PE20030653A1 - COMPUESTOS BICICLICOS[1,2,4]-TRIAZOL COMO ANTAGONISTAS DE RECEPTORES DE ADENOSINA A2a - Google Patents
COMPUESTOS BICICLICOS[1,2,4]-TRIAZOL COMO ANTAGONISTAS DE RECEPTORES DE ADENOSINA A2aInfo
- Publication number
- PE20030653A1 PE20030653A1 PE2002001149A PE2002001149A PE20030653A1 PE 20030653 A1 PE20030653 A1 PE 20030653A1 PE 2002001149 A PE2002001149 A PE 2002001149A PE 2002001149 A PE2002001149 A PE 2002001149A PE 20030653 A1 PE20030653 A1 PE 20030653A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- alcoxy
- group
- triazole
- cr3r3a
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical compound C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 title abstract 2
- 102000007471 Adenosine A2A receptor Human genes 0.000 title 1
- 108010085277 Adenosine A2A receptor Proteins 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical group C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 206010061921 Psychotic disorder due to a general medical condition Diseases 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- 125000006355 carbonyl methylene group Chemical group [H]C([H])([*:2])C([*:1])=O 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000001149 cognitive effect Effects 0.000 abstract 1
- 230000000626 neurodegenerative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33438501P | 2001-11-30 | 2001-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030653A1 true PE20030653A1 (es) | 2003-08-04 |
Family
ID=23306955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002001149A PE20030653A1 (es) | 2001-11-30 | 2002-11-28 | COMPUESTOS BICICLICOS[1,2,4]-TRIAZOL COMO ANTAGONISTAS DE RECEPTORES DE ADENOSINA A2a |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US6875772B2 (https=) |
| EP (1) | EP1453836B1 (https=) |
| JP (2) | JP4429724B2 (https=) |
| KR (1) | KR20050044600A (https=) |
| CN (1) | CN1688581A (https=) |
| AR (1) | AR037681A1 (https=) |
| AT (1) | ATE358130T1 (https=) |
| AU (1) | AU2002352933A1 (https=) |
| CA (1) | CA2468658C (https=) |
| DE (1) | DE60219196T2 (https=) |
| ES (1) | ES2283625T3 (https=) |
| HU (1) | HUP0402324A3 (https=) |
| IL (1) | IL161573A0 (https=) |
| MX (1) | MXPA04005158A (https=) |
| PE (1) | PE20030653A1 (https=) |
| TW (1) | TW200300689A (https=) |
| WO (1) | WO2003048163A1 (https=) |
| ZA (1) | ZA200404168B (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20030739A1 (es) | 2001-11-30 | 2003-08-28 | Schering Corp | Antagonistas del receptor de adenosina a2a |
| ES2283625T3 (es) * | 2001-11-30 | 2007-11-01 | Schering Corporation | Antagonistas del receptopr a2a de adenosina de (1,2,4)-triazol biciclicos. |
| EP1483256A2 (en) * | 2002-03-12 | 2004-12-08 | Wyeth | Process for making chiral 1,4-disubstituted piperazines |
| EP1544200A1 (en) * | 2002-09-24 | 2005-06-22 | Kyowa Hakko Kogyo Co., Ltd. | 1,2,4 -TRIAZOLO 1,5-c PYRIMIDINE DERIVATIVE |
| JP2006514697A (ja) * | 2002-12-19 | 2006-05-11 | シェーリング コーポレイション | アデノシンＡ２ａレセプターアンタゴニストの使用 |
| WO2004092173A2 (en) | 2003-04-09 | 2004-10-28 | Biogen Idec Ma Inc. | A2a adenosine receptor antagonists |
| US7674791B2 (en) | 2003-04-09 | 2010-03-09 | Biogen Idec Ma Inc. | Triazolopyrazines and methods of making and using the same |
| US20070010522A1 (en) * | 2003-04-09 | 2007-01-11 | Chi Vu | Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosine receptor antagonists |
| EP1615930A2 (en) | 2003-04-09 | 2006-01-18 | Biogen Idec MA, Inc. | Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagonists |
| TW200507850A (en) * | 2003-07-25 | 2005-03-01 | Kyowa Hakko Kogyo Kk | Pharmaceutical composition |
| WO2006129626A1 (ja) * | 2005-05-30 | 2006-12-07 | Kyowa Hakko Kogyo Co., Ltd. | [1,2,4]トリアゾロ[1,5-c]ピリミジン誘導体の製造法 |
| EP1902716A4 (en) * | 2005-06-07 | 2009-05-13 | Kyowa Hakko Kirin Co Ltd | PROPHYLACTIC AND / OR THERAPEUTIC AGENT FOR MOTOR TROUBLESHOOTING |
| WO2006131524A1 (en) * | 2005-06-08 | 2006-12-14 | Neurosearch A/S | Novel n-phenyl-piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| TW200803856A (en) | 2005-09-02 | 2008-01-16 | Mount Cook Biosciences Inc | Method of treating parkinson's disease with diarylmethylpiperazine compounds exhibiting delta receptor agonist activity |
| ES2273599B1 (es) | 2005-10-14 | 2008-06-01 | Universidad De Barcelona | Compuestos para el tratamiento de la fibrilacion auricular. |
| US7615556B2 (en) * | 2006-01-27 | 2009-11-10 | Bristol-Myers Squibb Company | Piperazinyl derivatives as modulators of chemokine receptor activity |
| CN102014959B (zh) | 2008-03-10 | 2016-01-20 | 康奈尔大学 | 血脑屏障通透性的调节 |
| WO2010008775A1 (en) * | 2008-06-23 | 2010-01-21 | Ligand Pharmaceuticals Inc. | Aminopyridopyrazinone derivatives for treating neurodegenerative diseases |
| GB201214106D0 (en) * | 2012-08-07 | 2012-09-19 | Univ Strathclyde | Immunomodulatory compounds |
| US10973815B2 (en) | 2016-03-31 | 2021-04-13 | Versi Group, Llc | Delta opioid agonist mu opioid antagonist compositions and methods for treating Parkinsons disease |
| CN106866582A (zh) * | 2017-01-10 | 2017-06-20 | 广州隽沐生物科技有限公司 | 一种氟班色林中间体的制备方法 |
| JP7175034B2 (ja) * | 2018-06-26 | 2022-11-18 | チョーチヤン ビムグリーン ファーマシューティカルズ、リミテッド | Ａ２ａ受容体拮抗薬として用いられるトリアゾロトリアジン誘導体 |
| WO2020227156A1 (en) * | 2019-05-03 | 2020-11-12 | Nektar Therapeutics | Adenosine 2 receptor antagonists |
| WO2021129843A1 (zh) * | 2019-12-26 | 2021-07-01 | 浙江春禾医药科技有限公司 | 三唑并三嗪衍生物在治疗疾病中的用途 |
| AU2022262777C1 (en) * | 2021-04-23 | 2025-02-13 | Chong Kun Dang Pharmaceutical Corp. | Compound as adenosine a2a receptor antagonist and pharmaceutical composition comprising same |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1264901B1 (it) | 1993-06-29 | 1996-10-17 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina |
| EP0666079B1 (en) * | 1993-07-27 | 2001-11-07 | Kyowa Hakko Kogyo Co., Ltd. | Remedy for parkinson's disease |
| IT1277392B1 (it) | 1995-07-28 | 1997-11-10 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina |
| JP4195729B2 (ja) * | 1997-03-24 | 2008-12-10 | 協和醗酵工業株式会社 | ［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体 |
| IT1291372B1 (it) | 1997-05-21 | 1999-01-07 | Schering Plough S P A | Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie |
| WO1999043678A1 (en) * | 1998-02-24 | 1999-09-02 | Kyowa Hakko Kogyo Co., Ltd. | Remedies/preventives for parkinson's disease |
| IL142128A0 (en) * | 1998-09-22 | 2002-03-10 | Kyowa Hakko Kogyo Kk | [1,2,4] triazolo [1,5-c] pyrimidine derivatives |
| US6355653B1 (en) | 1999-09-06 | 2002-03-12 | Hoffmann-La Roche Inc. | Amino-triazolopyridine derivatives |
| JP2002037787A (ja) * | 2000-05-16 | 2002-02-06 | Kyowa Hakko Kogyo Co Ltd | ［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体の製造法 |
| SI1283839T1 (https=) | 2000-05-26 | 2005-08-31 | Schering Corp | |
| JP4545437B2 (ja) | 2001-10-15 | 2010-09-15 | シェーリング コーポレイション | アデノシンａ２ａ受容体アンタゴニストとしてのイミダゾ（４，３−ｅ）−１，２，４−トリアゾロ（１，５−ｃ）ピリミジン |
| ES2283625T3 (es) * | 2001-11-30 | 2007-11-01 | Schering Corporation | Antagonistas del receptopr a2a de adenosina de (1,2,4)-triazol biciclicos. |
-
2002
- 2002-11-26 ES ES02789893T patent/ES2283625T3/es not_active Expired - Lifetime
- 2002-11-26 KR KR1020047007953A patent/KR20050044600A/ko not_active Withdrawn
- 2002-11-26 CA CA002468658A patent/CA2468658C/en not_active Expired - Fee Related
- 2002-11-26 CN CNA028239679A patent/CN1688581A/zh active Pending
- 2002-11-26 EP EP02789893A patent/EP1453836B1/en not_active Expired - Lifetime
- 2002-11-26 AU AU2002352933A patent/AU2002352933A1/en not_active Abandoned
- 2002-11-26 AT AT02789893T patent/ATE358130T1/de not_active IP Right Cessation
- 2002-11-26 JP JP2003549353A patent/JP4429724B2/ja not_active Expired - Fee Related
- 2002-11-26 MX MXPA04005158A patent/MXPA04005158A/es active IP Right Grant
- 2002-11-26 IL IL16157302A patent/IL161573A0/xx unknown
- 2002-11-26 DE DE60219196T patent/DE60219196T2/de not_active Expired - Lifetime
- 2002-11-26 HU HU0402324A patent/HUP0402324A3/hu unknown
- 2002-11-26 US US10/304,939 patent/US6875772B2/en not_active Expired - Lifetime
- 2002-11-26 WO PCT/US2002/037915 patent/WO2003048163A1/en not_active Ceased
- 2002-11-27 AR ARP020104562A patent/AR037681A1/es unknown
- 2002-11-27 TW TW091134487A patent/TW200300689A/zh unknown
- 2002-11-28 PE PE2002001149A patent/PE20030653A1/es not_active Application Discontinuation
-
2004
- 2004-05-27 ZA ZA200404168A patent/ZA200404168B/en unknown
- 2004-10-26 US US10/973,642 patent/US7078408B2/en not_active Expired - Lifetime
-
2009
- 2009-10-26 JP JP2009245977A patent/JP2010018634A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP4429724B2 (ja) | 2010-03-10 |
| HUP0402324A2 (hu) | 2005-02-28 |
| AR037681A1 (es) | 2004-12-01 |
| JP2005511697A (ja) | 2005-04-28 |
| CN1688581A (zh) | 2005-10-26 |
| WO2003048163A1 (en) | 2003-06-12 |
| HK1064097A1 (en) | 2005-01-21 |
| HUP0402324A3 (en) | 2008-09-29 |
| KR20050044600A (ko) | 2005-05-12 |
| ZA200404168B (en) | 2005-09-02 |
| DE60219196T2 (de) | 2008-01-03 |
| US20050113380A1 (en) | 2005-05-26 |
| CA2468658C (en) | 2009-04-14 |
| ATE358130T1 (de) | 2007-04-15 |
| CA2468658A1 (en) | 2003-06-12 |
| AU2002352933A1 (en) | 2003-06-17 |
| EP1453836A1 (en) | 2004-09-08 |
| EP1453836B1 (en) | 2007-03-28 |
| TW200300689A (en) | 2003-06-16 |
| DE60219196D1 (de) | 2007-05-10 |
| US20030191130A1 (en) | 2003-10-09 |
| JP2010018634A (ja) | 2010-01-28 |
| US7078408B2 (en) | 2006-07-18 |
| MXPA04005158A (es) | 2004-08-11 |
| IL161573A0 (en) | 2004-09-27 |
| US6875772B2 (en) | 2005-04-05 |
| ES2283625T3 (es) | 2007-11-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |