PE20160679A1 - Inhibidores de pirimidina del fgfr4 - Google Patents

Inhibidores de pirimidina del fgfr4

Info

Publication number
PE20160679A1
PE20160679A1 PE2016000460A PE2016000460A PE20160679A1 PE 20160679 A1 PE20160679 A1 PE 20160679A1 PE 2016000460 A PE2016000460 A PE 2016000460A PE 2016000460 A PE2016000460 A PE 2016000460A PE 20160679 A1 PE20160679 A1 PE 20160679A1
Authority
PE
Peru
Prior art keywords
phenyl
fgfr4
methyl
hydrogen
compounds
Prior art date
Application number
PE2016000460A
Other languages
English (en)
Inventor
Ming-Hong Hao
Sudeep Prajapati
John Wang
Takashi Satoh
Anand Selvaraj
Dominic Reynolds
Original Assignee
Eisai Randd Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Randd Man Co Ltd filed Critical Eisai Randd Man Co Ltd
Publication of PE20160679A1 publication Critical patent/PE20160679A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/16—Halogenated acetic acids
    • C07C53/18—Halogenated acetic acids containing fluorine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Se refiere a compuestos de formula (I) donde: R3 es alquilo C1-C6, alcoxi C1-C6 - alquilo C1-C6, entre otros; E es –NR13C(O)CR14=CHR15, entre otros, siendo R13 hidrogeno o metilo, R14 y R15 son hidrogeno, metilo, entre otros; R12 es hidrogeno, halo, entre otros; R1 es fenilo sustituido de 2 a 4 veces por halo o alcoxi C1-C6. Son compuestos especificos: N-[2-{6-[3-(2,6-dicloro-3,5-dimetoxi-feniI)-1-metil-ureido-pirimidin-4-ilamino}-fenil)-acrilamida; N-[2-{6-[3-(2,6-dicloro-3,5-dimetoxi-fenil)-1-piridin-3-ilmetil-ureido]- pirimidin-4-ilamino}-fenil-acrilamida, entre otros. Tambien se refiere a una composicion farmaceutica y un metodo de tratamiento. Dichos compuestos son inhibidores de FGFR4 siendo utiles en el tratamiento de carcinoma hepatocelular
PE2016000460A 2013-10-18 2014-10-16 Inhibidores de pirimidina del fgfr4 PE20160679A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361892881P 2013-10-18 2013-10-18

Publications (1)

Publication Number Publication Date
PE20160679A1 true PE20160679A1 (es) 2016-08-04

Family

ID=51842899

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2016000460A PE20160679A1 (es) 2013-10-18 2014-10-16 Inhibidores de pirimidina del fgfr4

Country Status (33)

