HUP0002966A2 - Alfa-2-adrenoreceptor agonistákként alkalmazható [(2-imidazolidinilidén)-amino]-benzoxazol-származékok és az ezeket tartalmazó gyógyszerkészítmények - Google Patents
Alfa-2-adrenoreceptor agonistákként alkalmazható [(2-imidazolidinilidén)-amino]-benzoxazol-származékok és az ezeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP0002966A2 HUP0002966A2 HU0002966A HUP0002966A HUP0002966A2 HU P0002966 A2 HUP0002966 A2 HU P0002966A2 HU 0002966 A HU0002966 A HU 0002966A HU P0002966 A HUP0002966 A HU P0002966A HU P0002966 A2 HUP0002966 A2 HU P0002966A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- amino
- alkylamino
- mercapto
- hydroxy
- Prior art date
Links
- 102000030484 alpha-2 Adrenergic Receptor Human genes 0.000 title abstract 2
- 108020004101 alpha-2 Adrenergic Receptor Proteins 0.000 title abstract 2
- 239000000556 agonist Substances 0.000 title 1
- WWGDPXQOBQLMRI-UHFFFAOYSA-N n-(4,5-dihydroimidazol-1-yl)-1,3-benzoxazol-2-amine Chemical class C1=NCCN1NC1=NC2=CC=CC=C2O1 WWGDPXQOBQLMRI-UHFFFAOYSA-N 0.000 title 1
- -1 hydroxy, mercapto Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000000355 1,3-benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
A találmány (I) általános képletű végyületekre - amelyek képletében a)R1, R2 és R3 hidrogénatom; szubsztituálatlan alkil-, alkenil- vagyalkinilcsoport, cikloalkil-, cikloalkenil-, szubsztituálatlan alkil-tio- vagy alkoxicsoport, hidroxi-, merkapto-, nitro-, ciano-, amino-,alkil-amino-, dialkil-amino-csoport, vagy halogénatom; b) R4hidrogénatom; szubsztituálatlan alkil-, amino-, hidroxi-, merkapto-,szubsztituálatlan alkil-tio- vagy alkoxicsoport; alkil-amino- vagydialkil-amino-csoport, vagy halogénatom; c) R5 hidrogénatom vagyalkilcsoport vagy nincs jelen; d) ahol R5 nincs jelen, (a) kötésjelentése kettős kötés; és e) a[(2-imidazolidinilidén)-amino]-csoporta benzoxazol 5-ös vagy 6-os helyzetéhez kapcsolódik - és a vegyületekenantiomereire, optikai izomereire, sztereoizomereire,diasztereomereire, tautomereire, addíciós sóira, biohidrolizálhatóamidjaira és észtereire, az új vegyületeket tartalmazógyógyszerkészítményekre, valamint a vegyületek a2-adrenoreceptorokáltal modulált rendellenességek megelőzésére vagy kezelésére történőfelhasználására vonatkozik. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3178796P | 1996-11-25 | 1996-11-25 | |
| PCT/US1997/020803 WO1998023611A1 (en) | 1996-11-25 | 1997-11-21 | 2-imidazolinylaminobenzoxazole compounds useful as alpha-2 adrenoceptor agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0002966A2 true HUP0002966A2 (hu) | 2001-09-28 |
| HUP0002966A3 HUP0002966A3 (en) | 2001-10-29 |
Family
ID=21861392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0002966A HUP0002966A3 (en) | 1996-11-25 | 1997-11-21 | 2-imidazolinylaminobenzoxazole compounds useful as alpha-2 adrenoceptor agonists |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6110952A (hu) |
| EP (1) | EP0944622A1 (hu) |
| JP (1) | JP2001506601A (hu) |
| KR (1) | KR20000069128A (hu) |
| AU (1) | AU736992B2 (hu) |
| BR (1) | BR9713537A (hu) |
| CA (1) | CA2272683A1 (hu) |
| CO (1) | CO4910150A1 (hu) |
| CZ (1) | CZ183699A3 (hu) |
| HU (1) | HUP0002966A3 (hu) |
| ID (1) | ID22060A (hu) |
| IL (1) | IL130094A (hu) |
| NO (1) | NO313755B1 (hu) |
| PE (1) | PE16599A1 (hu) |
| SK (1) | SK74999A3 (hu) |
| TR (1) | TR199901486T2 (hu) |
| WO (1) | WO1998023611A1 (hu) |
| ZA (1) | ZA9710579B (hu) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0002966A3 (en) * | 1996-11-25 | 2001-10-29 | Procter & Gamble | 2-imidazolinylaminobenzoxazole compounds useful as alpha-2 adrenoceptor agonists |
| WO2000051625A1 (en) * | 1999-03-05 | 2000-09-08 | The Trustees Of University Technology Corporation | Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses |
| EP1815206B1 (en) * | 2004-10-13 | 2016-04-06 | PTC Therapeutics, Inc. | Compounds for nonsense suppression, and methods for their use |
| EP2218442A1 (en) | 2005-11-09 | 2010-08-18 | CombinatoRx, Inc. | Methods, compositions, and kits for the treatment of ophthalmic disorders |
| US20100202979A1 (en) * | 2008-08-01 | 2010-08-12 | Gerald Horn | Compositions and methods for treatment of pulmonary diseases and conditions |
| US20100028266A1 (en) * | 2008-08-01 | 2010-02-04 | Alpha Synergy Development. Inc. | Composition and methods for treating allergic response |
