CO5700714A2 - Metodo para el tratamiento de la enfermedad asociada con adamts-5 - Google Patents

Metodo para el tratamiento de la enfermedad asociada con adamts-5

Info

Publication number
CO5700714A2
CO5700714A2 CO06053408A CO06053408A CO5700714A2 CO 5700714 A2 CO5700714 A2 CO 5700714A2 CO 06053408 A CO06053408 A CO 06053408A CO 06053408 A CO06053408 A CO 06053408A CO 5700714 A2 CO5700714 A2 CO 5700714A2
Authority
CO
Colombia
Prior art keywords
adamts
treatment
agent
halogen
alkyl
Prior art date
Application number
CO06053408A
Other languages
English (en)
Inventor
Elisabeth Morris
Sonya S Glasson
Jason Shaoyun Xiang
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CO5700714A2 publication Critical patent/CO5700714A2/es

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

1.- Un método para tratar una enfermedad asociada con ADAMTS-5 en un sujeto que la presenta que consta de la administración al sujeto de un agente que inhiba a ADAMTS-5.18.- Un método para identificar un agente potencial útil para el tratamiento de una enfermedad asociada con ADAMTS-5-que comprende poner en contacto ADAMTS-5 con el agente potencial y medir la actividad de ADAMTS-5 en presencia del agente potencial, donde una reducción en la actividad indica que el agente potencial es útil para el tratamiento de la enfermedad.24.- Un método para modular la actividad de ADAMTS-5 que comprende poner en contacto a ADAMTS-5 con un compuesto de la fórmula I:donde:R1 es H o C1-C6 alquilo;R2 es H, C1-C6 alquilo, (CH2)nR2&#39, fenilo o bencilo;n es 0-6; R2&#39 es arilo, heteroarilo, cicloalquilo o heterocicloalquilo;R3 es, independientemente de cada incidencia, H, halógeno, OC(halógeno)3, C(halógeno)3, alcoxi o C1-C6 alquilo;X se selecciona a partir de CH2O, OCH2, C(R3)=C(R3), C(R3)2-C(R3)2, CH2NHC(=O), O(C=O)NH, O, C(=O)CH2, SO2CH2C(=O)NH, SO2NH, OC(=O), CH2S(O) y CH2S(O)2; y Z es al menos una porción arilo o heteroarilo.
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