PE20121504A1 - Variantes de glucoamilasa - Google Patents
Variantes de glucoamilasaInfo
- Publication number
- PE20121504A1 PE20121504A1 PE2012000228A PE2012000228A PE20121504A1 PE 20121504 A1 PE20121504 A1 PE 20121504A1 PE 2012000228 A PE2012000228 A PE 2012000228A PE 2012000228 A PE2012000228 A PE 2012000228A PE 20121504 A1 PE20121504 A1 PE 20121504A1
- Authority
- PE
- Peru
- Prior art keywords
- seq
- sequence
- amino acids
- variant
- loop
- Prior art date
Links
- 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 title abstract 3
- 102100022624 Glucoamylase Human genes 0.000 title abstract 3
- 150000001413 amino acids Chemical group 0.000 abstract 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000007859 condensation product Substances 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
- A23L29/35—Degradation products of starch, e.g. hydrolysates, dextrins; Enzymatically modified starches
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12C—BEER; PREPARATION OF BEER BY FERMENTATION; PREPARATION OF MALT FOR MAKING BEER; PREPARATION OF HOPS FOR MAKING BEER
- C12C5/00—Other raw materials for the preparation of beer
- C12C5/004—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12C—BEER; PREPARATION OF BEER BY FERMENTATION; PREPARATION OF MALT FOR MAKING BEER; PREPARATION OF HOPS FOR MAKING BEER
- C12C7/00—Preparation of wort
- C12C7/04—Preparation or treatment of the mash
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
- C12N9/2411—Amylases
- C12N9/2428—Glucan 1,4-alpha-glucosidase (3.2.1.3), i.e. glucoamylase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/02—Monosaccharides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/20—Preparation of compounds containing saccharide radicals produced by the action of an exo-1,4 alpha-glucosidase, e.g. dextrose
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01003—Glucan 1,4-alpha-glucosidase (3.2.1.3), i.e. glucoamylase
-
- C—CHEMISTRY; METALLURGY
- C13—SUGAR INDUSTRY
- C13K—SACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
- C13K1/00—Glucose; Glucose-containing syrups
- C13K1/06—Glucose; Glucose-containing syrups obtained by saccharification of starch or raw materials containing starch
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Food Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Emergency Medicine (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23514009P | 2009-08-19 | 2009-08-19 | |
| US36089110P | 2010-07-01 | 2010-07-01 | |
| DKPA201070337 | 2010-07-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20121504A1 true PE20121504A1 (es) | 2012-11-05 |
Family
ID=42797171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012000228A PE20121504A1 (es) | 2009-08-19 | 2010-08-18 | Variantes de glucoamilasa |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8809023B2 (https=) |
| EP (1) | EP2467474A1 (https=) |
| JP (1) | JP5827227B2 (https=) |
| CN (4) | CN107299123A (https=) |
| AR (1) | AR077942A1 (https=) |
| AU (1) | AU2010284963C1 (https=) |
| BR (1) | BR112012003787A2 (https=) |
| CA (1) | CA2770607C (https=) |
| EA (1) | EA023194B1 (https=) |
| MX (1) | MX2012002032A (https=) |
| PE (1) | PE20121504A1 (https=) |
| WO (2) | WO2011020852A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010284963C1 (en) * | 2009-08-19 | 2014-11-27 | Danisco Us Inc. | Variants of glucoamylase |
