NO20034236D0 - Ny fremgangsmåte for den industrielle syntese av tetraestere av 5-[bis(karboksymetyl)amino]-3-karboksymetyl-4-cyano-2-tiofenkarboksylsyre, oganvendelse isyntesen av bivalente salter av ranelinsyre og deres hydrater - Google Patents
Ny fremgangsmåte for den industrielle syntese av tetraestere av 5-[bis(karboksymetyl)amino]-3-karboksymetyl-4-cyano-2-tiofenkarboksylsyre, oganvendelse isyntesen av bivalente salter av ranelinsyre og deres hydraterInfo
- Publication number
- NO20034236D0 NO20034236D0 NO20034236A NO20034236A NO20034236D0 NO 20034236 D0 NO20034236 D0 NO 20034236D0 NO 20034236 A NO20034236 A NO 20034236A NO 20034236 A NO20034236 A NO 20034236A NO 20034236 D0 NO20034236 D0 NO 20034236D0
- Authority
- NO
- Norway
- Prior art keywords
- carboxymethyl
- tetraesters
- cyano
- bis
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0211765A FR2844797B1 (fr) | 2002-09-24 | 2002-09-24 | Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20034236D0 true NO20034236D0 (no) | 2003-09-23 |
| NO20034236L NO20034236L (no) | 2004-03-25 |
| NO328626B1 NO328626B1 (no) | 2010-04-12 |
Family
ID=29415191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20034236A NO328626B1 (no) | 2002-09-24 | 2003-09-23 | Ny fremgangsmate for den industrielle syntese av tetraestere av 5-[bis(karboksymetyl)amino]-3-karboksymetyl-4-cyano-2-tiofenkarboksylsyre, og anvendelse i syntesen av bivalente salter av ranelinsyre og deres hydrater |
Country Status (39)
| Country | Link |
|---|---|
| US (1) | US7091364B2 (no) |
| EP (1) | EP1403265B1 (no) |
| JP (1) | JP4136866B2 (no) |
| KR (1) | KR100551502B1 (no) |
| CN (1) | CN1280286C (no) |
| AP (1) | AP1972A (no) |
| AR (1) | AR041357A1 (no) |
| AT (1) | ATE449767T1 (no) |
| AU (2) | AU2003248280B2 (no) |
| BR (1) | BR0304203A (no) |
| CA (1) | CA2442881C (no) |
| CY (1) | CY1109831T1 (no) |
| DE (1) | DE60330213D1 (no) |
| DK (1) | DK1403265T3 (no) |
| EA (1) | EA007108B1 (no) |
| EC (1) | ECSP055743A (no) |
| ES (1) | ES2337348T3 (no) |
| FR (1) | FR2844797B1 (no) |
| GE (1) | GEP20074139B (no) |
| HK (1) | HK1061846A1 (no) |
| HR (1) | HRP20050361B1 (no) |
| IL (1) | IL167315A (no) |
| IS (1) | IS2728B (no) |
| MA (1) | MA26100A1 (no) |
| ME (1) | ME00453B (no) |
| MX (1) | MXPA03008647A (no) |
| MY (1) | MY134924A (no) |
| NO (1) | NO328626B1 (no) |
| NZ (1) | NZ528401A (no) |
| OA (1) | OA12932A (no) |
| PL (1) | PL215879B1 (no) |
| PT (1) | PT1403265E (no) |
| RS (1) | RS51551B (no) |
| SG (1) | SG110069A1 (no) |
| SI (1) | SI1403265T1 (no) |
| TN (1) | TNSN05088A1 (no) |
| UA (1) | UA79157C2 (no) |
| WO (1) | WO2004029034A1 (no) |
| ZA (1) | ZA200307411B (no) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2844795B1 (fr) * | 2002-09-24 | 2004-10-22 | Servier Lab | Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates |
| FR2844796A1 (fr) * | 2002-09-24 | 2004-03-26 | Servier Lab | Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates |
| WO2004098619A2 (en) * | 2003-05-07 | 2004-11-18 | Osteologix A/S | Treating cartilage / bone conditions with water-soluble strontium salts |
| US20060275503A1 (en) * | 2003-05-07 | 2006-12-07 | Nordic Bone A/S | Combination treatment with strontium for the prophylaxis and/or treatment of cartilage and/or bone conditions |
| US20050085531A1 (en) * | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
| AU2005216596B2 (en) * | 2004-02-26 | 2011-03-24 | Osteologix A/S | Strontium-containing compounds for use in the prevention or treatment of necrotic bone conditions |
| AU2005256317B2 (en) | 2004-06-25 | 2011-09-15 | Mokwalo Spf S.A. | Compositions comprising strontium and vitamin D and uses thereof |
| FR2875807B1 (fr) * | 2004-09-30 | 2006-11-17 | Servier Lab | Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent |
| CN100391955C (zh) * | 2005-04-30 | 2008-06-04 | 河北医科大学 | 一种雷尼酸锶中间体的合成方法 |
| US20070292529A1 (en) * | 2006-06-19 | 2007-12-20 | Tabbiner Philip S | Strontium compositions and methods of treating osteoporotic conditions |
| US20070292535A1 (en) * | 2006-06-19 | 2007-12-20 | Tabbiner Philip S | Strontium compositions and methods of treating arthritic and or osteoporitic conditions |
| FR2921367B1 (fr) | 2007-09-26 | 2009-10-30 | Servier Lab | Nouveau procede de synthese du ranelate de strontium et de ses hydrates |
| US20120123131A1 (en) * | 2008-08-22 | 2012-05-17 | Koilpillai Joseph Prabahar | Process for the preparation of strontium ranelate |
| CN101665483B (zh) * | 2008-09-01 | 2013-01-23 | 河北医科大学 | 一种雷尼酸锶中间体化合物ⅱ的合成方法 |
| WO2011124992A1 (en) * | 2010-03-24 | 2011-10-13 | Actavis Group Ptc Ehf | Substantially pure strontium ranelate |
| CN101812048B (zh) * | 2010-04-06 | 2012-11-14 | 浙江东亚药业有限公司 | 雷尼酸锶及其水合物的合成方法 |
| EP2602248A1 (en) | 2011-12-05 | 2013-06-12 | University Of Leicester | Novel pyrrole compounds |
| WO2013113319A1 (en) | 2012-01-31 | 2013-08-08 | Pharmathen S.A. | Process for the preparation of strontium ranelate, intermediate or hydrates thereof |
| EP2756841B1 (en) | 2013-01-21 | 2015-05-13 | Galenicum Health S.L. | Pharmaceutical compositions comprising an acid salt |
| GB201310126D0 (en) * | 2013-06-06 | 2013-07-24 | Univ Leicester | Novel pyrrole derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3624304A1 (de) | 1986-07-18 | 1988-01-28 | Bayer Ag | Fungizide verwendung von substituierten thienylaminen |
| GB8715925D0 (en) * | 1987-07-07 | 1987-08-12 | Shell Int Research | Thiapentanamide derivatives |
| FR2651497B1 (fr) | 1989-09-01 | 1991-10-25 | Adir | Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
| DE19528380A1 (de) * | 1995-08-02 | 1997-02-06 | Hoechst Ag | Heterogene Vinylacetat/Ethylen-Dispersion |
| FR2749759B1 (fr) * | 1996-06-17 | 1999-11-26 | Adir | Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose |
| DE19650196A1 (de) * | 1996-12-04 | 1998-06-10 | Bayer Ag | Thienylsulfonylamino(thio)carbonylverbindungen |
| US6835745B2 (en) * | 2002-01-15 | 2004-12-28 | Wyeth | Phenyl substituted thiophenes as estrogenic agents |
-
2002
