CO4910150A1 - Compuestos de 2-imidazolinilaminobenzoxazol utiles con agonistas de alfa-2 adrenoceptores - Google Patents

Compuestos de 2-imidazolinilaminobenzoxazol utiles con agonistas de alfa-2 adrenoceptores

Info

Publication number
CO4910150A1
CO4910150A1 CO97068611A CO97068611A CO4910150A1 CO 4910150 A1 CO4910150 A1 CO 4910150A1 CO 97068611 A CO97068611 A CO 97068611A CO 97068611 A CO97068611 A CO 97068611A CO 4910150 A1 CO4910150 A1 CO 4910150A1
Authority
CO
Colombia
Prior art keywords
compounds
hydrogen
unsubstituted
alpha
imidazolinylaminobenzoxazole
Prior art date
Application number
CO97068611A
Other languages
English (en)
Inventor
Raymond Todd Henry
William Lee Seibel
Russell James Sheldon
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of CO4910150A1 publication Critical patent/CO4910150A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

La presente invención se relaciona con compuestos que tienenla siguiente estructura en donde: a) R1 , R2 y R3 se seleccionan cada uno independientemente de hidrógeno; o alcanilo, alquenilo o alquinilo C1 -C3 insustituido; cicloalcanilo, cicloalquenilo, alquiltio o alcoxi C1 -C3 insustituido; hidroxi; tio; nitro; ciano; amino; alquilamino C1 -C3 o dialquilamino C1 -C3 y halo; b) R4 se selecciona de hidrógeno; alcanilo C1 -C3 insustituido; amino; hidroxi; mercapto; alquiltio o alcoxi C1 -C3 ; alquilamino C1 -C3 o dialquilamino C1 -C3 o halo; c) R5 es hidrógeno; o alquilo o nada; d) donde R5 es nada, el enlace (a) es un enlace doble; y e) la mitad de imidazoliminalino está unida a la 5- o la 6- posición del anillo de benzoxazol; y enantiómeros, isómeros ópticos, estereoisómeros, diastereómeros, tautómeros, sales de adición, amidas y ésteres biohidrolizables, y composiciones farmacéuticas que contienen tales nuevos compuestos, y el uso de tales compuestos para prevenir o tratar trastornos modulados por alfa-2 adrenoceptores.
CO97068611A 1996-11-25 1997-11-24 Compuestos de 2-imidazolinilaminobenzoxazol utiles con agonistas de alfa-2 adrenoceptores CO4910150A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3178796P 1996-11-25 1996-11-25

Publications (1)

Publication Number Publication Date
CO4910150A1 true CO4910150A1 (es) 2000-04-24

Family

ID=21861392

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97068611A CO4910150A1 (es) 1996-11-25 1997-11-24 Compuestos de 2-imidazolinilaminobenzoxazol utiles con agonistas de alfa-2 adrenoceptores

Country Status (18)