| US8952011B2 (en) | 2008-08-01 | 2015-02-10 | Eye Therapies Llc | Compositions and methods for the treatment of nasal conditions |
| US20100197694A1 (en) * | 2008-08-01 | 2010-08-05 | Gerald Horn | Compositions and methods for treatment of diseases and conditions with increased vascular permeability |
| US20110003823A1 (en) * | 2008-08-01 | 2011-01-06 | Alpha Synergy Development, Inc. | Compositions and methods for treatment of diseases and conditions associated with vasodilation and/or vascular leakage |
| US20100203165A1 (en) | 2008-08-01 | 2010-08-12 | Gerald Horn | Compositions and methods for treatment of disorders or conditions of the eye |
| WO2010074753A1 (en) | 2008-12-23 | 2010-07-01 | Map Pharmaceuticals, Inc. | Inhalation devices and related methods for administration of sedative hypnotic compounds |
| US8987270B2 (en) | 2009-07-27 | 2015-03-24 | Eye Therapies Llc | Formulations of selective alpha-2 agonists and methods of use thereof |
| JP6052685B2 (ja) * | 2011-07-25 | 2016-12-27 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | α２アドレナリン受容体の調節因子としてのＮ−（イミダゾリジン−２−イリデン）−ヘテロシクロペンタ［ｂ］ピリジン誘導体 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE795970A (fr) * | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
| US3830804A (en) * | 1972-11-20 | 1974-08-20 | Eastman Kodak Co | Fluorescent(pyrimidinotriazolyl)-2-styrylbenzoxazoles |
| US4398028A (en) * | 1977-01-14 | 1983-08-09 | Sandoz Ltd. | Bicyclic heterocyclic amino derivatives |
| FR2521140A1 (fr) * | 1982-02-05 | 1983-08-12 | Synthelabo | Derives d'imidazolidine, leur preparation et leur application en therapeutique |
| US5091528A (en) * | 1990-09-12 | 1992-02-25 | Allergan, Inc. | 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents |
| GB9110017D0 (en) * | 1991-05-09 | 1991-07-03 | Nat Res Dev | Spectroscopic investigation using organometallic compounds |
| EP0741709B1 (en) * | 1994-01-24 | 2001-07-25 | Allergan Sales, Inc. | Aromatic 2-amino-imidazole derivatives as alpha-2a adrenoceptor agonists |
| WO1996004270A1 (en) * | 1994-08-04 | 1996-02-15 | Synaptic Pharmaceutical Corporation | Novel benzimidazole derivatives |
| KR100215541B1 (ko) * | 1996-04-19 | 1999-08-16 | 박원훈 | 벤족사졸계 비선형 광학 유도체 및 이들로부터 얻어진고분자 |
| HUP0002966A3 (en) * | 1996-11-25 | 2001-10-29 | Procter & Gamble | 2-imidazolinylaminobenzoxazole compounds useful as alpha-2 adrenoceptor agonists |
-
1997
- 1997-11-21 HU HU0002966A patent/HUP0002966A3/hu unknown
- 1997-11-21 TR TR1999/01486T patent/TR199901486T2/xx unknown
- 1997-11-21 CZ CZ991836A patent/CZ183699A3/cs unknown
- 1997-11-21 CA CA002272683A patent/CA2272683A1/en not_active Abandoned
- 1997-11-21 ID IDW990411A patent/ID22060A/id unknown
- 1997-11-21 SK SK749-99A patent/SK74999A3/sk unknown
- 1997-11-21 IL IL13009497A patent/IL130094A/en not_active IP Right Cessation
- 1997-11-21 AU AU54382/98A patent/AU736992B2/en not_active Ceased
- 1997-11-21 EP EP97948291A patent/EP0944622A1/en not_active Withdrawn
- 1997-11-21 JP JP52469598A patent/JP2001506601A/ja active Pending
- 1997-11-21 WO PCT/US1997/020803 patent/WO1998023611A1/en not_active Application Discontinuation
- 1997-11-21 BR BR9713537A patent/BR9713537A/pt not_active Application Discontinuation
- 1997-11-21 US US09/308,792 patent/US6110952A/en not_active Expired - Fee Related
- 1997-11-21 KR KR1019997004616A patent/KR20000069128A/ko not_active IP Right Cessation
- 1997-11-24 CO CO97068611A patent/CO4910150A1/es unknown
- 1997-11-25 PE PE1997001065A patent/PE16599A1/es not_active Application Discontinuation
- 1997-11-25 ZA ZA9710579A patent/ZA9710579B/xx unknown
-
1999
- 1999-05-25 NO NO19992500A patent/NO313755B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK74999A3 (en) | 2000-02-14 |
| PE16599A1 (es) | 1999-03-12 |
| AU736992B2 (en) | 2001-08-09 |
| ZA9710579B (en) | 1998-06-25 |
| IL130094A (en) | 2001-09-13 |
| HUP0002966A3 (en) | 2001-10-29 |
| NO992500L (no) | 1999-07-26 |
| CZ183699A3 (cs) | 1999-09-15 |
| CA2272683A1 (en) | 1998-06-04 |
| AU5438298A (en) | 1998-06-22 |
| WO1998023611A1 (en) | 1998-06-04 |
| JP2001506601A (ja) | 2001-05-22 |
| TR199901486T2 (xx) | 1999-10-21 |
| CO4910150A1 (es) | 2000-04-24 |
| KR20000069128A (ko) | 2000-11-25 |
| EP0944622A1 (en) | 1999-09-29 |
| NO992500D0 (no) | 1999-05-25 |
| BR9713537A (pt) | 2000-03-21 |
| ID22060A (id) | 1999-08-26 |
| IL130094A0 (en) | 2000-02-29 |
| NO313755B1 (no) | 2002-11-25 |
| US6110952A (en) | 2000-08-29 |
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