PE25498A1 - Compuestos de 1-fenil-2-dimetilaminometil-ciclohexan-1-ol, procedimientos para su preparacion y la aplicacion de estos compuestos en medicamentos - Google Patents

Compuestos de 1-fenil-2-dimetilaminometil-ciclohexan-1-ol, procedimientos para su preparacion y la aplicacion de estos compuestos en medicamentos

Info

Publication number
PE25498A1
PE25498A1 PE1996000875A PE00087596A PE25498A1 PE 25498 A1 PE25498 A1 PE 25498A1 PE 1996000875 A PE1996000875 A PE 1996000875A PE 00087596 A PE00087596 A PE 00087596A PE 25498 A1 PE25498 A1 PE 25498A1
Authority
PE
Peru
Prior art keywords
compounds
formula
phenyl
dimethylaminomethyl
reacted
Prior art date
Application number
PE1996000875A
Other languages
English (en)
Inventor
Ivars Graudums
Werner Winter
Edeltraud Frankus
Wolfgang Werner Alfred Strassburger
Elmar Josef Friderichs
Original Assignee
Gruenenthal Chemie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Chemie filed Critical Gruenenthal Chemie
Publication of PE25498A1 publication Critical patent/PE25498A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/64—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/52—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIEREN A COMPUESTOS DE FORMULA (I), EN DONDE PREFERIBLEMENTE LA CONFIGURACION ENTRE EL CICLO FENILICO Y EL GRUPO DIMETILAMINOMETILO SE ENCUENTRA EN POSICION TRANS; -Y=Z ES (a) -CH2-CH, (b) -CH=, o (c) -O-CH; "X" ES O o S; R1 ES H, ALQUILO C1-C6 O CICLOALQUILO C5-C7, ENTRE OTROS; R2 ES CICLOPENTILMETILO, FENILO U BENCILO OPCIONALMENTE SUSTITUIDOS, ENTRE OTROS. TAMBIEN SE REFIERE AL PROCEDIMIENTO DE PREPARACION DE (I), QUE COMPRENDE: 1) HACER REACCIONAR LA CETONA DE FORMULA (XV) EN DONDE: "A" ES CnH2n; n ES 2; 3; 4; 5 o 6 CON CLORURO DE DIMETILAMONIOMETILENO; 2) HACER REACCIONAR LA �-DIMETILAMINO CETONA OBTENIDA EN (1) CON UN COMPUESTO ORGANOMETALICO; 3) DESACETILACION POR CATALISIS PROTONICA; 4) REDUCCION HASTA UN 4-HIDROXI-DERIVADO; SI -Y=Z ES (c), ENTONCES: 5) LO OBTENIDO EN (3) SE HACE REACCIONAR CON R2-G, EN DONDE: "G" ES Cl, Br, I o TOLUENO SULFONILOXI; SI -Y=Z ES (b), ENTONCES: 6) LO OBTENIDO EN (3) SE HACE REACCIONAR CON UN COMPUESTO DE FORMULA (XX) EN DONDE: n ES 1; 2 o 3; SI -Y=Z ES (a), ENTONCES: 7) HIDROGENAR LO OBTENIDO EN (6). LOS COMPUESTOS OBTENIDOS SON ANALGESICOS NO OPIOIDES, UTILIZABLES INCLUSO EN ESTADOS DOLOROSOS EXTREMADAMENTE INTENSOS PARA LOS CUALES YA NO ES SUFICIENTE UN EFECTO OPIOIDE DE EFICACIA MEDIA
PE1996000875A 1995-12-20 1996-12-05 Compuestos de 1-fenil-2-dimetilaminometil-ciclohexan-1-ol, procedimientos para su preparacion y la aplicacion de estos compuestos en medicamentos PE25498A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19547766A DE19547766A1 (de) 1995-12-20 1995-12-20 1-Phenyl-2-dimethylaminomethyl-cyclohexan-1-ol-verbindungen als pharmazeutische Wirkstoffe

Publications (1)

Publication Number Publication Date
PE25498A1 true PE25498A1 (es) 1998-05-23

Family

ID=7780779

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1996000875A PE25498A1 (es) 1995-12-20 1996-12-05 Compuestos de 1-fenil-2-dimetilaminometil-ciclohexan-1-ol, procedimientos para su preparacion y la aplicacion de estos compuestos en medicamentos

Country Status (23)

