PE20120669A1 - Proceso para la preparacion de acidos de 1,2,4-oxadiazol benzoico - Google Patents
Proceso para la preparacion de acidos de 1,2,4-oxadiazol benzoicoInfo
- Publication number
- PE20120669A1 PE20120669A1 PE2011001405A PE2011001405A PE20120669A1 PE 20120669 A1 PE20120669 A1 PE 20120669A1 PE 2011001405 A PE2011001405 A PE 2011001405A PE 2011001405 A PE2011001405 A PE 2011001405A PE 20120669 A1 PE20120669 A1 PE 20120669A1
- Authority
- PE
- Peru
- Prior art keywords
- preparation
- benzoic acids
- oxadiazole benzoic
- hours
- product obtained
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- -1 1,2,4-OXADIAZOLE BENZOIC ACIDS Chemical class 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 abstract 2
- DTNSDCJFTHMDAK-UHFFFAOYSA-N 2-cyanobenzoic acid Chemical compound OC(=O)C1=CC=CC=C1C#N DTNSDCJFTHMDAK-UHFFFAOYSA-N 0.000 abstract 1
- RAAGZOYMEQDCTD-UHFFFAOYSA-N 2-fluorobenzoyl chloride Chemical compound FC1=CC=CC=C1C(Cl)=O RAAGZOYMEQDCTD-UHFFFAOYSA-N 0.000 abstract 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 150000004702 methyl esters Chemical class 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84359506P | 2006-09-08 | 2006-09-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20120669A1 true PE20120669A1 (es) | 2012-06-01 |
Family
ID=38935880
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007001203A PE20080771A1 (es) | 2006-09-08 | 2007-09-07 | Procesos para la preparacion de acidos de 1,2,4-oxadiazol benzoico |
| PE2011001405A PE20120669A1 (es) | 2006-09-08 | 2007-09-07 | Proceso para la preparacion de acidos de 1,2,4-oxadiazol benzoico |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007001203A PE20080771A1 (es) | 2006-09-08 | 2007-09-07 | Procesos para la preparacion de acidos de 1,2,4-oxadiazol benzoico |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7678922B2 (enExample) |
| EP (1) | EP2059513B1 (enExample) |
| JP (2) | JP5955494B2 (enExample) |
| KR (1) | KR101466368B1 (enExample) |
| CN (1) | CN101535284B (enExample) |
| AR (3) | AR062715A1 (enExample) |
| AU (1) | AU2007292915B2 (enExample) |
| BR (1) | BRPI0716996B8 (enExample) |
| CA (2) | CA2662749C (enExample) |
| CL (1) | CL2007002606A1 (enExample) |
| DK (1) | DK2059513T3 (enExample) |
| ES (1) | ES2404348T3 (enExample) |
| IL (1) | IL197445A (enExample) |
| MX (1) | MX2009002439A (enExample) |
| MY (1) | MY148598A (enExample) |
| NZ (2) | NZ575511A (enExample) |
| PE (2) | PE20080771A1 (enExample) |
| PL (1) | PL2059513T3 (enExample) |
| PT (1) | PT2059513E (enExample) |
| RU (1) | RU2495030C2 (enExample) |
| TW (1) | TWI482761B (enExample) |
| UA (1) | UA99265C2 (enExample) |
| WO (1) | WO2008030570A1 (enExample) |
| ZA (1) | ZA200901782B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6992096B2 (en) | 2003-04-11 | 2006-01-31 | Ptc Therapeutics, Inc. | 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease |
| PT1874306E (pt) | 2005-04-08 | 2012-10-11 | Ptc Therapeutics Inc | Composições de um 1,2,4-oxadiazole oralmente activo para terapia de supressão de mutações sem sentido (ou nonsense) |
| SG170819A1 (en) | 2006-03-30 | 2011-05-30 | Ptc Therapeutics Inc | Methods for the production of functional protein from dna having a nonsense mutation and the treatment of disorders associated therewith |
| CN101535284B (zh) * | 2006-09-08 | 2014-12-10 | Ptc医疗公司 | 制备1,2,4-噁二唑苯甲酸的方法 |
| DK2076501T3 (da) * | 2006-09-25 | 2016-02-29 | Ptc Therapeutics Inc | Krystallinske former af 3-[5-(2-fluorphenyl)-[1,2,4]oxadiazol-3-yl]-benzoesyre |
| WO2008130370A1 (en) | 2006-09-25 | 2008-10-30 | Ptc Therapeutics, Inc. | Hydroxylated 1,2,4-oxadiazole benzoic acid compounds, compositions thereof and the use for nonsense suppression |
| EP2073805B1 (en) | 2006-10-12 | 2015-03-04 | PTC Therapeutics, Inc. | Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy |
| CN101714009A (zh) * | 2009-05-14 | 2010-05-26 | 翁印嵩 | 集成通用电话功能的计算机 |
| US9050347B2 (en) | 2011-01-25 | 2015-06-09 | Viviabiotech, S.L. | 1,2,4-oxadiazole derivatives as drugs modulating the GLP-1 peptide receptor |
| DK2867230T3 (da) | 2012-07-02 | 2020-04-14 | Monsanto Technology Llc | Fremgangsmåde til fremstilling af 3,5-disubstitueret 1,2,4-oxadiazoler |
| US9873677B2 (en) | 2014-03-06 | 2018-01-23 | Ptc Therapeutics, Inc. | Pharmaceutical compositions and salts of a 1,2,4-oxadiazole benzoic acid |
| CN105461650B (zh) * | 2014-09-12 | 2018-04-13 | 杭州普晒医药科技有限公司 | 一种噁二唑化合物的溶剂化物及其制备方法 |
| CN106316885B (zh) * | 2015-07-03 | 2019-02-12 | 普济生物科技（台州）有限公司 | 一种3-[5-(2-氟苯基)-1,2,4-噁二唑-3-基]苯甲酸的制备方法 |
| MX2018005361A (es) | 2015-10-30 | 2018-06-07 | Ptc Therapeutics Inc | Metodos para tratar epilepsia. |
| TW201808922A (zh) | 2016-06-20 | 2018-03-16 | 台灣神隆股份有限公司 | 製備阿塔魯仁及其中間體的方法 |
| US12268669B2 (en) | 2018-12-20 | 2025-04-08 | Pfizer Inc. | Pharmaceutical compositions and methods comprising a combination of a benzoxazole transthyretin stabilizer and an additional therapeutic agent |
| CN114007608A (zh) | 2019-04-10 | 2022-02-01 | Ptc医疗公司 | 在儿科患者中治疗无义突变介导的杜氏肌营养不良症的方法 |
| WO2022112919A1 (en) | 2020-11-25 | 2022-06-02 | Pfizer Inc. | (aza)benzothiazolyl substituted pyrazole compounds |
| CN113045510B (zh) * | 2021-03-31 | 2022-05-27 | 北京大学生命科学华东产业研究院 | 一种阿塔鲁伦的制备方法 |
| CN114920667B (zh) * | 2022-06-30 | 2024-06-21 | 湖南大学 | 一种阿塔鲁伦酯的电化学制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2801509A1 (de) * | 1978-01-12 | 1979-07-19 | Schering Ag | 1,2,4-oxadiazolderivate, verfahren zur herstellung dieser verbindungen sowie diese enthaltende selektive herbizide mittel |
| DE3905242A1 (de) * | 1989-02-21 | 1990-08-23 | Basf Ag | Verfahren zur herstellung von phenyloxdiazolylanilinen |
| NZ234760A (en) * | 1989-08-18 | 1991-09-25 | Sterling Drug Inc | Antiviral oxazole compounds and compositions |
| DE4425794A1 (de) * | 1994-07-21 | 1996-01-25 | Basf Ag | Nitrofarbstoffe |
| US6660753B2 (en) * | 1999-08-19 | 2003-12-09 | Nps Pharmaceuticals, Inc. | Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists |
| EP1406632A4 (en) * | 2001-06-08 | 2009-11-04 | Cytovia Inc | SUBSTITUTED 3-ARYL-5-ARYL-1,2,4-OXADIAZOLE AND ANALOGUE AS ACTIVATORS OF CASPASES AND APOPTOSIS INDUCTORS AND THEIR USE |
| MY151199A (en) * | 2001-11-02 | 2014-04-30 | Rigel Pharmaceuticals Inc | Substituted diphenyl heterocycles useful for treating hcv infection |
| JP2006506340A (ja) * | 2002-08-09 | 2006-02-23 | アストラゼネカ アクチボラグ | 代謝調節型グルタミン酸受容体５のモジュレーターとしてのオキサジアゾール |
| GB0303503D0 (en) | 2003-02-14 | 2003-03-19 | Novartis Ag | Organic compounds |
| US6992096B2 (en) * | 2003-04-11 | 2006-01-31 | Ptc Therapeutics, Inc. | 1,2,4-oxadiazole benzoic acid compounds and their use for nonsense suppression and the treatment of disease |
| WO2004110351A2 (en) * | 2003-05-14 | 2004-12-23 | Anadys Pharmaceuticals, Inc. | Heterocyclic compounds for treating hepatitis c virus |
| PT1874306E (pt) * | 2005-04-08 | 2012-10-11 | Ptc Therapeutics Inc | Composições de um 1,2,4-oxadiazole oralmente activo para terapia de supressão de mutações sem sentido (ou nonsense) |
| CN101535284B (zh) * | 2006-09-08 | 2014-12-10 | Ptc医疗公司 | 制备1,2,4-噁二唑苯甲酸的方法 |
-
2007
- 2007-09-06 CN CN200780041169.XA patent/CN101535284B/zh active Active
- 2007-09-06 BR BRPI0716996A patent/BRPI0716996B8/pt active IP Right Grant
- 2007-09-06 AU AU2007292915A patent/AU2007292915B2/en active Active
- 2007-09-06 MY MYPI20090941A patent/MY148598A/en unknown
- 2007-09-06 ZA ZA200901782A patent/ZA200901782B/xx unknown
- 2007-09-06 NZ NZ575511A patent/NZ575511A/en unknown
- 2007-09-06 RU RU2009113019/04A patent/RU2495030C2/ru active
- 2007-09-06 CA CA2662749A patent/CA2662749C/en active Active
- 2007-09-06 ES ES07837899T patent/ES2404348T3/es active Active
- 2007-09-06 NZ NZ598012A patent/NZ598012A/xx unknown
- 2007-09-06 KR KR1020097007202A patent/KR101466368B1/ko not_active Expired - Fee Related
- 2007-09-06 UA UAA200903350A patent/UA99265C2/ru unknown
- 2007-09-06 JP JP2009527430A patent/JP5955494B2/ja active Active
- 2007-09-06 WO PCT/US2007/019561 patent/WO2008030570A1/en not_active Ceased
- 2007-09-06 US US11/899,813 patent/US7678922B2/en active Active - Reinstated
- 2007-09-06 EP EP07837899A patent/EP2059513B1/en active Active
- 2007-09-06 PT PT78378999T patent/PT2059513E/pt unknown
- 2007-09-06 CA CA2842625A patent/CA2842625C/en active Active
- 2007-09-06 DK DK07837899.9T patent/DK2059513T3/da active
- 2007-09-06 MX MX2009002439A patent/MX2009002439A/es active IP Right Grant
- 2007-09-06 PL PL07837899T patent/PL2059513T3/pl unknown
- 2007-09-07 PE PE2007001203A patent/PE20080771A1/es active IP Right Grant
- 2007-09-07 CL CL200702606A patent/CL2007002606A1/es unknown
- 2007-09-07 PE PE2011001405A patent/PE20120669A1/es active IP Right Grant
- 2007-09-07 TW TW096133607A patent/TWI482761B/zh active
- 2007-09-07 AR ARP070103975A patent/AR062715A1/es not_active Application Discontinuation
-
2009
- 2009-03-05 IL IL197445A patent/IL197445A/en active IP Right Grant
- 2009-11-13 US US12/617,757 patent/US8367841B2/en active Active
-
2014
- 2014-05-20 JP JP2014103966A patent/JP2014193896A/ja active Pending
-
2017
- 2017-01-27 AR ARP170100223A patent/AR107474A2/es not_active Application Discontinuation
-
2020
- 2020-05-12 AR ARP200101362A patent/AR118922A2/es unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20120669A1 (es) | Proceso para la preparacion de acidos de 1,2,4-oxadiazol benzoico | |
| Horiuchi et al. | Hydrogen‐bonding molecular chains for high‐temperature ferroelectricity | |
| AR061968A1 (es) | Ester isopropilico del acido 4-[5-metoxi-6-(2-metil-6-[1,2,4]triazol-i-il-piridin-3-il-amino)-pirimidin-4-iloxi]-piperidin-i-carboxilico, composicion farmaceutica que lo comprende y un metodo de preparacion de la misma y el uso de este compuesto para el tratamiento de trastornos metabolicos | |