| WO2012140075A2 (en) * | 2011-04-15 | 2012-10-18 | Novozymes A/S | Method for production of brewers wort |
| ES2616917T3 (es) * | 2011-12-22 | 2017-06-14 | Dupont Nutrition Biosciences Aps | Polipéptidos que tienen actividad de glucoamilasa y método para producirlos |
| US20150152458A1 (en) | 2012-03-28 | 2015-06-04 | Danisco Us Inc. | Low temperature method for making high glucose syrup |
| BR112015003124B1 (pt) * | 2012-08-14 | 2020-12-29 | Danisco Us Inc. | variantes de glicoamilase de trichoderma reesei, composição enzimática e método de processamento de amido |
| MX2015002099A (es) * | 2012-08-22 | 2015-05-11 | Dupont Nutrition Biosci Aps | Variantes que tienen actividad glucoamilasa. |
| WO2014060474A1 (en) * | 2012-10-17 | 2014-04-24 | Novozymes A/S | Method for production of brewers wort |
| EP3027741B1 (en) * | 2013-07-29 | 2019-10-23 | Danisco US Inc. | Gh61 enzyme variants |
| WO2015118123A1 (en) | 2014-02-07 | 2015-08-13 | Novozymes A/S | Compositions for producing glucose syrups |
| US9982284B2 (en) | 2014-02-27 | 2018-05-29 | E I Du Pont De Nemours And Company | Enzymatic hydrolysis of disaccharides and oligosaccharides using alpha-glucosidase enzymes |
| BR112017011275A2 (pt) | 2014-12-01 | 2018-04-03 | Novozymes A/S | composição, e, processo para a produção de xarope de glicose. |
| EP3234166A1 (en) * | 2014-12-19 | 2017-10-25 | Danisco US Inc. | Glucoamylase blends |
| CN107250163A (zh) | 2015-02-06 | 2017-10-13 | 嘉吉公司 | 修饰的葡糖淀粉酶和具有增强的生物产物产生的酵母菌株 |
| EP3274461A1 (en) | 2015-03-27 | 2018-01-31 | Cargill, Incorporated | Glucoamylase-modified yeast strains and methods for bioproduct production |
| WO2017106739A1 (en) | 2015-12-17 | 2017-06-22 | Cargill, Incorporated | Sugar transporter-modified yeast strains and methods for bioproduct production |
| US9670472B1 (en) | 2016-08-05 | 2017-06-06 | Fornia Biosolutions, Inc | 2G16 glucoamylase compositions and methods |
| WO2018027131A1 (en) | 2016-08-05 | 2018-02-08 | Cargill, Incorporated | Leader-modified glucoamylase polypeptides and engineered yeast strains having enhanced bioproduct production |
| US10227578B2 (en) | 2016-08-05 | 2019-03-12 | Fornia Biosolutions, Inc. | 2G16 glucoamylase compositions and methods |
| US10053678B2 (en) | 2016-08-05 | 2018-08-21 | Fornia Biosolutions, Inc. | G16 glucoamylase compositions and methods |
| US9598680B1 (en) * | 2016-08-05 | 2017-03-21 | Fornia Biosolutions, Inc. | G16 glucoamylase compositions and methods |
| RU2733294C1 (ru) | 2016-11-18 | 2020-10-01 | Балтика Брюэрис - Парт Оф Зе Карлсберг Груп | Способ получения зернового солода и солодовый продукт, полученный таким способом |
| CN111971379B (zh) * | 2018-02-28 | 2025-03-25 | 嘉吉公司 | 葡糖淀粉酶工程化酵母和发酵方法 |
| CA3093378A1 (en) * | 2018-03-09 | 2019-09-12 | Danisco Us Inc | Glucoamylases and methods of use thereof |
| EP3869978A4 (en) * | 2018-10-22 | 2022-11-23 | DuPont Nutrition Biosciences ApS | ENZYMES FOR AN INFUSION PROCESS IN ADDITIONAL BREWERY TECHNICAL AREA |
| US11535836B2 (en) | 2018-12-21 | 2022-12-27 | Fornia Biosolutions, Inc. | Variant G6P G7P glucoamylase compositions and methods |
| US20230167386A1 (en) * | 2020-05-21 | 2023-06-01 | Dupont Nutrition Biosciences Aps | Uninhibited amylases for brewing with high tannin materials |
| CN114457058B (zh) * | 2021-10-19 | 2024-05-14 | 安徽农业大学 | 一种饲用α淀粉酶的突变改良方法及应用 |
| EP4525615A2 (en) | 2022-05-14 | 2025-03-26 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
