BRPI0815540A8 - Novas formas de éster metílico de cddo - Google Patents

Novas formas de éster metílico de cddo

Info

Publication number
BRPI0815540A8
BRPI0815540A8 BRPI0815540A BRPI0815540A BRPI0815540A8 BR PI0815540 A8 BRPI0815540 A8 BR PI0815540A8 BR PI0815540 A BRPI0815540 A BR PI0815540A BR PI0815540 A BRPI0815540 A BR PI0815540A BR PI0815540 A8 BRPI0815540 A8 BR PI0815540A8
Authority
BR
Brazil
Prior art keywords
methyl ester
cddo methyl
new forms
cddo
usually
Prior art date
Application number
BRPI0815540A
Other languages
English (en)
Inventor
Walling John
D Parent Stephan
t jonaitis David
M Kral Robert
Original Assignee
Reata Pharmaceuticals Inc
Reata Pharmaceuticals Holdings Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reata Pharmaceuticals Inc, Reata Pharmaceuticals Holdings Llc filed Critical Reata Pharmaceuticals Inc
Publication of BRPI0815540A2 publication Critical patent/BRPI0815540A2/pt
Publication of BRPI0815540A8 publication Critical patent/BRPI0815540A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Glass Compositions (AREA)

Abstract

NOVAS FORMAS DO ÉSTER METÍLICO DE CDDO. Composto triterpenoide, metil 2-ciano-3,12-dioxoleano-1,9 (11) -dien-28-oato (éster metílico de CDDO), com uma forma vítrea não cristalina e uma forma cristalina não hidratada que podem ser preparadas, por exemplo, a partir de uma solução saturada em metanol. A forma vítrea tem biodisponibilidade superior à da forma cristalina não hidratada. Cada forma do éster metílico de CDDO é um candidato de nível superior para uso, geralmente em dose sólida, no tratamento de uma série de estados patológicos, normalmente associados a processos inflamatórios.
BRPI0815540A 2007-08-15 2008-08-14 Novas formas de éster metílico de cddo BRPI0815540A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95593907P 2007-08-15 2007-08-15
PCT/US2008/009703 WO2009023232A1 (en) 2007-08-15 2008-08-14 Novel forms of cddo methyl ester

Publications (2)

Publication Number Publication Date
BRPI0815540A2 BRPI0815540A2 (pt) 2014-09-30
BRPI0815540A8 true BRPI0815540A8 (pt) 2023-04-11

Family

ID=40351005

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0815540A BRPI0815540A8 (pt) 2007-08-15 2008-08-14 Novas formas de éster metílico de cddo

Country Status (29)