Country Link
US (1) US5801201A (es)
EP (1) EP0780369B1 (es)
JP (1) JP3987598B2 (es)
KR (1) KR100439283B1 (es)
CN (1) CN1071309C (es)
AR (1) AR004357A1 (es)
AT (1) ATE188961T1 (es)
AU (1) AU705970B2 (es)
CA (1) CA2193337C (es)
CO (1) CO4480100A1 (es)
DE (2) DE19547766A1 (es)
DK (1) DK0780369T3 (es)
ES (1) ES2144192T3 (es)
GR (1) GR3032486T3 (es)
HK (1) HK1001860A1 (es)
HU (1) HU223340B1 (es)
IL (1) IL119864A (es)
PE (1) PE25498A1 (es)
PL (1) PL185813B1 (es)
PT (1) PT780369E (es)
RU (1) RU2167148C2 (es)
SI (1) SI0780369T1 (es)
ZA (1) ZA9610650B (es)

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DE10049483A1 (de) 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte 1-Aminobutan-3-ol-Derivate
DE10049481A1 (de) * 2000-09-29 2002-05-02 Gruenenthal Gmbh Substituierte C-Cyclohexylmethylamin-Derivate
US20050176790A1 (en) 2001-02-28 2005-08-11 Johannes Bartholomaus Pharmaceutical salts
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DE10161818A1 (de) 2001-12-14 2003-06-26 Gruenenthal Gmbh Substituierte 1,5-Diaminopentan-3-ol-Verbindungen
DE10164581A1 (de) * 2001-12-14 2003-06-26 Gruenenthal Gmbh Substituierte Aminoalkohole
DE10206405A1 (de) * 2002-02-14 2003-08-28 Gruenenthal Gmbh Synthese von substituierten Carbamidestern
DE10206403A1 (de) * 2002-02-14 2003-08-28 Gruenenthal Gmbh Synthese von Beta-Aminoketonen
DE10213051B4 (de) * 2002-03-23 2013-03-07 Grünenthal GmbH Substituierte 4-Aminocyclohexanole
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DE102004032051A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE102004019916A1 (de) * 2004-04-21 2005-11-17 Grünenthal GmbH Gegen Missbrauch gesichertes wirkstoffhaltiges Pflaster
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102005033732B4 (de) * 2005-05-27 2014-02-13 Grünenthal GmbH Trennung stereoisomerer N,N-Dialkylamino-2-alkyl-3-hydroxy-3-phenyl-alkane
DE202005014347U1 (de) 2005-09-09 2007-01-18 Grünenthal GmbH Applikationssystem für ein wirkstoffhaltiges Pflaster und Wirkstoffabgaberegulierungsmittel
SA07280459B1 (ar) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
MY153910A (en) * 2007-09-28 2015-04-15 Daiichi Sankyo Co Ltd BICYCLIC y-AMINO ACID DERIVATIVE
BRPI0906467C1 (pt) 2008-01-25 2021-05-25 Gruenenthal Gmbh forma de dosagem farmacêutica com formato exterior modificado resistente à ruptura e com liberação controlada
ES2366604T3 (es) * 2008-02-29 2011-10-21 Grünenthal GmbH Procedimiento para preparar 6-dimetilaminometil-fenil-ciclohexano-1,3-dioles.
CN102026959A (zh) * 2008-02-29 2011-04-20 格吕伦塔尔有限公司 制造(1rs，3rs，6rs)-6-二甲基氨基甲基-1-(3-甲氧基苯基)-环己烷-1，3-二醇的方法
LT2273983T (lt) 2008-05-09 2016-10-25 Grünenthal GmbH Tarpinės miltelių kompozicijos gamybos būdas ir galutinė kieta dozavimo forma naudojant purškalo kietinimo stadija
EP2456427B1 (en) 2009-07-22 2015-03-04 Grünenthal GmbH Hot-melt extruded controlled release dosage form
AU2010275754B2 (en) 2009-07-22 2014-05-15 Grünenthal GmbH Tamper-resistant dosage form for oxidation-sensitive opioids
WO2011095314A2 (en) 2010-02-03 2011-08-11 Grünenthal GmbH Preparation of a powdery pharmaceutical composition by means of an extruder
MX2013002293A (es) 2010-09-02 2013-05-09 Gruenenthal Gmbh Forma de dosificacion resistente a alteracion que comprende un polimero anionico.
WO2012028319A1 (en) 2010-09-02 2012-03-08 Grünenthal GmbH Tamper resistant dosage form comprising inorganic salt
WO2012100423A1 (en) * 2011-01-27 2012-08-02 Eli Lilly And Company Analgesic compounds, methods, and formulations
LT2736497T (lt) 2011-07-29 2017-11-10 Grünenthal GmbH Sugadinimui atspari tabletė, pasižyminti greitu vaisto atpalaidavimu
BR112014002022A2 (pt) 2011-07-29 2017-02-21 Gruenenthal Gmbh comprimido resistente à violação proporcionando liberação de fármaco imediata
US20130225697A1 (en) 2012-02-28 2013-08-29 Grunenthal Gmbh Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
AU2013248351B2 (en) 2012-04-18 2018-04-26 Grunenthal Gmbh Tamper resistant and dose-dumping resistant pharmaceutical dosage form
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
JP6466417B2 (ja) 2013-05-29 2019-02-06 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 二峰性放出プロファイルを有する改変防止（ｔａｍｐｅｒ−ｒｅｓｉｓｔａｎｔ）剤形
CA2907950A1 (en) 2013-05-29 2014-12-04 Grunenthal Gmbh Tamper-resistant dosage form containing one or more particles
EA032465B1 (ru) 2013-07-12 2019-05-31 Грюненталь Гмбх Защищенная от применения не по назначению пероральная фармацевтическая лекарственная форма, содержащая этиленвинилацетатный полимер, и способ ее изготовления
AU2014356581C1 (en) 2013-11-26 2020-05-28 Grunenthal Gmbh Preparation of a powdery pharmaceutical composition by means of cryo-milling
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CN106456550A (zh) 2014-05-26 2017-02-22 格吕伦塔尔有限公司 避免乙醇剂量倾泻的多颗粒
AU2016251854A1 (en) 2015-04-24 2017-10-19 Grunenthal Gmbh Tamper-resistant dosage form with immediate release and resistance against solvent extraction
JP2018526414A (ja) 2015-09-10 2018-09-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護
WO2019053494A1 (en) 2017-09-18 2019-03-21 R L Fine Chem Private Limited PROCESS FOR THE PREPARATION OF O-DESMETHYLTRAMADOL AND SALTS THEREOF
WO2021088758A1 (zh) * 2019-11-06 2021-05-14 复旦大学 一类阿片受体激动剂及其制备方法和药物用途
CN112759587B (zh) * 2019-11-06 2022-12-30 复旦大学 3-(二甲氨基甲基)哌啶-4-醇类衍生物及其制备方法和药物用途
CN112759544B (zh) * 2019-11-06 2022-08-26 复旦大学 3-(二甲氨基甲基)哌啶-4-醇衍生物制备方法和药物用途
CN112759545B (zh) * 2019-11-06 2022-12-13 复旦大学 3-(二甲氨基甲基)哌啶-4-醇类衍生物及其制备方法和药物用途
CN112759538B (zh) * 2019-11-06 2022-01-18 复旦大学 3-(二甲氨基甲基)环己-4-醇衍生物及其制备方法和药物用途
CN112759546B (zh) * 2019-11-06 2022-08-26 复旦大学 3-(二甲氨基甲基)哌啶-4-醇衍生物及其制备方法和药物用途

