PE16599A1 - Compuestos de (2-imidazolinilamino) benzoxazol utiles como agonistas de alfa-2 adrenoreceptores - Google Patents
Compuestos de (2-imidazolinilamino) benzoxazol utiles como agonistas de alfa-2 adrenoreceptoresInfo
- Publication number
- PE16599A1 PE16599A1 PE1997001065A PE00106597A PE16599A1 PE 16599 A1 PE16599 A1 PE 16599A1 PE 1997001065 A PE1997001065 A PE 1997001065A PE 00106597 A PE00106597 A PE 00106597A PE 16599 A1 PE16599 A1 PE 16599A1
- Authority
- PE
- Peru
- Prior art keywords
- imidazolinylamine
- compounds
- alpha
- imidazolinilamino
- alkyltio
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE: R1, R2 Y R3 SON H, ALQUILO C1-C3, ALQUENILO C1-C3, ALQUINILO C1-C3, CICLOALQUILO, CICLOALQUENILO, ALQUILTIO C1-C3, ALCOXI C1-C3, OH, TIO, NITRO, CN, AMINO, ALQUILAMINO C1-C3, DIALQUILAMINO C1-C3 o HALOGENO; R4 ES H, ALQUILO C1-C3, AMINO, OH, MERCAPTO, ALQUILTIO C1-C3, ALCOXI C1-C3, ALQUILAMINO C1-C3, DIALQUILAMINO C1-C3 o HALOGENO; R5 ES H, ALQUILO o NO EXISTE, CUANDO EL ENLACE (a) ES UN DOBLE ENLACE; EN DONDE EL RADICAL IMIDAZOLINILAMINO ESTA UNIDO EN LA POSICION 5 o 6 DEL ANILLO DE BENZOXAZOL; SON COMPUESTOS (I) PREFERIDOS: 5-(2-IMIDAZOLINILAMINO)-4-METIL BENZOXAZOL Y 4-ETIL-5-(2-IMIDAZOLINILAMINO)BENZOXAZOL. TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE: UN COMPUESTO (I) Y UNO O MAS PRINCIPIOS ACTIVOS SELECCIONADOS DE UN ANTIHISTAMINICO, UN ANTIINFLAMATORIO, ENTRE OTROS. LOS COMPUESTOS DE FORMULA (I) ACTUAN COMO AGONISTAS ALFA 2 ADRENORECEPTORES, SIENDO UTILES EN EL TRATAMIENTO DE LA CONGESTION NASAL, OTITIS MEDIA, SINUSITIS, ASMA, DOLOR, MIGRANA, ABUSO DE SUSTANCIAS Y ADICCION, TRASTORNO GASTROINTESTINAL, ULCERA, HIPERACIDEZ ESTOMACAL, HIPERTROFIA PROSTATICA BENIGNA, ENTRE OTROS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3178796P | 1996-11-25 | 1996-11-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE16599A1 true PE16599A1 (es) | 1999-03-12 |
Family
ID=21861392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1997001065A PE16599A1 (es) | 1996-11-25 | 1997-11-25 | Compuestos de (2-imidazolinilamino) benzoxazol utiles como agonistas de alfa-2 adrenoreceptores |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6110952A (es) |
| EP (1) | EP0944622A1 (es) |
| JP (1) | JP2001506601A (es) |
| KR (1) | KR20000069128A (es) |
| AU (1) | AU736992B2 (es) |
| BR (1) | BR9713537A (es) |
| CA (1) | CA2272683A1 (es) |
| CO (1) | CO4910150A1 (es) |
| CZ (1) | CZ183699A3 (es) |
| HU (1) | HUP0002966A3 (es) |
| ID (1) | ID22060A (es) |
| IL (1) | IL130094A (es) |
| NO (1) | NO313755B1 (es) |
| PE (1) | PE16599A1 (es) |
| SK (1) | SK74999A3 (es) |
| TR (1) | TR199901486T2 (es) |
| WO (1) | WO1998023611A1 (es) |
| ZA (1) | ZA9710579B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20000069128A (ko) * | 1996-11-25 | 2000-11-25 | 데이비드 엠 모이어 | 알파-2 아드레날린수용체 아고니스트로서 유용한 2-이미다졸리닐아미노벤즈옥사졸 화합물 |
| AU3864000A (en) * | 1999-03-05 | 2000-09-21 | Trustees Of University Technology Corporation, The | Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses |
| EP1815206B1 (en) * | 2004-10-13 | 2016-04-06 | PTC Therapeutics, Inc. | Compounds for nonsense suppression, and methods for their use |
| CA2628570A1 (en) | 2005-11-09 | 2007-05-18 | Combinatorx, Incorporated | Methods, compositions, and kits for the treatment of medical conditions |
| US20100197694A1 (en) * | 2008-08-01 | 2010-08-05 | Gerald Horn | Compositions and methods for treatment of diseases and conditions with increased vascular permeability |