Country Link
US (3) US8088824B2 (pt)
EP (2) EP2450057B1 (pt)
JP (4) JP5005812B2 (pt)
KR (2) KR101544766B1 (pt)
CN (2) CN103254267B (pt)
AR (2) AR073155A1 (pt)
AT (1) ATE549035T1 (pt)
AU (1) AU2008287388B2 (pt)
BR (1) BRPI0815540A8 (pt)
CA (2) CA2871864C (pt)
CL (1) CL2008002417A1 (pt)
CY (2) CY1112864T1 (pt)
DK (2) DK2450057T3 (pt)
EA (2) EA018704B1 (pt)
ES (2) ES2382571T3 (pt)
HK (1) HK1143537A1 (pt)
HR (2) HRP20120350T1 (pt)
HU (1) HUE031866T2 (pt)
IL (2) IL203824A (pt)
LT (1) LT2450057T (pt)
MX (1) MX2010001628A (pt)
NZ (1) NZ583269A (pt)
PL (2) PL2450057T3 (pt)
PT (2) PT2187741E (pt)
SG (2) SG10201504650VA (pt)
SI (2) SI2450057T1 (pt)
TW (2) TWI419899B (pt)
WO (1) WO2009023232A1 (pt)
ZA (1) ZA201001066B (pt)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326507B1 (en) * 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US7435755B2 (en) 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
WO2003059339A1 (en) 2002-01-15 2003-07-24 Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
US7714012B2 (en) 2006-11-17 2010-05-11 Trustees Of Dartmouth University Synthesis and biological activities of new tricyclic-bis-enones (TBEs)
WO2008064132A2 (en) 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
US8088824B2 (en) * 2007-08-15 2012-01-03 Reata Pharmaceuticals Inc. Forms of CDDO methyl ester
EA022166B1 (ru) * 2008-01-11 2015-11-30 Ритэ Фамэсутиклс, Инк. Синтетические тритерпеноиды и их применение в лечении заболеваний
CN102083442B (zh) 2008-04-18 2014-08-13 里亚塔医药公司 抗氧化剂炎症调节剂：在c-17具有氨基和其它修饰的齐墩果酸衍生物
KR101713140B1 (ko) 2008-04-18 2017-03-08 리타 파마슈티컬스 잉크. Ｃ-환에서 포화된 산화방지성 염증 조절제 올레아놀산 유도체
TWI584808B (zh) 2008-04-18 2017-06-01 瑞塔醫藥有限責任公司 抗氧化發炎調節劑：ｃ－１７同系齊墩果酸衍生物
MX339476B (es) 2008-04-18 2016-05-27 Reata Pharmaceuticals Inc Compuestos que incluyen un nucleo farmaceutico antiinflamatorio y sus metodos de uso.
WO2009146216A2 (en) 2008-04-18 2009-12-03 Reata Pharmaceuticals. Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
CA2731650A1 (en) 2008-07-22 2010-01-28 Tadashi Honda Monocyclic cyanoenones and methods of use thereof
KR20140016441A (ko) 2009-02-13 2014-02-07 리아타 파마슈티컬즈, 아이엔씨. 무정형 ｃｄｄｏ-ｍｅ를 포함하는, 지연 방출형 경구 투여 조성물
US8759535B2 (en) 2010-02-18 2014-06-24 High Point Pharmaceuticals, Llc Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof
SG182629A1 (en) 2010-02-18 2012-08-30 High Point Pharmaceuticals Llc Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof
CA2795320C (en) 2010-04-12 2019-01-22 Reata Pharmaceuticals, Inc. Method of treating obesity using antioxidant inflammation modulators
CN103596929B (zh) 2010-12-17 2016-10-19 里亚塔医药公司 作为抗氧化发炎调节剂的吡唑及嘧啶三环烯酮
UY33946A (es) 2011-03-11 2012-08-31 Reata Pharmaceuticals Inc Derivados de c4-monometil triterpenoides y sus métodos de uso
CN103156861B (zh) * 2011-12-08 2015-11-25 陈丽梅 齐敦果酸衍生物及其可药用盐在治疗糖尿病眼病中的应用
JP6410710B2 (ja) 2012-04-27 2018-10-24 リアタ ファーマシューティカルズ インコーポレイテッド バルドキソロンメチルの２，２−ジフルオロプロピオンアミド誘導体、その多形体および使用方法
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
US8981144B2 (en) 2012-05-08 2015-03-17 Trustees Of Dartmouth College Method for synthesizing 2-cyano-3,12-dioxoolean-1, 9(11)-dien-28-oic acid methyl ester and derivatives thereof
WO2013188818A1 (en) 2012-06-15 2013-12-19 Reata Pharmaceuticals, Inc. A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof
US9278912B2 (en) 2012-09-10 2016-03-08 Reata Pharmaceuticals, Inc. C13-hydroxy derivatives of oleanolic acid and methods of use thereof
US9512094B2 (en) 2012-09-10 2016-12-06 Reata Pharmaceuticals, Inc. C17-heteroaryl derivatives of oleanolic acid and methods of use thereof
EP2892910B1 (en) * 2012-09-10 2016-09-07 AbbVie Inc. Glycyrrhetinic acid derivatives with anti-inflammatory activity
US9593074B2 (en) 2012-09-10 2017-03-14 Reata Pharmaceuticals, Inc. C17-alkanediyl and alkenediyl derivatives of oleanolic acid and methods of use thereof
EP2739639A4 (en) 2012-09-28 2014-11-05 Applied Pharmaceutical Science Inc POLYMORPHS OF CDDO ETHYL ESTER AND USES THEREOF
CN102887936A (zh) * 2012-10-24 2013-01-23 苏州晶云药物科技有限公司 2-氰基-3,12-二氧代齐墩果-1,9(11)-二烯-28-酸甲酯晶型
CN102875634B (zh) * 2012-10-24 2014-08-20 苏州晶云药物科技有限公司 2-氰基-3,12-二氧代齐墩果-1,9(11)-二烯-28-酸甲酯的几种晶型
EP2977381B1 (en) 2013-03-19 2018-09-26 Daiichi Sankyo Company, Limited Terpenoid derivative
UY35534A (es) 2013-04-24 2014-10-31 Abbvie Inc Derivados de 2,2-difluoropropanamida y metil bardoxolona, formas polimórficas y métodos de uso
TWI716341B (zh) * 2013-08-23 2021-01-21 美商瑞塔醫藥有限責任公司 使用齊墩果酸（ｂａｒｄｏｘｏｌｏｎｅ ｍｅｔｈｙｌ）或其類似物治療和預防內皮功能障礙之方法
US10189791B2 (en) 2014-08-26 2019-01-29 Trustees Of Dartmouth College Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole
US9896475B2 (en) 2014-08-26 2018-02-20 Trustees Of Dartmouth College Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole
CN106661080A (zh) 2014-09-10 2017-05-10 第三共株式会社 用于治疗和预防眼科疾病的缓释药物组合物
WO2016089648A1 (en) 2014-12-01 2016-06-09 Vtv Therapeutics Llc Bach 1 inhibitors in combination with nrf2 activators and pharmaceutical compositions thereof
US11591302B2 (en) 2014-12-19 2023-02-28 Geistlich Pharm A Ag Processes for preparing oxathiazin-like compounds
MX369462B (es) 2014-12-19 2019-11-08 Geistlich Pharma Ag Procedimientos para preparar compuestos de tipo oxatiazina.
CN107428698B (zh) 2015-02-12 2021-10-26 里亚塔医药公司 作为抗氧化炎症调节剂的咪唑基三环烯酮
ES2895802T3 (es) * 2015-07-02 2022-02-22 Acerta Pharma Bv Formas sólidas y formulaciones de (S)-4-(8-amino-3-(1-(but-2-inoil)pirrolidin-2-il)imidazo[1,5-a]pirazin-1-il)-N-(piridin-2-il)benzamida
WO2017053868A1 (en) 2015-09-23 2017-03-30 Reata Pharmaceutical, Inc. C4-modified oleanolic acid derivatives for inhibition of il-17 and other uses
MX2019005401A (es) * 2016-11-08 2019-08-05 Reata Pharmaceuticals Inc Metodos para tratar el sindrome de alport con bardoxolona metilo o analogos de la misma.
TWI831738B (zh) 2016-12-16 2024-02-11 美商瑞塔醫藥有限責任公司 用於抑制ＲＯＲγ及其他用途的嘧啶三環烯酮衍生物
EP3652193A1 (en) 2017-07-13 2020-05-20 Pliva Hrvatska D.O.O. New crystalline polymorphs of bardoxolone methyl
CA3094591C (en) 2018-04-06 2024-03-26 Capsugel Belgium Nv Spray drying process for low aspect ratio particles comprising poly[(methyl methacrylate)-co-(methacrylic acid)]
MX2020013692A (es) 2018-06-15 2021-02-26 Reata Pharmaceuticals Inc Compuestos de pirazol e imidazol para la inhibicion de il-17 y rorgamma.
WO2019246461A1 (en) 2018-06-20 2019-12-26 Reata Pharmaceuticals, Inc. Cysteine-dependent inverse agonists of nuclear receptors ror-gamma/ror-gamma-t and methods of treating diseases or disorders therewith
JPWO2020111089A1 (ja) 2018-11-27 2021-10-14 協和キリン株式会社 医薬組成物
CA3177913A1 (en) 2020-05-09 2021-11-18 Deborah FERGUSON Methods of treating covid-19 using bardoxolone methyl or analogs thereof
US12059419B2 (en) 2020-10-16 2024-08-13 Idience Co., Ltd. Pharmaceutical composition comprising phthalazinone derivatives
EP4259155A1 (en) 2020-12-11 2023-10-18 Reata Pharmaceuticals Holdings, LLC Synthetic triterpenoids for use in therapy

