AR041357A1 - Un procedimiento de sintesis industrial de los tetraesteres del acido 5- (bis ( carboximetil) amino) -3-carboximetil - 4- ciano-2- tiofenocarboxilico, y su aplicacion a la producción industrial de sales bivalentes del acido ranelico y de sus hidratos - Google Patents
Un procedimiento de sintesis industrial de los tetraesteres del acido 5- (bis ( carboximetil) amino) -3-carboximetil - 4- ciano-2- tiofenocarboxilico, y su aplicacion a la producción industrial de sales bivalentes del acido ranelico y de sus hidratosInfo
- Publication number
- AR041357A1 AR041357A1 ARP030103455A ARP030103455A AR041357A1 AR 041357 A1 AR041357 A1 AR 041357A1 AR P030103455 A ARP030103455 A AR P030103455A AR P030103455 A ARP030103455 A AR P030103455A AR 041357 A1 AR041357 A1 AR 041357A1
- Authority
- AR
- Argentina
- Prior art keywords
- acid
- carboximetil
- formula
- compound
- application
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Aplicación a la síntesis de sales bivalentes de ácido ranélico y más especialmente ranelato de estroncio y sus hidratos. Reivindicación 1: Procedimiento de síntesis industrial de compuestos de fórmula (1), donde R y R', idénticos o diferentes,representan cada uno un grupo alquilo (C1-6) lineal o ramificado, caracterizado porque se hace reaccionar un compuesto de fórmula (2), donde R es como se definiera precedentemente, con un compuesto de fórmula (3), donde R' es como se definieraprecedentemente, en presencia de una cantidad catalítica de un amonio cuaternario de tipo C8-10, y de carbonato de potasio, a reflujo de un solvente orgánico, filtrándose a continuación la mezcla de reacción, luego que se concentra el medio pordestilación, agregándose a continuación un cosolvente, enfriando y filtrando la mezcla de reacción, para alcanzar, después de secado del polvo así obtenido, el compuesto de fórmula (1), por amonio cuaternario de tipo C8-10, se entiende un compuestode fórmula o una mezcla de compuestos de fórmula: R1R2R3R4-N+-X, donde R1 representa un grupo alquilo (C1-6), R2, R3 y R4, idénticos o diferentes, representa cada uno un grupo alquilo (C8-10), y X representa un átomo de halógeno.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0211765A FR2844797B1 (fr) | 2002-09-24 | 2002-09-24 | Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR041357A1 true AR041357A1 (es) | 2005-05-11 |
Family
ID=29415191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030103455A AR041357A1 (es) | 2002-09-24 | 2003-09-23 | Un procedimiento de sintesis industrial de los tetraesteres del acido 5- (bis ( carboximetil) amino) -3-carboximetil - 4- ciano-2- tiofenocarboxilico, y su aplicacion a la producción industrial de sales bivalentes del acido ranelico y de sus hidratos |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US7091364B2 (es) |
| EP (1) | EP1403265B1 (es) |
| JP (1) | JP4136866B2 (es) |
| KR (1) | KR100551502B1 (es) |
| CN (1) | CN1280286C (es) |
| AP (1) | AP1972A (es) |
| AR (1) | AR041357A1 (es) |
| AT (1) | ATE449767T1 (es) |
| AU (2) | AU2003248280B2 (es) |
| BR (1) | BR0304203A (es) |
| CA (1) | CA2442881C (es) |
| CY (1) | CY1109831T1 (es) |
| DE (1) | DE60330213D1 (es) |
| DK (1) | DK1403265T3 (es) |
| EA (1) | EA007108B1 (es) |
| EC (1) | ECSP055743A (es) |
