1997-11-21 WO PCT/US1997/020551 patent/WO1998023609A1/en not_active Application Discontinuation
- 1997-11-21 CA CA002272644A patent/CA2272644A1/en not_active Abandoned
- 1997-11-21 ID IDW990412A patent/ID22676A/en unknown
- 1997-11-21 KR KR1019997004569A patent/KR20000069104A/en not_active Application Discontinuation
- 1997-11-21 IL IL13006797A patent/IL130067A0/en unknown
- 1997-11-21 NZ NZ335882A patent/NZ335882A/en unknown
- 1997-11-21 BR BR9713535A patent/BR9713535A/en unknown
- 1997-11-21 CZ CZ991839A patent/CZ183999A3/en unknown
- 1997-11-21 TR TR1999/01542T patent/TR199901542T2/en unknown
- 1997-11-21 HU HU9904660A patent/HUP9904660A3/en unknown
- 1997-11-21 AU AU54339/98A patent/AU5433998A/en not_active Abandoned
- 1997-11-21 EP EP97948238A patent/EP0944620A1/en not_active Withdrawn
- 1997-11-21 JP JP52468698A patent/JP2001506599A/en active Pending
- 1997-11-24 CO CO97068615A patent/CO4910166A1/en unknown
- 1997-11-25 AR ARP970105524A patent/AR010643A1/en unknown
- 1997-11-25 ZA ZA9710576A patent/ZA9710576B/en unknown
- 1997-11-25 PE PE1997001067A patent/PE47099A1/en not_active Application Discontinuation
-
1999
- 1999-05-25 NO NO992502A patent/NO992502L/en not_active Application Discontinuation
- 1999-05-25 SK SK696-99A patent/SK69699A3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ID22676A (en) | 1999-12-09 |
| SK69699A3 (en) | 2000-06-12 |
| WO1998023609A1 (en) | 1998-06-04 |
| KR20000069104A (en) | 2000-11-25 |
| CO4910166A1 (en) | 2000-04-24 |
| HUP9904660A3 (en) | 2002-02-28 |
| HUP9904660A2 (en) | 2000-06-28 |
| NO992502D0 (en) | 1999-05-25 |
| AU5433998A (en) | 1998-06-22 |
| EP0944620A1 (en) | 1999-09-29 |
| ZA9710576B (en) | 1998-09-16 |
| PE47099A1 (en) | 1999-06-12 |
| IL130067A0 (en) | 2000-02-29 |
| TR199901542T2 (en) | 2000-01-21 |
| AR010643A1 (en) | 2000-06-28 |
| CN1244864A (en) | 2000-02-16 |
| NO992502L (en) | 1999-07-26 |
| JP2001506599A (en) | 2001-05-22 |
| CA2272644A1 (en) | 1998-06-04 |
| CZ183999A3 (en) | 1999-11-17 |
| BR9713535A (en) | 2000-03-21 |
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