DE60330213D1 - Industrielles Verfahren zur Herstellung von 5-ibis(carboxymethyl)amino -3-carboxymethyl-4-cyano-2-thiophencarbonsäure-tetraestern und Verwendung zur Synthese von zweiwertigen Ranetansäuresalzen und deren Hydraten - Google Patents

Industrielles Verfahren zur Herstellung von 5-ibis(carboxymethyl)amino -3-carboxymethyl-4-cyano-2-thiophencarbonsäure-tetraestern und Verwendung zur Synthese von zweiwertigen Ranetansäuresalzen und deren Hydraten

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Publication number
DE60330213D1
DE60330213D1 DE60330213T DE60330213T DE60330213D1 DE 60330213 D1 DE60330213 D1 DE 60330213D1 DE 60330213 T DE60330213 T DE 60330213T DE 60330213 T DE60330213 T DE 60330213T DE 60330213 D1 DE60330213 D1 DE 60330213D1
Authority
DE
Germany
Prior art keywords
carboxymethyl
ranetanic
ibis
hydrates
divalent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60330213T
Other languages
English (en)
Inventor
Lucile Vaysse-Ludot
Jean-Pierre Lecouve
Pascal Langlois
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Original Assignee
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Servier SAS filed Critical Laboratoires Servier SAS
Application granted granted Critical
Publication of DE60330213D1 publication Critical patent/DE60330213D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE60330213T 2002-09-24 2003-09-22 Industrielles Verfahren zur Herstellung von 5-ibis(carboxymethyl)amino -3-carboxymethyl-4-cyano-2-thiophencarbonsäure-tetraestern und Verwendung zur Synthese von zweiwertigen Ranetansäuresalzen und deren Hydraten Expired - Lifetime DE60330213D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0211765A FR2844797B1 (fr) 2002-09-24 2002-09-24 Nouveau procede de synthese industriel des tetraesters de l'acide 5-[bis (carboxymethyl)]-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates

Publications (1)

Publication Number Publication Date
DE60330213D1 true DE60330213D1 (de) 2010-01-07

Family

ID=29415191

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60330213T Expired - Lifetime DE60330213D1 (de) 2002-09-24 2003-09-22 Industrielles Verfahren zur Herstellung von 5-ibis(carboxymethyl)amino -3-carboxymethyl-4-cyano-2-thiophencarbonsäure-tetraestern und Verwendung zur Synthese von zweiwertigen Ranetansäuresalzen und deren Hydraten

Country Status (39)

Country Link
US (1) US7091364B2 (de)
EP (1) EP1403265B1 (de)
JP (1) JP4136866B2 (de)
KR (1) KR100551502B1 (de)
CN (1) CN1280286C (de)
AP (1) AP1972A (de)
AR (1) AR041357A1 (de)
AT (1) ATE449767T1 (de)
AU (2) AU2003299095A1 (de)
BR (1) BR0304203A (de)
CA (1) CA2442881C (de)
CY (1) CY1109831T1 (de)
DE (1) DE60330213D1 (de)
DK (1) DK1403265T3 (de)
EA (1) EA007108B1 (de)
EC (1) ECSP055743A (de)
ES (1) ES2337348T3 (de)
FR (1) FR2844797B1 (de)
GE (1) GEP20074139B (de)
HK (1) HK1061846A1 (de)
HR (1) HRP20050361B1 (de)
IL (1) IL167315A (de)
IS (1) IS2728B (de)
MA (1) MA26100A1 (de)
ME (1) ME00453B (de)
MX (1) MXPA03008647A (de)
MY (1) MY134924A (de)
NO (1) NO328626B1 (de)
NZ (1) NZ528401A (de)
OA (1) OA12932A (de)
PL (1) PL215879B1 (de)
PT (1) PT1403265E (de)
RS (1) RS51551B (de)
SG (1) SG110069A1 (de)
SI (1) SI1403265T1 (de)
TN (1) TNSN05088A1 (de)
UA (1) UA79157C2 (de)
WO (1) WO2004029034A1 (de)
ZA (1) ZA200307411B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2844795B1 (fr) * 2002-09-24 2004-10-22 Servier Lab Nouveau procede de synthese industriel du ranelate de strontium et de ses hydrates
FR2844796A1 (fr) * 2002-09-24 2004-03-26 Servier Lab Nouveau procede de synthese industrielle du diester methylique de l'acide 5-amino-3-carboxymethyl-4-cyano-2- thiophenecarboxylique, et application a la synthese des sels bivalents de l'acide ranelique et de leurs hydrates
CA2524610C (en) * 2003-05-07 2014-03-25 Osteologix A/S Strontium combinations for prophylaxis/treatment of cartilage and/or bone conditions
PL1534305T3 (pl) * 2003-05-07 2007-03-30 Osteologix As Leczenie zaburzeń chrząstek i kości solami strontu rozpuszczalnymi w wodzie
US20050085531A1 (en) * 2003-10-03 2005-04-21 Hodge Carl N. Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
KR101165614B1 (ko) * 2004-02-26 2012-07-18 오스테올로지스 에이에스 괴사성 골 질환의 예방 또는 치료에 사용하기 위한스트론튬 함유 화합물
US8658206B2 (en) 2004-06-25 2014-02-25 Mokwalo SA Compositions comprising strontium and vitamin D and uses thereof
FR2875807B1 (fr) * 2004-09-30 2006-11-17 Servier Lab Forme cristalline alpha du ranelate de strontium, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
CN100391955C (zh) * 2005-04-30 2008-06-04 河北医科大学 一种雷尼酸锶中间体的合成方法
US20070292535A1 (en) * 2006-06-19 2007-12-20 Tabbiner Philip S Strontium compositions and methods of treating arthritic and or osteoporitic conditions
US20070292529A1 (en) * 2006-06-19 2007-12-20 Tabbiner Philip S Strontium compositions and methods of treating osteoporotic conditions
FR2921367B1 (fr) 2007-09-26 2009-10-30 Servier Lab Nouveau procede de synthese du ranelate de strontium et de ses hydrates
US20120123131A1 (en) * 2008-08-22 2012-05-17 Koilpillai Joseph Prabahar Process for the preparation of strontium ranelate
CN101665483B (zh) * 2008-09-01 2013-01-23 河北医科大学 一种雷尼酸锶中间体化合物ⅱ的合成方法
WO2011124992A1 (en) * 2010-03-24 2011-10-13 Actavis Group Ptc Ehf Substantially pure strontium ranelate
CN101812048B (zh) * 2010-04-06 2012-11-14 浙江东亚药业有限公司 雷尼酸锶及其水合物的合成方法
EP2602248A1 (de) 2011-12-05 2013-06-12 University Of Leicester Neue Pyrrol Verbindungen
WO2013113319A1 (en) 2012-01-31 2013-08-08 Pharmathen S.A. Process for the preparation of strontium ranelate, intermediate or hydrates thereof
EP2756841B1 (de) 2013-01-21 2015-05-13 Galenicum Health S.L. Pharmazeutische Zusammensetzungen mit einem Säuresalz
GB201310126D0 (en) * 2013-06-06 2013-07-24 Univ Leicester Novel pyrrole derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3624304A1 (de) 1986-07-18 1988-01-28 Bayer Ag Fungizide verwendung von substituierten thienylaminen
GB8715925D0 (en) * 1987-07-07 1987-08-12 Shell Int Research Thiapentanamide derivatives
FR2651497B1 (fr) 1989-09-01 1991-10-25 Adir Nouveaux sels de metaux bivalents de l'acide n, n-di (carboxymethyl)amino-2 cyano-3 carboxymethyl-4 carboxy-5 thiophene, leur procede de preparation et les compositions pharmaceutiques les renfermant.
DE19528380A1 (de) * 1995-08-02 1997-02-06 Hoechst Ag Heterogene Vinylacetat/Ethylen-Dispersion
FR2749759B1 (fr) * 1996-06-17 1999-11-26 Adir Utilisation de sels de strontium pour l'obtention de compositions pharmaceutiques destinees au traitement de l'arthrose
DE19650196A1 (de) * 1996-12-04 1998-06-10 Bayer Ag Thienylsulfonylamino(thio)carbonylverbindungen
US6835745B2 (en) * 2002-01-15 2004-12-28 Wyeth Phenyl substituted thiophenes as estrogenic agents

