NO950849D0 - Derivater av valproin og 2-valproensyreamider og anvendelse som antikonvulsanter - Google Patents

Derivater av valproin og 2-valproensyreamider og anvendelse som antikonvulsanter

Info

Publication number
NO950849D0
NO950849D0 NO950849A NO950849A NO950849D0 NO 950849 D0 NO950849 D0 NO 950849D0 NO 950849 A NO950849 A NO 950849A NO 950849 A NO950849 A NO 950849A NO 950849 D0 NO950849 D0 NO 950849D0
Authority
NO
Norway
Prior art keywords
valproin
anticonvulsants
derivatives
acid amides
valproic acid
Prior art date
Application number
NO950849A
Other languages
English (en)
Other versions
NO950849L (no
NO308792B1 (no
Inventor
Meir Bialer
Salim Hadad
Jacob Herzig
Jeff Sterling
David Lerner
Mitchell Shirvan
Original Assignee
Yissum Res Dev Co
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Res Dev Co, Teva Pharma filed Critical Yissum Res Dev Co
Publication of NO950849D0 publication Critical patent/NO950849D0/no
Publication of NO950849L publication Critical patent/NO950849L/no
Publication of NO308792B1 publication Critical patent/NO308792B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/49—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/47—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/29—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups and acylated amino groups bound to the carbon skeleton
NO950849A 1993-07-06 1995-03-03 Derivater av valproinsyre og 2-valproensyreamider, farmasøytisk sammensetning derav og deres anvendelse for fremstilling av et farmasøytisk preparat NO308792B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/088,074 US5585358A (en) 1993-07-06 1993-07-06 Derivatives of valproic acid amides and 2-valproenoic acid amides, method of making and use thereof as anticonvulsant agents
PCT/US1994/007498 WO1995001956A1 (en) 1993-07-06 1994-07-06 Derivatives of valproic and 2-valproenoic acid amides and use as anticonvulsants

Publications (3)

Publication Number Publication Date
NO950849D0 true NO950849D0 (no) 1995-03-03
NO950849L NO950849L (no) 1995-04-26
NO308792B1 NO308792B1 (no) 2000-10-30

Family

ID=22209256

Family Applications (1)

Application Number Title Priority Date Filing Date
NO950849A NO308792B1 (no) 1993-07-06 1995-03-03 Derivater av valproinsyre og 2-valproensyreamider, farmasøytisk sammensetning derav og deres anvendelse for fremstilling av et farmasøytisk preparat

Country Status (23)