| ES2575565T3 (es) | Procedimiento para la preparación de monohidrato de treprostinilo y su utilización para el almacenamiento y el envío | |
| PE20091456A1 (es) | Nuevas formas cristalinas de acido 4-[4-(2-adamantilcarbamoil)-5-tert-butil-pirazol-1-il]benzoico- 471 | |
| PE20140879A1 (es) | Antagonistas del receptor de acido lisofosfatidico para el tratamiento de fibrosis | |
| AR061967A1 (es) | Ester isopropilico del acido 4-[6-(6-metanosulfonil-2-metil-piridin-3-il-amino)-5-metil-pirimidin-4-iloxi]-piperidin-i-carboxilico, composicion farmaceutica que lo comprende y un metodo de preparacion de la misma y el uso de este compuesto para el tratamiento de trastornos metabolicos | |
| EA200900553A1 (ru) | Гербицидные композиции | |
| AR082222A1 (es) | Composiciones herbicidas sinergicas que contienen aminopiralid, acido 2,4-diclorofenoxiacetico y atrazina | |
| EA201370109A1 (ru) | НОВЫЕ ФОРМЫ МЕТИЛОВОГО ЭФИРА 2-ЦИАНО-3,12-ДИОКСООЛЕАН-1,9(11)-ДИЕН-28-ОВОЙ КИСЛОТЫ (CDDO-Me) | |
| BR112013003439A2 (pt) | "inibidores de oxadiazol de produção de leucotrieno" | |
| RU2011121300A (ru) | Производные 1,3,4-оксадиазола и их применение для лечения диабета | |
| EA201170131A1 (ru) | Соединения антагонистов phk для ингибирования экспрессии митохондриальной глицерин-3-фосфатацилтрансферазы 1 (mtgpat1) | |
| UY30404A1 (es) | Nuevas formas cristalinas de acido (trans-4-{4-[({5-[(3,4-difluorofenil)amino]-1,3,4-oxadiazol-2-il}carbonil)amino]fenil}cilohexil)acético, composiciones y aplicaciones | |
| CR10102A (es) | Acido 3-(4-{[4-(4{[3-(3,3,-dimetil-1piperidinil) propil) oxi} fenil)1-piperidinil]carbonil}-1-naftalenil)propanoico o proponeico como antagonistas del receptor h1 h3 para el tratamiento de disfunciones inflamatorias y/o alergicas | |
| NZ591870A (en) | Crystalline form of an alkoxyimidazol-1-ylmethyl biphenyl carboxylic acid | |
| UA102539C2 (ru) | Производные оксадиазола, активные в отношении сфингозин-1-фосфата (s1p) | |
| DOP2010000135A (es) | Acido 4-[4-(2-adamantilcarbamoil)-5-tert-butilpirazol-1-il]benzoico-465 | |
| PE20080554A1 (es) | Formulacion acuosa del acido 4-[((4-carboxibutil)-{2-[(4-fenetilbencil)oxi]fenil}amino)metil]benzoico | |
| AR128147A1 (es) | Procedimiento para la preparación del ácido (5s)-[2-(4-carboxifenil)etil][2-(2-[3-cloro-4-(trifluorometil)bifenil-4-il]metoxifenil)etil]amino-5,6,7,8-tetrahidroquinolina-2-carboxílico y sus formas cristalinas para su uso como compuesto farmacéuticamente activo | |
| AR057909A1 (es) | Proceso para preparar montelukast y compuestos relacionados, que utiliza un compuesto intermediario derivado de un ester sulfonico. | |
| DE602007007824D1 (de) | Verfahren zur herstellung von abacavir | |
| BR112013016348A2 (pt) | processo de produção de compostos nitrila-ácido graxo | |
| AR061623A1 (es) | Derivados de acido fenilacetico | |
| EA201101014A1 (ru) | Сульфонамиды, предназначенные для лечения респираторных нарушений |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal | ||
| AE | Restoration of lapsed or forfeited application | ||
| FG | Grant, registration |