NO20050740L - Ny fremgangsmate for syntesen av (7-metoksy-1-naftyl)acetonitril og anvendelse i syntesen av agomelatin - Google Patents
Ny fremgangsmate for syntesen av (7-metoksy-1-naftyl)acetonitril og anvendelse i syntesen av agomelatinInfo
- Publication number
- NO20050740L NO20050740L NO20050740A NO20050740A NO20050740L NO 20050740 L NO20050740 L NO 20050740L NO 20050740 A NO20050740 A NO 20050740A NO 20050740 A NO20050740 A NO 20050740A NO 20050740 L NO20050740 L NO 20050740L
- Authority
- NO
- Norway
- Prior art keywords
- synthesis
- agomelatine
- naphthyl
- acetonitrile
- methoxy
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 4
- 238000003786 synthesis reaction Methods 0.000 title abstract 4
- YJYPHIXNFHFHND-UHFFFAOYSA-N agomelatine Chemical compound C1=CC=C(CCNC(C)=O)C2=CC(OC)=CC=C21 YJYPHIXNFHFHND-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002629 agomelatine Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- PYJMGUQHJINLLD-UHFFFAOYSA-N 2-(7-methoxynaphthalen-1-yl)acetonitrile Chemical compound C1=CC=C(CC#N)C2=CC(OC)=CC=C21 PYJMGUQHJINLLD-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
- F16B37/00—Nuts or like thread-engaging members
- F16B37/14—Cap nuts; Nut caps or bolt caps
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mechanical Engineering (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Fremgangsmåte for den industrielle syntese av forbindelsen med formel (I). Anvendelse i syntesen av agomelatin.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0401438A FR2866334B1 (fr) | 2004-02-13 | 2004-02-13 | Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20050740D0 NO20050740D0 (no) | 2005-02-11 |
NO20050740L true NO20050740L (no) | 2005-08-15 |
NO333488B1 NO333488B1 (no) | 2013-06-24 |
Family
ID=34685018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20050740A NO333488B1 (no) | 2004-02-13 | 2005-02-11 | Ny fremgangsmate for syntesen av (7-metoksy-1-naftyl)acetonitril og anvendelse i syntesen av agomelatin |
Country Status (33)
Country | Link |
---|---|
US (2) | US7476751B2 (no) |
EP (1) | EP1564203B1 (no) |
JP (1) | JP4252040B2 (no) |
KR (1) | KR100682697B1 (no) |
CN (1) | CN1315794C (no) |
AR (1) | AR047667A1 (no) |
AT (1) | ATE452873T1 (no) |
AU (1) | AU2005200620B8 (no) |
BR (1) | BRPI0500395B8 (no) |
CA (1) | CA2495960C (no) |
CY (1) | CY1109737T1 (no) |
DE (1) | DE602005018403D1 (no) |
DK (1) | DK1564203T3 (no) |
EA (1) | EA007789B1 (no) |
ES (1) | ES2338664T3 (no) |
FR (1) | FR2866334B1 (no) |
GE (1) | GEP20063961B (no) |
HK (1) | HK1079187A1 (no) |
HR (1) | HRP20100103T1 (no) |
MA (1) | MA27517A1 (no) |
ME (1) | ME01806B (no) |
MX (1) | MXPA05001634A (no) |
MY (2) | MY143737A (no) |
NO (1) | NO333488B1 (no) |
NZ (1) | NZ538192A (no) |
PL (1) | PL1564203T3 (no) |
PT (1) | PT1564203E (no) |
RS (1) | RS51212B (no) |
SG (1) | SG114702A1 (no) |
SI (1) | SI1564203T1 (no) |
UA (1) | UA79479C2 (no) |
WO (1) | WO2005077890A1 (no) |
ZA (1) | ZA200501256B (no) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2866336B1 (fr) * | 2004-02-13 | 2006-03-24 | Servier Lab | Nouveau procede de synthese du (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile et application a la synthese de l'agomelatine |
CN101161638B (zh) * | 2006-10-13 | 2010-09-29 | 北京德众万全药物技术开发有限公司 | 一种新的阿戈美拉汀重要中间体的制备方法 |
CN101585779B (zh) * | 2009-03-10 | 2014-04-02 | 上海医药工业研究院 | 阿戈美拉汀的晶型vi及其制备方法和应用 |
CN101723855B (zh) * | 2009-12-03 | 2012-08-08 | 浙江科技学院 | 一种(7-甲氧基-1-萘基)乙腈的合成方法 |
CN101792400B (zh) * | 2010-03-16 | 2013-01-30 | 华东师范大学 | 一种阿戈美拉汀的合成方法 |
