PE20160508A1 - Diacuerpos fc monovalentes biespecificos que son capaces de unirse a cd32b y cd79b y usos de los mismos - Google Patents

Diacuerpos fc monovalentes biespecificos que son capaces de unirse a cd32b y cd79b y usos de los mismos

Info

Publication number
PE20160508A1
PE20160508A1 PE2016000227A PE2016000227A PE20160508A1 PE 20160508 A1 PE20160508 A1 PE 20160508A1 PE 2016000227 A PE2016000227 A PE 2016000227A PE 2016000227 A PE2016000227 A PE 2016000227A PE 20160508 A1 PE20160508 A1 PE 20160508A1
Authority
PE
Peru
Prior art keywords
cd32b
cd79b
binding
diabodies
bispecific monovalent
Prior art date
Application number
PE2016000227A
Other languages
English (en)
Inventor
Paul A Moore
Wei Chen
Leslie S Johnson
Kalpana Shah
Ling Huang
Ezio Bonvini
Original Assignee
Macrogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Macrogenics Inc filed Critical Macrogenics Inc
Publication of PE20160508A1 publication Critical patent/PE20160508A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624—Disulfide-stabilized antibody (dsFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)

Abstract

La presente invencion se refiere a diacuerpos monovalentes biespecificos que incluyen un dominio Fc de inmunoglobulina (“diacuerpos Fc monovalentes biespecificos”) y se componen de tres cadenas de polipeptidos y que poseen al menos un sitio de union especifico para un epitope de CD32B y un sitio de union especifico para un epitope de CD79b (p. ej, un “diacuerpo Fc monovalente biespecifico CD32B x CD79b”). Los diacuerpos Fc monovalentes biespecificos del presente invento son capaces de unirse simultaneamente a CD32B y CD79b. El invento se dirige a dichas composiciones, a composiciones farmaceuticas que contienen dichos diacuerpos Fc monovalentes biespecificos y a metodos para su uso en el tratamiento de enfermedades o trastornos inflamatorios, y en particular, lupus eritematoso sistemico (SLE) y enfermedad de injerto contra huesped
PE2016000227A 2013-08-09 2014-08-06 Diacuerpos fc monovalentes biespecificos que son capaces de unirse a cd32b y cd79b y usos de los mismos PE20160508A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361864217P 2013-08-09 2013-08-09
US201361866416P 2013-08-15 2013-08-15
US201361869519P 2013-08-23 2013-08-23
US201361907525P 2013-11-22 2013-11-22

Publications (1)

Publication Number Publication Date
PE20160508A1 true PE20160508A1 (es) 2016-05-21

Family

ID=52461888

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2016000227A PE20160508A1 (es) 2013-08-09 2014-08-06 Diacuerpos fc monovalentes biespecificos que son capaces de unirse a cd32b y cd79b y usos de los mismos

Country Status (25)

Country Link
US (1) US10344092B2 (es)
EP (1) EP3030264B1 (es)
JP (1) JP6395834B2 (es)
KR (1) KR102294018B1 (es)
CN (2) CN112898432B (es)
AU (1) AU2014306105B2 (es)
CA (1) CA2920021C (es)
CL (1) CL2016000293A1 (es)
DK (1) DK3030264T3 (es)
DO (1) DOP2016000044A (es)
EA (1) EA033658B1 (es)
ES (1) ES2720730T3 (es)
GE (1) GEP201706794B (es)
HU (1) HUE043229T2 (es)
IL (1) IL244009B (es)
MX (1) MX2016001741A (es)
PE (1) PE20160508A1 (es)
PH (1) PH12016500242A1 (es)
PL (1) PL3030264T4 (es)
PT (1) PT3030264T (es)
SG (1) SG11201600855VA (es)
TN (1) TN2016000042A1 (es)
TW (1) TW201536805A (es)
UA (1) UA116479C2 (es)
WO (1) WO2015021089A1 (es)

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PE20181066A1 (es) * 2015-08-17 2018-07-04 Macrogenics Inc Diacuerpos monovalentes biespecificos que son capaces de unirse a b7-h3 y cd3, y usos de los mismos
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