CO6300941A2 - Compuestos de quinuclidina como ligandos del receptor nicotinico de acetilcolina alfa 7 - Google Patents
Compuestos de quinuclidina como ligandos del receptor nicotinico de acetilcolina alfa 7Info
- Publication number
- CO6300941A2 CO6300941A2 CO10131169A CO10131169A CO6300941A2 CO 6300941 A2 CO6300941 A2 CO 6300941A2 CO 10131169 A CO10131169 A CO 10131169A CO 10131169 A CO10131169 A CO 10131169A CO 6300941 A2 CO6300941 A2 CO 6300941A2
- Authority
- CO
- Colombia
- Prior art keywords
- ligands
- nicotinic receptor
- acetilcoline
- compounds
- quinuclidine compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
La revelación proporciona compuestos de fórmula I, incluyendo sus sales, así como composiciones y procedimientos de uso de los compuestos. Los compuestos son ligandos para el receptor nicotínico a7 y pueden ser útiles para el tratamiento de diversos trastornos del sistema nervioso central, en especial trastornos afectivos y neurodegenerativos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4721108P | 2008-04-23 | 2008-04-23 | |
US12/423,299 US7863291B2 (en) | 2008-04-23 | 2009-04-14 | Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6300941A2 true CO6300941A2 (es) | 2011-07-21 |
Family
ID=41215599
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO10131169A CO6300941A2 (es) | 2008-04-23 | 2010-10-22 | Compuestos de quinuclidina como ligandos del receptor nicotinico de acetilcolina alfa 7 |
Country Status (27)
Country | Link |
---|---|
US (1) | US7863291B2 (es) |
EP (1) | EP2271650B1 (es) |
JP (1) | JP5389905B2 (es) |
KR (1) | KR20110015565A (es) |
CN (1) | CN102066384B (es) |
AR (1) | AR071215A1 (es) |
AU (1) | AU2009239575B2 (es) |
BR (1) | BRPI0911542A2 (es) |
CA (1) | CA2722325A1 (es) |
CL (1) | CL2009000975A1 (es) |
CO (1) | CO6300941A2 (es) |
CY (1) | CY1117045T1 (es) |
DK (1) | DK2271650T3 (es) |
EA (1) | EA017628B1 (es) |
ES (1) | ES2553753T3 (es) |
HR (1) | HRP20151111T1 (es) |
HU (1) | HUE028302T2 (es) |
IL (1) | IL208673A (es) |
MX (1) | MX2010011374A (es) |
NZ (1) | NZ588649A (es) |
PE (1) | PE20091977A1 (es) |
PL (1) | PL2271650T3 (es) |
PT (1) | PT2271650E (es) |
SI (1) | SI2271650T1 (es) |
TW (1) | TWI431007B (es) |
WO (1) | WO2009131926A1 (es) |
ZA (1) | ZA201007527B (es) |
Families Citing this family (75)
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BRPI0911410A2 (pt) | 2008-04-23 | 2015-10-06 | Gilead Sciences Inc | análogos de carba-nucleosídeo para tratamento antiviral |
US8309577B2 (en) * | 2008-04-23 | 2012-11-13 | Bristol-Myers Squibb Company | Quinuclidine compounds as α-7 nicotinic acetylcholine receptor ligands |
BRPI0916576A2 (pt) * | 2008-08-04 | 2017-06-27 | Chdi Inc | pelo menos uma entidade química, composição farmacêutica, e, método para tratar uma condição ou distúrbio. |
TWI453207B (zh) * | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶,其組合物及使用其之治療方法 |
SI2480559T1 (sl) | 2009-09-21 | 2013-10-30 | Gilead Sciences, Inc. | Postopki in intermediati za pripravo 1'-ciano-karbanukleozidnih analogov |
US8278320B2 (en) * | 2009-10-28 | 2012-10-02 | Bristol-Myers Squibb Company | Azabicyclo[2.2.1]heptane compounds as alpha-7 nicotinic acetylcholine receptor ligands |
US8507516B2 (en) | 2009-10-28 | 2013-08-13 | Bristol-Myers Squibb Company | Azabicyclic compounds as alpha-7 nicotinic acetylcholine receptor ligands |
NZ600240A (en) * | 2009-10-29 | 2014-04-30 | Bristol Myers Squibb Co | Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands |
KR101764607B1 (ko) * | 2010-01-14 | 2017-08-03 | 사노피 | 2,5-치환된 옥사졸로피리미딘 유도체 |
US8481555B2 (en) * | 2010-04-30 | 2013-07-09 | Bristol-Myers Squibb Company | Aza-bicyclic amine N-oxide compounds as alpha-7 nicotinic acetylcholine receptor ligand pro-drugs |
KR101789129B1 (ko) | 2010-06-30 | 2017-11-20 | 후지필름 가부시키가이샤 | 신규 니코틴아미드 유도체 또는 그 염 |
KR20200052384A (ko) | 2010-07-19 | 2020-05-14 | 길리애드 사이언시즈, 인코포레이티드 | 부분입체 이성질성으로 순수한 포스포라미데이트 전구약물의 제조 방법 |
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MX364378B (es) | 2011-08-30 | 2019-01-21 | Chdi Foundation Inc | Inhibidores de la quinurenina-3-monooxigenasa, sus composiciones farmaceuticas y metodos para uso. |
WO2013056070A2 (en) | 2011-10-14 | 2013-04-18 | Ambit Biosciences Corporation | Heterocyclic compounds and methods of use thereof |
AR090037A1 (es) | 2011-11-15 | 2014-10-15 | Xention Ltd | Derivados de tieno y/o furo-pirimidinas y piridinas inhibidores de los canales de potasio |
WO2013177024A1 (en) | 2012-05-24 | 2013-11-28 | Bristol-Myers Squibb Company | QUINUCLIDINE, 1-AZABICYCLO[2.2.1]HEPTANE, 1-AZABICYCLO [3.2.1]OCTANE, and 1-AZABICYCLO[3.2.2]NONANE COMPOUNDS AS ALPHA-7 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS |
PT3176170T (pt) | 2012-06-13 | 2019-02-05 | Incyte Holdings Corp | Compostos tricíclicos substituídos como inibidores de fgfr |
US9388185B2 (en) | 2012-08-10 | 2016-07-12 | Incyte Holdings Corporation | Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors |
US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
CN105143222B (zh) * | 2013-03-14 | 2018-02-02 | 默克专利有限公司 | 糖苷酶抑制剂 |
PE20152033A1 (es) | 2013-04-19 | 2016-01-21 | Incyte Holdings Corp | Heterociclos bicicliclos como inhibidores de fgfr |
WO2015116904A1 (en) | 2014-02-03 | 2015-08-06 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ror-gamma |
JP5714745B2 (ja) * | 2014-04-28 | 2015-05-07 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | α7ニコチン性アセチルコリン受容体リガンドとしてのキヌクリジン化合物 |
MX2017000779A (es) | 2014-07-17 | 2017-07-27 | Chdi Foundation Inc | Metodos y composiciones para el tratamiento de trastornos relacionados con el vih. |
JP6563017B2 (ja) | 2014-08-28 | 2019-08-21 | エースニューロン・ソシエテ・アノニム | グリコシダーゼ阻害剤 |
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WO2016073407A1 (en) * | 2014-11-04 | 2016-05-12 | Bristol-Myers Squibb Company | Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands |
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CN110869028B (zh) | 2017-03-14 | 2023-01-20 | 吉利德科学公司 | 治疗猫冠状病毒感染的方法 |
MX2019010302A (es) | 2017-03-30 | 2019-11-21 | Hoffmann La Roche | Isoquinolinas como inhibidores de hpk1. |
CN115403626A (zh) | 2017-05-01 | 2022-11-29 | 吉利德科学公司 | 新结晶形式 |
AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
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MA49685A (fr) | 2017-07-24 | 2021-04-14 | Vitae Pharmaceuticals Llc | INHIBITEURS DE ROR gamma |
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US11213525B2 (en) | 2017-08-24 | 2022-01-04 | Asceneuron Sa | Linear glycosidase inhibitors |
CN107868039A (zh) * | 2017-11-27 | 2018-04-03 | 中国药科大学 | 一种贝曲沙班中间体n-(5-氯-2-吡啶基)-2-[(4-氰基苯甲酰基)氨基]-5-甲氧基苯甲酰胺的制备方法 |
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CA3179226A1 (en) | 2020-05-29 | 2021-12-02 | Tomas Cihlar | Remdesivir treatment methods |
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Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8808433D0 (en) * | 1988-04-11 | 1988-05-11 | Merck Sharp & Dohme | Therapeutic agents |
