PE20120670A1 - Metodos para dosificar un 1, 2, 4-oxadiazol oralmente activo para terapia de supresion de mutacion sin sentido - Google Patents

Metodos para dosificar un 1, 2, 4-oxadiazol oralmente activo para terapia de supresion de mutacion sin sentido

Info

Publication number
PE20120670A1
PE20120670A1 PE2011001559A PE2011001559A PE20120670A1 PE 20120670 A1 PE20120670 A1 PE 20120670A1 PE 2011001559 A PE2011001559 A PE 2011001559A PE 2011001559 A PE2011001559 A PE 2011001559A PE 20120670 A1 PE20120670 A1 PE 20120670A1
Authority
PE
Peru
Prior art keywords
senseness
oxadiazole
dosage
methods
orally active
Prior art date
Application number
PE2011001559A
Other languages
English (en)
Spanish (es)
Inventor
Langdon Miller
Samit Hirawat
Original Assignee
Pct Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39102963&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20120670(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pct Therapeutics Inc filed Critical Pct Therapeutics Inc
Publication of PE20120670A1 publication Critical patent/PE20120670A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
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    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Inorganic Chemistry (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
PE2011001559A 2006-10-12 2007-10-12 Metodos para dosificar un 1, 2, 4-oxadiazol oralmente activo para terapia de supresion de mutacion sin sentido PE20120670A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85145006P 2006-10-12 2006-10-12

Publications (1)

Publication Number Publication Date
PE20120670A1 true PE20120670A1 (es) 2012-06-01

Family

ID=39102963

Family Applications (4)

Application Number Title Priority Date Filing Date
PE2007001386A PE20080982A1 (es) 2006-10-12 2007-10-12 Metodos para dosificar un 1,2,4-oxadiazol oralmente activo para terapia de supresion de mutacion sin sentido
PE2016000659A PE20160947A1 (es) 2006-10-12 2007-10-12 Composicion farmaceutica oral que comprende acido 3-[5-(2-fluorofenil)-[1,2,4]oxadiazol-3-il]benzoico
PE2020002230A PE20212245A1 (es) 2006-10-12 2007-10-12 Composicion farmaceutica oral que comprende acido 3-[5-(2-fluorofenil)- [1,2,4]oxadiazol-3-il]-benzoico
PE2011001559A PE20120670A1 (es) 2006-10-12 2007-10-12 Metodos para dosificar un 1, 2, 4-oxadiazol oralmente activo para terapia de supresion de mutacion sin sentido

Family Applications Before (3)

Application Number Title Priority Date Filing Date
PE2007001386A PE20080982A1 (es) 2006-10-12 2007-10-12 Metodos para dosificar un 1,2,4-oxadiazol oralmente activo para terapia de supresion de mutacion sin sentido
PE2016000659A PE20160947A1 (es) 2006-10-12 2007-10-12 Composicion farmaceutica oral que comprende acido 3-[5-(2-fluorofenil)-[1,2,4]oxadiazol-3-il]benzoico
PE2020002230A PE20212245A1 (es) 2006-10-12 2007-10-12 Composicion farmaceutica oral que comprende acido 3-[5-(2-fluorofenil)- [1,2,4]oxadiazol-3-il]-benzoico

Country Status (24)

Country Link
US (7) US9226919B2 (ko)
EP (2) EP2073805B1 (ko)
JP (4) JP2010506840A (ko)
KR (4) KR20090074231A (ko)
CN (2) CN101553226B (ko)
AU (1) AU2007308067B2 (ko)
BR (2) BRPI0719276A2 (ko)
CA (1) CA2675518C (ko)
CL (1) CL2007002923A1 (ko)
DK (1) DK2073805T3 (ko)
ES (1) ES2538359T3 (ko)
HK (2) HK1136214A1 (ko)
HR (1) HRP20150590T1 (ko)
IL (2) IL198147A (ko)
MX (1) MX2009003909A (ko)
NO (1) NO342061B1 (ko)
PE (4) PE20080982A1 (ko)
PL (1) PL2073805T3 (ko)
PT (1) PT2073805E (ko)
RS (1) RS54025B1 (ko)
RU (1) RU2462247C2 (ko)
SI (1) SI2073805T1 (ko)
TW (1) TWI405570B (ko)
WO (1) WO2008045566A1 (ko)