Country Link
US (4) US9434697B2 (es)
EP (2) EP3421457B1 (es)
JP (2) JP6139788B2 (es)
KR (1) KR101826015B1 (es)
CN (2) CN105899490B (es)
AR (1) AR098048A1 (es)
AU (2) AU2014337291B9 (es)
BR (1) BR112016008110B1 (es)
CA (1) CA2924206C (es)
CL (1) CL2016000918A1 (es)
CY (1) CY1121129T1 (es)
DK (1) DK3057943T3 (es)
ES (1) ES2679521T3 (es)
HK (1) HK1223091A1 (es)
HR (1) HRP20181129T1 (es)
HU (1) HUE039268T2 (es)
IL (1) IL244373B (es)
JO (1) JO3515B1 (es)
LT (1) LT3057943T (es)
MX (1) MX2016004933A (es)
MY (1) MY184733A (es)
NZ (1) NZ717559A (es)
PE (1) PE20160679A1 (es)
PH (1) PH12016500676A1 (es)
PL (1) PL3057943T3 (es)
PT (1) PT3057943T (es)
RS (1) RS57444B1 (es)
RU (1) RU2715708C2 (es)
SG (1) SG11201602069WA (es)
SI (1) SI3057943T1 (es)
TW (1) TWI597268B (es)
UA (1) UA116920C2 (es)
WO (2) WO2015057938A1 (es)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8754114B2 (en) 2010-12-22 2014-06-17 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
ME03300B (me) 2012-06-13 2019-07-20 Incyte Holdings Corp Supsтituisana triciklična jedinjenja као inhibiтori fgfr
DK2872491T3 (da) 2012-07-11 2021-08-09 Blueprint Medicines Corp Inhibitorer af fibroblastvækstfaktorreceptoren
WO2014026125A1 (en) 2012-08-10 2014-02-13 Incyte Corporation Pyrazine derivatives as fgfr inhibitors
US9321786B2 (en) 2013-03-15 2016-04-26 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
CN111793068A (zh) 2013-03-15 2020-10-20 西建卡尔有限责任公司 杂芳基化合物和其用途
EP3943087A1 (en) 2013-03-15 2022-01-26 Celgene CAR LLC Heteroaryl compounds and uses thereof
DK2986610T5 (en) 2013-04-19 2018-12-10 Incyte Holdings Corp BICYCLIC HETEROCYCLES AS FGFR INHIBITORS
TWI597268B (zh) 2013-10-18 2017-09-01 衛材Ｒ＆Ｄ企管股份有限公司 纖維母細胞受體４（ｆｇｆｒ４）抑制劑
SG11201602183QA (en) 2013-10-25 2016-05-30 Novartis Ag Ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors
JP6458023B2 (ja) 2013-10-25 2019-01-23 ブループリント メディシンズ コーポレイション 繊維芽細胞成長因子受容体の阻害剤
US9695165B2 (en) 2014-01-15 2017-07-04 Blueprint Medicines Corporation Inhibitors of the fibroblast growth factor receptor
EP3200786B1 (en) 2014-10-03 2019-08-28 Novartis AG Use of ring-fused bicyclic pyridyl derivatives as fgfr4 inhibitors
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
EA038045B1 (ru) 2015-02-20 2021-06-28 Инсайт Корпорейшн Бициклические гетероциклы в качестве ингибиторов fgfr
WO2016134294A1 (en) 2015-02-20 2016-08-25 Incyte Corporation Bicyclic heterocycles as fgfr4 inhibitors
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
US9802917B2 (en) 2015-03-25 2017-10-31 Novartis Ag Particles of N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((4-methyl-2-oxopiperazin-1-yl)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide
WO2016164703A1 (en) * 2015-04-09 2016-10-13 Eisai R & D Management Co., Ltd. Fgfr4 inhibitors
ES2864712T3 (es) * 2015-04-14 2021-10-14 Eisai R&D Man Co Ltd Compuesto inhibidor de FGFR4 cristalino y usos del mismo
EP3325469A4 (en) * 2015-07-20 2019-01-23 Dana Farber Cancer Institute, Inc. NOVEL PYRIMIDINES USEFUL AS EGFR INHIBITORS AND METHODS OF TREATING DISORDERS
CN108348519A (zh) * 2015-07-20 2018-07-31 台北医学大学 经氯苯取代的氮杂芳基化合物
CN105418441A (zh) * 2015-12-22 2016-03-23 中国工程物理研究院化工材料研究所 2,3-二氯-4-羟基苯胺的制备方法
US10934311B2 (en) 2016-01-08 2021-03-02 Hangzhou Innogate Pharma Co., Ltd. Heterocyclic compound used as FGFR inhibitor
WO2017196854A1 (en) * 2016-05-10 2017-11-16 Eisai R&D Management Co., Ltd. Drug combinations for reducing cell viability and/or cell proliferation
CN108884097B (zh) * 2016-05-20 2021-05-28 浙江海正药业股份有限公司 嘧啶类衍生物、其制备方法和其在医药上的用途
CN107400092B (zh) * 2016-05-20 2021-08-24 浙江海正药业股份有限公司 嘧啶类衍生物及其制备方法和其在医药上的用途
CN105884760B (zh) * 2016-06-13 2019-01-04 厦门市蔚嘉化学科技有限公司 一种可比司他中间体的制备方法
