CN101535284B - 制备1,2,4-噁二唑苯甲酸的方法 - Google Patents

制备1,2,4-噁二唑苯甲酸的方法 Download PDF

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Publication number
CN101535284B
CN101535284B CN200780041169.XA CN200780041169A CN101535284B CN 101535284 B CN101535284 B CN 101535284B CN 200780041169 A CN200780041169 A CN 200780041169A CN 101535284 B CN101535284 B CN 101535284B
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steps
substituted
organic solvent
butanol
followed
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Chinese (zh)
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CN101535284A (zh
Inventor
尼尔·G·阿姆斯泰德
彼得·承佑·黄
希蒙·派恩斯
穆英春
杰姆士·J·高杉
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PTC Therapeutics Inc
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PTC Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN200780041169.XA 2006-09-08 2007-09-06 制备1,2,4-噁二唑苯甲酸的方法 Active CN101535284B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84359506P 2006-09-08 2006-09-08
US60/843,595 2006-09-08
PCT/US2007/019561 WO2008030570A1 (en) 2006-09-08 2007-09-06 Processes for the preparation of 1,2,4-oxadiazole benzoic acids

Publications (2)

Publication Number Publication Date
CN101535284A CN101535284A (zh) 2009-09-16
CN101535284B true CN101535284B (zh) 2014-12-10

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ID=38935880

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CN200780041169.XA Active CN101535284B (zh) 2006-09-08 2007-09-06 制备1,2,4-噁二唑苯甲酸的方法

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US (2) US7678922B2 (enExample)
EP (1) EP2059513B1 (enExample)
JP (2) JP5955494B2 (enExample)
KR (1) KR101466368B1 (enExample)
CN (1) CN101535284B (enExample)
AR (3) AR062715A1 (enExample)
AU (1) AU2007292915B2 (enExample)
BR (1) BRPI0716996B8 (enExample)
CA (2) CA2842625C (enExample)
CL (1) CL2007002606A1 (enExample)
DK (1) DK2059513T3 (enExample)
ES (1) ES2404348T3 (enExample)
IL (1) IL197445A (enExample)
MX (1) MX2009002439A (enExample)
MY (1) MY148598A (enExample)
NZ (2) NZ598012A (enExample)
PE (2) PE20120669A1 (enExample)
PL (1) PL2059513T3 (enExample)
PT (1) PT2059513E (enExample)
RU (1) RU2495030C2 (enExample)
TW (1) TWI482761B (enExample)
UA (1) UA99265C2 (enExample)
WO (1) WO2008030570A1 (enExample)
ZA (1) ZA200901782B (enExample)

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EP3178816A1 (en) 2003-04-11 2017-06-14 PTC Therapeutics, Inc. 1,2,4-oxadiazole benzoic acid compound and its use for nonsense suppression and the treatment of disease
JP5800451B2 (ja) 2005-04-08 2015-10-28 ピーティーシー セラピューティクス，インコーポレーテッド ナンセンス突然変異抑制治療用の、経口的に活性な１，２，４−オキサジアゾール組成物
CN101505739A (zh) * 2006-03-30 2009-08-12 Ptc医疗公司 由具有无义突变的dna生产功能蛋白的方法以及相关疾病的治疗
DK2059513T3 (da) * 2006-09-08 2013-05-06 Ptc Therapeutics Inc Fremgangsmåde til fremstillingen af 1,2,4-oxadiazolbenzoesyrer
AU2007300542B2 (en) * 2006-09-25 2012-05-17 Ptc Therapeutics, Inc. Crystalline forms of 3-[5-(2-fluorophenyl)-[1,2,4]oxadiazol-3-yl]-benzoic acid
WO2008130370A1 (en) 2006-09-25 2008-10-30 Ptc Therapeutics, Inc. Hydroxylated 1,2,4-oxadiazole benzoic acid compounds, compositions thereof and the use for nonsense suppression
EP2073805B1 (en) 2006-10-12 2015-03-04 PTC Therapeutics, Inc. Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy
CN101714009A (zh) * 2009-05-14 2010-05-26 翁印嵩 集成通用电话功能的计算机
EP2668951B9 (en) 2011-01-25 2017-03-15 Viviabiotech, S.L. 1,2,4-oxadiazole derivatives as drugs modulating the glp-1 peptide receptor
ES2782509T3 (es) 2012-07-02 2020-09-15 Monsanto Technology Llc Procedimiento para la preparación de 1,2,4-oxadiazoles 3,5-disustituidos
TWI636978B (zh) 2014-03-06 2018-10-01 美商Ｐｔｃ治療公司 １，２，４－二唑苯甲酸之鹽及醫藥組合物
CN105461650B (zh) * 2014-09-12 2018-04-13 杭州普晒医药科技有限公司 一种噁二唑化合物的溶剂化物及其制备方法
CN106316885B (zh) * 2015-07-03 2019-02-12 普济生物科技（台州）有限公司 一种3-[5-(2-氟苯基)-1,2,4-噁二唑-3-基]苯甲酸的制备方法
KR20180081516A (ko) 2015-10-30 2018-07-16 피티씨 테라퓨틱스, 인크. 간질 치료 방법
TW201808922A (zh) 2016-06-20 2018-03-16 台灣神隆股份有限公司 製備阿塔魯仁及其中間體的方法
US12268669B2 (en) 2018-12-20 2025-04-08 Pfizer Inc. Pharmaceutical compositions and methods comprising a combination of a benzoxazole transthyretin stabilizer and an additional therapeutic agent
KR20210151131A (ko) 2019-04-10 2021-12-13 피티씨 테라퓨틱스, 인크. 소아 환자에서 넌센스 돌연변이 매개된 뒤센 근이영양증의 치료 방법
WO2022112919A1 (en) 2020-11-25 2022-06-02 Pfizer Inc. (aza)benzothiazolyl substituted pyrazole compounds
CN113045510B (zh) * 2021-03-31 2022-05-27 北京大学生命科学华东产业研究院 一种阿塔鲁伦的制备方法
CN114920667B (zh) * 2022-06-30 2024-06-21 湖南大学 一种阿塔鲁伦酯的电化学制备方法

