PE20051004A1 - Compuestos de biaril sulfonamidas como inhibidores de metaloproteinasas - Google Patents

Compuestos de biaril sulfonamidas como inhibidores de metaloproteinasas

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Publication number
PE20051004A1
PE20051004A1 PE2004001191A PE2004001191A PE20051004A1 PE 20051004 A1 PE20051004 A1 PE 20051004A1 PE 2004001191 A PE2004001191 A PE 2004001191A PE 2004001191 A PE2004001191 A PE 2004001191A PE 20051004 A1 PE20051004 A1 PE 20051004A1
Authority
PE
Peru
Prior art keywords
compounds
methyl
inhibitors
metaloproteinases
iloximethyl
Prior art date
Application number
PE2004001191A
Other languages
English (en)
Inventor
Jason Shaoyun Xiang
Steve Yik-Kai Tam
Yonghan Hu
Phaik-Eng Sum
David Brain How
Darrin William Hopper
Matthew Douglas Vera
Joshua James Sabatini
Iii Thomas Saltmarsh Rush
Elisabeth Ann Morris
Katy Evangelia Georgiadis
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of PE20051004A1 publication Critical patent/PE20051004A1/es

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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Abstract

SE REFIERE A COMPUESTO DE FORMULA (I), DONDE R1 ES H, ALQUILO C1-C6; R2 ES H, ALQUILO C1-C6, FENILO, BENCILO, ENTRE OTROS; R3 ES H, HALOGENO, OC(HALOGENO)3, ENTRE OTROS; Z ES ARILO O HETEROARILO; X ES CH2O, OCH2, CH2S(O), ENTRE OTROS; Z ES ARILO O HETROARILO. SON COMPUESTOS PREFERIDOS: ACIDO 3- METIL-2-[4´-(3-METIL-QUINOLIN-2-ILOXIMETIL)-BIFENIL-4-SULFONILAMINO]-BUTIRICO; ACIDO 3-METIL-2-[4´-(5-TRIFLUOROMETIL-PIRIDIN-2-ILOXIMETIL)-BIFENIL-4-SULFONILAMINO]-BUTIRICO; ACIDO 2-[4´-(2,8-BIS-TRIFLUOROMETIL-QUINOLIN-4-ILOXIMETIL)-BIFENIL-4-SULFONILAMINO]-3-METIL-BUTIRICO, ENTRE OTROS. DICHOS COMPUESTOS SON INHIBIDORES DE METALOPROTEINASAS DE MATRIZ (MMPS) UTILES EN EL TRATAMIENTO DE CANCER, OSTEOARTRITIS, ASMA, ATEROSCLEROSIS, ENTRE OTROS
PE2004001191A 2003-12-04 2004-12-03 Compuestos de biaril sulfonamidas como inhibidores de metaloproteinasas PE20051004A1 (es)

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