| US8952011B2 (en) | 2008-08-01 | 2015-02-10 | Eye Therapies Llc | Compositions and methods for the treatment of nasal conditions |
| US20110003823A1 (en) * | 2008-08-01 | 2011-01-06 | Alpha Synergy Development, Inc. | Compositions and methods for treatment of diseases and conditions associated with vasodilation and/or vascular leakage |
| US20100202979A1 (en) * | 2008-08-01 | 2010-08-12 | Gerald Horn | Compositions and methods for treatment of pulmonary diseases and conditions |
| EP2320911B1 (en) * | 2008-08-01 | 2014-10-08 | Eye Therapies LLC | Vasoconstriction compositions and methods of use |
| US20100203165A1 (en) | 2008-08-01 | 2010-08-12 | Gerald Horn | Compositions and methods for treatment of disorders or conditions of the eye |
| WO2010074753A1 (en) | 2008-12-23 | 2010-07-01 | Map Pharmaceuticals, Inc. | Inhalation devices and related methods for administration of sedative hypnotic compounds |
| US8987270B2 (en) | 2009-07-27 | 2015-03-24 | Eye Therapies Llc | Formulations of selective alpha-2 agonists and methods of use thereof |
| EP2736906B1 (en) * | 2011-07-25 | 2016-10-19 | Allergan, Inc. | N-(IMIDAZOLIDIN-2-YLIDENE)-HETEROCYCLOPENTA[b]PYRIDINE DERIVATIVES AS MODULATORS OF ALPHA 2 ADRENERGIC RECEPTORS |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE795970A (fr) * | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
| US3830804A (en) * | 1972-11-20 | 1974-08-20 | Eastman Kodak Co | Fluorescent(pyrimidinotriazolyl)-2-styrylbenzoxazoles |
| US4398028A (en) * | 1977-01-14 | 1983-08-09 | Sandoz Ltd. | Bicyclic heterocyclic amino derivatives |
| FR2521140A1 (fr) * | 1982-02-05 | 1983-08-12 | Synthelabo | Derives d'imidazolidine, leur preparation et leur application en therapeutique |
| US5091528A (en) * | 1990-09-12 | 1992-02-25 | Allergan, Inc. | 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents |
| GB9110017D0 (en) * | 1991-05-09 | 1991-07-03 | Nat Res Dev | Spectroscopic investigation using organometallic compounds |
| EP0741709B1 (en) * | 1994-01-24 | 2001-07-25 | Allergan Sales, Inc. | Aromatic 2-amino-imidazole derivatives as alpha-2a adrenoceptor agonists |
| AU704972B2 (en) * | 1994-08-04 | 1999-05-13 | H. Lundbeck A/S | Novel benzimidazole derivatives |
| KR100215541B1 (ko) * | 1996-04-19 | 1999-08-16 | 박원훈 | 벤족사졸계 비선형 광학 유도체 및 이들로부터 얻어진고분자 |
| KR20000069128A (ko) * | 1996-11-25 | 2000-11-25 | 데이비드 엠 모이어 | 알파-2 아드레날린수용체 아고니스트로서 유용한 2-이미다졸리닐아미노벤즈옥사졸 화합물 |
-
1997
- 1997-11-21 KR KR1019997004616A patent/KR20000069128A/ko not_active IP Right Cessation
- 1997-11-21 IL IL13009497A patent/IL130094A/en not_active IP Right Cessation
- 1997-11-21 HU HU0002966A patent/HUP0002966A3/hu unknown
- 1997-11-21 AU AU54382/98A patent/AU736992B2/en not_active Ceased
- 1997-11-21 SK SK749-99A patent/SK74999A3/sk unknown
- 1997-11-21 TR TR1999/01486T patent/TR199901486T2/xx unknown
- 1997-11-21 WO PCT/US1997/020803 patent/WO1998023611A1/en not_active Application Discontinuation
- 1997-11-21 BR BR9713537A patent/BR9713537A/pt not_active Application Discontinuation
- 1997-11-21 EP EP97948291A patent/EP0944622A1/en not_active Withdrawn
- 1997-11-21 CA CA002272683A patent/CA2272683A1/en not_active Abandoned
- 1997-11-21 ID IDW990411A patent/ID22060A/id unknown
- 1997-11-21 US US09/308,792 patent/US6110952A/en not_active Expired - Fee Related
- 1997-11-21 JP JP52469598A patent/JP2001506601A/ja active Pending
- 1997-11-21 CZ CZ991836A patent/CZ183699A3/cs unknown
- 1997-11-24 CO CO97068611A patent/CO4910150A1/es unknown