| WO2024137350A2 (en) | 2022-12-19 | 2024-06-27 | Danisco Us Inc. | Recombinant fungal strains and methods thereof for producing consistent proteins |
| PL447340A1 (pl) * | 2023-12-28 | 2025-06-30 | Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie | Zastosowanie preparatu enzymatycznego z Trichoderma reesei oraz kombinacji preparatów enzymatycznych z Trichoderma reesei i Aspergillus niger do zmiany aromatu piwa chmielonego na zimno |
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| JPS5534046A (en) | 1978-09-01 | 1980-03-10 | Cpc International Inc | Novel glucoamyrase having excellent heat resistance and production |
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| US4794175A (en) | 1983-12-20 | 1988-12-27 | Cetus Corporation | Glucoamylase CDNA |
| US4618579A (en) | 1984-09-28 | 1986-10-21 | Genencor, Inc. | Raw starch saccharification |
| JPH0630586B2 (ja) | 1984-12-15 | 1994-04-27 | サントリー株式会社 | グルコアミラ−ゼ遺伝子 |
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| CA2038485A1 (en) | 1990-03-23 | 1991-09-24 | Donald K. Hadden | Nanofiltration process for making dextrose |
| US5162210A (en) * | 1990-06-29 | 1992-11-10 | Iowa State University Research Foundation | Process for enzymatic hydrolysis of starch to glucose |
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| US6255084B1 (en) | 1997-11-26 | 2001-07-03 | Novozymes A/S | Thermostable glucoamylase |
| US6352851B1 (en) | 1998-07-15 | 2002-03-05 | Novozymes A/S | Glucoamylase variants |
| ATE373703T1 (de) | 1998-07-15 | 2007-10-15 | Novozymes As | Varianten der glukoamylase |
| MXPA01000352A (es) * | 1998-07-15 | 2002-06-04 | Novozymes As | Varientes de glucoamilasa. |
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| US6254914B1 (en) | 1999-07-02 | 2001-07-03 | The Board Of Trustees Of The University Of Illinois | Process for recovery of corn coarse fiber (pericarp) |
| CN100510067C (zh) * | 1999-07-09 | 2009-07-08 | 诺维信公司 | 葡糖淀粉酶变体 |
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| GB0129864D0 (en) | 2001-12-13 | 2002-02-06 | Danisco | Animal feed |
| EP1527157A1 (en) * | 2002-07-25 | 2005-05-04 | Novozymes A/S | Mashing process |
| US20040219649A1 (en) | 2003-03-10 | 2004-11-04 | Novozymes A/S | Alcohol product processes |
| CN102210376B (zh) | 2003-03-10 | 2014-12-31 | 波伊特研究股份有限公司 | 利用生淀粉生产乙醇的方法 |
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| US6899910B2 (en) | 2003-06-12 | 2005-05-31 | The United States Of America As Represented By The Secretary Of Agriculture | Processes for recovery of corn germ and optionally corn coarse fiber (pericarp) |
| SI1685244T1 (sl) | 2003-11-21 | 2012-06-29 | Danisco Us Inc | Ekspresija encimov, ki hidrolizirajo zrnat škrob, v Trichodermi in postopek za proizvajanje glukoze iz zrnatih škrobnih substratov |
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| US7037704B2 (en) | 2004-05-27 | 2006-05-02 | Genencor International, Inc. | Heterologous expression of an Aspergillus kawachi acid-stable alpha amylase and applications in granular starch hydrolysis |
| GB0423139D0 (en) | 2004-10-18 | 2004-11-17 | Danisco | Enzymes |
| CN101068922B (zh) | 2004-11-30 | 2015-06-03 | 金克克国际有限公司 | 里氏木霉葡糖淀粉酶及其同源物 |
| EP2363460A3 (en) | 2004-12-30 | 2011-12-28 | Genencor International, Inc. | Acid fungal proteases |
