PE20211096A1 - Anticuerpos anti-cd33 y metodos para usarlos - Google Patents
Anticuerpos anti-cd33 y metodos para usarlosInfo
- Publication number
- PE20211096A1 PE20211096A1 PE2021000264A PE2021000264A PE20211096A1 PE 20211096 A1 PE20211096 A1 PE 20211096A1 PE 2021000264 A PE2021000264 A PE 2021000264A PE 2021000264 A PE2021000264 A PE 2021000264A PE 20211096 A1 PE20211096 A1 PE 20211096A1
- Authority
- PE
- Peru
- Prior art keywords
- hvr
- seq
- amino acid
- acid sequence
- sequence selected
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Un anticuerpo aislado que se une a CD33, en el que el anticuerpo comprende una region variable de cadena pesada y una region variable de cadena ligera, en el que la region variable de cadena pesada comprende: un HVR-H1 que comprende una secuencia de aminoacidos seleccionada de SEQ ID NO: 8 -30, un HVR-H2 que comprende la secuencia de aminoacidos de SEQ ID NO: 33, un HVR-H3 que comprende una secuencia de aminoacidos seleccionada de SEQ ID NO: 39-40, un HVR-L1 que comprende la secuencia de aminoacidos de SEQ ID NO: 47, un HVR-L2 que comprende una secuencia de aminoacidos seleccionada de las SEC ID NO: 53-55, y un HVR-L3 que comprende una secuencia de aminoacidos seleccionada de las SEC ID NO: 58-62.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862726053P | 2018-08-31 | 2018-08-31 | |
PCT/US2019/048994 WO2020047374A1 (en) | 2018-08-31 | 2019-08-30 | Anti-cd33 antibodies and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20211096A1 true PE20211096A1 (es) | 2021-06-14 |
Family
ID=67957407
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2021000264A PE20211096A1 (es) | 2018-08-31 | 2019-08-30 | Anticuerpos anti-cd33 y metodos para usarlos |
Country Status (22)
Country | Link |
---|---|
US (1) | US20210317208A1 (es) |
EP (1) | EP3843851A1 (es) |
JP (1) | JP2021534797A (es) |
KR (1) | KR20210070986A (es) |
CN (2) | CN112912144A (es) |
AR (1) | AR119259A1 (es) |
AU (1) | AU2019331018A1 (es) |
BR (1) | BR112021003016A2 (es) |
CA (1) | CA3108808A1 (es) |
CL (1) | CL2021000501A1 (es) |
CO (1) | CO2021003078A2 (es) |
CR (1) | CR20210155A (es) |
EA (1) | EA202190235A1 (es) |
EC (1) | ECSP21022299A (es) |
IL (1) | IL281008A (es) |
MA (1) | MA53492A (es) |
MX (1) | MX2021002299A (es) |
PE (1) | PE20211096A1 (es) |
PH (1) | PH12021550332A1 (es) |
SG (1) | SG11202101552SA (es) |
TW (1) | TW202016307A (es) |
WO (1) | WO2020047374A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JOP20190248A1 (ar) | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
AU2018310985A1 (en) | 2017-08-03 | 2019-11-07 | Alector Llc | Anti-CD33 antibodies and methods of use thereof |
WO2023081898A1 (en) | 2021-11-08 | 2023-05-11 | Alector Llc | Soluble cd33 as a biomarker for anti-cd33 efficacy |
CN115724959B (zh) * | 2022-11-11 | 2023-06-20 | 杭州华葵金配生物科技有限公司 | 靶向甲型流感病毒核蛋白的抗体及其应用 |
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-
2019
- 2019-08-30 SG SG11202101552SA patent/SG11202101552SA/en unknown
- 2019-08-30 CA CA3108808A patent/CA3108808A1/en active Pending
- 2019-08-30 JP JP2021511561A patent/JP2021534797A/ja active Pending
- 2019-08-30 TW TW108131323A patent/TW202016307A/zh unknown
- 2019-08-30 BR BR112021003016-6A patent/BR112021003016A2/pt not_active Application Discontinuation
- 2019-08-30 KR KR1020217009223A patent/KR20210070986A/ko active Search and Examination
- 2019-08-30 MA MA053492A patent/MA53492A/fr unknown
- 2019-08-30 MX MX2021002299A patent/MX2021002299A/es unknown
- 2019-08-30 AR ARP190102478A patent/AR119259A1/es unknown
- 2019-08-30 CR CR20210155A patent/CR20210155A/es unknown
- 2019-08-30 PE PE2021000264A patent/PE20211096A1/es unknown
- 2019-08-30 WO PCT/US2019/048994 patent/WO2020047374A1/en unknown
- 2019-08-30 US US17/272,083 patent/US20210317208A1/en active Pending
- 2019-08-30 AU AU2019331018A patent/AU2019331018A1/en not_active Abandoned
- 2019-08-30 CN CN201980070570.9A patent/CN112912144A/zh active Pending
- 2019-08-30 EA EA202190235A patent/EA202190235A1/ru unknown
- 2019-08-30 EP EP19769302.1A patent/EP3843851A1/en active Pending
- 2019-08-30 CN CN202110955735.XA patent/CN113801229A/zh active Pending
-
2021
- 2021-02-16 PH PH12021550332A patent/PH12021550332A1/en unknown
- 2021-02-21 IL IL281008A patent/IL281008A/en unknown
- 2021-02-26 CL CL2021000501A patent/CL2021000501A1/es unknown
- 2021-03-09 CO CONC2021/0003078A patent/CO2021003078A2/es unknown
- 2021-03-30 EC ECSENADI202122299A patent/ECSP21022299A/es unknown
Also Published As
Publication number | Publication date |
---|---|
MA53492A (fr) | 2021-09-15 |
ECSP21022299A (es) | 2021-04-29 |
CN112912144A (zh) | 2021-06-04 |
WO2020047374A1 (en) | 2020-03-05 |
KR20210070986A (ko) | 2021-06-15 |
PH12021550332A1 (en) | 2021-10-04 |
MX2021002299A (es) | 2021-04-28 |
EA202190235A1 (ru) | 2021-07-02 |
JP2021534797A (ja) | 2021-12-16 |
TW202016307A (zh) | 2020-05-01 |
AR119259A1 (es) | 2021-12-09 |
BR112021003016A2 (pt) | 2021-05-18 |
CO2021003078A2 (es) | 2021-03-19 |
IL281008A (en) | 2021-04-29 |
SG11202101552SA (en) | 2021-03-30 |
CN113801229A (zh) | 2021-12-17 |
AU2019331018A1 (en) | 2021-03-11 |
CL2021000501A1 (es) | 2021-07-23 |
CA3108808A1 (en) | 2020-03-05 |
EP3843851A1 (en) | 2021-07-07 |
CR20210155A (es) | 2021-05-10 |
US20210317208A1 (en) | 2021-10-14 |
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