CN102276492B (zh) * | 2010-06-08 | 2013-04-10 | 上海医药工业研究院 | 阿戈美拉汀中间体及其制备方法 |
WO2011154140A2 (en) | 2010-06-10 | 2011-12-15 | Gador S.A. | New process for the preparation of n-[2-(7-methoxy-1-naphthyl)-ethyl]acetamide and new crystalline form |
CN102060733B (zh) * | 2010-12-06 | 2014-01-29 | 威海迪素制药有限公司 | (7-甲氧基-3,4-二氢-1-萘基)乙腈的制备方法 |
FR2970000B1 (fr) | 2011-01-05 | 2013-01-04 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
WO2013054273A2 (en) | 2011-10-11 | 2013-04-18 | Ranbaxy Laboratories Limited | Process for the preparation of agomelatine |
WO2013080095A1 (en) | 2011-12-01 | 2013-06-06 | Ranbaxy Laboratories Limited | Process for the preparation of agomelatine |
CN103319370B (zh) * | 2012-03-21 | 2016-08-03 | 黑龙江福和华星制药集团股份有限公司 | 一种(7-甲氧基-1-萘基)乙腈的制备方法 |
ITMI20121444A1 (it) | 2012-08-27 | 2014-02-28 | Procos Spa | Processo per la produzione di agomelatine |
CN102875408B (zh) * | 2012-10-09 | 2014-07-16 | 江西同和药业有限责任公司 | 一种阿戈美拉汀的制备方法 |
CN102875415B (zh) * | 2012-10-09 | 2014-08-20 | 江西同和药业有限责任公司 | 一种化合物及其制备方法和应用 |
WO2016046833A2 (en) * | 2014-09-24 | 2016-03-31 | Symed Labs Limited | Improved processes for the preparation of agomelatine using novel intermediates |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4327022A (en) * | 1973-08-16 | 1982-04-27 | Sterling Drug Inc. | Heterocyclic alkyl naphthols |
US3931188A (en) * | 1974-05-06 | 1976-01-06 | Bristol-Myers Company | 3-Hydroxy-5,6-benzomorphinan derivatives |
US3992403A (en) * | 1975-05-30 | 1976-11-16 | Schering Corporation | 2-Imidazolines and their use as hypoglycemic agents |
FR2658818B1 (fr) * | 1990-02-27 | 1993-12-31 | Adir Cie | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
FR2866336B1 (fr) * | 2004-02-13 | 2006-03-24 | Servier Lab | Nouveau procede de synthese du (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile et application a la synthese de l'agomelatine |
FR2866335B1 (fr) * | 2004-02-13 | 2006-05-26 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
-
2004
- 2004-02-13 FR FR0401438A patent/FR2866334B1/fr not_active Expired - Fee Related
-
2005
- 2005-02-03 CA CA002495960A patent/CA2495960C/fr active Active
- 2005-02-07 MY MYPI20091874A patent/MY143737A/en unknown
- 2005-02-07 MY MYPI20050477A patent/MY142270A/en unknown
- 2005-02-07 US US11/052,629 patent/US7476751B2/en active Active
- 2005-02-07 SG SG200500676A patent/SG114702A1/en unknown
- 2005-02-10 MX MXPA05001634A patent/MXPA05001634A/es active IP Right Grant
- 2005-02-11 DE DE602005018403T patent/DE602005018403D1/de active Active
- 2005-02-11 MA MA28100A patent/MA27517A1/fr unknown
- 2005-02-11 NO NO20050740A patent/NO333488B1/no unknown
- 2005-02-11 ES ES05290307T patent/ES2338664T3/es active Active
- 2005-02-11 GE GEAP8624A patent/GEP20063961B/en unknown
- 2005-02-11 WO PCT/FR2005/000326 patent/WO2005077890A1/fr active Application Filing
- 2005-02-11 AR ARP050100501A patent/AR047667A1/es unknown
- 2005-02-11 ZA ZA2005/01256A patent/ZA200501256B/en unknown
- 2005-02-11 AU AU2005200620A patent/AU2005200620B8/en active Active
- 2005-02-11 SI SI200530911T patent/SI1564203T1/sl unknown
- 2005-02-11 PT PT05290307T patent/PT1564203E/pt unknown
- 2005-02-11 PL PL05290307T patent/PL1564203T3/pl unknown
- 2005-02-11 AT AT05290307T patent/ATE452873T1/de active
- 2005-02-11 RS RSP-2010/0042A patent/RS51212B/sr unknown
- 2005-02-11 DK DK05290307.7T patent/DK1564203T3/da active
- 2005-02-11 ME MEP-2010-42A patent/ME01806B/me unknown
- 2005-02-11 EP EP05290307A patent/EP1564203B1/fr active Active
