PE20091977A1 - Compuestos de quinuclidina como ligandos del receptor nicotinico de acetilcolina alfa-7 - Google Patents
Compuestos de quinuclidina como ligandos del receptor nicotinico de acetilcolina alfa-7Info
- Publication number
- PE20091977A1 PE20091977A1 PE2009000562A PE2009000562A PE20091977A1 PE 20091977 A1 PE20091977 A1 PE 20091977A1 PE 2009000562 A PE2009000562 A PE 2009000562A PE 2009000562 A PE2009000562 A PE 2009000562A PE 20091977 A1 PE20091977 A1 PE 20091977A1
- Authority
- PE
- Peru
- Prior art keywords
- nicotinium
- receptor
- alpha
- acetylcholine
- binders
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE QUINUCLIDINA DE FORMULA (I), DONDE R1 ES ISOXAZOLILO, PIRAZOLILO, OXAZOLILO, ENTRE OTROS. SON COMPUESTOS SELECCIONADOS: (R)-N-(6-(2,2,2-TRIFLUOROETOXI)PIRIMIDIN-4-IL)-4H-1'-AZASPIRO[OXAZOL-5,3'-BICICLO[2.2.2]OCTAN]-2-AMINA; (R)-N-(5-BROMO-4-ISOPROPILPIRIMIDIN-2-IL)-4H-1'-AZASPIRO[OXAZOL-5,3'-BICICLO[2.2.2]OCTAN]-2-AMINA; (R)-N-(5-BROMO-4-PIRIDIN-3-IL)PIRIMIDIN-2-IL)-4H-1'-AZASPIRO[OXAZOL-5,3'-BICICLO[2.2.2]OCTAN]-2-AMINA; ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO Y UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON LIGANDOS DEL RECEPTOR NICOTINICO (alfa)7 SIENDO UTIL EN EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL TALES COMO ESQUIZOFRENIA, ENFERMEDAD DE ALZHEIMER, ENTRE OTROS
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4721108P | 2008-04-23 | 2008-04-23 | |
US12/423,299 US7863291B2 (en) | 2008-04-23 | 2009-04-14 | Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20091977A1 true PE20091977A1 (es) | 2010-01-15 |
Family
ID=41215599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2009000562A PE20091977A1 (es) | 2008-04-23 | 2009-04-23 | Compuestos de quinuclidina como ligandos del receptor nicotinico de acetilcolina alfa-7 |
Country Status (27)
Country | Link |
---|---|
US (1) | US7863291B2 (es) |
EP (1) | EP2271650B1 (es) |
JP (1) | JP5389905B2 (es) |
KR (1) | KR20110015565A (es) |
CN (1) | CN102066384B (es) |
AR (1) | AR071215A1 (es) |
AU (1) | AU2009239575B2 (es) |
BR (1) | BRPI0911542A2 (es) |
CA (1) | CA2722325A1 (es) |
CL (1) | CL2009000975A1 (es) |
CO (1) | CO6300941A2 (es) |
CY (1) | CY1117045T1 (es) |
DK (1) | DK2271650T3 (es) |
EA (1) | EA017628B1 (es) |
ES (1) | ES2553753T3 (es) |
HR (1) | HRP20151111T1 (es) |
HU (1) | HUE028302T2 (es) |
IL (1) | IL208673A (es) |
MX (1) | MX2010011374A (es) |
NZ (1) | NZ588649A (es) |
PE (1) | PE20091977A1 (es) |
PL (1) | PL2271650T3 (es) |
PT (1) | PT2271650E (es) |
SI (1) | SI2271650T1 (es) |
TW (1) | TWI431007B (es) |
WO (1) | WO2009131926A1 (es) |
ZA (1) | ZA201007527B (es) |
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US8309577B2 (en) * | 2008-04-23 | 2012-11-13 | Bristol-Myers Squibb Company | Quinuclidine compounds as α-7 nicotinic acetylcholine receptor ligands |
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CN102686595A (zh) * | 2009-10-28 | 2012-09-19 | 百时美施贵宝公司 | 作为α-7 烟碱乙酰胆碱受体配体的氮杂二环化合物 |
CA2779177C (en) * | 2009-10-29 | 2016-08-30 | Bristol-Myers Squibb Company | Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands |
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BR112012033770A2 (pt) | 2010-06-30 | 2016-11-22 | Fujifilm Corp | novo derivado de nicotinamida ou sal do mesmo |
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EP2855471B1 (en) | 2012-05-24 | 2017-11-15 | Bristol-Myers Squibb Company | QUINUCLIDINE, 1-AZABICYCLO[2.2.1]HEPTANE, 1-AZABICYCLO [3.2.1]OCTANE, and 1-AZABICYCLO[3.2.2]NONANE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS |
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GB8808433D0 (en) * | 1988-04-11 | 1988-05-11 | Merck Sharp & Dohme | Therapeutic agents |
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BRPI0412382A (pt) | 2003-07-08 | 2006-09-19 | Astrazeneca Ab | composto , método para a verificação de novos compostos medicinais que se ligam a e modulam a atividade, por agonismo , agonismo parcial, ou antagonismo, do receptor de acetilcolina nicotìnico alfa7, método de tratamento ou profilaxia de uma doença ou condição humana, método para tratamento de jetlag, induzindo interrupção de fumar, vìcio em nicotina, abstinência, dor, e para colite ulcerativa, composição farmacêutica, e, método de tratamento ou prevenção de uma condição ou distúrbio que surge da disfunção de neurotransmissão do receptor de acetilcolina nicotìnico em um mamìfero, e, uso de um composto |
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2009
- 2009-04-14 US US12/423,299 patent/US7863291B2/en active Active
- 2009-04-20 CA CA2722325A patent/CA2722325A1/en not_active Abandoned
- 2009-04-20 PL PL09733949T patent/PL2271650T3/pl unknown
- 2009-04-20 JP JP2011506374A patent/JP5389905B2/ja not_active Expired - Fee Related
- 2009-04-20 HU HUE09733949A patent/HUE028302T2/en unknown
- 2009-04-20 NZ NZ588649A patent/NZ588649A/en unknown
- 2009-04-20 PT PT97339493T patent/PT2271650E/pt unknown
- 2009-04-20 CN CN200980123841.9A patent/CN102066384B/zh not_active Expired - Fee Related
- 2009-04-20 MX MX2010011374A patent/MX2010011374A/es active IP Right Grant
- 2009-04-20 ES ES09733949.3T patent/ES2553753T3/es active Active
- 2009-04-20 BR BRPI0911542A patent/BRPI0911542A2/pt not_active IP Right Cessation
- 2009-04-20 WO PCT/US2009/041076 patent/WO2009131926A1/en active Application Filing
- 2009-04-20 AU AU2009239575A patent/AU2009239575B2/en not_active Ceased
- 2009-04-20 SI SI200931324T patent/SI2271650T1/sl unknown
- 2009-04-20 EP EP09733949.3A patent/EP2271650B1/en active Active
- 2009-04-20 DK DK09733949.3T patent/DK2271650T3/en active
- 2009-04-20 EA EA201001696A patent/EA017628B1/ru not_active IP Right Cessation
- 2009-04-20 KR KR1020107026057A patent/KR20110015565A/ko not_active Application Discontinuation
- 2009-04-23 AR ARP090101442A patent/AR071215A1/es unknown
- 2009-04-23 TW TW098113525A patent/TWI431007B/zh not_active IP Right Cessation
- 2009-04-23 CL CL2009000975A patent/CL2009000975A1/es unknown
- 2009-04-23 PE PE2009000562A patent/PE20091977A1/es not_active Application Discontinuation
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2010
- 2010-10-12 IL IL208673A patent/IL208673A/en not_active IP Right Cessation
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2015
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