| ES (1) | ES2337348T3 (es) |
| FR (1) | FR2844797B1 (es) |
| GE (1) | GEP20074139B (es) |
| HK (1) | HK1061846A1 (es) |
| HR (1) | HRP20050361B1 (es) |
| IL (1) | IL167315A (es) |
| IS (1) | IS2728B (es) |
| MA (1) | MA26100A1 (es) |
| ME (1) | ME00453B (es) |
| MX (1) | MXPA03008647A (es) |
| MY (1) | MY134924A (es) |
| NO (1) | NO328626B1 (es) |
| NZ (1) | NZ528401A (es) |
| OA (1) | OA12932A (es) |
| PL (1) | PL215879B1 (es) |
| PT (1) | PT1403265E (es) |
| RS (1) | RS51551B (es) |
| SG (1) | SG110069A1 (es) |
| SI (1) | SI1403265T1 (es) |
| TN (1) | TNSN05088A1 (es) |
| UA (1) | UA79157C2 (es) |
| WO (1) | WO2004029034A1 (es) |
| ZA (1) | ZA200307411B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2844796A1 (fr) * | 2002-09-24 | 2004-03-26 | Servier Lab | Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
| FR2844795B1 (fr) * | 2002-09-24 | 2004-10-22 | Servier Lab | Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates |
| AU2004237439B2 (en) * | 2003-05-07 | 2009-09-10 | Osteologix A/S | Treating cartilage/bone conditions with water-soluble strontium salts |
| CA2524610C (en) * | 2003-05-07 | 2014-03-25 | Osteologix A/S | Strontium combinations for prophylaxis/treatment of cartilage and/or bone conditions |
| US20050085531A1 (en) * | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
| AU2005216596B2 (en) * | 2004-02-26 | 2011-03-24 | Osteologix A/S | Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions |
| ATE443541T1 (de) | 2004-06-25 | 2009-10-15 | Strontin Aps | Zusammensetzungen mit strontium und vitamin d und ihre verwendungen |
| FR2875807B1 (fr) * | 2004-09-30 | 2006-11-17 | Servier Lab | Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| CN100391955C (zh) * | 2005-04-30 | 2008-06-04 | 河北医科大学 | 一种雷尼酸锶中间体的合成方法 |
| US20070292529A1 (en) * | 2006-06-19 | 2007-12-20 | Tabbiner Philip S | Strontium compositions and methods of treating osteoporotic conditions |
| US20070292535A1 (en) * | 2006-06-19 | 2007-12-20 | Tabbiner Philip S | Strontium compositions and methods of treating arthritic and or osteoporitic conditions |
| FR2921367B1 (fr) | 2007-09-26 | 2009-10-30 | Servier Lab | Nouveau procede de synthese du ranelate de strontium et de ses hydrates |
| US20120123131A1 (en) * | 2008-08-22 | 2012-05-17 | Koilpillai Joseph Prabahar | Process for the preparation of strontium ranelate |
| CN101665483B (zh) * | 2008-09-01 | 2013-01-23 | 河北医科大学 | 一种雷尼酸锶中间体化合物ⅱ的合成方法 |
| WO2011124992A1 (en) * | 2010-03-24 | 2011-10-13 | Actavis Group Ptc Ehf | Substantially pure strontium ranelate |
| CN101812048B (zh) * | 2010-04-06 | 2012-11-14 | 浙江东亚药业有限公司 | 雷尼酸锶及其水合物的合成方法 |
| EP2602248A1 (en) | 2011-12-05 | 2013-06-12 | University Of Leicester | Novel pyrrole compounds |
| WO2013113319A1 (en) | 2012-01-31 | 2013-08-08 | Pharmathen S.A. | Process for the preparation of strontium ranelate, intermediate or hydrates thereof |
| ES2505716T3 (es) | 2013-01-21 | 2015-09-04 | Galenicum Health S.L. | Composiciones farmacéuticas que comprenden una sal de ácido |
| GB201310126D0 (en) * | 2013-06-06 | 2013-07-24 | Univ Leicester | Novel pyrrole derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3624304A1 (de) | 1986-07-18 | 1988-01-28 | Bayer Ag | Fungizide verwendung von substituierten thienylaminen |
