PE20210114A1 - .COMPOSICIONES DE ARNi CONTRA EL ANGIOTENSINOGENO (AGT) Y METODOS PARA SU USO - Google Patents

.COMPOSICIONES DE ARNi CONTRA EL ANGIOTENSINOGENO (AGT) Y METODOS PARA SU USO

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Publication number
PE20210114A1
PE20210114A1 PE2020001865A PE2020001865A PE20210114A1 PE 20210114 A1 PE20210114 A1 PE 20210114A1 PE 2020001865 A PE2020001865 A PE 2020001865A PE 2020001865 A PE2020001865 A PE 2020001865A PE 20210114 A1 PE20210114 A1 PE 20210114A1
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PE
Peru
Prior art keywords
agt
methods
compositions against
rnai compositions
angiotensinogen
Prior art date
Application number
PE2020001865A
Other languages
English (en)
Inventor
Donald Foster
Gregory Hinkle
Mark K Schlegel
Original Assignee
Alnylam Pharmaceuticals Inc
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Publication date
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of PE20210114A1 publication Critical patent/PE20210114A1/es

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/312—Phosphonates
    • C12N2310/3125—Methylphosphonates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/322—2'-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/343—Spatial arrangement of the modifications having patterns, e.g. ==--==--==--
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
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  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invencion se relaciona con agentes de ARNi, por ejemplo, agentes de ARN de hebra doble (ARNhd), dirigidos contra el gen AGT. La invencion ademas se relaciona con metodos para usar dichos agentes de ARNi para inhibir la expresion de un gen AGT y con metodos para prevenir y tratar un trastorno asociado con AGT, por ejemplo, presion arterial elevada
PE2020001865A 2018-05-14 2019-05-14 .COMPOSICIONES DE ARNi CONTRA EL ANGIOTENSINOGENO (AGT) Y METODOS PARA SU USO PE20210114A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862671094P 2018-05-14 2018-05-14
US201862727141P 2018-09-05 2018-09-05
US201962816996P 2019-03-12 2019-03-12
PCT/US2019/032150 WO2019222166A1 (en) 2018-05-14 2019-05-14 Angiotensinogen (agt) irna compositions and methods of use thereof

Publications (1)

Publication Number Publication Date
PE20210114A1 true PE20210114A1 (es) 2021-01-19

Family

ID=66770566

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2020001865A PE20210114A1 (es) 2018-05-14 2019-05-14 .COMPOSICIONES DE ARNi CONTRA EL ANGIOTENSINOGENO (AGT) Y METODOS PARA SU USO

Country Status (27)

Country Link
US (3) US11015201B2 (es)
EP (2) EP3794122B1 (es)
JP (2) JP7346460B2 (es)
KR (1) KR20210010529A (es)
CN (4) CN118685406A (es)
AU (1) AU2019269418A1 (es)
BR (1) BR112020022943A2 (es)
CA (1) CA3100003A1 (es)
CL (3) CL2020002865A1 (es)
CO (1) CO2020015314A2 (es)
DK (1) DK3794122T5 (es)
ES (1) ES2967713T3 (es)
FI (1) FI3794122T3 (es)
HR (1) HRP20231412T1 (es)
HU (1) HUE064073T2 (es)
IL (2) IL292877B2 (es)
LT (1) LT3794122T (es)
MX (1) MX2020012048A (es)
PE (1) PE20210114A1 (es)
PH (1) PH12020551904A1 (es)
PL (1) PL3794122T3 (es)
PT (1) PT3794122T (es)
RS (1) RS64812B1 (es)
SG (1) SG11202011144QA (es)
SI (1) SI3794122T1 (es)
WO (1) WO2019222166A1 (es)
ZA (1) ZA202108348B (es)

Families Citing this family (17)

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MX2016015126A (es) 2014-05-22 2017-02-23 Alnylam Pharmaceuticals Inc Composiciones de angiotensinogeno (agt) arni y metodos de uso de las mismas.
CN118685406A (zh) 2018-05-14 2024-09-24 阿尔尼拉姆医药品有限公司 血管紧张素原(AGT)iRNA组合物及其使用方法
CA3161703A1 (en) * 2019-11-13 2021-05-20 Alnylam Pharmaceuticals, Inc. Methods and compositions for treating an angiotensinogen- (agt-) associated disorder
WO2021231552A1 (en) * 2020-05-12 2021-11-18 Duke University Compositions and methods for controlling blood pressure
WO2023014765A1 (en) * 2021-08-04 2023-02-09 Alnylam Pharmaceuticals, Inc. iRNA COMPOSITIONS AND METHODS FOR SILENCING ANGIOTENSINOGEN (AGT)
CN113862268A (zh) * 2021-10-20 2021-12-31 厦门甘宝利生物医药有限公司 Agt抑制剂及其用途
CR20240196A (es) * 2021-11-16 2024-07-08 Shanghai Argo Biopharmaceutical Co Ltd Composiciones y métodos para inhibir la expresión de la proteína angiotensinógeno (agt)
KR20240107327A (ko) * 2021-11-19 2024-07-09 투오지에 바이오텍 (상하이) 컴퍼니 리미티드 안지오텐시노겐을 표적으로 하는 siRNA 및 이의 의약적 용도
CN118541487A (zh) * 2022-01-20 2024-08-23 上海拓界生物医药科技有限公司 一种dsRNA、其应用及制备方法
WO2023155909A1 (zh) * 2022-02-18 2023-08-24 南京明德新药研发有限公司 三氮唑核苷类似物及其作为嵌入基团的应用
AU2023245480A1 (en) * 2022-04-01 2024-10-10 Adarx Pharmaceuticals, Inc. Angiotensinogen-modulating compositions and methods of use thereof
WO2023208128A1 (zh) * 2022-04-29 2023-11-02 南京明德新药研发有限公司 一类含核苷酸类似物的双链RNAi类似物的缀合物
CN117264948B (zh) * 2022-06-14 2024-05-10 广州必贝特医药股份有限公司 抑制血管紧张素原基因表达的RNAi抑制剂及其应用
WO2024013334A1 (en) * 2022-07-15 2024-01-18 Silence Therapeutics Gmbh Nucleic acids for inhibiting expression of agt in a cell
US20240052348A1 (en) * 2022-08-05 2024-02-15 Sanegene Bio Usa Inc. Double stranded rna targeting angiotensinogen (agt) and methods of use thereof
WO2024168010A2 (en) 2023-02-09 2024-08-15 Alnylam Pharmaceuticals, Inc. Reversir molecules and methods of use thereof
CN118685411A (zh) * 2024-08-27 2024-09-24 苏州炫景生物科技有限公司 抑制agt基因表达的双链寡核苷酸、其缀合物及用途

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