DK0901466T3 - Biphenylsulfonamid-matriksmetalloproteinase-inhibitorer - Google Patents
Biphenylsulfonamid-matriksmetalloproteinase-inhibitorerInfo
- Publication number
- DK0901466T3 DK0901466T3 DK97918788T DK97918788T DK0901466T3 DK 0901466 T3 DK0901466 T3 DK 0901466T3 DK 97918788 T DK97918788 T DK 97918788T DK 97918788 T DK97918788 T DK 97918788T DK 0901466 T3 DK0901466 T3 DK 0901466T3
- Authority
- DK
- Denmark
- Prior art keywords
- matriksmetalloproteinase
- biphenylsulfonamide
- inhibitors
- alkyl
- nhoh
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
- C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/42—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1746096P | 1996-05-17 | 1996-05-17 | |
| PCT/US1997/006801 WO1997044315A1 (en) | 1996-05-17 | 1997-04-24 | Biphenylsulfonamide matrix metalloproteinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0901466T3 true DK0901466T3 (da) | 2002-02-18 |
Family
ID=21782716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97918788T DK0901466T3 (da) | 1996-05-17 | 1997-04-24 | Biphenylsulfonamid-matriksmetalloproteinase-inhibitorer |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0901466B1 (da) |
| JP (1) | JP2000511175A (da) |
| KR (1) | KR20000011095A (da) |
| CN (1) | CN1077885C (da) |
| AT (1) | ATE207891T1 (da) |
| BG (1) | BG63940B1 (da) |
| BR (1) | BR9710841A (da) |
| CA (1) | CA2253342A1 (da) |
| CZ (1) | CZ294063B6 (da) |
| DE (1) | DE69707865T2 (da) |
| DK (1) | DK0901466T3 (da) |
| EA (1) | EA001561B1 (da) |
| EE (1) | EE03965B1 (da) |
| ES (1) | ES2167733T3 (da) |
| HK (1) | HK1019585A1 (da) |
| IL (1) | IL126832A0 (da) |
| NO (1) | NO312510B1 (da) |
| NZ (1) | NZ332711A (da) |
| PL (1) | PL186416B1 (da) |
| PT (1) | PT901466E (da) |
| SK (1) | SK282863B6 (da) |
| WO (1) | WO1997044315A1 (da) |
| ZA (1) | ZA974223B (da) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2303850B (en) * | 1994-06-22 | 1998-06-10 | British Biotech Pharm | Metalloproteinase inhibitors |
| US6124333A (en) * | 1995-06-22 | 2000-09-26 | British Biotech Pharmaceuticals Limited | Metalloproteinase inhibitors |
| JP2001526631A (ja) * | 1996-12-09 | 2001-12-18 | ワーナー−ランバート・コンパニー | 心不全および心拡張症の治療および予防方法 |
| EP1366765A1 (en) * | 1996-12-17 | 2003-12-03 | Warner-Lambert Company Llc | Use of matrix metalloproteinase inhibitors for treating neurological disorders and promoting wound healing |
| PT946166E (pt) | 1996-12-17 | 2004-06-30 | Warner Lambert Co | Utilizacao de inibidores das metaloproteinases da matriz para tratar disturbios neurologicos e promover a cicatrizacao de feridas |
| GB9706255D0 (en) | 1997-03-26 | 1997-05-14 | Smithkline Beecham Plc | Novel compounds |
| DE19719621A1 (de) * | 1997-05-09 | 1998-11-12 | Hoechst Ag | Sulfonylaminocarbonsäuren |
| NZ502274A (en) * | 1997-07-22 | 2001-03-30 | Shionogi & Co | The use of a therapeutic or prophylactic agent containing a sulphonamide derivative for treating glomerulopathy |
| DK1047450T3 (da) * | 1997-12-23 | 2003-01-27 | Warner Lambert Co | Kombinationer af ACE-inhibitorer og MMP-inhibitorer |
| US6410580B1 (en) | 1998-02-04 | 2002-06-25 | Novartis Ag | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases |
| EP1918278A1 (en) * | 1998-02-04 | 2008-05-07 | Novartis AG | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases |
| WO1999047138A1 (en) * | 1998-03-17 | 1999-09-23 | Warner-Lambert Company | Statin-matrix metalloproteinase inhibitor combinations |
| EP0967201A1 (en) * | 1998-05-20 | 1999-12-29 | Roche Diagnostics GmbH | Pharmaceutical agents containing sulfonamids as matrix metalloproteinase inhibitors |
| CA2337828C (en) * | 1998-07-16 | 2010-08-17 | Aventis Pharma Deutschland Gmbh | Phosphinic and phosphonic acid derivatives used as pharmaceuticals |
| CA2335062A1 (en) * | 1998-07-21 | 2000-02-03 | Thomas Michael Andrew Bocan | Coadministration of acat and mmp inhibitors for the treatment of atherosclerotic lesions |
| DE19851184A1 (de) * | 1998-11-06 | 2000-05-11 | Aventis Pharma Gmbh | N-Arylsulfonyl-aminosäure-omega-amide |
| CA2367395A1 (en) * | 1999-04-19 | 2000-10-26 | Shionogi & Co., Ltd. | Cyclic amine derivatives and use thereof |
| GB9918684D0 (en) | 1999-08-09 | 1999-10-13 | Novartis Ag | Organic compounds |