| GB8715925D0 (en) * | 1987-07-07 | 1987-08-12 | Shell Int Research | Thiapentanamide derivatives |
| FR2651497B1 (fr) * | 1989-09-01 | 1991-10-25 | Adir | Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
| DE19528380A1 (de) * | 1995-08-02 | 1997-02-06 | Hoechst Ag | Heterogene Vinylacetat/Ethylen-Dispersion |
| FR2749759B1 (fr) * | 1996-06-17 | 1999-11-26 | Adir | Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose |
| DE19650196A1 (de) * | 1996-12-04 | 1998-06-10 | Bayer Ag | Thienylsulfonylamino(thio)carbonylverbindungen |
| US6835745B2 (en) * | 2002-01-15 | 2004-12-28 | Wyeth | Phenyl substituted thiophenes as estrogenic agents |
-
2002
- 2002-09-24 FR FR0211765A patent/FR2844797B1/fr not_active Expired - Fee Related
-
2003
- 2003-09-17 MY MYPI20033533A patent/MY134924A/en unknown
- 2003-09-22 AT AT03292318T patent/ATE449767T1/de active
- 2003-09-22 UA UAA200503860A patent/UA79157C2/uk unknown
- 2003-09-22 GE GEAP20038759A patent/GEP20074139B/en unknown
- 2003-09-22 AU AU2003248280A patent/AU2003248280B2/en not_active Ceased
- 2003-09-22 DK DK03292318.7T patent/DK1403265T3/da active
- 2003-09-22 OA OA1200500081A patent/OA12932A/en unknown
- 2003-09-22 ES ES03292318T patent/ES2337348T3/es not_active Expired - Lifetime
- 2003-09-22 JP JP2003330439A patent/JP4136866B2/ja not_active Expired - Fee Related
- 2003-09-22 AP AP2005003255A patent/AP1972A/xx active
- 2003-09-22 AU AU2003299095A patent/AU2003299095A1/en not_active Abandoned
- 2003-09-22 ME MEP-2008-687A patent/ME00453B/me unknown
- 2003-09-22 WO PCT/FR2003/002775 patent/WO2004029034A1/fr not_active Application Discontinuation
- 2003-09-22 EP EP03292318A patent/EP1403265B1/fr not_active Expired - Lifetime
- 2003-09-22 DE DE60330213T patent/DE60330213D1/de not_active Expired - Lifetime
- 2003-09-22 SI SI200331715T patent/SI1403265T1/sl unknown
- 2003-09-22 RS YUP-2005/0241A patent/RS51551B/en unknown
- 2003-09-22 PT PT03292318T patent/PT1403265E/pt unknown
- 2003-09-23 NO NO20034236A patent/NO328626B1/no not_active IP Right Cessation
- 2003-09-23 CA CA2442881A patent/CA2442881C/fr not_active Expired - Fee Related
- 2003-09-23 AR ARP030103455A patent/AR041357A1/es not_active Application Discontinuation
- 2003-09-23 MX MXPA03008647A patent/MXPA03008647A/es active IP Right Grant
- 2003-09-23 KR KR1020030065784A patent/KR100551502B1/ko not_active IP Right Cessation
- 2003-09-23 BR BR0304203-0A patent/BR0304203A/pt not_active Application Discontinuation
- 2003-09-23 PL PL362366A patent/PL215879B1/pl unknown
- 2003-09-23 ZA ZA200307411A patent/ZA200307411B/xx unknown
- 2003-09-23 EA EA200300927A patent/EA007108B1/ru not_active IP Right Cessation
- 2003-09-23 NZ NZ528401A patent/NZ528401A/en not_active IP Right Cessation
- 2003-09-24 US US10/669,302 patent/US7091364B2/en not_active Expired - Fee Related
- 2003-09-24 CN CNB031348122A patent/CN1280286C/zh not_active Expired - Fee Related
- 2003-09-24 MA MA27319A patent/MA26100A1/fr unknown
- 2003-09-24 SG SG200305553A patent/SG110069A1/en unknown
-
2004
- 2004-07-05 HK HK04104809A patent/HK1061846A1/xx not_active IP Right Cessation
-
2005
- 2005-03-08 IL IL167315A patent/IL167315A/en not_active IP Right Cessation
- 2005-03-23 TN TNP2005000088A patent/TNSN05088A1/fr unknown
