AR081514A1 - El compuesto 4-[etil(dimetil)amonio]butanoato, el metodo para la preparacion del mismo y el uso en el tratamiento de la enfermedad cardiovascular - Google Patents
El compuesto 4-[etil(dimetil)amonio]butanoato, el metodo para la preparacion del mismo y el uso en el tratamiento de la enfermedad cardiovascularInfo
- Publication number
- AR081514A1 AR081514A1 ARP100103859A ARP100103859A AR081514A1 AR 081514 A1 AR081514 A1 AR 081514A1 AR P100103859 A ARP100103859 A AR P100103859A AR P100103859 A ARP100103859 A AR P100103859A AR 081514 A1 AR081514 A1 AR 081514A1
- Authority
- AR
- Argentina
- Prior art keywords
- ethyl
- dimethyl
- butanoate
- ammonium
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
El compuesto 4-[etil(dimetil)amonio]butanoato, el método para la preparación del mismo y el uso en el tratamiento de la enfermedad cardiovascular.Reivindicación 1: 4-[Etil(dimetil)amonio]butanoato de fórmula (1). Reivindicación 2: Un proceso para preparar 4-[etil(dimetil)amonio]butanoato que comprende: a) agregar bromuro de etilo a 4-(dimetilamonio)butanoato en acetona para producir el bromuro de N-etil-4-metoxi-N,N-dimetil-4-oxo-1-butanaminio; b) tratar el N-etil-4-metoxi-N,N-dimetil-4-oxo-1-butanaminio con solución de hidróxido de potasio en etanol para obtener el compuesto deseado de 4-[etil(dimetil)amonio] butanoato. Reivindicación 8: El uso de 4-[etil(dimetil)amonio]butanoato para la fabricación de un medicamento para el tratamiento de las enfermedades cardiovasculares.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LVP-09-181A LV14345B (lv) | 2009-10-22 | 2009-10-22 | 4-[Etil(dimetil)amonija]butanoāts un tā izmantošana kardiovaskulāro slimību ārstēšanai |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR081514A1 true AR081514A1 (es) | 2012-10-03 |
Family
ID=43530044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100103859A AR081514A1 (es) | 2009-10-22 | 2010-10-22 | El compuesto 4-[etil(dimetil)amonio]butanoato, el metodo para la preparacion del mismo y el uso en el tratamiento de la enfermedad cardiovascular |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US9278907B2 (es) |
| EP (1) | EP2491005B1 (es) |
| JP (1) | JP5552169B2 (es) |
| KR (1) | KR101355417B1 (es) |
| CN (1) | CN102666476B (es) |
| AR (1) | AR081514A1 (es) |
| AU (1) | AU2010309756B2 (es) |
| BR (1) | BR112012009162B8 (es) |
| CA (1) | CA2781499C (es) |
| CL (1) | CL2012001010A1 (es) |
| CO (1) | CO6531459A2 (es) |
| CU (1) | CU20120065A7 (es) |
| DK (1) | DK2491005T3 (es) |
| EA (1) | EA020303B1 (es) |
| ES (1) | ES2508117T3 (es) |
| GE (1) | GEP20146123B (es) |
| HK (1) | HK1169824A1 (es) |
| HR (1) | HRP20140964T1 (es) |
| IL (1) | IL219217A0 (es) |
| LV (1) | LV14345B (es) |
| ME (1) | ME01917B (es) |
| MX (1) | MX2012004630A (es) |
| NZ (1) | NZ599521A (es) |
| PE (1) | PE20121473A1 (es) |
| PL (1) | PL2491005T3 (es) |
| PT (1) | PT2491005E (es) |
| RS (1) | RS53620B1 (es) |
| SI (1) | SI2491005T1 (es) |
| SM (1) | SMT201400176B (es) |
| TN (1) | TN2012000174A1 (es) |
| UA (1) | UA107201C2 (es) |
| WO (1) | WO2011048201A1 (es) |
| ZA (1) | ZA201202916B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8565150B2 (en) * | 2009-03-11 | 2013-10-22 | At&T Mobility Ii Llc | Architectural model for LTE (long term evolution) EPC (evolved packet core) deployment |
| AU2012247467B2 (en) * | 2011-04-27 | 2016-07-28 | Grindeks, A Joint Stock Company | Use of 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium salts in the treatment of cardiovascular disease |
| DE102012109911A1 (de) | 2011-10-19 | 2013-04-25 | Electronics And Telecommunications Research Institute | Energy harvesting device using electromagnetic interference signal and sensor system including the same |
| JO3117B1 (ar) * | 2012-12-20 | 2017-09-20 | Grindeks Jsc | استعمال 3- كربوكسي- ن-إيثيل- ن، ن- ثاني ميثيل بروبان-1– أمينيوم أو ملح منه مقبول صيدلانياً في معالجة تصلب الشرايين |
| JO3333B1 (ar) * | 2013-09-26 | 2019-03-13 | Grindeks Jsc | استعمال 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium أو ملح مقبول دوائيا منه للوقاية من السكري وعلاجه |
| CN107879944B (zh) * | 2017-10-30 | 2020-05-22 | 杭州海尔希畜牧科技有限公司 | 一种制备丁基甜菜碱的方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1238868A (es) | 1967-08-08 | 1971-07-14 | ||