| CN1391469B (zh) | 1999-11-26 | 2010-05-26 | 盐野义制药株式会社 | Npy y5拮抗剂 |
| KR20030030036A (ko) * | 2000-09-29 | 2003-04-16 | 시오노기세이야쿠가부시키가이샤 | 티아졸 또는 옥사졸 유도체 |
| GB0103303D0 (en) | 2001-02-09 | 2001-03-28 | Novartis Ag | Organic compounds |
| MXPA01013326A (es) * | 2001-02-14 | 2002-08-26 | Warner Lambert Co | Bifenil sulfonamidas utiles como inhibisdores de metaloproteinasa de matriz. |
| WO2003035610A1 (fr) * | 2001-10-26 | 2003-05-01 | Shionogi & Co., Ltd. | Derive de sulfonamide a effet inhibiteur sur les mmp |
| GB0314488D0 (en) * | 2003-06-20 | 2003-07-23 | Glaxo Group Ltd | Therapeutically useful compounds |
| AU2003304638A1 (en) * | 2003-12-04 | 2005-07-14 | Wyeth | Biaryl sulfonamides and methods for using same |
| PL1735274T3 (pl) * | 2004-03-22 | 2010-05-31 | Southern Res Inst | Niepeptydowe inhibitory metaloproteinaz macierzy zewnątrzkomórkowej |
| CN101279956B (zh) * | 2008-04-25 | 2011-06-15 | 南昌大学 | 一种基质金属蛋白酶抑制剂及合成方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5506242A (en) * | 1993-01-06 | 1996-04-09 | Ciba-Geigy Corporation | Arylsufonamido-substituted hydroxamic acids |
| GB2303850B (en) * | 1994-06-22 | 1998-06-10 | British Biotech Pharm | Metalloproteinase inhibitors |
-
1997
- 1997-04-24 SK SK1577-98A patent/SK282863B6/sk unknown
- 1997-04-24 JP JP09542377A patent/JP2000511175A/ja not_active Abandoned
- 1997-04-24 EE EE9800397A patent/EE03965B1/xx not_active IP Right Cessation
- 1997-04-24 KR KR1019980709253A patent/KR20000011095A/ko not_active Application Discontinuation
- 1997-04-24 WO PCT/US1997/006801 patent/WO1997044315A1/en not_active Application Discontinuation
- 1997-04-24 PL PL97329929A patent/PL186416B1/pl not_active IP Right Cessation
- 1997-04-24 AT AT97918788T patent/ATE207891T1/de not_active IP Right Cessation
- 1997-04-24 ES ES97918788T patent/ES2167733T3/es not_active Expired - Lifetime
- 1997-04-24 DK DK97918788T patent/DK0901466T3/da active
- 1997-04-24 IL IL12683297A patent/IL126832A0/xx unknown
- 1997-04-24 EP EP97918788A patent/EP0901466B1/en not_active Expired - Lifetime
- 1997-04-24 EA EA199800988A patent/EA001561B1/ru not_active IP Right Cessation
- 1997-04-24 CA CA002253342A patent/CA2253342A1/en not_active Abandoned
- 1997-04-24 BR BR9710841A patent/BR9710841A/pt not_active IP Right Cessation
- 1997-04-24 NZ NZ332711A patent/NZ332711A/en unknown
- 1997-04-24 DE DE69707865T patent/DE69707865T2/de not_active Expired - Fee Related
- 1997-04-24 CN CN97194719A patent/CN1077885C/zh not_active Expired - Fee Related
- 1997-04-24 PT PT97918788T patent/PT901466E/pt unknown
- 1997-04-24 CZ CZ19983668A patent/CZ294063B6/cs not_active IP Right Cessation
- 1997-05-15 ZA ZA9704223A patent/ZA974223B/xx unknown
-
1998
- 1998-11-12 BG BG102918A patent/BG63940B1/bg unknown
- 1998-11-16 NO NO19985326A patent/NO312510B1/no not_active IP Right Cessation
-
1999
- 1999-10-27 HK HK99104791A patent/HK1019585A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000511175A (ja) | 2000-08-29 |
| EE9800397A (et) | 1999-06-15 |
| BR9710841A (pt) | 1999-08-17 |
| PL329929A1 (en) | 1999-04-26 |
| AU713286B2 (en) | 1999-11-25 |
| CN1219166A (zh) | 1999-06-09 |
| CZ294063B6 (cs) | 2004-09-15 |
| EA001561B1 (ru) | 2001-04-23 |
| ES2167733T3 (es) | 2002-05-16 |
| KR20000011095A (ko) | 2000-02-25 |
| PT901466E (pt) | 2002-04-29 |
| SK282863B6 (sk) | 2002-12-03 |
| EP0901466A1 (en) | 1999-03-17 |
| PL186416B1 (pl) | 2004-01-30 |
| IL126832A0 (en) | 1999-08-17 |
| EE03965B1 (et) | 2003-02-17 |
| NO985326L (no) | 1999-01-14 |
| NO985326D0 (no) | 1998-11-16 |
| AU2680397A (en) | 1997-12-09 |
| BG63940B1 (bg) | 2003-07-31 |
| CZ366898A3 (cs) | 1999-02-17 |
| ZA974223B (en) | 1997-12-10 |
| EP0901466B1 (en) | 2001-10-31 |
| DE69707865D1 (de) | 2001-12-06 |
| BG102918A (en) | 1999-09-30 |
| HK1019585A1 (en) | 2000-02-18 |
| SK157798A3 (en) | 1999-04-13 |
| WO1997044315A1 (en) | 1997-11-27 |
| EA199800988A1 (ru) | 1999-04-29 |
| CN1077885C (zh) | 2002-01-16 |
| NO312510B1 (no) | 2002-05-21 |
| NZ332711A (en) | 2000-06-23 |
| DE69707865T2 (de) | 2002-05-02 |
| CA2253342A1 (en) | 1997-11-27 |
| ATE207891T1 (de) | 2001-11-15 |
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