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07121911B2 (ja) * 1986-03-26 1995-12-25 クミアイ化学工業株式会社 ４（１ｈ）−ピリジノン誘導体および農園芸用殺菌剤
JPH01273020A (ja) * 1988-04-26 1989-10-31 Toray Ind Inc 有機非線形光学材料
US5064823A (en) * 1988-08-24 1991-11-12 Research Triangle Institute Pentacyclic triterpenoid compounds as topoisomerase inhibitors or cell differentiation inducers
JP2876144B2 (ja) * 1990-03-23 1999-03-31 東洋フアルマー株式会社 ３―フェニルクマリン―７―イルオキシ酢酸誘導体とその製法及び用途
GB9622173D0 (en) * 1996-10-24 1996-12-18 Glaxo Group Ltd Particulate Products
US20050276836A1 (en) * 1997-06-11 2005-12-15 Michelle Wilson Coated vaginal devices for vaginal delivery of therapeutically effective and/or health-promoting agents
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US6890946B2 (en) * 1999-12-23 2005-05-10 Indiana University Research And Technology Corporation Use of parthenolide to inhibit cancer
US7435755B2 (en) * 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
AU2002243246A1 (en) * 2000-11-28 2002-06-24 Board Of Regents, The University Of Texas System Cddo-compounds and combination therapies thereof
US6974801B2 (en) * 2002-05-13 2005-12-13 The Trustees Of Dartmounth College Inhibitors and methods of use thereof
JP3618341B2 (ja) * 2003-04-15 2005-02-09 山之内製薬株式会社 臭化物及びその結晶
FR2861299B1 (fr) * 2003-10-28 2006-01-27 Pf Medicament Compositions pharmaceutiques a base de derives d'idasoxan sous formes polymorphes
US7652654B2 (en) 2003-12-08 2010-01-26 Sony Corporation Liquid crystal display and backlight adjusting method
US20060167097A1 (en) * 2004-04-16 2006-07-27 Cheppail Ramachandran Compositions and uses of Amooranin compounds
EP1904480A2 (en) * 2005-05-23 2008-04-02 Novartis Pharma AG Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one lactic acid salts
DE102005041613A1 (de) 2005-09-01 2007-03-08 Ergonex Pharma Gmbh Pharmazeutische Zusammensetzungen zur Behandlung von Karzinoid-Syndrom
CA2633033C (en) 2005-12-12 2016-11-22 Mosamedix B.V. Annexin derivatives suitable for pretargeting in therapy and diagnosis
US8088824B2 (en) * 2007-08-15 2012-01-03 Reata Pharmaceuticals Inc. Forms of CDDO methyl ester