Country Link
US (1) US5585358A (no)
EP (1) EP0659174B1 (no)
JP (1) JP3856464B2 (no)
KR (1) KR100362424B1 (no)
CN (2) CN100457720C (no)
AT (1) ATE176664T1 (no)
AU (1) AU673766B2 (no)
CA (1) CA2143636C (no)
CZ (1) CZ288328B6 (no)
DE (1) DE69416501T2 (no)
DK (1) DK0659174T3 (no)
ES (1) ES2131207T3 (no)
GR (1) GR3030183T3 (no)
HK (1) HK1055726A1 (no)
HU (1) HU221968B1 (no)
IL (3) IL110216A (no)
NO (1) NO308792B1 (no)
NZ (1) NZ269643A (no)
RO (1) RO113461B1 (no)
RU (1) RU2140904C1 (no)
SK (1) SK282456B6 (no)
WO (1) WO1995001956A1 (no)
ZA (1) ZA944884B (no)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4326465A1 (de) * 1993-01-20 1995-02-09 Thomae Gmbh Dr K Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US6028102A (en) * 1998-02-24 2000-02-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Anticonvulsant drugs and pharmaceutical compositions thereof
CN1251758C (zh) * 2000-07-21 2006-04-19 特瓦制药工业有限公司 丙戊酸和2－丙基戊烯酸酰胺的衍生物在制备治疗双极情感障碍症躁狂病药物中的用途
US6323365B1 (en) * 2000-07-28 2001-11-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Active derivative of valproic acid for the treatment of neurological and psychotic disorders and a method for their preparation
IL154470A0 (en) * 2000-08-17 2003-09-17 Teva Pharma Use of derivatives of valproic acid amides and 2-valproenic acid amides for the treatment or prevention of pain and/or headache disorders
US6521790B2 (en) 2000-11-01 2003-02-18 Abbott Laboratories Alkynyl amides and their therapeutic applications
WO2002036546A2 (en) 2000-11-01 2002-05-10 Abbott Laboratories Alkynyl amides and their therapeutic applications
EP1243262B1 (en) 2001-03-20 2006-05-31 Schwarz Pharma Ag Novel use of a peptide class of compound for treating non-neuropathic inflammatory pain
ES2185606T3 (es) * 2001-03-21 2003-05-01 Sanol Arznei Schwarz Gmbh Nuevo uso de una clase de compuestos peptidicos para tratamiento de la alodinia u otros tipos diferentes de dolor cronico o fantasma.
US6958416B2 (en) * 2001-06-26 2005-10-25 Yissum Research Development Company Of The Hebrew University Of Jerusalem Valproyltaurinamide derivatives as anticonvulsant amd CNS active agents
EP1483283A4 (en) 2002-03-13 2007-04-11 Signum Biosciences Inc MODULATION OF PROTEIN METHYLATION AND PHOSPHOPROTEIN PHOSPHATE
WO2004022526A1 (en) * 2002-09-04 2004-03-18 Merck Frosst Canada & Co. Cathepsin cysteine protease inhibitors
EP1626707A4 (en) * 2003-02-05 2009-07-01 Yissum Res Dev Co CONTINUOUSLY RELEASE FORMULA OF N- (2-PROPYLPENTANOYL) GLYCINAMIDE, AND ASSOCIATED COMPOUNDS
US20040176463A1 (en) * 2003-02-05 2004-09-09 Daniella Licht Immediate release formulation of n-(2-propylpentanoyl)glycinamide
IL157751A0 (en) * 2003-02-28 2004-03-28 Yissum Res Dev Co New amide derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid, a method for their synthesis and pharmaceutical compositions containing them
ES2325995T3 (es) * 2003-12-02 2009-09-28 Schwarz Pharma Ag Nueva utilizacion de compuestos peptidicos para tratamiento del dolor neuropatico central.
US20060009384A1 (en) * 2003-12-05 2006-01-12 David Rudd Novel use of peptide compounds for treating status epilepticus or related conditions
US20070042969A1 (en) * 2004-03-26 2007-02-22 Srz Properties, Inc. Combination therapy for pain in painful diabetic neuropathy
US20100256179A1 (en) * 2004-03-26 2010-10-07 Ucb Pharma Gmbh Combination therapy for pain in painful diabetic neuropathy
EP1579858A1 (en) * 2004-03-26 2005-09-28 Schwarz Pharma Ag Novel use of peptide compounds for treating pain in painful diabetic neuropathy
KR20070007931A (ko) * 2004-04-16 2007-01-16 쉬바르츠파르마에이지 만성 두통의 예방 및 치료를 위한 펩티드 화합물의 용도
EP1604655A1 (en) 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating pain in trigeminal neuralgia
US20060025477A1 (en) * 2004-07-22 2006-02-02 Artman Linda D Analogs of isovaleramide, a pharmaceutical composition including the same, and a method of treating central nervous system conditions or diseases
KR20070045271A (ko) * 2004-08-27 2007-05-02 쉬바르츠파르마에이지 골암 통증, 화학요법- 및 뉴클레오시드- 유도 통증의치료를 위한 펩티드 화합물의 용도
EP1642889A1 (en) * 2004-10-02 2006-04-05 Schwarz Pharma Ag Improved synthesis scheme for lacosamide
US20060252749A1 (en) * 2005-01-28 2006-11-09 Srz Properties, Inc. Lacosamide for add-on therapy of psychosis
CA2601777A1 (en) 2005-02-03 2006-08-10 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
US7923041B2 (en) 2005-02-03 2011-04-12 Signum Biosciences, Inc. Compositions and methods for enhancing cognitive function
EP1754476A1 (en) * 2005-08-18 2007-02-21 Schwarz Pharma Ag Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia
US20070043120A1 (en) * 2005-08-18 2007-02-22 Bettina Beyreuther Therapeutic combination for painful medical conditions
US20080234213A1 (en) * 2005-09-02 2008-09-25 Matthias Wabl Oncogenic regulatory RNAs for diagnostics and therapeutics
EP1937236A2 (en) * 2005-09-07 2008-07-02 Braincells, Inc. Modulation of neurogenesis by hdac inhibition
US7459280B2 (en) * 2006-02-27 2008-12-02 Picobella, Llc Methods for diagnosing and treating kidney cancer
CN101466390B (zh) 2006-06-15 2014-03-12 优时比制药有限公司 用于治疗难治性癫痫持续状态的肽类化合物
EA027836B1 (ru) * 2006-06-15 2017-09-29 ЮСиБи ФАРМА ГМБХ Фармацевтическая комбинация для профилактики, облегчения и/или лечения приступов эпилепсии и ее применение
EP1873527A1 (en) * 2006-06-30 2008-01-02 Schwarz Pharma Ag Method for identifying CRMP modulators
US20080267977A1 (en) * 2007-04-26 2008-10-30 Friedrich-Alexander University Of Erlangen-Nuremberg Combined immunological agent and sensitizing agent for the treatment of cancer
ES2326355B1 (es) * 2008-02-25 2010-08-10 Centro Atlantico Del Medicamento, S.A. Acido 1-(di-n-propilacetilaminometil)-ciclohexilacetico.
JP5607025B2 (ja) 2008-04-21 2014-10-15 シグナム バイオサイエンシーズ， インコーポレイテッド 化合物、組成物およびそれらを作製する方法
EP2468261A1 (en) 2010-12-02 2012-06-27 UCB Pharma GmbH Formulation of lacosamide
SG10201913247XA (en) 2015-10-23 2020-02-27 Eureka Therapeutics Inc Antibody/t-cell receptor chimeric constructs and uses thereof
KR20200014294A (ko) 2017-04-26 2020-02-10 유레카 쎄라퓨틱스, 인코포레이티드 키메라 항체/t-세포 수용체 구축물 및 그의 용도
CN112972449B (zh) * 2019-12-18 2023-03-21 四川科瑞德制药股份有限公司 一种安全性高的药物组合物及其制备方法
WO2021245503A1 (en) * 2020-06-05 2021-12-09 Cellix Bio Private Limited Process for the preparation of eflornithine derivatives and their pharmaceutical acceptable salts thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3050800C2 (no) * 1979-03-22 1989-06-22 Continental Pharma Inc., Bruessel/Bruxelles, Be
FR2489319A1 (fr) * 1980-08-27 1982-03-05 Clin Midy Derives de l'acide amino-4 butyrique et les medicaments, actifs notamment sur le systeme nerveux central, en contenant
BE885303A (fr) * 1980-09-19 1981-03-19 Continental Pharma Glycinamides
DK373383A (da) * 1982-08-20 1984-02-21 Midit Fremgangsmaade til fremstilling af omega-aminosyrederivater
US4913906B1 (en) * 1985-02-28 2000-06-06 Yissum Res Dev Co Controlled release dosage form of valproic acid
IT1190133B (it) * 1986-06-19 1988-02-10 Chiesi Farma Spa Derivati di acido valproico e di acido (e)-2-valproenoico,procedimento per la loro preparazione e relative composizioni farmaceutiche
FR2620447B1 (fr) * 1987-09-15 1990-01-26 Sanofi Sa Procede de preparation du di-n-propylacetonitrile