CN109803684B (zh) * 2016-08-23 2022-08-23 卫材 R&D 管理有限公司 用于治疗肝细胞癌的组合疗法
CN110022900A (zh) 2016-09-08 2019-07-16 蓝图药品公司 成纤维细胞生长因子受体4抑制剂与细胞周期蛋白依赖性激酶抑制剂的组合
WO2018055503A1 (en) 2016-09-20 2018-03-29 Novartis Ag Combination comprising a pd-1 antagonist and an fgfr4 inhibitor
RU2742033C2 (ru) 2016-11-02 2021-02-01 Новартис Аг Комбинации ингибиторов fgfr4 и секвестрантов желчных кислот
JP7063899B2 (ja) * 2016-11-17 2022-05-09 グアンドン ジョンシェン ファーマシューティカル カンパニー リミテッド Ｆｇｆｒ４阻害剤、その製造方法及び使用
KR101812266B1 (ko) 2016-11-25 2017-12-27 한국과학기술연구원 4-((2-아크릴아미도페닐)아미노)티에노[3,2-d]피리미딘-7-카복스아미드 유도체 및 그의 약학적 활용
CN108239069B (zh) * 2016-12-26 2021-01-05 南京药捷安康生物科技有限公司 一种用于成纤维细胞生长因子受体的抑制剂及其用途
CN108503593B (zh) * 2017-02-28 2021-04-27 暨南大学 2-氨基嘧啶类化合物及其应用
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
EP3663285B1 (en) * 2017-08-04 2024-01-24 Abbisko Therapeutics Co., Ltd. Formylpyridine derivative having fgfr4 inhibitory activity, preparation method therefor and use thereof
CN109422760B (zh) * 2017-09-01 2022-05-27 南京圣和药物研发有限公司 Fgfr4抑制剂及其应用
US11279697B2 (en) 2017-09-05 2022-03-22 Bioardis Llc Aromatic derivative, preparation method for same, and medical applications thereof
EP3737377A1 (en) 2018-01-10 2020-11-18 Eisai R&D Management Co., Ltd. Combination therapies for the treatment of hepatocellular carcinoma
EA202092649A1 (ru) 2018-05-04 2021-06-21 Инсайт Корпорейшн Соли ингибитора fgfr
US11466004B2 (en) 2018-05-04 2022-10-11 Incyte Corporation Solid forms of an FGFR inhibitor and processes for preparing the same
CN112313207B (zh) * 2018-06-22 2023-02-14 北京赛特明强医药科技有限公司 一种氰基取代吡啶及氰基取代嘧啶类化合物、制备方法及其应用
WO2020177067A1 (en) 2019-03-05 2020-09-10 Bioardis Llc Aromatic derivatives, preparation methods, and medical uses thereof
US11628162B2 (en) 2019-03-08 2023-04-18 Incyte Corporation Methods of treating cancer with an FGFR inhibitor
LT3966206T (lt) 2019-05-10 2023-11-10 Deciphera Pharmaceuticals, Llc Heteroarilaminopirimidino amido autofagijos inhibitoriai ir jų naudojimo būdai
EP3966207B1 (en) 2019-05-10 2023-11-01 Deciphera Pharmaceuticals, LLC Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof
EP3983081A1 (en) 2019-06-17 2022-04-20 Deciphera Pharmaceuticals, LLC Aminopyrimidine amide autophagy inhibitors and methods of use thereof
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
CN112341344B (zh) * 2019-08-09 2021-10-26 上海喀露蓝科技有限公司 一种激酶抑制剂中间体的制备方法
IL291901A (en) 2019-10-14 2022-06-01 Incyte Corp Bicyclyl heterocycles as fgr suppressors
WO2021076728A1 (en) 2019-10-16 2021-04-22 Incyte Corporation Bicyclic heterocycles as fgfr inhibitors
WO2021113479A1 (en) 2019-12-04 2021-06-10 Incyte Corporation Tricyclic heterocycles as fgfr inhibitors
KR20220131900A (ko) 2019-12-04 2022-09-29 인사이트 코포레이션 Fgfr 억제제의 유도체
TWI781497B (zh) * 2019-12-23 2022-10-21 大陸商北京賽特明強醫藥科技有限公司 氰基取代吡啶及氰基取代嘧啶類化合物、製備方法及其應用
JP2023533903A (ja) 2020-05-15 2023-08-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 Ｆｇｆｒ４阻害剤の経口製剤によるがんの治療方法
US20230172867A1 (en) 2020-05-15 2023-06-08 Eisai R&D Management Co., Ltd. A method for treating cancer with an oral dosage form of an fgfr4 inhibitor
TW202228692A (zh) 2020-10-05 2022-08-01 日商凱依歐姆 生物科學股份有限公司 癌症治療用醫藥
AR126102A1 (es) 2021-06-09 2023-09-13 Incyte Corp Heterociclos tricíclicos como inhibidores de fgfr
CN115490670A (zh) * 2021-06-17 2022-12-20 浙江海正药业股份有限公司 Fgfr4选择性抑制剂的盐及其制备方法和用途
CN115504965A (zh) 2021-06-23 2022-12-23 浙江海正药业股份有限公司 嘧啶类衍生物的晶型及其制备方法
CN114276266A (zh) * 2021-12-30 2022-04-05 兰州康鹏威耳化工有限公司 一种4-氨基-2-氟苯甲酰胺的制备方法
CN114560815A (zh) * 2022-03-04 2022-05-31 北京工业大学 (2-((5-氯-取代苯基氨基嘧啶-2-基)氨基)苯基)氨基甲酸叔丁酯类衍生物
CN114835640B (zh) * 2022-05-24 2024-02-13 中国药科大学 成纤维细胞生长因子受体抑制剂、制备方法及应用

