BR0318625A - biaril sulfonamidas e métodos para usar as mesmas - Google Patents

biaril sulfonamidas e métodos para usar as mesmas

Info

Publication number
BR0318625A
BR0318625A BRPI0318625-3A BR0318625A BR0318625A BR 0318625 A BR0318625 A BR 0318625A BR 0318625 A BR0318625 A BR 0318625A BR 0318625 A BR0318625 A BR 0318625A
Authority
BR
Brazil
Prior art keywords
methods
halogen
alkyl
biaryl sulfonamides
aryl
Prior art date
Application number
BRPI0318625-3A
Other languages
English (en)
Inventor
Jason Shaoyun Xiang
Steve Yik-Kai Tam
Yonghan Hu
Phaik-Eng Sum
David Brian How
Darrin William Hopper
Matthew Douglas Vera
Joshua James Sabatini
Thomas Saltmarsh Rush
Elisabeth Ann Morris
Katy Evangelia Georgiadis
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BR0318625A publication Critical patent/BR0318625A/pt

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
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    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

"BIARIL SULFONAMIDAS E MéTODOS PARA USAR AS MESMAS". A presente invenção se refere a biaril sulfonamidas de fórmula 1, em que R¬ 1¬ é H ou C~ 1~ - C~ 6~ alquila; R¬ 2¬ é H, C~ 1~ - C~ 6~ alquila, (CH~ 2~)~ n~R¬ 2¬, fenila ou benzila; n é 0 - 6; R¬ 2<39>¬ é arila, heteroarila, cicloalquila ou heterocicloalquila; R¬ 3¬ é, independentemente com relação a cada ocorrência, H, halogênio, OC(halogênio)~ 3~, C(halogênio)~ 3~, alcóxi ou C~ 1~ - C~ 6~ alquila; X é selecionado em CH~ 2~O, OCH~ 2~, C(R¬ 3¬)=(R¬ 3¬)~ 2~-C(R¬ 3¬)~ 2~, CH~ 2~NHC(=O), O(C=O)NH, O, C(=O)CH~ 2~, SO~ 2~CH~ 2~C(=O)NH, SO~ 2~NH, OC(=O), CH~ 2~S(O) e CH~ 2~S(O)~ 2~; e Z é pelo menos uma porção arila ou heteroarila, e seu uso como, por exemplo, inibidores de metaloproteinase.
BRPI0318625-3A 2003-12-04 2003-12-22 biaril sulfonamidas e métodos para usar as mesmas BR0318625A (pt)