- 2005-02-11 UA UAA200501278A patent/UA79479C2/uk unknown
- 2005-02-11 NZ NZ538192A patent/NZ538192A/en unknown
- 2005-02-12 KR KR1020050011748A patent/KR100682697B1/ko active Protection Beyond IP Right Term
- 2005-02-14 JP JP2005035757A patent/JP4252040B2/ja active Active
- 2005-02-14 BR BRPI0500395A patent/BRPI0500395B8/pt active IP Right Grant
- 2005-02-14 EA EA200500201A patent/EA007789B1/ru unknown
- 2005-02-16 CN CNB200510007756XA patent/CN1315794C/zh active Active
- 2005-12-06 HK HK05111121A patent/HK1079187A1/xx unknown
-
2008
- 2008-12-09 US US12/315,983 patent/US7999129B2/en active Active
-
2010
- 2010-01-19 CY CY20101100052T patent/CY1109737T1/el unknown
- 2010-02-26 HR HR20100103T patent/HRP20100103T1/hr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20050740L (no) | Ny fremgangsmate for syntesen av (7-metoksy-1-naftyl)acetonitril og anvendelse i syntesen av agomelatin | |
NO20050738L (no) | Ny fremgangsmate for syntesen av (7-metoksy-3,4-dihydro-1-naftalanyl)acetonitril og dens anvendelse i syntesen av agomelatin | |
CY1116754T1 (el) | Παραγωγα νιτροκατεχολης ως αναστολεις της comt | |
NO20050741D0 (no) | Ny fremgangsmate for syntesen og ny krystallinsk form av agomelatin og farmasoytiske sammensetninger inneholdende den | |
NO20054185L (no) | Methods of radiofluorination of biologically active vectors | |
DE602006020327D1 (de) | 2-phenoxy-n-(1,3,4-thiadizol-2-yl)pyridin-3-aminder-hemmer zur behandlung thromboembolischer erkrankungen | |
IL185546A0 (en) | N - (n - sulfonylaminomethyl) cyclopropanecarboxamide derivatives useful for the treatment of pain | |
ATE368031T1 (de) | Neue gamma secretase inhibitoren | |
DE602004017037D1 (de) | 2,3-dihydro-6-nitroimidazoä2,1-büoxazolverbindungen zur behandlung von tuberkulose | |
DE60325498D1 (de) | 1-acyl-pyrrolidin-derivate für die behandlung von viralen infektionen | |
EA200700400A1 (ru) | Производные n-(1h-индолил)-1н-индол-2-карбоксамидов, их получение и их применение в терапии | |
NO20050739L (no) | Ny fremgsmate for syntesen av (7-metoksy-1-naftyl)acetonitril og dens anvendelse i syntesen av agomelatin | |
CY1109740T1 (el) | Νεα μεθοδος συνθεσης παραγωγων της 1,3,4,5 -τετραϋδρο-2η- 3-βενζαζεπιν-2-ονης και εφαρμογη στη συνθεση της ιβαβραδινης και των αλατων προσθηκης της σε ενα φαρμακευτικως αποδεκτο οξυ | |
SE0403171D0 (sv) | New compounds | |
PL376324A1 (en) | Piperazinyl and diazapanyl benzamides and benzthioamides | |
MY160226A (en) | New process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and application in the synthesis of agomelatine | |
NO20050885D0 (no) | Ny fremgangsmate for syntesen av 1,3-dihydro-2H-3-benzazepin-2-onforbindelser, og anvendelse i syntesen av ivabradin og addisjonssalter derav med en farmasoytisk akseptabel syre | |
HRP20040920A2 (en) | Novel form of n-(trans-4-isopropylcyclohexylcarbonyl)-d-phenylalanine | |
RS52260B (en) | N- (2-hydroxyethyl) -N-methyl-4- (quinoline-8-yl (1- (thiazol-4-ylmethyl) piperidin-4-ylidene) methyl) benzamide, a process for its production as well as its use for treatment PAIN, TENSION AND DEPRESSION | |
SE0402284D0 (sv) | New heterocyclic amides | |
RS20060206A (en) | Aminopyridine-derivatives as inducible no-synthase inhibitors | |
NO20055399L (no) | Hydroksamsyrer anvendelige ved behandling av hyper-proliferative forstyrrelser | |
UY28145A1 (es) | Nuevos compuestos farmaceuticos | |
DE602004030633D1 (de) | Reinigung von Amidderivaten | |
SE0402459D0 (sv) | New hydroxymethylbenzothiazoles amides |