- 1997-11-25 PE PE1997001065A patent/PE16599A1/es not_active Application Discontinuation
- 1997-11-25 ZA ZA9710579A patent/ZA9710579B/xx unknown
-
1999
- 1999-05-25 NO NO19992500A patent/NO313755B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ID22060A (id) | 1999-08-26 |
| HUP0002966A2 (hu) | 2001-09-28 |
| SK74999A3 (en) | 2000-02-14 |
| IL130094A (en) | 2001-09-13 |
| ZA9710579B (en) | 1998-06-25 |
| TR199901486T2 (xx) | 1999-10-21 |
| EP0944622A1 (en) | 1999-09-29 |
| BR9713537A (pt) | 2000-03-21 |
| IL130094A0 (en) | 2000-02-29 |
| US6110952A (en) | 2000-08-29 |
| AU736992B2 (en) | 2001-08-09 |
| CA2272683A1 (en) | 1998-06-04 |
| CO4910150A1 (es) | 2000-04-24 |
| KR20000069128A (ko) | 2000-11-25 |
| AU5438298A (en) | 1998-06-22 |
| WO1998023611A1 (en) | 1998-06-04 |
| NO313755B1 (no) | 2002-11-25 |
| NO992500D0 (no) | 1999-05-25 |
| NO992500L (no) | 1999-07-26 |
| CZ183699A3 (cs) | 1999-09-15 |
| JP2001506601A (ja) | 2001-05-22 |
| HUP0002966A3 (en) | 2001-10-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE16299A1 (es) | Compuestos de 2-imidazolinilaminoindol utiles como agonistas de alfa-2 adrenoreceptores | |
| PE16599A1 (es) | Compuestos de (2-imidazolinilamino) benzoxazol utiles como agonistas de alfa-2 adrenoreceptores | |
| PE16399A1 (es) | Compuestos heterociclicos de guanidinilo utiles como agonistas de alfa-2 adrenoreceptores | |
| PE20040840A1 (es) | Derivados de 4-oxoquinolina como inhibidores de la integrasa del vih | |
| PE20051054A1 (es) | Compuestos heterociclicos utiles como secretagogos de la hormona de crecimiento | |
| PE20020858A1 (es) | Indanil aminas aciladas | |
| SV2002000637A (es) | Derivados de piridina ref. rck 00004/sv | |
| AR021297A1 (es) | 2-fenilbenzimidazoles y 2-fenilindoles, su preparacion y aplicacion | |
| PE20030471A1 (es) | Compuesto de imidazopiridin como moduladores del receptor 5-ht4 | |
| AR247213A1 (es) | Preparacion de acido 7-¡(1-carboxi-3-fenilpropil)amino¿-3,4,6,7,8,12b-octahidro-6-oxopirido ¡2,1-a¿ o hexahidro-6-oxo-1h(1,4-tiazino¡3,4-a¿¡2¿-benzazepin-4-carboxilico, agentes hipertensivos. | |
| DE69011318D1 (de) | Diazinderivate als Angiotensin II Rezeptor Antagonisten. | |
| PE20050460A1 (es) | COMPUESTOS HETEROCICLICOS COMO ANTAGONISTAS CaSR (RECEPTOR SENSIBLE AL CALCIO) | |
| ES2172580T3 (es) | 1,3-oxatiolanos sustituidos con propiedades antiviricas. | |
| PE20040672A1 (es) | Derivados de fenil o heteroaril amino alcano | |
| PE20080734A1 (es) | Inhibidores no nucleosidicos de la transcriptasa inversa | |
| FI980471A (fi) | 1,3-substituoidut sykloalkeenit ja sykloalkaanit keskushermostoon vaikuttavina aineina | |
| PE20081781A1 (es) | Agonistas de adrenoreceptores alfa2c funcionalmente selectivos | |
| PE20040698A1 (es) | Derivados de isoindolina | |
| AR017019A1 (es) | Compuestos derivados del 2-(4-aril o heteroarilpiperazin-1-ilmetil)-1h-indol, composiciones y su uso en la manufactura de medicamentos | |
| SE8503207D0 (sv) | Pharmacologically active substituted benzamides | |
| CO4970744A1 (es) | Caspasas y apoptosis | |
| AR033426A1 (es) | Uso de compuestos carbamatos en la prevencion o el tratamiento de trastornos de movimiento | |
| SE8808452A (sv) | Pharmacologically active substituted benzamides | |
| PT1189900E (pt) | Derivados de aminopirrolidina heterociclicos utilizados como agentes melatonergicos | |
| AR033427A1 (es) | Uso de compuestos carbamatos en el tratamiento del dolor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FX | Voluntary withdrawal |