CO4910168A1 - 2-IMIDAZOLINYLAMINOBENZOTIAZOLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS - Google Patents

2-IMIDAZOLINYLAMINOBENZOTIAZOLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS

Info

Publication number
CO4910168A1
CO4910168A1 CO97068605A CO97068605A CO4910168A1 CO 4910168 A1 CO4910168 A1 CO 4910168A1 CO 97068605 A CO97068605 A CO 97068605A CO 97068605 A CO97068605 A CO 97068605A CO 4910168 A1 CO4910168 A1 CO 4910168A1
Authority
CO
Colombia
Prior art keywords
unsubstituted
hydrogen
compounds
alpha
imidazolinylaminobenzotiazole
Prior art date
Application number
CO97068605A
Other languages
Spanish (es)
Inventor
Thomas Lee Cupps
Sophie Eva Bogdan
Raymond Todd Henry
Russell James Sheldon
William Lee Seibel
Jeffrey Joseph Ares
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of CO4910168A1 publication Critical patent/CO4910168A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

La presente invención se relaciona con compuestos que tienenla siguiente estructura:en donde: a) R1, R2 y R3 se seleccionan cada uno independientemente de hidrógeno, alcanilo, alquenilo o alquinilo C1-C3 insustituido; cicloalcanilo, cicloalquenilo; alquiltio o alcoxi C1-C3 insustituido; hidroxi; tio; nitro; ciano; amino; alquilamino C1-C3 o dialquilamino C1-C3 y halo; b) R4 se selecciona de hidrógeno; alcanilo C1-C3 insustituido; amino, hidroxi, mercapto; alquiltio o alcoxi C1-C3; alquilamino C1-C3 o dialquilamino C1-C3 y halo; c) R5 es hidrógeno, o alquilo o nada; d) donde R5 es nada, el enlace (a) es un enlace doble; y e) la mitad de imidazolinilamino está unida a la 5- o 6-posición del anillo de benzotiazol; y enantiómeros, isómeros ópticos, esteroisómeros, diastereómeros, tautómeros, sales de adición amidas y ésteres biohibrolizables, y composiciones farmacéuticas que contienen tales nuevos compuestos, y el uso de tales compuestos para prevenir o tratar trastornos modulados por alfa-2 adrenoceptores.The present invention relates to compounds having the following structure: wherein: a) R1, R2, and R3 are each independently selected from unsubstituted hydrogen, alkanyl, alkenyl, or C1-C3 alkynyl; cycloalkanyl, cycloalkenyl; unsubstituted C 1 -C 3 -alkylthio or alkoxy; hydroxy; uncle; nitro; cyano; Not me; C1-C3 alkylamino or C1-C3 dialkylamino and halo; b) R4 is selected from hydrogen; unsubstituted C1-C3 alkanyl; amino, hydroxy, mercapto; C1-C3-alkylthio or alkoxy; C1-C3 alkylamino or C1-C3 dialkylamino and halo; c) R5 is hydrogen, or alkyl or nothing; d) where R5 is nothing, bond (a) is a double bond; and e) the imidazolinylamino moiety is attached to the 5- or 6-position of the benzothiazole ring; and enantiomers, optical isomers, steroisomers, diastereomers, tautomers, amide addition salts and biohybridizable esters, and pharmaceutical compositions containing such new compounds, and the use of such compounds to prevent or treat alpha-2 adrenoceptor modulated disorders.

CO97068605A 1996-11-25 1997-11-24 2-IMIDAZOLINYLAMINOBENZOTIAZOLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS CO4910168A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3175696P 1996-11-25 1996-11-25

Publications (1)

Publication Number Publication Date
CO4910168A1 true CO4910168A1 (en) 2000-04-24

Family

ID=21861233

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97068605A CO4910168A1 (en) 1996-11-25 1997-11-24 2-IMIDAZOLINYLAMINOBENZOTIAZOLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS

Country Status (6)

Country Link
AR (1) AR010644A1 (en)
AU (1) AU5433898A (en)
CO (1) CO4910168A1 (en)
PE (1) PE16199A1 (en)
WO (1) WO1998023612A1 (en)
ZA (1) ZA9710574B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677321A (en) 1996-02-29 1997-10-14 Synaptic Pharmaceutical Corporation 5- and 6-(2-imidazolin-2-ylamino) and -(2-thiazolin-2-ylamino)-benzothiazoles as alpha-2 adrenergic ligands
MXPA03001437A (en) * 2000-09-08 2005-06-03 Warner Lambert Co Prevention of acute sinusitis and sinus attack.
WO2010074753A1 (en) 2008-12-23 2010-07-01 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
JP6052685B2 (en) 2011-07-25 2016-12-27 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ N- (imidazolidine-2-ylidene) -heterocyclopenta [b] pyridine derivatives as modulators of α2 adrenergic receptors
CN112538074A (en) * 2020-12-24 2021-03-23 艾希尔（深圳）药物研发有限公司 Preparation method of debrominated impurities of brimonidine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754832A (en) * 1969-08-14 1971-02-15 Beecham Group Ltd IMINAZOLINES
BE795970A (en) * 1972-02-29 1973-08-27 Pfizer NEW DERIVATIVES OF QUINOLEINE, QUINOXALINE AND QUINAZOLINE ER PHARMACEUTICAL COMPOSITION CONTAINING THEM
FR2521140A1 (en) * 1982-02-05 1983-08-12 Synthelabo IMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
US5021410A (en) * 1989-05-22 1991-06-04 Allergan, Inc. Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
US5180721A (en) * 1989-05-22 1993-01-19 Allergan, Inc. Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
US5091528A (en) * 1990-09-12 1992-02-25 Allergan, Inc. 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents
US5677321A (en) * 1996-02-29 1997-10-14 Synaptic Pharmaceutical Corporation 5- and 6-(2-imidazolin-2-ylamino) and -(2-thiazolin-2-ylamino)-benzothiazoles as alpha-2 adrenergic ligands