- 2005-04-18 IS IS7803A patent/IS2728B/is unknown
- 2005-04-21 HR HRP20050361AA patent/HRP20050361B1/hr not_active IP Right Cessation
- 2005-04-22 EC EC2005005743A patent/ECSP055743A/es unknown
-
2010
- 2010-01-19 CY CY20101100055T patent/CY1109831T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR041357A1 (es) | Un procedimiento de sintesis industrial de los tetraesteres del acido 5- (bis ( carboximetil) amino) -3-carboximetil - 4- ciano-2- tiofenocarboxilico, y su aplicacion a la producción industrial de sales bivalentes del acido ranelico y de sus hidratos | |
| AR049401A1 (es) | Aza-biciclononanos | |
| AR064732A1 (es) | Derivados de 2,4-dianilinopirimidinas, su preparacion, composiciones farmaceuticas y usos como inhibidores de ikk | |
| CO6241076A2 (es) | Compuestos de benzamida y aplicaciones de los mismos | |
| AR064730A1 (es) | Derivados de 2,4-dianilinopirimidinas, su preparacion, composiciones farmaceuticas y usos como inhibidores de ikk | |
| RS50672B (sr) | Postupak za pripremanje n-fenilpirazol-1-karboksamida | |
| AR079491A1 (es) | Metodos de sintesis de inhibidores del factor xa tal como el betrixaban y composiciones farmaceuticas que contienen la base libre de betrixaban o su sal sustancialmente pura. | |
| DE60124692D1 (de) | Verfahren zur herstellung von optisch-aktiven sulfoxid-derivaten | |
| CU20100021A7 (es) | Derivado de oxopirazina y herbicida | |
| AR041355A1 (es) | Un procedimiento para sintesis industrial de ranelato de estroncio y sus hidratos | |
| AR073136A1 (es) | Compuestos de pirrol | |
| CO6220910A2 (es) | Proceso para la producir compuestos pesticidas de benzamidas | |
| PT88992A (pt) | Processo para a preparacao de compostos contendo fosforo uteis como inibidores de colagenase | |
| PE20051004A1 (es) | Compuestos de biaril sulfonamidas como inhibidores de metaloproteinasas | |
| AR068056A1 (es) | Derivados de n, n'-2, 4 - dianilinopirimidinas, su preparacion, su uso como medicamentos, composiciones farmaceuticas y especialmente como inhibidores de ikk. | |
| NO20051627L (no) | Kjemisk mellomprodukt. | |
| AR047686A1 (es) | Un procedimiento de sintesis de compuestos de 1,3-dihidro-2h-3-benzazepin-2-ona, y su aplicacion a la sintesis de la ivabradina y sus sales de adicion con un acido farmaceuticamente aceptable | |
| DE502005003737D1 (de) | Leitsalze fur galvanische zellen, deren herstellung und verwendung | |
| PT90912A (pt) | Processo para a preparacao de derivados de tiofenol | |
| EA200300926A1 (ru) | Новый способ промышленного синтеза метил дисложного эфира 5-амино-3-карбоксиметил-4-циано-2-тиофенкарбоновой кислоты и применение для синтеза бивалентных солей ранелиновой кислоты и их гидратов | |
| ATE483677T1 (de) | Verfahren zur herstellung von enantiomerenreinen pyrethroid-insektiziden | |
| AR043505A1 (es) | Preparacion de beta-cetoamidas e intermediarios de reaccion | |
| AR066430A1 (es) | Proceso para preparar inhibidores de aromatasa y forma cristalina de exemestano | |
| Yang et al. | Cationic Micelle‐catalyzed Ring‐Opening Reactions of Aziridines with Thiols in Water | |
| AR047887A1 (es) | Procesos para preparar pioglitazona y sus intermediarios |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed, e.g., due to non-payment of fee |