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SI3345895T1 (sl) 2003-04-11 2020-03-31 Ptc Therapeutics, Inc. Spojina 1,2,4-oksadiazol benzojske kisline in njena uporaba za supresijo nesmiselne in zdravljenje bolezni
EP2387995A1 (en) 2006-03-30 2011-11-23 PTC Therapeutics, Inc. Methods for the production of functional protein from DNA having a nonsense mutation and the treatment of disorders associated therewith
RS54025B1 (en) 2006-10-12 2015-10-30 Ptc Therapeutics Inc. DOSAGE PROCEDURES FOR ORALLY ACTIVE 1,2,4-OXADIAZOLE FOR NONSENS MUTATION SUPPRESSION THERAPY
EP2714937B1 (en) 2011-06-03 2018-11-14 Eisai R&D Management Co., Ltd. Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds
CA2942147C (en) 2014-03-06 2022-12-13 Ptc Therapeutics, Inc. Pharmaceutical compositions and salts of a 1,2,4-oxadiazole benzoic acid
ES2926687T3 (es) 2014-08-28 2022-10-27 Eisai R&D Man Co Ltd Derivado de quinolina muy puro y método para su producción
US20180028662A1 (en) 2015-02-25 2018-02-01 Eisai R&D Management Co., Ltd. Method for Suppressing Bitterness of Quinoline Derivative
CA2988707C (en) 2015-06-16 2023-10-10 Eisai R&D Management Co., Ltd. Combination of cbp/catenin inhibitor and immune checkpoint inhibitor for treating cancer
AR106530A1 (es) 2015-10-30 2018-01-24 Ptc Therapeutics Inc Métodos para tratar epilepsia
JP7235741B2 (ja) 2017-10-19 2023-03-08 シプラ ユーエスエイ， インコーポレイテッド 抗菌性アミノグリコシド類似体の合成
EP3713934B1 (en) 2017-11-23 2022-04-13 Universita' degli Studi di Palermo Oxadiazole derivatives for the treatment of genetic diseases due to nonsense mutations
US20240139183A1 (en) * 2021-02-16 2024-05-02 Ribotech Co., Ltd. Compound for suppressing nonsense-mediated mrna decay
KR102378381B1 (ko) * 2021-08-23 2022-03-24 라이보텍(주) 넌센스-매개 mRNA 분해를 억제하기 위한 화합물
EP4337267A1 (en) * 2021-05-11 2024-03-20 RegenxBio Inc. Treatment of duchenne muscular dystrophy and combinations thereof
KR102665711B1 (ko) * 2021-12-21 2024-05-14 재단법인 아산사회복지재단 Ras 활성도를 이용한 신경섬유종증 치료제에 대한 감수성 예측용 바이오마커 조성물 및 Ras 활성 억제제를 포함하는 신경섬유종증 예방 또는 치료용 약학적 조성물

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Publication number Publication date
US20180140583A1 (en) 2018-05-24
EP2460520A1 (en) 2012-06-06
WO2008045566B1 (en) 2008-06-19
EP2460520B1 (en) 2015-09-30
IL198147A0 (en) 2009-12-24
HRP20150590T1 (hr) 2015-07-03
NO20091826L (no) 2009-07-08
PE20080982A1 (es) 2008-07-19
HK1170690A1 (zh) 2013-03-08
US20210038572A1 (en) 2021-02-11
IL236519A (en) 2017-03-30
ES2538359T3 (es) 2015-06-19
US20170049752A1 (en) 2017-02-23
PT2073805E (pt) 2015-07-13
JP2017081946A (ja) 2017-05-18
EP2073805A1 (en) 2009-07-01
RU2009117590A (ru) 2010-11-20
CL2007002923A1 (es) 2008-06-06
US10849885B2 (en) 2020-12-01
KR101758341B1 (ko) 2017-07-14
KR20170100072A (ko) 2017-09-01
HK1136214A1 (en) 2010-06-25
KR20160128468A (ko) 2016-11-07
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MX2009003909A (es) 2009-05-25
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WO2008045566A1 (en) 2008-04-17
CN103211766B (zh) 2015-03-11
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SI2073805T1 (sl) 2015-10-30
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IL198147A (en) 2016-02-29
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NO342061B1 (no) 2018-03-19
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TWI405570B (zh) 2013-08-21
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US10172836B2 (en) 2019-01-08
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TW200820968A (en) 2008-05-16
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