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Also Published As

Publication number Publication date
CO4480100A1 (es) 1997-07-09
AR004357A1 (es) 1998-11-04
IL119864A (en) 2004-05-12
JP3987598B2 (ja) 2007-10-10
EP0780369B1 (de) 2000-01-19
MX9606264A (es) 1997-10-31
CN1157815A (zh) 1997-08-27
IL119864A0 (en) 1997-03-18
HUP9603495A2 (en) 1997-12-29
AU705970B2 (en) 1999-06-03
PT780369E (pt) 2000-06-30
ATE188961T1 (de) 2000-02-15
HK1001860A1 (en) 1998-07-17
JPH09221460A (ja) 1997-08-26
ES2144192T3 (es) 2000-06-01
SI0780369T1 (en) 2000-04-30
PL185813B1 (pl) 2003-08-29
ZA9610650B (en) 1997-06-27
PL317595A1 (en) 1997-06-23
EP0780369A1 (de) 1997-06-25
KR19980049739A (ko) 1998-09-15
HUP9603495A3 (en) 1998-04-28
CN1071309C (zh) 2001-09-19
AU7547196A (en) 1997-06-26
HU9603495D0 (en) 1997-02-28
CA2193337C (en) 2005-09-27
US5801201A (en) 1998-09-01
GR3032486T3 (en) 2000-05-31
DE59604226D1 (de) 2000-02-24
DK0780369T3 (da) 2000-06-13
RU2167148C2 (ru) 2001-05-20
KR100439283B1 (ko) 2004-09-16
CA2193337A1 (en) 1997-06-21
HU223340B1 (hu) 2004-06-28
DE19547766A1 (de) 1997-06-26

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