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Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE411306T1 (de) * 2003-12-04 2008-10-15 Wyeth Corp Biarylsulfonamide als mmp-inhibitoren
JP2007525406A (ja) * 2003-12-04 2007-09-06 ワイス ビアリールスルホンアミドおよびその使用方法
US20080119513A1 (en) * 2004-09-06 2008-05-22 Fumihiko Watanabe Sulfonamide Derivative Selectively Inhibiting Mmp-13
JP5181118B2 (ja) * 2005-07-11 2013-04-10 ワイス・エルエルシー グルタミン酸アグリカナーゼ阻害剤
US7625731B2 (en) * 2005-08-25 2009-12-01 Wyeth Aggrecanase structure
US7615363B2 (en) * 2005-08-25 2009-11-10 Wyeth Aggrecanase structure
BRPI0617348A2 (pt) 2005-10-13 2011-07-26 Wyeth Corp mÉtodos para a preparaÇço de derivados de Ácido glutÂmico; e compostos preparados por esses mÉtodos
US20090069304A1 (en) 2006-03-03 2009-03-12 Shionogi & Co., Ltd. Mmp-13 selective inhibitor
CA2662091A1 (en) * 2006-09-08 2008-03-13 Novartis Ag N-biaryl (hetero) arylsulphonamide derivatives useful in the treatment of diseases mediated by lymphocytes interactions
CA2667003A1 (en) * 2006-10-20 2008-05-02 Merck & Co., Inc. Substituted imidazoles as bombesin receptor subtype-3 modulators
JP5047299B2 (ja) * 2006-10-20 2012-10-10 メルク・シャープ・エンド・ドーム・コーポレイション ボンベシン受容体サブタイプ−３モジュレータとしての置換イミダゾール
AU2007309568A1 (en) * 2006-10-20 2008-05-02 Merck Sharp & Dohme Corp. Substituted imidazoles as bombesin receptor subtype-3 modulators
EP2128134A1 (en) 2006-11-02 2009-12-02 Shionogi&Co., Ltd. Sulfonylurea derivative capable of selectively inhibiting mmp-13
US9156914B2 (en) * 2006-12-19 2015-10-13 Ablynx N.V. Amino acid sequences directed against a metalloproteinase from the ADAM family and polypeptides comprising the same for the treatment of ADAM-related diseases and disorders
EP2147684A1 (en) * 2008-07-22 2010-01-27 Bracco Imaging S.p.A Diagnostic Agents Selective Against Metalloproteases
AU2013203591B2 (en) * 2009-05-01 2017-01-19 University Court Of The University Of Dundee Treatment or prophylaxis of proliferative conditions
GB0907551D0 (en) * 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
KR20120098587A (ko) * 2009-07-02 2012-09-05 글락소 그룹 리미티드 폴리펩티드 및 치료 방법
EP2678027A4 (en) * 2011-02-24 2015-09-02 Glaxo Group Ltd METHODS OF IDENTIFYING PATIENT POPULATION
HUE031089T2 (en) * 2012-04-13 2017-06-28 Rottapharm Biotech Srl Anti-ADAMTS-5 antibody, derivatives and uses
GB201312311D0 (en) * 2013-07-09 2013-08-21 Uni I Oslo Uses of enzyme inhibitors
WO2016061642A1 (en) * 2014-10-22 2016-04-28 Katholieke Universiteit Leuven Ku Leuven Research & Development Modulating adipose tissue and adipogenesis
US10377818B2 (en) 2015-01-30 2019-08-13 The Board Of Trustees Of The Leland Stanford Junior University Method of treating glioma
US11813307B2 (en) 2017-06-02 2023-11-14 Merck Patent Gmbh Polypeptides binding ADAMTS5, MMP13 and aggrecan
BR112019024333A2 (pt) 2017-06-02 2020-07-28 Merck Patent Gmbh imunoglobulinas de ligação adamts
KR20200118827A (ko) 2018-02-02 2020-10-16 마베릭스 온콜로지, 잉크. 젬시타빈 모노포스페이트의 소분자 약물 컨쥬게이트
CN111187289B (zh) * 2020-02-26 2021-03-23 湖南中大检测技术集团有限公司 一种过氧化氢荧光探针及其制备方法和应用
US20240092939A1 (en) * 2022-09-07 2024-03-21 Synoa Therapeutics, Llc Methods and compositions comprising novel bispecific antibodies

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69737605T2 (de) * 1996-01-23 2008-04-03 Shionogi & Co., Ltd. Sulfonierte aminosäurederivate und metalloproteinase-inhibitoren, die diese enthalten
DK0901466T3 (da) * 1996-05-17 2002-02-18 Warner Lambert Co Biphenylsulfonamid-matriksmetalloproteinase-inhibitorer
EP0998572A2 (en) 1997-07-25 2000-05-10 Du Pont Pharmaceuticals Company Aggrecan degrading metallo proteases
AU756248B2 (en) * 1998-04-03 2003-01-09 Sankyo Company Limited Sulfonamide derivatives
NZ513830A (en) * 1999-03-03 2001-09-28 Procter & Gamble Dihetero-substituted metalloprotease inhibitors
AU4180900A (en) * 1999-04-02 2000-10-23 Du Pont Pharmaceuticals Company Novel amide derivatives as inhibitors of matrix metalloproteinases, tnf-alpha, and aggrecanase
US6391610B1 (en) * 1999-08-06 2002-05-21 The Cleveland Clinic Foundation Nucleic acids encoding zinc metalloproteases
AU8014500A (en) 1999-10-14 2001-04-23 Procter & Gamble Company, The Beta disubstituted metalloprotease inhibitors
KR100819680B1 (ko) * 2000-08-15 2008-04-04 아크조 노벨 엔.브이. 트리옥세판 화합물
EP1480946A2 (en) * 2001-07-09 2004-12-01 MP Biomedicals, L.L.C. A hydroxamic acid thrombospondin peptide analog that inhibits aggrecanase activity
WO2003066822A2 (en) * 2002-02-05 2003-08-14 Wyeth Truncated aggrecanase molecules
ATE411306T1 (de) 2003-12-04 2008-10-15 Wyeth Corp Biarylsulfonamide als mmp-inhibitoren
JP2007525406A (ja) * 2003-12-04 2007-09-06 ワイス ビアリールスルホンアミドおよびその使用方法

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