Country Link
US (1) US6110952A (es)
EP (1) EP0944622A1 (es)
JP (1) JP2001506601A (es)
KR (1) KR20000069128A (es)
AU (1) AU736992B2 (es)
BR (1) BR9713537A (es)
CA (1) CA2272683A1 (es)
CO (1) CO4910150A1 (es)
CZ (1) CZ183699A3 (es)
HU (1) HUP0002966A3 (es)
ID (1) ID22060A (es)
IL (1) IL130094A (es)
NO (1) NO313755B1 (es)
PE (1) PE16599A1 (es)
SK (1) SK74999A3 (es)
TR (1) TR199901486T2 (es)
WO (1) WO1998023611A1 (es)
ZA (1) ZA9710579B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9713537A (pt) * 1996-11-25 2000-03-21 Procter & Gamble omo agonistas a alfa-2-adrenorreceptor
WO2000051625A1 (en) * 1999-03-05 2000-09-08 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses
EP1812071A2 (en) * 2004-10-13 2007-08-01 PTC Therapeutics, Inc. Compounds for nonsense suppression, use of these compounds for the manufacture of a medicament for treating somatic mutation-related diseases
NZ568694A (en) 2005-11-09 2011-09-30 Zalicus Inc Method, compositions, and kits for the treatment of medical conditions
US8283350B2 (en) * 2008-08-01 2012-10-09 Alpha Synergy Development, Inc. Compositions and methods for reducing capillary permeability
US20100197694A1 (en) * 2008-08-01 2010-08-05 Gerald Horn Compositions and methods for treatment of diseases and conditions with increased vascular permeability
US20110003823A1 (en) * 2008-08-01 2011-01-06 Alpha Synergy Development, Inc. Compositions and methods for treatment of diseases and conditions associated with vasodilation and/or vascular leakage
US8952011B2 (en) 2008-08-01 2015-02-10 Eye Therapies Llc Compositions and methods for the treatment of nasal conditions
US20100202979A1 (en) * 2008-08-01 2010-08-12 Gerald Horn Compositions and methods for treatment of pulmonary diseases and conditions
US20100203165A1 (en) 2008-08-01 2010-08-12 Gerald Horn Compositions and methods for treatment of disorders or conditions of the eye
US8555875B2 (en) * 2008-12-23 2013-10-15 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
US8987270B2 (en) 2009-07-27 2015-03-24 Eye Therapies Llc Formulations of selective alpha-2 agonists and methods of use thereof
JP6052685B2 (ja) * 2011-07-25 2016-12-27 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ α２アドレナリン受容体の調節因子としてのＮ−（イミダゾリジン−２−イリデン）−ヘテロシクロペンタ［ｂ］ピリジン誘導体

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE795970A (fr) * 1972-02-29 1973-08-27 Pfizer Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant
US3830804A (en) * 1972-11-20 1974-08-20 Eastman Kodak Co Fluorescent(pyrimidinotriazolyl)-2-styrylbenzoxazoles
US4398028A (en) * 1977-01-14 1983-08-09 Sandoz Ltd. Bicyclic heterocyclic amino derivatives
FR2521140A1 (fr) * 1982-02-05 1983-08-12 Synthelabo Derives d'imidazolidine, leur preparation et leur application en therapeutique
US5091528A (en) * 1990-09-12 1992-02-25 Allergan, Inc. 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents
GB9110017D0 (en) * 1991-05-09 1991-07-03 Nat Res Dev Spectroscopic investigation using organometallic compounds
CA2181909C (en) * 1994-01-24 2008-10-07 Stephen A. Munk Aromatic 2-amino-imidazole derivatives as alpha-2a adrenoceptor agonists
CA2196792A1 (en) * 1994-08-04 1996-02-15 Yoon T. Jeon Novel benzimidazole derivatives
KR100215541B1 (ko) * 1996-04-19 1999-08-16 박원훈 벤족사졸계 비선형 광학 유도체 및 이들로부터 얻어진고분자
BR9713537A (pt) * 1996-11-25 2000-03-21 Procter & Gamble omo agonistas a alfa-2-adrenorreceptor

Also Published As

Publication number Publication date
NO313755B1 (no) 2002-11-25
ZA9710579B (en) 1998-06-25
CZ183699A3 (cs) 1999-09-15
NO992500L (no) 1999-07-26
SK74999A3 (en) 2000-02-14
US6110952A (en) 2000-08-29
PE16599A1 (es) 1999-03-12
ID22060A (id) 1999-08-26
JP2001506601A (ja) 2001-05-22
AU736992B2 (en) 2001-08-09
BR9713537A (pt) 2000-03-21
EP0944622A1 (en) 1999-09-29
NO992500D0 (no) 1999-05-25
IL130094A (en) 2001-09-13
HUP0002966A2 (hu) 2001-09-28
TR199901486T2 (xx) 1999-10-21
CA2272683A1 (en) 1998-06-04
KR20000069128A (ko) 2000-11-25
HUP0002966A3 (en) 2001-10-29
IL130094A0 (en) 2000-02-29
WO1998023611A1 (en) 1998-06-04
AU5438298A (en) 1998-06-22

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