Also Published As

Publication number Publication date
EP2187741B1 (en) 2012-03-14
NZ583269A (en) 2012-03-30
HK1143537A1 (en) 2011-01-07
JP2010536754A (ja) 2010-12-02
ATE549035T1 (de) 2012-03-15
US20090048204A1 (en) 2009-02-19
JP2015164939A (ja) 2015-09-17
CN103254267B (zh) 2016-03-16
CA2696330A1 (en) 2009-02-19
IL251419A0 (en) 2017-05-29
JP2012188438A (ja) 2012-10-04
LT2450057T (lt) 2016-12-27
JP2018009001A (ja) 2018-01-18
EP2187741A1 (en) 2010-05-26
US20120330050A1 (en) 2012-12-27
TW200916476A (en) 2009-04-16
US8088824B2 (en) 2012-01-03
HUE031866T2 (en) 2017-08-28
MX2010001628A (es) 2010-06-02
EA023550B1 (ru) 2016-06-30
CY1118329T1 (el) 2017-06-28
CA2871864C (en) 2016-05-17
AU2008287388A1 (en) 2009-02-19
CN101820758A (zh) 2010-09-01
KR20140024063A (ko) 2014-02-27
US20120071684A1 (en) 2012-03-22
TWI419899B (zh) 2013-12-21
AR119704A2 (es) 2022-01-05
CL2008002417A1 (es) 2009-03-27
DK2187741T3 (da) 2012-04-16
TW201402597A (zh) 2014-01-16
CA2696330C (en) 2015-03-24
BRPI0815540A2 (pt) 2014-09-30
CN101820758B (zh) 2013-03-06
TWI486357B (zh) 2015-06-01
KR20100056488A (ko) 2010-05-27
EP2450057B1 (en) 2016-09-28
SI2187741T1 (sl) 2012-07-31
PL2187741T3 (pl) 2012-08-31
EP2450057A1 (en) 2012-05-09
HRP20120350T1 (hr) 2012-05-31
CY1112864T1 (el) 2016-04-13
ES2382571T3 (es) 2012-06-11
ZA201001066B (en) 2010-10-27
JP5005812B2 (ja) 2012-08-22
PT2187741E (pt) 2012-06-21
ES2602978T3 (es) 2017-02-23
CN103254267A (zh) 2013-08-21
EA201070149A1 (ru) 2010-08-30
SG10201504650VA (en) 2015-07-30
US8633243B2 (en) 2014-01-21
PT2450057T (pt) 2016-12-15
EP2187741A4 (en) 2010-08-25
CA2871864A1 (en) 2009-02-19
SG177905A1 (en) 2012-02-28
EA018704B1 (ru) 2013-10-30
WO2009023232A1 (en) 2009-02-19
KR101544766B1 (ko) 2015-08-17
DK2450057T3 (en) 2016-12-19
HRP20161503T1 (hr) 2017-01-13
IL203824A (en) 2017-04-30
KR101481764B1 (ko) 2015-01-13
AU2008287388B2 (en) 2014-11-06
SI2450057T1 (sl) 2017-01-31
PL2450057T3 (pl) 2017-02-28
EA201370109A1 (ru) 2014-01-30
US8309601B2 (en) 2012-11-13
AR073155A1 (es) 2010-10-20

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