DK0871626T3 - Triazoloner som apolipoprotein-B syntheseinhibitorer - Google Patents
Triazoloner som apolipoprotein-B syntheseinhibitorerInfo
- Publication number
- DK0871626T3 DK0871626T3 DK96910968T DK96910968T DK0871626T3 DK 0871626 T3 DK0871626 T3 DK 0871626T3 DK 96910968 T DK96910968 T DK 96910968T DK 96910968 T DK96910968 T DK 96910968T DK 0871626 T3 DK0871626 T3 DK 0871626T3
- Authority
- DK
- Denmark
- Prior art keywords
- 6alkyl
- formula
- substituted
- 6alkyloxy
- halo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Seasonings (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP95201010 | 1995-04-20 | ||
| PCT/EP1996/001585 WO1996033193A1 (en) | 1995-04-20 | 1996-04-12 | Novel triazolones as apolipoprotein-b synthesis inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0871626T3 true DK0871626T3 (da) | 2002-02-25 |
Family
ID=8220206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96910968T DK0871626T3 (da) | 1995-04-20 | 1996-04-12 | Triazoloner som apolipoprotein-B syntheseinhibitorer |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US5922718A (da) |
| EP (1) | EP0871626B1 (da) |
| JP (1) | JP3782455B2 (da) |
| KR (1) | KR100413219B1 (da) |
| CN (1) | CN1076727C (da) |
| AT (1) | ATE208386T1 (da) |
| AU (1) | AU699313B2 (da) |
| CA (1) | CA2217632A1 (da) |
| CZ (1) | CZ291737B6 (da) |
| DE (1) | DE69616825T2 (da) |
| DK (1) | DK0871626T3 (da) |
| ES (1) | ES2167555T3 (da) |
| HK (1) | HK1012186A1 (da) |
| HU (1) | HUP9801056A3 (da) |
| IL (1) | IL117980A (da) |
| NO (1) | NO312415B1 (da) |
| NZ (1) | NZ305869A (da) |
| PL (1) | PL183737B1 (da) |
| PT (1) | PT871626E (da) |
| TW (1) | TW457240B (da) |
| WO (1) | WO1996033193A1 (da) |
| ZA (1) | ZA963152B (da) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003074474A2 (en) | 2002-03-01 | 2003-09-12 | University Of South Florida | Multiple-component solid phases containing at least one active pharmaceutical ingredient |
| IL165383A0 (en) | 2002-06-21 | 2006-01-15 | Transform Pharmaceuticals Inc | Pharmaceutical compositions with improved dissolution |
| CA2525517C (en) * | 2003-06-19 | 2016-05-31 | Applied Research Systems Ars Holding N.V. | Use of prion conversion modulating agents |
| US20080057057A1 (en) * | 2004-03-18 | 2008-03-06 | Applied Research Systems Ars Holding N.V. | Anti-Lipid Rafts Antibodies |
| US20070293674A1 (en) * | 2004-04-22 | 2007-12-20 | Transform Pharmaceuticals, Inc. | Novel Saperconazole Crystalline Forms and Related Processes, Pharmaceutical Compositions and Methods |
| CA2609783A1 (en) * | 2005-05-27 | 2006-12-07 | Pfizer Products Inc. | Combination of a cannabinoid-1- receptor-antagonist and a microsomal triglyceride transfer protein inhibitor for treating obesity or mainataining weight loss |
| PL3003038T3 (pl) | 2013-06-07 | 2020-02-28 | The Scripps Research Institute | Pochodne 2H-1,2,3-triazoli jako inhibitory zwłóknienia |
| EP3169343B1 (en) | 2014-07-15 | 2020-03-25 | Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. | Isolated polypeptides of cd44 and uses thereof |
| KR102548066B1 (ko) | 2014-12-10 | 2023-06-26 | 더 스크립스 리서치 인스티튜트 | 섬유증의 소분자 억제제 |
| EP3611165B1 (en) | 2017-04-11 | 2023-08-16 | Mitsui Chemicals Crop & Life Solutions, Inc. | Pyridone compound, and agricultural and horticultural fungicide having this as active component |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3936470A (en) * | 1975-01-27 | 1976-02-03 | Janssen Pharmaceutica N.V. | 1,3-Dioxolan-2-ylmethylimidazoles |
| US4101666A (en) * | 1975-10-06 | 1978-07-18 | Janssen Pharmaceutica N.V. | 1-(2-Ar-4-R-1,3-dioxolan-2-ylmethyl)imidazoles |
| US4267179A (en) * | 1978-06-23 | 1981-05-12 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of (4-phenylpiperazin-1-yl-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles |
| US4321272A (en) * | 1980-08-25 | 1982-03-23 | Syntex (U.S.A.) Inc. | Derivatives of substituted N-alkylimidazoles |