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3881320D1 (de) * 1987-09-28 1993-07-01 Ciba Geigy Ag Schaedlingsbekaempfungsmittel.
ID27589A (id) 1998-05-26 2001-04-12 Warner Lambert Comapny Pirimidina bisiklik dan dihidropirimidina bisiklik 3,4 sebagai penghambat proliferasi selular
GB0103926D0 (en) 2001-02-17 2001-04-04 Astrazeneca Ab Chemical compounds
AU2003285012A1 (en) 2002-10-24 2004-05-13 Sepracor, Inc. Compositions comprising zopiclone derivatives and methods of making and using the same
MXPA06001098A (es) 2003-07-29 2006-04-24 Irm Llc Compuestos y composiciones utiles como inhibidores de proteina cinasa.
GB0512324D0 (en) * 2005-06-16 2005-07-27 Novartis Ag Organic compounds
WO2006038112A1 (en) 2004-10-01 2006-04-13 Warner-Lambert Company Llc Use of kinase inhibitors to promote neochondrogenesis
KR101406956B1 (ko) 2005-12-21 2014-06-13 노파르티스 아게 Ｆｇｆ 억제제로서의 피리미디닐 아릴 우레아 유도체
EP1918376A1 (en) 2006-11-03 2008-05-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. FGFR4 promotes cancer cell resistance in response to chemotherapeutic drugs
CA2702647C (en) * 2007-01-31 2016-03-22 Ym Biosciences Australia Pty Ltd Thiopyrimidine-based compounds and uses thereof
US20090062320A1 (en) 2007-08-28 2009-03-05 Vito Guagnano Method of Treating Disorders Mediated by the Fibroblast Growth Factor Receptor
ES2711249T3 (es) 2008-06-27 2019-04-30 Celgene Car Llc Compuestos de heteroarilo y usos de los mismos
AR079257A1 (es) * 2009-12-07 2012-01-04 Novartis Ag Formas cristalinas de 3-(2,6-dicloro-3-5-dimetoxi-fenil)-1-{6-[4-(4-etil-piperazin-1-il)-fenil-amino]-pirimidin-4-il}-1-metil-urea y sales de las mismas
EP2519517B1 (en) 2009-12-29 2015-03-25 Dana-Farber Cancer Institute, Inc. Type ii raf kinase inhibitors
AU2011205297A1 (en) 2010-01-14 2012-06-28 Yale University Inhibitors of receptor tyrosine kinases (RTK) and methods of use thereof
WO2011153553A2 (en) 2010-06-04 2011-12-08 The Regents Of The University Of California Methods and compositions for kinase inhibition
WO2012136732A1 (en) 2011-04-08 2012-10-11 Ab Science Treatment of multiple myeloma with masitinib
CN102816162B (zh) 2011-06-10 2016-04-27 中国科学院广州生物医药与健康研究院 嘧啶并嘧啶酮类化合物及其药用组合物和应用
RU2014133547A (ru) 2012-01-18 2016-03-10 Дженентек, Инк. Способы применения модуляторов fgf19
CN104144915B (zh) 2012-02-28 2016-08-24 安斯泰来制药有限公司 含氮芳香族杂环化合物
DK2872491T3 (da) 2012-07-11 2021-08-09 Blueprint Medicines Corp Inhibitorer af fibroblastvækstfaktorreceptoren
CN111793068A (zh) * 2013-03-15 2020-10-20 西建卡尔有限责任公司 杂芳基化合物和其用途
US10138256B2 (en) * 2013-03-15 2018-11-27 Celgene Car Llc MK2 inhibitors and uses thereof
US9783504B2 (en) 2013-07-09 2017-10-10 Dana-Farber Cancer Institute, Inc. Kinase inhibitors for the treatment of disease
TW201605452A (zh) 2013-08-28 2016-02-16 安斯泰來製藥股份有限公司 以嘧啶化合物作爲有效成分之醫藥組成物
TWI597268B (zh) * 2013-10-18 2017-09-01 衛材Ｒ＆Ｄ企管股份有限公司 纖維母細胞受體４（ｆｇｆｒ４）抑制劑
JP6458023B2 (ja) 2013-10-25 2019-01-23 ブループリント メディシンズ コーポレイション 繊維芽細胞成長因子受容体の阻害剤
US9695165B2 (en) 2014-01-15 2017-07-04 Blueprint Medicines Corporation Inhibitors of the fibroblast growth factor receptor
CN108884097B (zh) 2016-05-20 2021-05-28 浙江海正药业股份有限公司 嘧啶类衍生物、其制备方法和其在医药上的用途
JP7103952B2 (ja) 2016-05-20 2022-07-20 江▲蘇▼豪森▲薬▼▲業▼集▲団▼有限公司 Ｆｇｆｒ４阻害剤、その製造方法及び応用