Also Published As

Publication number Publication date
AR010644A1 (en) 2000-06-28
PE16199A1 (en) 1999-03-12
AU5433898A (en) 1998-06-22
ZA9710574B (en) 1998-06-10
WO1998023612A1 (en) 1998-06-04

Similar Documents

Publication Publication Date Title
CO4910149A1 (en) 2-IMIDAZOLINYLAMINOINDOL COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS
CO4910148A1 (en) GUANIDINYL HETERO-CYCLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS
PE20020786A1 (en) DERIVATIVES OF AZAINDOL ANTIVIRAL
AR059895A1 (en) BICYCLE DERIVATIVES OF CARBOXYLIC ACIDS THAT RESULT IN USEFULNESS TO TREAT METABOLIC DISORDERS
EA200702080A1 (en) POLYCYCLIC CARBOMOILPYRIDON DERIVATIVE, HAS INHIBITOR ACTIVITY AGAINST HIV INTEGRASES
CO5700824A2 (en) NEW USEFUL HETEROCICLIC COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THE PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
ES2053508T3 (en) COMPOUNDS OF 3-PIRROLIDINYL-THIO-1-AZABICICLO (3.2.0) HEPT-2-ENO-2-CARBOXILICOS.
CO4910150A1 (en) USEFUL 2-IMIDAZOLINYLAMINOBENZOXAZOLE COMPOUNDS WITH ALPHA-2 ADRENOCEPTOR AGONISTS
RS53108B (en) Amino 1,3,5-triazines n-substituted with chiral bicyclic radicals, process for their preparation, compositions thereof and their use as herbicides and plant growth regulators
AR018186A1 (en) CARBAZOLY COMPOUNDS OF 1,2,3,4-TETRAHYDROCARBAZOL REPLACED, USEFUL AS INHIBITORS OF THE RELEASE OF FATTY ACIDS THROUGH SPLA2, PROCEDURE TO PREPARE THEM; INTERMEDIATE APPLICATION COMPOUNDS IN SUCH PROCEDURES; PHARMACEUTICAL COMPOSITIONS THAT INCLUDE SUCH COMPOUND
AR055431A1 (en) ACID DERIVATIVES 4-AMINO-TIENO [3,2-C] PIRIDINA-7-CARBOXILICO
AU660469B2 (en) Pharmacologically active hydrazine derivatives and processes for the preparation thereof
AR002690A1 (en) DERIVATIVE OF BENCIMIDAZOLE OR SALTS OF THE SAME, PHARMACEUTICAL COMPOSITION, IMMUNOSUPPRESSIVE AGENT AND ANTI-INFLAMMATORY AGENT THAT CONTAIN IT AND PROCEDURES TO PREPARE SUCH DERIVATIVE.
IL132474A (en) 3,4-dihydrothienopyrimidine-4-(thi) ones for combating plant fungi and a novel such compound
AR026352A1 (en) IMIDAZOPIRIDINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE VII.
AR034734A1 (en) SYNTHESIS AND INTERMEDIARIES
NZ513594A (en) Heterocyclic compounds, intermediates thereof and elastase inhibitors
AR059031A1 (en) COMBINATION OF TRIAZINE DERIVATIVES AND INHIBITORS OF THE HMG- COA REDUCTASA
CO4910168A1 (en) 2-IMIDAZOLINYLAMINOBENZOTIAZOLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS
ES2249636T3 (en) TRIAZOLS AS ANTAGONISTS OF OXITOCINE.
AR035587A1 (en) A COMPOUND DERIVED FROM TRIPTAMINE AND ITS ANALOGS, AND A PHARMACEUTICAL COMPOSITION CONTAINING IT
CO4910166A1 (en) 2-IMIDAZOLINYLAMININDAZOLE COMPOUNDS USEFUL AS 2-ALPHA ADRENOCEPTOR AGONISTS
AR035765A1 (en) FUNGICIDE COMPOSITIONS OF N-2-PIRIDINYLMETILBENZAMIDE AND OF THE PROPIL ESTER OF ACID (3- (DIMETHYLAMINE) -PROPIL) CARBAMIC; CURATIVE OR PREVENTIVE PROCEDURES AGAINST FITOPATOGENOS OF CULTURES, USING SUCH COMPOSITIONS AND PRODUCTS OF COMBINED, SIMULTANEOUS, SEPARATE OR SEQUENCED APPLICATION
PE20050120A1 (en) KITCHENS WITH A MODIFIED LACTONE RING
AR009144A1 (en) GUANIDILAMINO HETERO-CYCLE COMPOUNDS, PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUND AND USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT