PE16199A1 - 2-IMIDAZOLINYLAMINOBENZOTIAZOLE COMPOUNDS USEFUL AS ALPHA-2 ADRENORECEPTOR AGONISTS - Google Patents

2-IMIDAZOLINYLAMINOBENZOTIAZOLE COMPOUNDS USEFUL AS ALPHA-2 ADRENORECEPTOR AGONISTS

Info

Publication number
PE16199A1
PE16199A1 PE00106497A PE00106497A PE16199A1 PE 16199 A1 PE16199 A1 PE 16199A1 PE 00106497 A PE00106497 A PE 00106497A PE 00106497 A PE00106497 A PE 00106497A PE 16199 A1 PE16199 A1 PE 16199A1
Authority
PE
Peru
Prior art keywords
unsubstituted
hydrogen
alpha
compounds
imidazolinylaminobenzotiazole
Prior art date
Application number
PE00106497A
Other languages
Spanish (es)
Inventor
William Lee Seibel
Jeffrey Joseph Ares
Russell James Sheldon
Raymond Todd Henry
Thomas Lee Cupps
Sophie Eva Bogdan
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of PE16199A1 publication Critical patent/PE16199A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

The invention involves compounds having following structure (I) wherein: a) R1, R2 and R3 are each independently selected from hydrogen; unsubstituted C1-C3 alkanyl, alkenyl or alkynyl; cycloalkanyl, cycloalkenyl; unsubstituted C1-C3 alkylthio or alkoxy; hydroxy; thio; nitro; cyano; amino; C1-C3 alkylamino or C1-C3 dialkylamino and halo; b) R4 is selected from hydrogen; unsubstituted C1-C3 alkanyl; amino, hydroxy, mercapto; C1-C3 alkylthio or alkoxy; C1-C3 alkylamino or C1-C3 dialkylamino and halo; c) R5 is hydrogen; or alkyl or nil; d) where R5 is nil, bond (a) is a double bond; e) the imidazolinylamino moiety is attached to the 5- or 6- position of the benzothiazole ring; and enantiomers, optical isomers, stereoisomers, diastereomers, tautomers, addition salts, biohydrolyzable amides and esters thereof, as well as pharmaceutical compositions comprising such novel compounds. The invention also relates to the use of such compounds for preventing or treating disorders modulated by alpha-2 adrenoceptors.
PE00106497A 1996-11-25 1997-11-25 2-IMIDAZOLINYLAMINOBENZOTIAZOLE COMPOUNDS USEFUL AS ALPHA-2 ADRENORECEPTOR AGONISTS PE16199A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3175696P 1996-11-25 1996-11-25

Publications (1)

Publication Number Publication Date
PE16199A1 true PE16199A1 (en) 1999-03-12

Family

ID=21861233

Family Applications (1)

Application Number Title Priority Date Filing Date
PE00106497A PE16199A1 (en) 1996-11-25 1997-11-25 2-IMIDAZOLINYLAMINOBENZOTIAZOLE COMPOUNDS USEFUL AS ALPHA-2 ADRENORECEPTOR AGONISTS

Country Status (6)

Country Link
AR (1) AR010644A1 (en)
AU (1) AU5433898A (en)
CO (1) CO4910168A1 (en)
PE (1) PE16199A1 (en)
WO (1) WO1998023612A1 (en)
ZA (1) ZA9710574B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677321A (en) * 1996-02-29 1997-10-14 Synaptic Pharmaceutical Corporation 5- and 6-(2-imidazolin-2-ylamino) and -(2-thiazolin-2-ylamino)-benzothiazoles as alpha-2 adrenergic ligands
JP2004508324A (en) * 2000-09-08 2004-03-18 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー Prevent acute sinusitis and sinus attacks
WO2010074753A1 (en) 2008-12-23 2010-07-01 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
MX336578B (en) 2011-07-25 2016-01-25 Allergan Inc N-(IMIDAZOLIDIN-2-YLIDENE)-HETEROCYCLOPENTA[b]PYRIDINE DERIVATIVES AS MODULATORS OF ALPHA 2 ADRENERGIC RECEPTORS.
CN112538074A (en) * 2020-12-24 2021-03-23 艾希尔（深圳）药物研发有限公司 Preparation method of debrominated impurities of brimonidine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754832A (en) * 1969-08-14 1971-02-15 Beecham Group Ltd IMINAZOLINES
BE795970A (en) * 1972-02-29 1973-08-27 Pfizer NEW DERIVATIVES OF QUINOLEINE, QUINOXALINE AND QUINAZOLINE ER PHARMACEUTICAL COMPOSITION CONTAINING THEM
FR2521140A1 (en) * 1982-02-05 1983-08-12 Synthelabo IMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
US5180721A (en) * 1989-05-22 1993-01-19 Allergan, Inc. Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
US5021410A (en) * 1989-05-22 1991-06-04 Allergan, Inc. Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
US5091528A (en) * 1990-09-12 1992-02-25 Allergan, Inc. 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents
US5677321A (en) * 1996-02-29 1997-10-14 Synaptic Pharmaceutical Corporation 5- and 6-(2-imidazolin-2-ylamino) and -(2-thiazolin-2-ylamino)-benzothiazoles as alpha-2 adrenergic ligands

Also Published As

Publication number Publication date
ZA9710574B (en) 1998-06-10
AR010644A1 (en) 2000-06-28
CO4910168A1 (en) 2000-04-24
AU5433898A (en) 1998-06-22
WO1998023612A1 (en) 1998-06-04

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