- 2002-09-24 FR FR0211765A patent/FR2844797B1/fr not_active Expired - Fee Related
-
2003
- 2003-09-17 MY MYPI20033533A patent/MY134924A/en unknown
- 2003-09-22 PT PT03292318T patent/PT1403265E/pt unknown
- 2003-09-22 AP AP2005003255A patent/AP1972A/xx active
- 2003-09-22 DK DK03292318.7T patent/DK1403265T3/da active
- 2003-09-22 WO PCT/FR2003/002775 patent/WO2004029034A1/fr not_active Application Discontinuation
- 2003-09-22 OA OA1200500081A patent/OA12932A/en unknown
- 2003-09-22 AU AU2003248280A patent/AU2003248280B2/en not_active Ceased
- 2003-09-22 AU AU2003299095A patent/AU2003299095A1/en not_active Abandoned
- 2003-09-22 AT AT03292318T patent/ATE449767T1/de active
- 2003-09-22 SI SI200331715T patent/SI1403265T1/sl unknown
- 2003-09-22 GE GEAP20038759A patent/GEP20074139B/en unknown
- 2003-09-22 ME MEP-2008-687A patent/ME00453B/me unknown
- 2003-09-22 UA UAA200503860A patent/UA79157C2/uk unknown
- 2003-09-22 ES ES03292318T patent/ES2337348T3/es not_active Expired - Lifetime
- 2003-09-22 RS YUP-2005/0241A patent/RS51551B/en unknown
- 2003-09-22 JP JP2003330439A patent/JP4136866B2/ja not_active Expired - Fee Related
- 2003-09-22 EP EP03292318A patent/EP1403265B1/fr not_active Expired - Lifetime
- 2003-09-22 DE DE60330213T patent/DE60330213D1/de not_active Expired - Lifetime
- 2003-09-23 ZA ZA200307411A patent/ZA200307411B/xx unknown
- 2003-09-23 BR BR0304203-0A patent/BR0304203A/pt not_active Application Discontinuation
- 2003-09-23 CA CA2442881A patent/CA2442881C/fr not_active Expired - Fee Related
- 2003-09-23 KR KR1020030065784A patent/KR100551502B1/ko not_active IP Right Cessation
- 2003-09-23 NZ NZ528401A patent/NZ528401A/en not_active IP Right Cessation
- 2003-09-23 MX MXPA03008647A patent/MXPA03008647A/es active IP Right Grant
- 2003-09-23 NO NO20034236A patent/NO328626B1/no not_active IP Right Cessation
- 2003-09-23 PL PL362366A patent/PL215879B1/pl unknown
- 2003-09-23 AR ARP030103455A patent/AR041357A1/es not_active Application Discontinuation
- 2003-09-23 EA EA200300927A patent/EA007108B1/ru not_active IP Right Cessation
- 2003-09-24 CN CNB031348122A patent/CN1280286C/zh not_active Expired - Fee Related
- 2003-09-24 MA MA27319A patent/MA26100A1/fr unknown
- 2003-09-24 US US10/669,302 patent/US7091364B2/en not_active Expired - Fee Related
- 2003-09-24 SG SG200305553A patent/SG110069A1/en unknown
-
2004
- 2004-07-05 HK HK04104809A patent/HK1061846A1/xx not_active IP Right Cessation
-
2005
- 2005-03-08 IL IL167315A patent/IL167315A/en not_active IP Right Cessation
- 2005-03-23 TN TNP2005000088A patent/TNSN05088A1/fr unknown
- 2005-04-18 IS IS7803A patent/IS2728B/is unknown
- 2005-04-21 HR HRP20050361AA patent/HRP20050361B1/hr not_active IP Right Cessation
- 2005-04-22 EC EC2005005743A patent/ECSP055743A/es unknown
-
2010
- 2010-01-19 CY CY20101100055T patent/CY1109831T1/el unknown
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Legal Events
| Date | Code | Title | Description |
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| MM1K | Lapsed by not paying the annual fees |