CO6470823A2 - Piperidinas sustituidas - Google Patents

Piperidinas sustituidas

Info

Publication number
CO6470823A2
CO6470823A2 CO11161612A CO11161612A CO6470823A2 CO 6470823 A2 CO6470823 A2 CO 6470823A2 CO 11161612 A CO11161612 A CO 11161612A CO 11161612 A CO11161612 A CO 11161612A CO 6470823 A2 CO6470823 A2 CO 6470823A2
Authority
CO
Colombia
Prior art keywords
piperidins
substituted
disorders
new
par
Prior art date
Application number
CO11161612A
Other languages
English (en)
Inventor
Dirk Heimbach
Susanne Rohring
Yolanda Cancho-Grande
Eckhard Bender
Katja Zimmermann
Anja Buchmuller
Christoph Gerdes
Mark Jean Gnoth
Kersten Matthias Gericke
Mario Jeske
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of CO6470823A2 publication Critical patent/CO6470823A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Non-Alcoholic Beverages (AREA)

Abstract

Nuevas piperidinas sustituidas, procedimientos para su preparación de compuestos de la fórmula 1: Nuevos antagonistas del PAR-1 para el tratamiento de trastornos cardiovasculares y trastornos tromboembólicos, así como trastornos tumorales, en seres humanos y animales.
CO11161612A 2009-05-27 2011-11-24 Piperidinas sustituidas CO6470823A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102009022896A DE102009022896A1 (de) 2009-05-27 2009-05-27 Substituierte Piperidine

Publications (1)

Publication Number Publication Date
CO6470823A2 true CO6470823A2 (es) 2012-06-29

Family

ID=42543057

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11161612A CO6470823A2 (es) 2009-05-27 2011-11-24 Piperidinas sustituidas

Country Status (28)

Country Link
US (2) US20120220563A1 (es)
EP (1) EP2435427A1 (es)
JP (1) JP5718320B2 (es)
KR (1) KR20120044289A (es)
CN (2) CN104744452A (es)
AR (1) AR076692A1 (es)
AU (1) AU2010252345A1 (es)
BR (1) BRPI1012055A2 (es)
CA (1) CA2763400A1 (es)
CL (1) CL2011002965A1 (es)
CO (1) CO6470823A2 (es)
CR (1) CR20110628A (es)
CU (1) CU20110215A7 (es)
DE (1) DE102009022896A1 (es)
DO (1) DOP2011000364A (es)
EA (1) EA201190312A1 (es)
EC (2) ECSP11011483A (es)
GT (1) GT201100300A (es)
IL (1) IL215901A0 (es)
MA (1) MA33290B1 (es)
MX (1) MX2011012505A (es)
PE (1) PE20120934A1 (es)
SG (1) SG175753A1 (es)
TN (1) TN2011000595A1 (es)
TW (1) TW201109326A (es)
UY (2) UY32636A (es)
WO (1) WO2010136144A1 (es)
ZA (1) ZA201108565B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009014484A1 (de) 2009-03-23 2010-09-30 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
DE102009022896A1 (de) 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
DE102009022894A1 (de) * 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
DE102009022892A1 (de) * 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
MY176126A (en) 2011-10-07 2020-07-24 Takeda Pharmaceuticals Co 1-arylcarbonyl-4-oxy-piperidine compounds useful for the treatment of neurodegenerative diseases
MX2018012840A (es) 2016-04-20 2019-03-11 Squibb Bristol Myers Co Compuestos heterociclicos biciclicos sustituidos.
BR112019008824A2 (pt) 2016-11-03 2019-07-09 Bristol-Myers Squibb Company derivados heterocíclicos bicíclicos substituídos úteis como inibidores de canal de romk
BR112019024950A2 (pt) 2017-06-01 2020-06-23 Bristol-Myers Squibb Company Compostos contendo nitrogênio substituído
WO2023044364A1 (en) 2021-09-15 2023-03-23 Enko Chem, Inc. Protoporphyrinogen oxidase inhibitors