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DE2801509A1 (de) * 1978-01-12 1979-07-19 Schering Ag 1,2,4-oxadiazolderivate, verfahren zur herstellung dieser verbindungen sowie diese enthaltende selektive herbizide mittel
DE3905242A1 (de) * 1989-02-21 1990-08-23 Basf Ag Verfahren zur herstellung von phenyloxdiazolylanilinen
NZ234760A (en) * 1989-08-18 1991-09-25 Sterling Drug Inc Antiviral oxazole compounds and compositions
DE4425794A1 (de) * 1994-07-21 1996-01-25 Basf Ag Nitrofarbstoffe
US6660753B2 (en) 1999-08-19 2003-12-09 Nps Pharmaceuticals, Inc. Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists
AU2002313633B2 (en) 2001-06-08 2007-03-01 Cytovia, Inc. Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs
MY151199A (en) 2001-11-02 2014-04-30 Rigel Pharmaceuticals Inc Substituted diphenyl heterocycles useful for treating hcv infection
US20040132726A1 (en) 2002-08-09 2004-07-08 Astrazeneca Ab And Nps Pharmaceuticals, Inc. New compounds
GB0303503D0 (en) 2003-02-14 2003-03-19 Novartis Ag Organic compounds
EP3178816A1 (en) 2003-04-11 2017-06-14 PTC Therapeutics, Inc. 1,2,4-oxadiazole benzoic acid compound and its use for nonsense suppression and the treatment of disease
US20050075375A1 (en) 2003-05-14 2005-04-07 Anadys Pharmaceuticals, Inc. Heterocyclic compounds for treating hepatitis C virus
JP5800451B2 (ja) 2005-04-08 2015-10-28 ピーティーシー セラピューティクス，インコーポレーテッド ナンセンス突然変異抑制治療用の、経口的に活性な１，２，４−オキサジアゾール組成物
DK2059513T3 (da) * 2006-09-08 2013-05-06 Ptc Therapeutics Inc Fremgangsmåde til fremstillingen af 1,2,4-oxadiazolbenzoesyrer

Also Published As

Publication number Publication date
NZ575511A (en) 2012-02-24
BRPI0716996B8 (pt) 2021-05-25
ZA200901782B (en) 2010-06-30
PE20080771A1 (es) 2008-06-13
EP2059513B1 (en) 2013-01-23
WO2008030570A1 (en) 2008-03-13
AR118922A2 (es) 2021-11-10
CA2662749A1 (en) 2008-03-13
ES2404348T3 (es) 2013-05-27
HK1134094A1 (en) 2010-04-16
CA2842625A1 (en) 2008-03-13
BRPI0716996B1 (pt) 2021-02-09
TW200823180A (en) 2008-06-01
PL2059513T3 (pl) 2013-06-28
KR101466368B1 (ko) 2014-11-27
PE20120669A1 (es) 2012-06-01
AR107474A2 (es) 2018-05-02
US20100063297A1 (en) 2010-03-11
CL2007002606A1 (es) 2008-04-18
US7678922B2 (en) 2010-03-16
NZ598012A (en) 2013-08-30
DK2059513T3 (da) 2013-05-06
IL197445A0 (en) 2009-12-24
JP5955494B2 (ja) 2016-07-20
CA2662749C (en) 2015-01-20
EP2059513A1 (en) 2009-05-20
RU2009113019A (ru) 2010-10-20
IL197445A (en) 2014-01-30
BRPI0716996A2 (pt) 2013-10-08
UA99265C2 (ru) 2012-08-10
PT2059513E (pt) 2013-04-30
KR20090054464A (ko) 2009-05-29
US20080139818A1 (en) 2008-06-12
RU2495030C2 (ru) 2013-10-10
AU2007292915B2 (en) 2012-07-26
AR062715A1 (es) 2008-11-26
AU2007292915A1 (en) 2008-03-13
TWI482761B (zh) 2015-05-01
CN101535284A (zh) 2009-09-16
US8367841B2 (en) 2013-02-05
MY148598A (en) 2013-05-15
JP2010502715A (ja) 2010-01-28
CA2842625C (en) 2016-07-12
JP2014193896A (ja) 2014-10-09
MX2009002439A (es) 2009-03-27

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