Also Published As

Publication number Publication date
AU2014337291B9 (en) 2020-05-07
AR098048A1 (es) 2016-04-27
NZ717559A (en) 2021-07-30
IL244373A0 (en) 2016-04-21
RS57444B1 (sr) 2018-09-28
CN105899490A (zh) 2016-08-24
RU2715708C2 (ru) 2020-03-03
CY1121129T1 (el) 2019-12-11
WO2015057938A1 (en) 2015-04-23
CA2924206C (en) 2022-10-25
IL244373B (en) 2018-10-31
TWI597268B (zh) 2017-09-01
US9730931B2 (en) 2017-08-15
JO3515B1 (ar) 2020-07-05
HRP20181129T1 (hr) 2018-09-21
AU2014337291A1 (en) 2016-03-17
EP3421457B1 (en) 2021-10-06
KR101826015B1 (ko) 2018-02-06
US9434697B2 (en) 2016-09-06
KR20160072113A (ko) 2016-06-22
DK3057943T3 (en) 2018-07-30
MY184733A (en) 2021-04-20
ES2679521T3 (es) 2018-08-28
JP2017160233A (ja) 2017-09-14
US10912774B2 (en) 2021-02-09
BR112016008110B1 (pt) 2019-07-02
PL3057943T3 (pl) 2018-09-28
JP6139788B2 (ja) 2017-05-31
AU2018271284A1 (en) 2018-12-20
EP3057943A1 (en) 2016-08-24
RU2016118981A3 (es) 2018-06-25
PT3057943T (pt) 2018-07-24
PH12016500676A1 (en) 2016-05-30
CN105899490B (zh) 2019-07-23
US10537571B2 (en) 2020-01-21
HUE039268T2 (hu) 2018-12-28
CA2924206A1 (en) 2015-04-23
UA116920C2 (uk) 2018-05-25
EP3057943B1 (en) 2018-04-25
CL2016000918A1 (es) 2016-11-11
HK1223091A1 (zh) 2017-07-21
TW201605802A (zh) 2016-02-16
SI3057943T1 (en) 2018-08-31
SG11201602069WA (en) 2016-04-28
AU2014337291B2 (en) 2018-12-13
US20170007601A1 (en) 2017-01-12
WO2015057963A1 (en) 2015-04-23
US20200206222A1 (en) 2020-07-02
RU2016118981A (ru) 2017-11-23
LT3057943T (lt) 2018-11-12
CN110354128A (zh) 2019-10-22
MX2016004933A (es) 2016-12-20
AU2018271284B2 (en) 2020-05-28
JP2016535000A (ja) 2016-11-10
US20160130237A1 (en) 2016-05-12
US20170360785A1 (en) 2017-12-21
EP3421457A1 (en) 2019-01-02