US5053412A (en) | 1990-04-10 | 1991-10-01 | Israel Institute For Biological Research | Spiro nitrogen-bridged heterocyclic compounds |
IL97726A (en) | 1990-04-10 | 1994-12-29 | Israel Inst Biolog Res | Pharmaceutical preparations containing compounds with bridged and unbridged heterocyclic groups connected via spiro-atop with oxazoline and thiazoline groups, and sharp compounds |
US5534520A (en) * | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
CN1056846C (zh) * | 1994-08-24 | 2000-09-27 | 阿斯特拉公司 | 治疗学上有效的螺-氮杂二环化合物 |
MXPA04010921A (es) | 2002-05-03 | 2005-05-27 | Israel Inst Biolog Res | Metodos y composiciones para el tratamietno de trastornos del sistema nervioso central y periferico y compuestos novedosos utiles para los mismos. |
EP1654264A1 (en) | 2003-07-08 | 2006-05-10 | AstraZeneca AB | Spiro [1-azabicyclo [2.2.2]octane-3,5'-oxazolidin-2'-one] derivatives with affinity to the alpha7 nicotinic acetylcholine receptor |
JP2008524208A (ja) | 2004-12-15 | 2008-07-10 | アストラゼネカ・アクチエボラーグ | ニコチン性アセチルコリン受容体リガンド |
US20070004715A1 (en) | 2005-06-30 | 2007-01-04 | Yifang Huang | Novel spiro-quinuclidinyl derivatives for the treatment of central nervous system disorders |
ITMI20061279A1 (it) | 2006-06-30 | 2008-01-01 | Consiglio Nazionale Ricerche | Agonisti nicotinici selettivi per il sottotipo recettoriale alfa7,procedimento per la loro preparazione e relative composizioni farmaceutiche |
US8309577B2 (en) * | 2008-04-23 | 2012-11-13 | Bristol-Myers Squibb Company | Quinuclidine compounds as α-7 nicotinic acetylcholine receptor ligands |
-
2009
- 2009-04-14 US US12/423,299 patent/US7863291B2/en active Active
- 2009-04-20 PL PL09733949T patent/PL2271650T3/pl unknown
- 2009-04-20 CA CA2722325A patent/CA2722325A1/en not_active Abandoned
- 2009-04-20 PT PT97339493T patent/PT2271650E/pt unknown
- 2009-04-20 AU AU2009239575A patent/AU2009239575B2/en not_active Ceased
- 2009-04-20 KR KR1020107026057A patent/KR20110015565A/ko not_active Application Discontinuation
- 2009-04-20 DK DK09733949.3T patent/DK2271650T3/en active
- 2009-04-20 EA EA201001696A patent/EA017628B1/ru not_active IP Right Cessation
- 2009-04-20 CN CN200980123841.9A patent/CN102066384B/zh not_active Expired - Fee Related
- 2009-04-20 HU HUE09733949A patent/HUE028302T2/en unknown
- 2009-04-20 WO PCT/US2009/041076 patent/WO2009131926A1/en active Application Filing
- 2009-04-20 JP JP2011506374A patent/JP5389905B2/ja not_active Expired - Fee Related
- 2009-04-20 MX MX2010011374A patent/MX2010011374A/es active IP Right Grant
- 2009-04-20 BR BRPI0911542A patent/BRPI0911542A2/pt not_active IP Right Cessation
- 2009-04-20 SI SI200931324T patent/SI2271650T1/sl unknown
- 2009-04-20 EP EP09733949.3A patent/EP2271650B1/en active Active
- 2009-04-20 NZ NZ588649A patent/NZ588649A/en unknown
- 2009-04-20 ES ES09733949.3T patent/ES2553753T3/es active Active
- 2009-04-23 TW TW098113525A patent/TWI431007B/zh not_active IP Right Cessation
- 2009-04-23 AR ARP090101442A patent/AR071215A1/es unknown
- 2009-04-23 PE PE2009000562A patent/PE20091977A1/es not_active Application Discontinuation
- 2009-04-23 CL CL2009000975A patent/CL2009000975A1/es unknown
-
2010
- 2010-10-12 IL IL208673A patent/IL208673A/en not_active IP Right Cessation
- 2010-10-21 ZA ZA2010/07527A patent/ZA201007527B/en unknown
- 2010-10-22 CO CO10131169A patent/CO6300941A2/es active IP Right Grant
-
2015
- 2015-10-21 HR HRP20151111TT patent/HRP20151111T1/hr unknown
- 2015-12-14 CY CY20151101139T patent/CY1117045T1/el unknown
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