Also Published As

Publication number Publication date
MA26100A1 (fr) 2004-04-01
JP4136866B2 (ja) 2008-08-20
SG110069A1 (en) 2005-04-28
CN1500784A (zh) 2004-06-02
AP1972A (en) 2009-03-12
NO20034236L (no) 2004-03-25
RS20050241A (en) 2007-06-04
TNSN05088A1 (fr) 2007-05-14
ZA200307411B (en) 2004-07-07
AU2003248280B2 (en) 2009-01-08
PL215879B1 (pl) 2014-02-28
CN1280286C (zh) 2006-10-18
SI1403265T1 (sl) 2010-01-29
ATE449767T1 (de) 2009-12-15
BR0304203A (pt) 2004-08-24
CA2442881C (fr) 2010-06-29
HRP20050361B1 (hr) 2014-03-14
HK1061846A1 (en) 2004-10-08
GEP20074139B (en) 2007-06-25
ECSP055743A (es) 2005-07-06
US20040059134A1 (en) 2004-03-25
NO20034236D0 (no) 2003-09-23
HRP20050361A2 (en) 2005-06-30
EA007108B1 (ru) 2006-06-30
CA2442881A1 (fr) 2004-03-24
AU2003299095A1 (en) 2004-04-19
IS2728B (is) 2011-04-15
RS51551B (en) 2011-06-30
WO2004029034A1 (fr) 2004-04-08
KR100551502B1 (ko) 2006-02-13
EP1403265A1 (de) 2004-03-31
DK1403265T3 (da) 2010-04-06
NZ528401A (en) 2004-05-28
AU2003248280A1 (en) 2004-04-08
US7091364B2 (en) 2006-08-15
OA12932A (en) 2006-10-13
UA79157C2 (en) 2007-05-25
KR20040026626A (ko) 2004-03-31
IL167315A (en) 2009-08-03
AR041357A1 (es) 2005-05-11
CY1109831T1 (el) 2014-09-10
EP1403265B1 (de) 2009-11-25
EA200300927A1 (ru) 2004-04-29
ME00453B (me) 2011-10-10
FR2844797A1 (fr) 2004-03-26
FR2844797B1 (fr) 2004-10-22
JP2004269496A (ja) 2004-09-30
PL362366A1 (en) 2004-04-05
IS7803A (is) 2005-04-18
MXPA03008647A (es) 2005-04-19
NO328626B1 (no) 2010-04-12
AP2005003255A0 (en) 2005-03-31
MY134924A (en) 2008-01-31
PT1403265E (pt) 2009-12-16
ES2337348T3 (es) 2010-04-23

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