PT1564203E - Novo processo de síntese do (7-metoxi-1-naftil)acetonitrilo e aplicação à síntese da agomelatina - Google Patents

Novo processo de síntese do (7-metoxi-1-naftil)acetonitrilo e aplicação à síntese da agomelatina Download PDF

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Publication number
PT1564203E
PT1564203E PT05290307T PT05290307T PT1564203E PT 1564203 E PT1564203 E PT 1564203E PT 05290307 T PT05290307 T PT 05290307T PT 05290307 T PT05290307 T PT 05290307T PT 1564203 E PT1564203 E PT 1564203E
Authority
PT
Portugal
Prior art keywords
agomelatine
naphtyl
synthesizing
acetonitrile
methoxy
Prior art date
Application number
PT05290307T
Other languages
English (en)
Inventor
Jean-Claude Souvie
Isaac Gonzalez Blanco
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Publication of PT1564203E publication Critical patent/PT1564203E/pt

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00Preparation of carboxylic acid nitriles
    • C07C253/30Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • FMECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16BDEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
    • F16B37/00Nuts or like thread-engaging members
    • F16B37/14Cap nuts; Nut caps or bolt caps
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/01Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/37Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mechanical Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
PT05290307T 2004-02-13 2005-02-11 Novo processo de síntese do (7-metoxi-1-naftil)acetonitrilo e aplicação à síntese da agomelatina PT1564203E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0401438A FR2866334B1 (fr) 2004-02-13 2004-02-13 Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine

Publications (1)

Publication Number Publication Date
PT1564203E true PT1564203E (pt) 2010-01-15

Family

ID=34685018

Family Applications (1)

Application Number Title Priority Date Filing Date
PT05290307T PT1564203E (pt) 2004-02-13 2005-02-11 Novo processo de síntese do (7-metoxi-1-naftil)acetonitrilo e aplicação à síntese da agomelatina

Country Status (33)

Country Link
US (2) US7476751B2 (pt)
EP (1) EP1564203B1 (pt)
JP (1) JP4252040B2 (pt)
KR (1) KR100682697B1 (pt)
CN (1) CN1315794C (pt)
AR (1) AR047667A1 (pt)
AT (1) ATE452873T1 (pt)
AU (1) AU2005200620B8 (pt)
BR (1) BRPI0500395B8 (pt)
CA (1) CA2495960C (pt)
CY (1) CY1109737T1 (pt)
DE (1) DE602005018403D1 (pt)
DK (1) DK1564203T3 (pt)
EA (1) EA007789B1 (pt)
ES (1) ES2338664T3 (pt)
FR (1) FR2866334B1 (pt)
GE (1) GEP20063961B (pt)
HK (1) HK1079187A1 (pt)
HR (1) HRP20100103T1 (pt)
MA (1) MA27517A1 (pt)
ME (1) ME01806B (pt)
MX (1) MXPA05001634A (pt)
MY (2) MY143737A (pt)
NO (1) NO333488B1 (pt)
NZ (1) NZ538192A (pt)
PL (1) PL1564203T3 (pt)
PT (1) PT1564203E (pt)
RS (1) RS51212B (pt)
SG (1) SG114702A1 (pt)
SI (1) SI1564203T1 (pt)
UA (1) UA79479C2 (pt)
WO (1) WO2005077890A1 (pt)
ZA (1) ZA200501256B (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2866336B1 (fr) * 2004-02-13 2006-03-24 Servier Lab Nouveau procede de synthese du (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile et application a la synthese de l'agomelatine
CN101161638B (zh) * 2006-10-13 2010-09-29 北京德众万全药物技术开发有限公司 一种新的阿戈美拉汀重要中间体的制备方法
CN101585779B (zh) * 2009-03-10 2014-04-02 上海医药工业研究院 阿戈美拉汀的晶型vi及其制备方法和应用
CN101723855B (zh) * 2009-12-03 2012-08-08 浙江科技学院 一种(7-甲氧基-1-萘基)乙腈的合成方法
CN101792400B (zh) * 2010-03-16 2013-01-30 华东师范大学 一种阿戈美拉汀的合成方法
CN102276492B (zh) * 2010-06-08 2013-04-10 上海医药工业研究院 阿戈美拉汀中间体及其制备方法
EP2580183B1 (en) 2010-06-10 2014-07-23 Gador S.A. New process for the preparation of n-[2-(7-methoxy-1-naphthyl)-ethyl]acetamide
CN102060733B (zh) * 2010-12-06 2014-01-29 威海迪素制药有限公司 (7-甲氧基-3,4-二氢-1-萘基)乙腈的制备方法
FR2970000B1 (fr) 2011-01-05 2013-01-04 Servier Lab Nouveau procede de synthese de l'agomelatine
WO2013054273A2 (en) 2011-10-11 2013-04-18 Ranbaxy Laboratories Limited Process for the preparation of agomelatine
EP2785681A1 (en) 2011-12-01 2014-10-08 Ranbaxy Laboratories Limited Process for the preparation of agomelatine
CN103319370B (zh) * 2012-03-21 2016-08-03 黑龙江福和华星制药集团股份有限公司 一种(7-甲氧基-1-萘基)乙腈的制备方法
ITMI20121444A1 (it) 2012-08-27 2014-02-28 Procos Spa Processo per la produzione di agomelatine
CN102875415B (zh) * 2012-10-09 2014-08-20 江西同和药业有限责任公司 一种化合物及其制备方法和应用
CN102875408B (zh) * 2012-10-09 2014-07-16 江西同和药业有限责任公司 一种阿戈美拉汀的制备方法
WO2016046833A2 (en) * 2014-09-24 2016-03-31 Symed Labs Limited Improved processes for the preparation of agomelatine using novel intermediates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4327022A (en) * 1973-08-16 1982-04-27 Sterling Drug Inc. Heterocyclic alkyl naphthols
US3931188A (en) * 1974-05-06 1976-01-06 Bristol-Myers Company 3-Hydroxy-5,6-benzomorphinan derivatives
US3992403A (en) * 1975-05-30 1976-11-16 Schering Corporation 2-Imidazolines and their use as hypoglycemic agents
FR2658818B1 (fr) * 1990-02-27 1993-12-31 Adir Cie Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2866336B1 (fr) * 2004-02-13 2006-03-24 Servier Lab Nouveau procede de synthese du (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile et application a la synthese de l'agomelatine
FR2866335B1 (fr) * 2004-02-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'agomelatine

