NO992502L - 2-Imidazolinylaminoindazolforbindelser nyttige som <alfa>-2 adrenerge reseptoragonister - Google Patents

2-Imidazolinylaminoindazolforbindelser nyttige som <alfa>-2 adrenerge reseptoragonister

Info

Publication number
NO992502L
NO992502L NO992502A NO992502A NO992502L NO 992502 L NO992502 L NO 992502L NO 992502 A NO992502 A NO 992502A NO 992502 A NO992502 A NO 992502A NO 992502 L NO992502 L NO 992502L
Authority
NO
Norway
Prior art keywords
hydrogen
unsubstituted
compounds
imidazolinylaminoindazole
alfa
Prior art date
Application number
NO992502A
Other languages
English (en)
Other versions
NO992502D0 (no
Inventor
Thomas Lee Cupps
Sophie Eva Bogdan
Raymond Todd Henry
Russell James Sheldon
William Lee Seibel
Jeffrey Joseph Ares
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of NO992502D0 publication Critical patent/NO992502D0/no
Publication of NO992502L publication Critical patent/NO992502L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Resins (AREA)

Abstract

Denne oppfinnelse vedrører forbindelser som har struktur (I) hvor: a) RT er hydrogen; eller alkyl; b) R2 er hydrogen; alkyl eller null; c) R3 er valgt fra hydrogen; usub- stituert C^ alkanyl; amino, hydroksy, merkapto; C^-C, alkyltio eller alkoksy; Ci-C3 alkylamino eller C^-C3 dialkyl- amino; cyano; og halo; d) R,, Rs og R, er hver uavhengig valgt fra hydrogen; usubstituert C^-C^ alkanyl, alkenyl eller alkynyl; cykloalkanyl, cykloalkenyl; usubstituert C^- C3 alkyltio eller alkoksy; hydroksy; tio; nitro; cyano; amino; C^-Cj alkylamino eller C^-C., dialkylamino og halo; e) når R2 er null, er binding (a) en dobbeIbinding; f) for- bindelsen er ikke 7-brom-6-(2-imidazolinylamino)indazol; og enantiomerer, optiske isomerer, stereoisomerer, diastereo- merer, tautomerer, addisjonssalter, biohydrolyserbare amider og estere, og farmasøytiske sammensetninger inne- holdende slike nye forbindelser, og anvendelsen av slike forbindelser for å forhindre eller behandle forstyrrelser modulert av alfa-2-adrenerge reseptorer.
NO992502A 1996-11-25 1999-05-25 2-Imidazolinylaminoindazolforbindelser nyttige som <alfa>-2 adrenerge reseptoragonister NO992502L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3174096P 1996-11-25 1996-11-25
PCT/US1997/020551 WO1998023609A1 (en) 1996-11-25 1997-11-21 2-imidazolinylaminoindazole compounds useful as alpha-2 adrenoceptor agonists

Publications (2)

Publication Number Publication Date
NO992502D0 NO992502D0 (no) 1999-05-25
NO992502L true NO992502L (no) 1999-07-26

Family

ID=21861136

Family Applications (1)

Application Number Title Priority Date Filing Date
NO992502A NO992502L (no) 1996-11-25 1999-05-25 2-Imidazolinylaminoindazolforbindelser nyttige som <alfa>-2 adrenerge reseptoragonister

Country Status (20)

Country Link
EP (1) EP0944620A1 (no)
JP (1) JP2001506599A (no)
KR (1) KR20000069104A (no)
CN (1) CN1244864A (no)
AR (1) AR010643A1 (no)
AU (1) AU5433998A (no)
BR (1) BR9713535A (no)
CA (1) CA2272644A1 (no)
CO (1) CO4910166A1 (no)
CZ (1) CZ183999A3 (no)
HU (1) HUP9904660A3 (no)
ID (1) ID22676A (no)
IL (1) IL130067A0 (no)
NO (1) NO992502L (no)
NZ (1) NZ335882A (no)
PE (1) PE47099A1 (no)
SK (1) SK69699A3 (no)
TR (1) TR199901542T2 (no)
WO (1) WO1998023609A1 (no)
ZA (1) ZA9710576B (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9908175D0 (en) * 1999-04-09 1999-06-02 Lilly Co Eli Method of treating neurological disorders
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
US20100311965A1 (en) 2007-12-28 2010-12-09 Carna Biosciences Inc. 2-aminoquinazoline derivative
WO2010074753A1 (en) 2008-12-23 2010-07-01 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
CN112538074A (zh) * 2020-12-24 2021-03-23 艾希尔（深圳）药物研发有限公司 一种溴莫尼定脱溴杂质的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH641782A5 (en) * 1978-12-07 1984-03-15 Siegfried Ag 1H- and 2H-indazole derivatives
US4526898A (en) * 1980-09-05 1985-07-02 Siegfried Aktiengesselschaft Antihypertensive 4-(2-imidazolin-2-yl-amino)-2-methyl-indazole
PT735877E (pt) * 1993-12-17 2000-12-29 Procter & Gamble Compostos de 6-(2-imidazolinilamino)quinoxalina uteis como agonistas do receptor alfa-2 adrenergico
US5478858A (en) * 1993-12-17 1995-12-26 The Procter & Gamble Company 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists

Also Published As

Publication number Publication date
ID22676A (id) 1999-12-09
SK69699A3 (en) 2000-06-12
WO1998023609A1 (en) 1998-06-04
KR20000069104A (ko) 2000-11-25
CO4910166A1 (es) 2000-04-24
HUP9904660A3 (en) 2002-02-28
HUP9904660A2 (hu) 2000-06-28
NO992502D0 (no) 1999-05-25
NZ335882A (en) 2000-12-22
AU5433998A (en) 1998-06-22
EP0944620A1 (en) 1999-09-29
ZA9710576B (en) 1998-09-16
PE47099A1 (es) 1999-06-12
IL130067A0 (en) 2000-02-29
TR199901542T2 (xx) 2000-01-21
AR010643A1 (es) 2000-06-28
CN1244864A (zh) 2000-02-16
JP2001506599A (ja) 2001-05-22
CA2272644A1 (en) 1998-06-04
CZ183999A3 (cs) 1999-11-17
BR9713535A (pt) 2000-03-21

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