Similar Documents

Publication Publication Date Title
PE20160679A1 (es) Inhibidores de pirimidina del fgfr4
EA201391822A1 (ru) Новые производные пиридина
PE20170004A1 (es) Inhibidores de biaril cinasa
PE20140245A1 (es) Compuesto de furo[3,2-d]pirimidina
EA201391290A1 (ru) Гетероциклические модуляторы синтеза липидов
PE20140502A1 (es) Pirimidinas sustituidas de diaminocarboxamida y diaminocarbonitrilo, composiciones de las mismas y metodos de tratamiento con las mismas
NZ716420A (en) Fused heterocyclic compounds as sodium channel modulators
PE20091458A1 (es) Compuestos heterociclicos antiviricos
NZ715838A (en) Pyridines, pyrimidines, and pyrazines, as btk inhibitors and uses thereof
EA201300873A1 (ru) Производные 7-азаиндола
MX2016002368A (es) Compuestos de sulfonamida heterociclica sustituida utiles como moduladores del canal del receptor de potencial transitorio a1 (trpa1).
NZ630099A (en) Phenicol antibacterials
RS54205B1 (en) L-PROLINE AND CO-CRYSTALS OF LUMIC ACID OF (2S, 3R, 4R, 5S, 6R) -2- (3 ((5- (4-FLUOROPHENYL) THIOPHEN-2-IL) METHYL-4-METHYLPHENYL) -6- (HYDROXYMETHYL) TETRAHYDRO-2H-PYRAN-3, 4, 5-TRIOLA
EA201291357A1 (ru) Способы лечения с применением ингибиторов tlr7 и/или tlr9
ECSP14030538A (es) Inhibidores de dgat1 de éter cíclico de cabeza de puente
MX347692B (es) Inhibidores del virus de la hepatitis c.
EA201100921A1 (ru) Соединения, фармацевтические композиции и способы их применения при лечении нарушений обмена веществ
EA201170653A1 (ru) Концентрированный шампунь
EA201691244A1 (ru) Фармацевтическая композиция, содержащая соединение пиридиламиноуксусной кислоты
MX2013011124A (es) Compuestos para el tratamiento del sindrome metabolico.
MX2013001234A (es) Derivados deuterados de tandospirona como agonistas del receptor 5-hidroxitriptamina 1a.
PE20170669A1 (es) Compuesto heterociclico
PH12019500467A1 (en) Benzo-fused heterocyclic derivatives useful agonists of gpr120
UA115158C2 (uk) Теплопровідний пластик
EA201500821A1 (ru) Производные 2-замещенных-6-биарилметиламино-9-циклопентил-9н-пуринов, их использование в качестве лекарственных средств и фармацевтических составов