| DE3144318A1 (de) * | 1981-11-07 | 1983-05-19 | Bayer Ag, 5090 Leverkusen | 2-imidazolylmethyl-2-phenyl-1, 3-dioxolane, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide |
| US4619931A (en) * | 1983-02-28 | 1986-10-28 | Janssen Pharmaceutica, N.V. | [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles |
| CA1292472C (en) * | 1985-12-03 | 1991-11-26 | Alfonsus Guilielmus Knaeps | Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl|-1,3-dioxolan-2-yl|methyl|-1h-imidazoles and 1h-1,2,4-triazoles |
| US4791111A (en) * | 1985-12-23 | 1988-12-13 | Janssen Pharmaceutica, N.V. | [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles having anti-microbial properties |
| US4916134A (en) * | 1987-03-25 | 1990-04-10 | Janssen Pharmacuetica N.V. | 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]me]phenyl]-1-piperazinyl]phenyl]triazolones |
| NZ223799A (en) * | 1987-03-25 | 1989-12-21 | Janssen Pharmaceutica Nv | Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions |
| ATE186540T1 (de) * | 1994-01-24 | 1999-11-15 | Janssen Pharmaceutica Nv | Wasserlösliche azol-antifungus |
-
1996
- 1996-03-22 TW TW085103449A patent/TW457240B/zh not_active IP Right Cessation
- 1996-04-12 CN CN96193235A patent/CN1076727C/zh not_active Expired - Fee Related
- 1996-04-12 CZ CZ19973288A patent/CZ291737B6/cs not_active IP Right Cessation
- 1996-04-12 ES ES96910968T patent/ES2167555T3/es not_active Expired - Lifetime
- 1996-04-12 KR KR1019970706751A patent/KR100413219B1/ko not_active IP Right Cessation
- 1996-04-12 US US08/930,847 patent/US5922718A/en not_active Expired - Fee Related
- 1996-04-12 NZ NZ305869A patent/NZ305869A/en unknown
- 1996-04-12 JP JP53146096A patent/JP3782455B2/ja not_active Expired - Fee Related
- 1996-04-12 PT PT96910968T patent/PT871626E/pt unknown
- 1996-04-12 CA CA002217632A patent/CA2217632A1/en not_active Abandoned
- 1996-04-12 AU AU53998/96A patent/AU699313B2/en not_active Ceased
- 1996-04-12 DE DE69616825T patent/DE69616825T2/de not_active Expired - Fee Related
- 1996-04-12 AT AT96910968T patent/ATE208386T1/de not_active IP Right Cessation
- 1996-04-12 DK DK96910968T patent/DK0871626T3/da active
- 1996-04-12 HU HU9801056A patent/HUP9801056A3/hu unknown
- 1996-04-12 PL PL96322872A patent/PL183737B1/pl not_active IP Right Cessation
- 1996-04-12 EP EP96910968A patent/EP0871626B1/en not_active Expired - Lifetime
- 1996-04-12 WO PCT/EP1996/001585 patent/WO1996033193A1/en active IP Right Grant
- 1996-04-19 IL IL11798096A patent/IL117980A/xx not_active IP Right Cessation
- 1996-04-19 ZA ZA9603152A patent/ZA963152B/xx unknown
-
1997
- 1997-10-10 NO NO19974690A patent/NO312415B1/no unknown
-
1998
- 1998-12-15 HK HK98113362A patent/HK1012186A1/xx not_active IP Right Cessation
-
1999
- 1999-02-17 US US09/251,989 patent/US6197972B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO974690D0 (no) | 1997-10-10 |
| KR19980703346A (ko) | 1998-10-15 |
| EP0871626B1 (en) | 2001-11-07 |
| ATE208386T1 (de) | 2001-11-15 |
| CN1076727C (zh) | 2001-12-26 |
| NZ305869A (en) | 1998-08-26 |
| DE69616825T2 (de) | 2002-06-27 |
| KR100413219B1 (ko) | 2004-05-31 |
| CA2217632A1 (en) | 1996-10-24 |
| CZ328897A3 (cs) | 1998-01-14 |
| US5922718A (en) | 1999-07-13 |
| US6197972B1 (en) | 2001-03-06 |
| HK1012186A1 (en) | 1999-07-30 |
| JP3782455B2 (ja) | 2006-06-07 |
| PT871626E (pt) | 2002-04-29 |
| TW457240B (en) | 2001-10-01 |
| AU5399896A (en) | 1996-11-07 |
| DE69616825D1 (en) | 2001-12-13 |
| EP0871626A1 (en) | 1998-10-21 |
| AU699313B2 (en) | 1998-12-03 |
| CZ291737B6 (cs) | 2003-05-14 |
| JPH11503739A (ja) | 1999-03-30 |
| NO312415B1 (no) | 2002-05-06 |
| NO974690L (no) | 1997-10-10 |
| PL322872A1 (en) | 1998-03-02 |
| WO1996033193A1 (en) | 1996-10-24 |
| HUP9801056A3 (en) | 1999-09-28 |
| HUP9801056A2 (hu) | 1999-06-28 |
| PL183737B1 (pl) | 2002-07-31 |
| IL117980A0 (en) | 1996-08-04 |
| ES2167555T3 (es) | 2002-05-16 |
| CN1181079A (zh) | 1998-05-06 |
| IL117980A (en) | 2000-02-17 |
| ZA963152B (en) | 1997-10-20 |
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