Also Published As

Publication number Publication date
CA2143636A1 (en) 1995-01-19
ZA944884B (en) 1995-02-20
IL110216A0 (en) 1994-10-21
CN1111907A (zh) 1995-11-15
HU221968B1 (hu) 2003-03-28
ATE176664T1 (de) 1999-02-15
CN1106379C (zh) 2003-04-23
IL133891A (en) 2003-02-12
DK0659174T3 (da) 1999-09-20
GR3030183T3 (en) 1999-08-31
EP0659174A1 (en) 1995-06-28
SK282456B6 (sk) 2002-02-05
DE69416501T2 (de) 1999-10-21
RU95108243A (ru) 1997-03-20
DE69416501D1 (de) 1999-03-25
CA2143636C (en) 2007-05-01
RO113461B1 (ro) 1998-07-30
HUT73771A (en) 1996-09-30
IL110216A (en) 2003-05-29
SK39595A3 (en) 1995-07-11
HK1055726A1 (en) 2004-01-21
NO950849L (no) 1995-04-26
NZ269643A (en) 1996-12-20
HU9500503D0 (en) 1995-04-28
KR100362424B1 (ko) 2003-10-17
EP0659174A4 (en) 1995-09-27
NO308792B1 (no) 2000-10-30
JPH08504831A (ja) 1996-05-28
RU2140904C1 (ru) 1999-11-10
CZ288328B6 (en) 2001-05-16
US5585358A (en) 1996-12-17
WO1995001956A1 (en) 1995-01-19
CN100457720C (zh) 2009-02-04
EP0659174B1 (en) 1999-02-10
CZ85395A3 (en) 1995-11-15
ES2131207T3 (es) 1999-07-16
AU7396894A (en) 1995-02-06
IL133891A0 (en) 2001-04-30
AU673766B2 (en) 1996-11-21
JP3856464B2 (ja) 2006-12-13
CN1418869A (zh) 2003-05-21

Similar Documents

Publication Publication Date Title
NO950849D0 (no) Derivater av valproin og 2-valproensyreamider og anvendelse som antikonvulsanter
ZA926093B (en) Arylethylamine compounds, processes for the preapration thereof and pharmaceutical compositions containing them
MX9202630A (es) Derivados de sulfamato anticonvulsivos.
CA2152486A1 (en) Anticonvulsant sorbopyranose sulfamates
FI931888A (fi) Kramploesande cykliska fruktopyranossulfiter -och sulfater
ATE33838T1 (de) Thiazolidinderivate, ihre herstellung und diese enthaltende zusammensetzungen.
DK0447285T3 (da) Nephtalenderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler indeholdende dem
WO2002007677A3 (en) Use of derivatives of valproic acid and 2-valproenic acid amides for the treatment of mania in bipolar disorder
GR3023934T3 (en) New naphthalene amides and sulfonamides, process for their preparation and pharmaceutical compositions containing them
ZA984114B (en) Substituted heterocyclic compounds a process for the preparation thereof and pharmaceutical compositions containing them
IL108856A0 (en) Hydroxymethyl-furazancarboxylic acid derivatives, their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees