PE20050907A1 - Pirimidinas sustituidas con sulfoximina como inhibidores de quinasa dependiente de ciclinas - Google Patents

Pirimidinas sustituidas con sulfoximina como inhibidores de quinasa dependiente de ciclinas

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Publication number
PE20050907A1
PE20050907A1 PE2004001003A PE2004001003A PE20050907A1 PE 20050907 A1 PE20050907 A1 PE 20050907A1 PE 2004001003 A PE2004001003 A PE 2004001003A PE 2004001003 A PE2004001003 A PE 2004001003A PE 20050907 A1 PE20050907 A1 PE 20050907A1
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PE
Peru
Prior art keywords
amino
pyrimidin
bromo
hydroxy
phenyl
Prior art date
Application number
PE2004001003A
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English (en)
Inventor
Ulrich Lucking
Gerhard Siemeister
Martin Kruger
Rolf Jautelat
Original Assignee
Schering Ag
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Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of PE20050907A1 publication Critical patent/PE20050907A1/es

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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE Q ES EL GRUPO A O B; D, E, G, L, M, T SON CADA UNO C, O, N, S; R1 ES H, ALQUILO C1-C10, CF3, CN, ENTRE OTROS; R2 ES H, ALQUILO C1-C10, ALQUENILO C2-C10, CICLOALQUILO C3-C10, ARILO SUSTITUIDO O NO, ENTRE OTROS; X ES O, S, -NH-, ENTRE OTROS; R3 ES H, OH, HALOGENO, CF3, OCF3, ENTRE OTROS; m ES 0-4; R4 ES H, NO2, -CR8, TRIMETILSILANILO, TER-BUTIL-DIMETILSILANILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (RS)-S-[3-({5-BROMO-4-[(R)-(2-HIDROXI-1-METILETIL)AMINO]PIRIMIDIN-2-IL}AMINO)FENIL]-S-METIL-N-NITROSULFOXIMIDA; (RS)-S-[4-({5-BROMO-4-[(1R,2R)-(2-HIDROXI-1-METILPROPIL)AMINO]PIRIMIDIN-2-IL}AMINO)FENIL]-S-METILSULFOXIMIDA; (RS)-S-[4-({5-BROMO-4-{(R)-(2-HIDROXI-1,2-DIMETILPROPIL)AMINO]PIRIMIDIN-2-IL}AMINO)FENIL]-S-CICLOPROPIL-SULFOXIMIDA; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA Y UN METODO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE CDK UTILES EN EL TRATAMIENTO DE CANCER, ANGIOFIBROMA, ARTRITIS, ENFERMEDADES AUTOINMUNES, ENTRE OTROS
PE2004001003A 2003-10-16 2004-10-15 Pirimidinas sustituidas con sulfoximina como inhibidores de quinasa dependiente de ciclinas PE20050907A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10349423A DE10349423A1 (de) 2003-10-16 2003-10-16 Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel

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PE20050907A1 true PE20050907A1 (es) 2005-11-02

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US (2) US8507510B2 (es)
EP (1) EP1673352B1 (es)
JP (1) JP4700006B2 (es)
KR (1) KR101117387B1 (es)
CN (1) CN1867553B (es)
AR (1) AR046119A1 (es)
AT (1) ATE427939T1 (es)
AU (1) AU2004281960B2 (es)
BR (1) BRPI0415421A (es)
CA (1) CA2542492C (es)
CR (1) CR8363A (es)
CY (1) CY1110058T1 (es)
DE (2) DE10349423A1 (es)
DK (1) DK1673352T3 (es)
EC (1) ECSP066568A (es)
ES (1) ES2324475T3 (es)
GT (1) GT200400206A (es)
HK (1) HK1093731A1 (es)
HR (1) HRP20090348T1 (es)
IL (1) IL174952A (es)
JO (1) JO2534B1 (es)
ME (1) ME00158B (es)
MX (1) MXPA06004091A (es)
MY (1) MY140291A (es)
NO (1) NO337290B1 (es)
NZ (1) NZ546510A (es)
PE (1) PE20050907A1 (es)
PL (1) PL1673352T3 (es)
PT (1) PT1673352E (es)
RS (1) RS51657B (es)
RU (1) RU2410378C2 (es)
SI (1) SI1673352T1 (es)
TW (1) TWI347844B (es)
UA (1) UA86041C2 (es)
WO (1) WO2005037800A1 (es)
ZA (1) ZA200603885B (es)

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