HUP9904215A2 - Alfa-2-adrenoreceptor agonistákként alkalmazható [(2-imidazolidinilidén)-amino]-indol-származékok - Google Patents

Alfa-2-adrenoreceptor agonistákként alkalmazható [(2-imidazolidinilidén)-amino]-indol-származékok

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Publication number
HUP9904215A2
HUP9904215A2 HU9904215A HUP9904215A HUP9904215A2 HU P9904215 A2 HUP9904215 A2 HU P9904215A2 HU 9904215 A HU9904215 A HU 9904215A HU P9904215 A HUP9904215 A HU P9904215A HU P9904215 A2 HUP9904215 A2 HU P9904215A2
Authority
HU
Hungary
Prior art keywords
alkenyl
amino
pipe
alkyl
cyclic
Prior art date
Application number
HU9904215A
Other languages
English (en)
Inventor
Raymond Todd Henry
William Lee Seibel
Russel James Sheldon
Original Assignee
The Procter & Gamble Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Procter & Gamble Co. filed Critical The Procter & Gamble Co.
Publication of HUP9904215A2 publication Critical patent/HUP9904215A2/hu
Publication of HUP9904215A3 publication Critical patent/HUP9904215A3/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány (I) általánős képletű vegyületekre -, amelyek képletében R1 hidrőgénatőm, alkilcsőpőrt; (a) kötés egyes vagy kettős kötés; R2 és R3 hidrőgénatőm, szűbsztitűálatlan alkil-, alkenil- vagyalkinilcsőpőrt, ciklőalkil-, ciklőalkenilcsőpőrt; szűbsztitűálatlanalkil-tiő- vagy alkőxicsőpőrt, hidrőxi-, merkaptő-, nitrő-, cianő-,aminő-, alkil-aminő-, dialkil-aminő-csőpőrt, halőgénatőm; R4, R5 és R6 hidrőgénatőm, szűbsztitűálatlan alkil-, alkeniil- vagyalkinilcsőpőrt, ciklőalkil-, ciklőalkenilcsőpőrt, szűbsztitűálatlanalkil-tiő- vagy alkőxicsőpőrt, hidrőxi-, merkaptő-, nitrő-, cianő-,aminő-, alkil-aminő-, dialkil-aminő-csőpőrt, halőgénatőm, és (2-imidazőlidinilidén)-aminő-csőpőrt, ahől R4, R5 és R6 egyikénekjelentése (2-imidazőlidinilidén)-aminő-csőpőrt; R7 hidrőgénatőm, szűbsztitűálatlan alkil-, alkenil- vagyalkinilcsőpőrt, ciklőalkil-, ciklőalkenilcsőpőrt, szűbsztitűálatlanalkiltiő- vagy alkőxicsőpőrt, hidrőxi-, merkaptő-, nitrő-, cianő-,aminő-, alkil-aminő-, dialkil-aminő-csőpőrt, és halőgénatőm, és és avegyület 4-[(2-imidazőlidinilidén)-aminő]-indőltól eltérő - és avegyületek enantiőmereire, őptikai izőmereire, sztereőizőmereire,diasztereőmereire, taűtőmereire, addíciós sóira, biőhidrőlizálhatóamidjaira és észtereire, az új vegyületeket tartalmazógyógyszerkészítményekre, valamint a vegyületek a2-adrenőreceptőrőkáltal mődűlált rendellenességek megelőzésére vagy kezelésére történőfelhasználására vőnatkőzik. ŕ
HU9904215A 1996-11-25 1997-11-21 2-imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agonists HUP9904215A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3177796P 1996-11-25 1996-11-25
PCT/US1997/020801 WO1998023610A1 (en) 1996-11-25 1997-11-21 2-imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agonists

Publications (2)

Publication Number Publication Date
HUP9904215A2 true HUP9904215A2 (hu) 2000-06-28
HUP9904215A3 HUP9904215A3 (en) 2002-01-28

Family

ID=21861336

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9904215A HUP9904215A3 (en) 1996-11-25 1997-11-21 2-imidazolinylaminoindole compounds useful as alpha-2 adrenoceptor agonists

Country Status (23)

Country Link
US (2) US6162818A (hu)
EP (1) EP0944621B1 (hu)
JP (1) JP2001506981A (hu)
KR (1) KR100395356B1 (hu)
CN (1) CN1092652C (hu)
AR (1) AR013875A1 (hu)
AT (1) ATE275142T1 (hu)
AU (1) AU735767B2 (hu)
BR (1) BR9713542A (hu)
CA (1) CA2271841C (hu)
CO (1) CO4910149A1 (hu)
CZ (1) CZ180599A3 (hu)
DE (1) DE69730516T2 (hu)
ES (1) ES2225998T3 (hu)
HU (1) HUP9904215A3 (hu)
ID (1) ID22812A (hu)
IL (1) IL130024A (hu)
NO (1) NO992470L (hu)
PE (1) PE16299A1 (hu)
SK (1) SK68399A3 (hu)
TR (1) TR199901885T2 (hu)
WO (1) WO1998023610A1 (hu)
ZA (1) ZA9710577B (hu)

Families Citing this family (22)

