BRPI0415433A - derivados de n-[fenil (alquilpiperidin-2-il)metil] benzamida, seu preparo e sua aplicação em terapêutica - Google Patents

derivados de n-[fenil (alquilpiperidin-2-il)metil] benzamida, seu preparo e sua aplicação em terapêutica

Info

Publication number
BRPI0415433A
BRPI0415433A BRPI0415433-9A BRPI0415433A BRPI0415433A BR PI0415433 A BRPI0415433 A BR PI0415433A BR PI0415433 A BRPI0415433 A BR PI0415433A BR PI0415433 A BRPI0415433 A BR PI0415433A
Authority
BR
Brazil
Prior art keywords
group
hydrogen atom
alkyl
alkylpiperidin
phenyl
Prior art date
Application number
BRPI0415433-9A
Other languages
English (en)
Inventor
Gihad Dargazanli
Genevieve Estenne-Bouhtou
Corinne Veronique
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of BRPI0415433A publication Critical patent/BRPI0415433A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Abstract

"DERIVADOS DE N-¢FENIL(ALQUILPIPERIDIN-2IL)METIL!BENZAMIDA, SEU PREPARO E SUA APLICAçãO EM TERAPêUTICA". A presente invenção refere-se a um composto de fórmula geral na qual R~ 1~ representa seja um átomo de hidrogênio, seja um grupo alquila, seja um grupo cicloalquila, seja um grupo cicloalquilalquila, seja um grupo fenilalquila, seja um grupo alcenila, seja um grupo alcinila; R~ 2~ representa seja um grupo alquila, seja um grupo cicloalquila, seja um grupo cicloalquilalquila; X representa seja um átomo de hidrogênio, seja um ou vários átomos de halogênio e/ ou grupos trifluorometila, alquila, ou alcóxi; R~ 3~ representa seja um átomo de hidrogênio, seja um ou vários átomos de halogênio e/ ou grupos trifluorometila, alquilacicloalquila, alcóxi, fenila, ciano, acetila, benzoíla,tioalquila, alquilsulfonila, carbóxi ou alcoxicarbonila, seja um grupo de fórmula geral NR~ 4~R~ 5~ OU SO~ 2~NR~ 4~R~ 5~ OU CONR~ 4~R~ 5~ nas quais R~ 4~ e R~ 5~ representam, cada um, um átomo de hidrogênio ou um grupo alquila, cicloalquila, ou NR~ 4~ e NR~ 5~ representa um ciclo pirrolidina, piperidina ou morfolina. Aplicação em terapêutica.
BRPI0415433-9A 2003-10-17 2004-10-15 derivados de n-[fenil (alquilpiperidin-2-il)metil] benzamida, seu preparo e sua aplicação em terapêutica BRPI0415433A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0312141A FR2861071B1 (fr) 2003-10-17 2003-10-17 Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique
PCT/FR2004/002642 WO2005037782A2 (fr) 2003-10-17 2004-10-15 Derives de n-[phenyl(alkylpiperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
BRPI0415433A true BRPI0415433A (pt) 2006-12-05

Family

ID=34385234

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415433-9A BRPI0415433A (pt) 2003-10-17 2004-10-15 derivados de n-[fenil (alquilpiperidin-2-il)metil] benzamida, seu preparo e sua aplicação em terapêutica

Country Status (26)

Country Link
US (1) US7790753B2 (pt)
EP (1) EP1682503B1 (pt)
JP (1) JP4754494B2 (pt)
CN (1) CN1882541B (pt)
AT (1) ATE359268T1 (pt)
AU (1) AU2004281216B2 (pt)
BR (1) BRPI0415433A (pt)
CA (1) CA2542925A1 (pt)
CY (1) CY1106653T1 (pt)
DE (1) DE602004005886T2 (pt)
DK (1) DK1682503T3 (pt)
ES (1) ES2282916T3 (pt)
FR (1) FR2861071B1 (pt)
HR (1) HRP20070203T3 (pt)
IL (1) IL174936A (pt)
MA (1) MA28100A1 (pt)
ME (1) MEP12708A (pt)
NO (1) NO20062031L (pt)
NZ (1) NZ547166A (pt)
PL (1) PL1682503T3 (pt)
PT (1) PT1682503E (pt)
RS (1) RS20060317A (pt)
RU (1) RU2351589C2 (pt)
SI (1) SI1682503T1 (pt)
WO (1) WO2005037782A2 (pt)
ZA (1) ZA200603942B (pt)

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AR075182A1 (es) * 2009-01-28 2011-03-16 Astrazeneca Ab Compuestos 2-aza-biciclo (2.2.2) octano y sus usos
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US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
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US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
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US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
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Also Published As

Publication number Publication date
RU2006116886A (ru) 2007-11-27
MA28100A1 (fr) 2006-08-01
RU2351589C2 (ru) 2009-04-10
CN1882541A (zh) 2006-12-20
ATE359268T1 (de) 2007-05-15
DE602004005886T2 (de) 2008-01-17
CN1882541B (zh) 2011-07-06
JP2007508360A (ja) 2007-04-05
US20060223861A1 (en) 2006-10-05
DE602004005886D1 (de) 2007-05-24
AU2004281216A1 (en) 2005-04-28
PT1682503E (pt) 2007-05-31
CA2542925A1 (fr) 2005-04-28
WO2005037782A2 (fr) 2005-04-28
IL174936A0 (en) 2006-08-20
US7790753B2 (en) 2010-09-07
PL1682503T3 (pl) 2008-01-31
CY1106653T1 (el) 2012-01-25
HRP20070203T3 (en) 2007-06-30
EP1682503A2 (fr) 2006-07-26
FR2861071B1 (fr) 2006-01-06
NO20062031L (no) 2006-07-06
MEP12708A (en) 2010-06-10
AU2004281216B2 (en) 2010-07-22
ES2282916T3 (es) 2007-10-16
ZA200603942B (en) 2007-11-28
WO2005037782A3 (fr) 2005-07-07
JP4754494B2 (ja) 2011-08-24
SI1682503T1 (sl) 2007-08-31
RS20060317A (en) 2008-11-28
FR2861071A1 (fr) 2005-04-22
IL174936A (en) 2011-01-31
NZ547166A (en) 2009-11-27
EP1682503B1 (fr) 2007-04-11
DK1682503T3 (da) 2007-07-16

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: PARA INT.CL: C07D 211/28, A61K 31/445, A61P 25/00

Ipc: C07D 211/28 (2011.01), A61K 31/445 (2011.01)

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014.