| US20080280328A1 (en) * | 2005-11-18 | 2008-11-13 | Novozymes A/S | Glucoamylase Variants |
| US7608436B2 (en) * | 2006-01-25 | 2009-10-27 | Tate & Lyle Ingredients Americas, Inc. | Process for producing saccharide oligomers |
| EP2061882A2 (en) | 2006-10-10 | 2009-05-27 | Danisco US, INC., Genencor Division | Glucoamylase variants with altered properties |
| PL2479267T3 (pl) * | 2006-12-21 | 2017-06-30 | Basf Enzymes Llc | Amylazy i glukoamylazy, kwasy nukleinowe kodujące te związki oraz sposoby wytwarzania tych związków oraz stosowania ich |
| ES2502743T3 (es) | 2007-10-09 | 2014-10-06 | Danisco Us Inc. | Variantes de glucoamilasa |
| ES2527586T3 (es) * | 2007-11-20 | 2015-01-27 | Danisco Us Inc. | Variantes de glucoamilasa con propiedades modificadas |
| EP2467475A1 (en) | 2009-08-19 | 2012-06-27 | Danisco US Inc. | Combinatorial variants of glucoamylase with improved specific activity and/or thermostability |
| AU2010284963C1 (en) * | 2009-08-19 | 2014-11-27 | Danisco Us Inc. | Variants of glucoamylase |
-
2010
- 2010-08-18 AU AU2010284963A patent/AU2010284963C1/en not_active Ceased
- 2010-08-18 WO PCT/EP2010/062035 patent/WO2011020852A1/en not_active Ceased
- 2010-08-18 JP JP2012525164A patent/JP5827227B2/ja not_active Expired - Fee Related
- 2010-08-18 EA EA201270286A patent/EA023194B1/ru not_active IP Right Cessation
- 2010-08-18 BR BR112012003787A patent/BR112012003787A2/pt not_active IP Right Cessation
- 2010-08-18 EP EP10744699A patent/EP2467474A1/en not_active Withdrawn
- 2010-08-18 PE PE2012000228A patent/PE20121504A1/es not_active Application Discontinuation
- 2010-08-18 US US13/390,769 patent/US8809023B2/en not_active Expired - Fee Related
- 2010-08-18 AR ARP100103027A patent/AR077942A1/es unknown
- 2010-08-18 CA CA2770607A patent/CA2770607C/en not_active Expired - Fee Related
- 2010-08-18 CN CN201710445803.1A patent/CN107299123A/zh active Pending
- 2010-08-18 MX MX2012002032A patent/MX2012002032A/es active IP Right Grant
- 2010-08-18 CN CN201080042420.6A patent/CN102575239B/zh not_active Expired - Fee Related
-
2011
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- 2011-06-30 CN CN201180032785.5A patent/CN103119157B/zh not_active Expired - Fee Related
- 2011-06-30 WO PCT/EP2011/061082 patent/WO2012001139A1/en not_active Ceased
- 2011-06-30 CN CN201811034644.7A patent/CN109295032A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010284963C1 (en) | 2014-11-27 |
| US20130309726A9 (en) | 2013-11-21 |
| MX2012002032A (es) | 2012-03-26 |
| JP5827227B2 (ja) | 2015-12-02 |
| JP2013502211A (ja) | 2013-01-24 |
| WO2011020852A1 (en) | 2011-02-24 |
| US20120149070A1 (en) | 2012-06-14 |
| AR077942A1 (es) | 2011-10-05 |
| CA2770607A1 (en) | 2011-02-24 |
| CN103119157B (zh) | 2018-10-09 |
| US8809023B2 (en) | 2014-08-19 |
| CN107299123A (zh) | 2017-10-27 |
| CN102575239B (zh) | 2017-06-16 |
| CN103119157A (zh) | 2013-05-22 |
| EA201270286A1 (ru) | 2013-02-28 |
| WO2012001139A1 (en) | 2012-01-05 |
| CN109295032A (zh) | 2019-02-01 |
| AU2010284963A1 (en) | 2012-03-08 |
| CN102575239A (zh) | 2012-07-11 |
| BR112012003787A2 (pt) | 2017-07-04 |
| CA2770607C (en) | 2019-02-26 |
| US9469848B2 (en) | 2016-10-18 |
| WO2012001139A9 (en) | 2012-02-23 |
| EP2467474A1 (en) | 2012-06-27 |
| EA023194B1 (ru) | 2016-05-31 |
| AU2010284963B2 (en) | 2014-03-20 |
| US20130102035A1 (en) | 2013-04-25 |
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