EA201070149A1 - Новые формы метилового эфира 2-циано-3,12-диоксоолеан-1,9(11)-диен-28-овой кислоты (cddo-me) - Google Patents

Новые формы метилового эфира 2-циано-3,12-диоксоолеан-1,9(11)-диен-28-овой кислоты (cddo-me)

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Publication number
EA201070149A1
EA201070149A1 EA201070149A EA201070149A EA201070149A1 EA 201070149 A1 EA201070149 A1 EA 201070149A1 EA 201070149 A EA201070149 A EA 201070149A EA 201070149 A EA201070149 A EA 201070149A EA 201070149 A1 EA201070149 A1 EA 201070149A1
Authority
EA
Eurasian Patent Office
Prior art keywords
cddo
dioxoolean
cyano
acid methyl
dien
Prior art date
Application number
EA201070149A
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English (en)
Other versions
EA018704B1 (ru
Inventor
Джон Уоллинг
Стивен Д. Пэрент
Дэвид Т. Джонаитис
Роберт М. Крэл
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Реата Фармасьютикалз, Инк.
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Publication date
Application filed by Реата Фармасьютикалз, Инк. filed Critical Реата Фармасьютикалз, Инк.
Publication of EA201070149A1 publication Critical patent/EA201070149A1/ru
Publication of EA018704B1 publication Critical patent/EA018704B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Glass Compositions (AREA)

Abstract

Тритерпеноидное соединение - метиловый эфир 2-циано-3,12-диоксоолеан-1,9(11)-диен-28-овой кислоты (CDDO-Me ) - находится в некристаллической твердой стекловидной форме и в безводной кристаллической форме, приготовляемых, например, из насыщенного раствора в метаноле. Стекловидная форма отличается улучшенной биодоступностью в сравнении с безводной кристаллической формой. Каждая форма CDDO-Me является превосходным кандидатом для применения обычно в твердой лекарственной форме при лечении различных заболеваний, как правило, связанных с воспалением.
EA201070149A 2007-08-15 2008-08-14 НОВЫЕ ФОРМЫ МЕТИЛОВОГО ЭФИРА 2-ЦИАНО-3,12-ДИОКСООЛЕАН-1,9(11)-ДИЕН-28-ОВОЙ КИСЛОТЫ (CDDO-Me) EA018704B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95593907P 2007-08-15 2007-08-15
PCT/US2008/009703 WO2009023232A1 (en) 2007-08-15 2008-08-14 Novel forms of cddo methyl ester

Publications (2)

Publication Number Publication Date
EA201070149A1 true EA201070149A1 (ru) 2010-08-30
EA018704B1 EA018704B1 (ru) 2013-10-30

Family

ID=40351005

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201370109A EA023550B1 (ru) 2007-08-15 2008-08-14 НОВЫЕ ФОРМЫ МЕТИЛОВОГО ЭФИРА 2-ЦИАНО-3,12-ДИОКСООЛЕАН-1,9(11)-ДИЕН-28-ОВОЙ КИСЛОТЫ (CDDO-Me)
EA201070149A EA018704B1 (ru) 2007-08-15 2008-08-14 НОВЫЕ ФОРМЫ МЕТИЛОВОГО ЭФИРА 2-ЦИАНО-3,12-ДИОКСООЛЕАН-1,9(11)-ДИЕН-28-ОВОЙ КИСЛОТЫ (CDDO-Me)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201370109A EA023550B1 (ru) 2007-08-15 2008-08-14 НОВЫЕ ФОРМЫ МЕТИЛОВОГО ЭФИРА 2-ЦИАНО-3,12-ДИОКСООЛЕАН-1,9(11)-ДИЕН-28-ОВОЙ КИСЛОТЫ (CDDO-Me)

Country Status (29)

Country Link
US (3) US8088824B2 (ru)
EP (2) EP2450057B1 (ru)
JP (4) JP5005812B2 (ru)
KR (2) KR101544766B1 (ru)
CN (2) CN101820758B (ru)
AR (2) AR073155A1 (ru)
AT (1) ATE549035T1 (ru)
AU (1) AU2008287388B2 (ru)
BR (1) BRPI0815540A8 (ru)
CA (2) CA2696330C (ru)
CL (1) CL2008002417A1 (ru)
CY (2) CY1112864T1 (ru)
DK (2) DK2450057T3 (ru)
EA (2) EA023550B1 (ru)
ES (2) ES2382571T3 (ru)
HK (1) HK1143537A1 (ru)
HR (2) HRP20120350T1 (ru)
HU (1) HUE031866T2 (ru)
IL (2) IL203824A (ru)
LT (1) LT2450057T (ru)
MX (1) MX2010001628A (ru)
NZ (1) NZ583269A (ru)
PL (2) PL2187741T3 (ru)
PT (2) PT2187741E (ru)
SG (2) SG10201504650VA (ru)
SI (2) SI2450057T1 (ru)
TW (2) TWI419899B (ru)
WO (1) WO2009023232A1 (ru)
ZA (1) ZA201001066B (ru)

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US9155721B2 (en) 2009-02-13 2015-10-13 Reata Pharmaceuticals, Inc. Delayed release, oral dosage compositions that contain amorphous CDDO-Me

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AU2008287388B2 (en) 2014-11-06
SG10201504650VA (en) 2015-07-30
KR20140024063A (ko) 2014-02-27
HK1143537A1 (en) 2011-01-07
EP2187741A4 (en) 2010-08-25
PT2187741E (pt) 2012-06-21
US8088824B2 (en) 2012-01-03
CN101820758B (zh) 2013-03-06
EP2187741A1 (en) 2010-05-26
IL251419A0 (en) 2017-05-29
HRP20161503T1 (hr) 2017-01-13
KR20100056488A (ko) 2010-05-27
US20120330050A1 (en) 2012-12-27
CY1112864T1 (el) 2016-04-13
EP2187741B1 (en) 2012-03-14
JP2010536754A (ja) 2010-12-02
CA2696330A1 (en) 2009-02-19
PL2187741T3 (pl) 2012-08-31
HRP20120350T1 (hr) 2012-05-31
TW200916476A (en) 2009-04-16
AU2008287388A1 (en) 2009-02-19
US8633243B2 (en) 2014-01-21
CN101820758A (zh) 2010-09-01
TWI486357B (zh) 2015-06-01
JP2015164939A (ja) 2015-09-17
CA2871864A1 (en) 2009-02-19
JP2018009001A (ja) 2018-01-18
DK2450057T3 (en) 2016-12-19
US8309601B2 (en) 2012-11-13
EP2450057A1 (en) 2012-05-09
CL2008002417A1 (es) 2009-03-27
JP5005812B2 (ja) 2012-08-22
EA018704B1 (ru) 2013-10-30
CN103254267A (zh) 2013-08-21
LT2450057T (lt) 2016-12-27
JP2012188438A (ja) 2012-10-04
CY1118329T1 (el) 2017-06-28
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