Also Published As

Publication number Publication date
GEP20063961B (en) 2006-11-10
CA2495960A1 (fr) 2005-08-13
AU2005200620A8 (en) 2011-06-02
UA79479C2 (en) 2007-06-25
MA27517A1 (fr) 2005-09-01
ME01806B (me) 2010-12-31
DK1564203T3 (da) 2010-04-12
SI1564203T1 (sl) 2010-03-31
BRPI0500395A (pt) 2005-09-27
ZA200501256B (en) 2005-11-30
EP1564203A1 (fr) 2005-08-17
MY143737A (en) 2011-07-04
CA2495960C (fr) 2007-11-27
AR047667A1 (es) 2006-02-01
NO20050740D0 (no) 2005-02-11
EA200500201A1 (ru) 2005-08-25
EP1564203B1 (fr) 2009-12-23
CY1109737T1 (el) 2014-09-10
KR100682697B1 (ko) 2007-02-15
CN1680296A (zh) 2005-10-12
FR2866334B1 (fr) 2006-05-26
NZ538192A (en) 2005-12-23
SG114702A1 (en) 2005-09-28
BRPI0500395B8 (pt) 2021-05-25
CN1315794C (zh) 2007-05-16
ATE452873T1 (de) 2010-01-15
HRP20100103T1 (hr) 2010-04-30
US7476751B2 (en) 2009-01-13
FR2866334A1 (fr) 2005-08-19
US20050182267A1 (en) 2005-08-18
NO20050740L (no) 2005-08-15
WO2005077890A1 (fr) 2005-08-25
AU2005200620A1 (en) 2005-09-01
PL1564203T3 (pl) 2010-06-30
RS51212B (sr) 2010-12-31
ES2338664T3 (es) 2010-05-11
BRPI0500395B1 (pt) 2018-11-06
MY142270A (en) 2010-11-15
AU2005200620B2 (en) 2011-05-19
US7999129B2 (en) 2011-08-16
DE602005018403D1 (de) 2010-02-04
HK1079187A1 (en) 2006-03-31
KR20060041902A (ko) 2006-05-12
JP2005239718A (ja) 2005-09-08
AU2005200620B8 (en) 2011-06-02
EA007789B1 (ru) 2007-02-27
US20090131719A1 (en) 2009-05-21
MXPA05001634A (es) 2005-08-19
NO333488B1 (no) 2013-06-24
JP4252040B2 (ja) 2009-04-08

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