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5767144A (en) * 1994-08-19 1998-06-16 Abbott Laboratories Endothelin antagonists
AU2722297A (en) 1996-04-03 1997-10-22 Merck & Co., Inc. Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
US6403612B2 (en) * 2000-01-31 2002-06-11 Merck & Co., Inc. Thrombin receptor antagonists
NZ531733A (en) 2001-10-15 2006-04-28 Janssen Pharmaceutica Nv Substituted 4-phenyl-4-[1H-imidazol-2-YL]- piperidine derivatives for reducing ischaemic damage
US7319104B2 (en) * 2002-03-01 2008-01-15 Smithkline Beecham Corporation hPPARs activators
JP2008504279A (ja) 2004-06-24 2008-02-14 インサイト・コーポレイション アミド化合物およびその医薬としての使用
JP2008504275A (ja) 2004-06-24 2008-02-14 インサイト・コーポレイション Ｎ−置換ピペリジンおよびその医薬としての使用
UA95769C2 (ru) * 2004-06-24 2011-09-12 Инсайт Корпорейшн N-замещенные пиперидины и их применение в качестве фармацевтических препаратов
NZ551602A (en) 2004-06-24 2010-11-26 Incyte Corp Amido compounds and their use as pharmaceuticals
BRPI0514230A (pt) 2004-08-10 2008-06-03 Incyte Corp compostos de amido e seu uso como produtos farmacêuticos
JP2007008913A (ja) * 2004-09-17 2007-01-18 Tanabe Seiyaku Co Ltd ピペリジン化合物およびその製法
DE102004045796A1 (de) * 2004-09-22 2006-03-23 Merck Patent Gmbh Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung
DE102004061750A1 (de) * 2004-12-22 2006-07-06 Bayer Healthcare Ag Heteroaryl-substituierte Pyrazoline
CA2621255A1 (en) 2005-09-21 2007-04-05 Incyte Corporation Amido compounds and their use as pharmaceuticals
WO2007089683A1 (en) 2006-01-31 2007-08-09 Incyte Corporation Amido compounds and their use as pharmaceuticals
US20070213311A1 (en) 2006-03-02 2007-09-13 Yun-Long Li Modulators of 11-beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
US20070293529A1 (en) 2006-05-01 2007-12-20 Yun-Long Li Tetrasubstituted ureas as modulators of 11-beta hydroxyl steroid dehydrogenase type 1
WO2009068214A2 (de) 2007-11-30 2009-06-04 Bayer Schering Pharma Aktiengesellschaft Heteroaryl-substituierte piperidine
DE102009014484A1 (de) * 2009-03-23 2010-09-30 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
DE102009022896A1 (de) 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
DE102009022897A1 (de) * 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine
DE102009022894A1 (de) * 2009-05-27 2010-12-02 Bayer Schering Pharma Aktiengesellschaft Substituierte Piperidine

Also Published As

Publication number Publication date
ZA201108565B (en) 2013-01-30
JP2012528090A (ja) 2012-11-12
CN102596944B (zh) 2015-08-26
IL215901A0 (en) 2012-01-31
TN2011000595A1 (en) 2013-05-24
UY32636A (es) 2010-12-31
EA201190312A1 (ru) 2012-05-30
CR20110628A (es) 2012-03-22
SG175753A1 (en) 2011-12-29
TW201109326A (en) 2011-03-16
ECSP11011482A (es) 2011-12-30
CN102596944A (zh) 2012-07-18
US20120220563A1 (en) 2012-08-30
JP5718320B2 (ja) 2015-05-13
KR20120044289A (ko) 2012-05-07
ECSP11011483A (es) 2011-12-30
UY32638A (es) 2010-10-29
MX2011012505A (es) 2011-12-14
CN104744452A (zh) 2015-07-01
EP2435427A1 (de) 2012-04-04
BRPI1012055A2 (pt) 2016-05-17
DOP2011000364A (es) 2012-02-29
PE20120934A1 (es) 2012-08-01
GT201100300A (es) 2013-08-21
AU2010252345A1 (en) 2011-12-08
AR076692A1 (es) 2011-06-29
WO2010136144A1 (de) 2010-12-02
MA33290B1 (fr) 2012-05-02
US20110021489A1 (en) 2011-01-27
CU20110215A7 (es) 2012-03-15
US8084469B2 (en) 2011-12-27
CA2763400A1 (en) 2010-12-02
CL2011002965A1 (es) 2012-07-06
DE102009022896A1 (de) 2010-12-02

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