| SU997646A1 (ru) | 1978-11-27 | 1983-02-23 | Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвсср | Кормова добавка |
| IT1210935B (it) | 1981-09-17 | 1989-09-29 | Inst Orch Sinteza Akademi Nauk | Composizione farmaceutica per il trattamento di malattie cardiovascolari. |
| IT1190280B (it) * | 1986-04-24 | 1988-02-16 | Sigma Tau Ind Farmaceuti | Procedimento per la preparazione di gamma-butirrobetaina |
| US4933103A (en) * | 1987-03-23 | 1990-06-12 | Kao Corporation | Bleaching composition |
| SU1680693A1 (ru) * | 1987-03-25 | 1991-09-30 | Институт Органического Синтеза Ан Латвсср | Этил-3-(2,2-диметил-2-этилгидразиний)пропионат иодистый, про вл ющий антиаритмическую активность |
| JPH0291049A (ja) * | 1988-09-21 | 1990-03-30 | Lonza Ag | ｒ―ブチロベタインの製造方法 |
| JP3119430B2 (ja) * | 1995-07-25 | 2000-12-18 | 大鵬薬品工業株式会社 | 水酸基ラジカル消去剤 |
| LV11728B (en) * | 1995-08-21 | 1997-08-20 | Kalvins Ivars | Pharmaceutical composition |
| US5973026A (en) | 1998-02-02 | 1999-10-26 | Xerox Corporation | Ink jet inks |
| JP2000239239A (ja) * | 1999-02-22 | 2000-09-05 | Kankyo Meneki Gijutsu Kenkyusho:Kk | クロルメコート類縁化合物のハプテン化合物、抗体及び測定方法 |
| CA2508094A1 (en) | 2005-05-20 | 2006-11-20 | Vivier Canada Inc. | Composition for accelerating collagen synthesis |
| US7863274B2 (en) | 2005-07-29 | 2011-01-04 | Concert Pharmaceuticals Inc. | Deuterium enriched analogues of tadalafil as PDE5 inhibitors |
| LV13705B (en) | 2006-11-06 | 2008-07-20 | Ivars Kalvins | Process for producing high purity intermolecular salt of 3-carboxy-n,n,n-trimethyl-propane-1-amine hydroxide |
| JP4761265B2 (ja) | 2007-10-17 | 2011-08-31 | 学校法人甲南学園 | 核酸合成を促進する化合物を含む組成物およびその利用、並びに当該化合物の製造方法 |
| CN101538214A (zh) * | 2009-04-24 | 2009-09-23 | 潍坊祥维斯化学品有限公司 | 生产γ-丁基甜菜碱及其盐酸盐的方法 |
| EP2702037A1 (en) * | 2011-04-27 | 2014-03-05 | Grindeks, A Joint Stock Company | 4-[(haloalkyl)(dimethyl)ammonio]butanoates and use thereof in the treatment of cardiovascular disease |
-
2009
- 2009-10-22 LV LVP-09-181A patent/LV14345B/lv unknown
-
2010
- 2010-10-22 WO PCT/EP2010/065924 patent/WO2011048201A1/en active Application Filing
- 2010-10-22 EP EP10773886.6A patent/EP2491005B1/en active Active
- 2010-10-22 CA CA2781499A patent/CA2781499C/en active Active
- 2010-10-22 BR BR112012009162A patent/BR112012009162B8/pt active IP Right Grant
- 2010-10-22 AU AU2010309756A patent/AU2010309756B2/en active Active
- 2010-10-22 UA UAA201204970A patent/UA107201C2/ru unknown
- 2010-10-22 RS RS20140547A patent/RS53620B1/en unknown
- 2010-10-22 KR KR1020127010343A patent/KR101355417B1/ko active IP Right Grant
- 2010-10-22 PT PT107738866T patent/PT2491005E/pt unknown
- 2010-10-22 US US13/503,144 patent/US9278907B2/en active Active
- 2010-10-22 NZ NZ599521A patent/NZ599521A/xx unknown
- 2010-10-22 CN CN201080047660.5A patent/CN102666476B/zh active Active
- 2010-10-22 MX MX2012004630A patent/MX2012004630A/es active IP Right Grant
- 2010-10-22 PL PL10773886T patent/PL2491005T3/pl unknown
- 2010-10-22 AR ARP100103859A patent/AR081514A1/es active IP Right Grant
- 2010-10-22 JP JP2012534709A patent/JP5552169B2/ja active Active
- 2010-10-22 GE GEAP201012677A patent/GEP20146123B/en unknown
- 2010-10-22 DK DK10773886.6T patent/DK2491005T3/da active
- 2010-10-22 EA EA201200514A patent/EA020303B1/ru unknown
- 2010-10-22 ME MEP-2014-131A patent/ME01917B/me unknown
- 2010-10-22 PE PE2012000523A patent/PE20121473A1/es active IP Right Grant
- 2010-10-22 SI SI201030752T patent/SI2491005T1/sl unknown
- 2010-10-22 ES ES10773886.6T patent/ES2508117T3/es active Active
-
2012
- 2012-04-16 IL IL219217A patent/IL219217A0/en active IP Right Grant
- 2012-04-16 TN TNP2012000174A patent/TN2012000174A1/en unknown
- 2012-04-20 CL CL2012001010A patent/CL2012001010A1/es unknown
- 2012-04-20 CO CO12065428A patent/CO6531459A2/es unknown
- 2012-04-20 ZA ZA2012/02916A patent/ZA201202916B/en unknown
- 2012-04-23 CU CUP2012000065A patent/CU20120065A7/es active IP Right Grant
- 2012-10-24 HK HK12110547.3A patent/HK1169824A1/xx unknown
-
2014
- 2014-10-07 HR HRP20140964AT patent/HRP20140964T1/hr unknown
- 2014-11-21 SM SM201400176T patent/SMT201400176B/xx unknown
-
2016
- 2016-01-27 US US15/007,543 patent/US9573882B2/en active Active
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Legal Events
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| FG | Grant, registration |