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Publication number Priority date Publication date Assignee Title
US5677321A (en) 1996-02-29 1997-10-14 Synaptic Pharmaceutical Corporation 5- and 6-(2-imidazolin-2-ylamino) and -(2-thiazolin-2-ylamino)-benzothiazoles as alpha-2 adrenergic ligands
ES2225998T3 (es) * 1996-11-25 2005-03-16 THE PROCTER & GAMBLE COMPANY Compuestos (2-imidazolinilamino)indol utiles como agonistas del adrenorreceptor alfa 2.
US5866579A (en) * 1997-04-11 1999-02-02 Synaptic Pharmaceutical Corporation Imidazole and imidazoline derivatives and uses thereof
CA2378047A1 (en) * 1999-07-15 2001-01-25 Methvin Isaac Heterocyclic compounds for the treatment of migraine
AU2042301A (en) * 1999-12-03 2001-06-12 Alcon Universal Limited 1-aminoalkyl-1H-indoles for treating glaucoma
US20030166732A1 (en) * 2002-02-27 2003-09-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ambroxol for the treatment of painful conditions in the mouth and pharyngeal cavity
EP1777223A1 (en) * 2002-06-24 2007-04-25 Schering Corporation Indole derivatives useful as histamine H3 antagonists
MXPA05004929A (es) 2002-11-07 2005-08-18 Akzo Nobel Nv Indoles utiles en el tratamiento de enfermedades relacionadas a receptor de androgeno.
DE10332473A1 (de) * 2003-07-16 2005-02-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ambroxol für die Behandlung von Epilepsie
TW200602317A (en) 2004-04-23 2006-01-16 Akzo Nobel Nv Novel androgens
CN101355876B (zh) 2005-11-09 2012-09-05 康宾纳特克斯公司 一种适用于眼部给药的组合物
TWI417099B (zh) 2007-03-23 2013-12-01 Neuraxon Inc 具抑制一氧化氮合成酶活性之喹諾酮、四氫喹啉及其相關化合物
WO2010014552A1 (en) 2008-08-01 2010-02-04 Alpha Synergy Development, Inc. Vasoconstriction compositions and methods of use
US20100197694A1 (en) * 2008-08-01 2010-08-05 Gerald Horn Compositions and methods for treatment of diseases and conditions with increased vascular permeability
US20100203165A1 (en) 2008-08-01 2010-08-12 Gerald Horn Compositions and methods for treatment of disorders or conditions of the eye
US20110003823A1 (en) * 2008-08-01 2011-01-06 Alpha Synergy Development, Inc. Compositions and methods for treatment of diseases and conditions associated with vasodilation and/or vascular leakage
US20100202979A1 (en) * 2008-08-01 2010-08-12 Gerald Horn Compositions and methods for treatment of pulmonary diseases and conditions
US8952011B2 (en) 2008-08-01 2015-02-10 Eye Therapies Llc Compositions and methods for the treatment of nasal conditions
EP2370136A4 (en) * 2008-12-01 2015-12-30 Map Pharmaceuticals Inc INHALATIVE RELEASE PROCEDURES AND DEVICES
US8555875B2 (en) 2008-12-23 2013-10-15 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
US8987270B2 (en) 2009-07-27 2015-03-24 Eye Therapies Llc Formulations of selective alpha-2 agonists and methods of use thereof
CN107628981B (zh) * 2017-10-31 2019-07-30 威海市妇女儿童医院 一种肉桂酰基吲哚啉化合物及其制备青光眼药物的应用

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US5478858A (en) * 1993-12-17 1995-12-26 The Procter & Gamble Company 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists
US5677321A (en) * 1996-02-29 1997-10-14 Synaptic Pharmaceutical Corporation 5- and 6-(2-imidazolin-2-ylamino) and -(2-thiazolin-2-ylamino)-benzothiazoles as alpha-2 adrenergic ligands
ES2225998T3 (es) * 1996-11-25 2005-03-16 THE PROCTER & GAMBLE COMPANY Compuestos (2-imidazolinilamino)indol utiles como agonistas del adrenorreceptor alfa 2.

Also Published As

Publication number Publication date
KR100395356B1 (ko) 2003-08-21
CA2271841C (en) 2003-07-08
SK68399A3 (en) 2000-07-11
DE69730516D1 (de) 2004-10-07
ATE275142T1 (de) 2004-09-15
EP0944621B1 (en) 2004-09-01
AU5438098A (en) 1998-06-22
BR9713542A (pt) 2000-01-25
US6162818A (en) 2000-12-19
NO992470D0 (no) 1999-05-21
US6395764B1 (en) 2002-05-28
CA2271841A1 (en) 1998-06-04
CO4910149A1 (es) 2000-04-24
ID22812A (id) 1999-12-09
AU735767B2 (en) 2001-07-12
NO992470L (no) 1999-07-26
CN1092652C (zh) 2002-10-16
CN1238771A (zh) 1999-12-15
JP2001506981A (ja) 2001-05-29
HUP9904215A3 (en) 2002-01-28
KR20000069088A (ko) 2000-11-25
TR199901885T2 (xx) 1999-10-21
AR013875A1 (es) 2001-01-31
WO1998023610A1 (en) 1998-06-04
CZ180599A3 (cs) 1999-11-17
DE69730516T2 (de) 2005-09-01
IL130024A0 (en) 2000-02-29
ZA9710577B (en) 1998-06-25
ES2225998T3 (es) 2005-03-16
EP0944621A1 (en) 1999-09-29
PE16299A1 (es) 1999-03-12
IL130024A (en) 2002-12-01

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