IL161573A0 - [1,2,4]-TRIAZOLE BICYCLIC ADENOSINE A2a RECEPTOR ANTAGONISTS - Google Patents
[1,2,4]-TRIAZOLE BICYCLIC ADENOSINE A2a RECEPTOR ANTAGONISTSInfo
- Publication number
- IL161573A0 IL161573A0 IL16157302A IL16157302A IL161573A0 IL 161573 A0 IL161573 A0 IL 161573A0 IL 16157302 A IL16157302 A IL 16157302A IL 16157302 A IL16157302 A IL 16157302A IL 161573 A0 IL161573 A0 IL 161573A0
- Authority
- IL
- Israel
- Prior art keywords
- adenosine
- receptor antagonists
- triazole
- bicyclic
- triazole bicyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33438501P | 2001-11-30 | 2001-11-30 | |
PCT/US2002/037915 WO2003048163A1 (en) | 2001-11-30 | 2002-11-26 | [1,2,4]-TRIAZOLE BICYCLIC ADENOSINE A2a RECEPTOR ANTAGONISTS |
Publications (1)
Publication Number | Publication Date |
---|---|
IL161573A0 true IL161573A0 (en) | 2004-09-27 |
Family
ID=23306955
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16157302A IL161573A0 (en) | 2001-11-30 | 2002-11-26 | [1,2,4]-TRIAZOLE BICYCLIC ADENOSINE A2a RECEPTOR ANTAGONISTS |
Country Status (19)
Country | Link |
---|---|
US (2) | US6875772B2 (xx) |
EP (1) | EP1453836B1 (xx) |
JP (2) | JP4429724B2 (xx) |
KR (1) | KR20050044600A (xx) |
CN (1) | CN1688581A (xx) |
AR (1) | AR037681A1 (xx) |
AT (1) | ATE358130T1 (xx) |
AU (1) | AU2002352933A1 (xx) |
CA (1) | CA2468658C (xx) |
DE (1) | DE60219196T2 (xx) |
ES (1) | ES2283625T3 (xx) |
HK (1) | HK1064097A1 (xx) |
HU (1) | HUP0402324A3 (xx) |
IL (1) | IL161573A0 (xx) |
MX (1) | MXPA04005158A (xx) |
PE (1) | PE20030653A1 (xx) |
TW (1) | TW200300689A (xx) |
WO (1) | WO2003048163A1 (xx) |
ZA (1) | ZA200404168B (xx) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2283625T3 (es) * | 2001-11-30 | 2007-11-01 | Schering Corporation | Antagonistas del receptopr a2a de adenosina de (1,2,4)-triazol biciclicos. |
PE20030739A1 (es) | 2001-11-30 | 2003-08-28 | Schering Corp | Antagonistas del receptor de adenosina a2a |
KR20040091119A (ko) * | 2002-03-12 | 2004-10-27 | 와이어쓰 | 키랄 1,4-이치환된 피페라진의 제조방법 |
EP1544200A1 (en) * | 2002-09-24 | 2005-06-22 | Kyowa Hakko Kogyo Co., Ltd. | 1,2,4 -TRIAZOLO 1,5-c PYRIMIDINE DERIVATIVE |
CN100415217C (zh) * | 2002-12-19 | 2008-09-03 | 先灵公司 | 腺苷A2a受体拮抗剂的应用 |
WO2004092173A2 (en) | 2003-04-09 | 2004-10-28 | Biogen Idec Ma Inc. | A2a adenosine receptor antagonists |
US7285550B2 (en) | 2003-04-09 | 2007-10-23 | Biogen Idec Ma Inc. | Triazolotriazines and pyrazolotriazines and methods of making and using the same |
EP1618109A2 (en) * | 2003-04-09 | 2006-01-25 | Biogen Idec MA Inc. | Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosine receptor antagonists |
US7674791B2 (en) | 2003-04-09 | 2010-03-09 | Biogen Idec Ma Inc. | Triazolopyrazines and methods of making and using the same |
TW200507850A (en) * | 2003-07-25 | 2005-03-01 | Kyowa Hakko Kogyo Kk | Pharmaceutical composition |
JPWO2006129626A1 (ja) * | 2005-05-30 | 2009-01-08 | 協和醗酵工業株式会社 | [1,2,4]トリアゾロ[1,5−c]ピリミジン誘導体の製造法 |
JPWO2006132275A1 (ja) * | 2005-06-07 | 2009-01-08 | 協和醗酵工業株式会社 | 運動障害の予防および/または治療剤 |
EP1896415A1 (en) * | 2005-06-08 | 2008-03-12 | NeuroSearch A/S | Novel n-phenyl-piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
TW200803856A (en) * | 2005-09-02 | 2008-01-16 | Mount Cook Biosciences Inc | Method of treating parkinson's disease with diarylmethylpiperazine compounds exhibiting delta receptor agonist activity |
ES2273599B1 (es) | 2005-10-14 | 2008-06-01 | Universidad De Barcelona | Compuestos para el tratamiento de la fibrilacion auricular. |
US7615556B2 (en) * | 2006-01-27 | 2009-11-10 | Bristol-Myers Squibb Company | Piperazinyl derivatives as modulators of chemokine receptor activity |
WO2009114533A2 (en) | 2008-03-10 | 2009-09-17 | Cornell University | Modulation of blood brain barrier permeability |
WO2010008775A1 (en) * | 2008-06-23 | 2010-01-21 | Ligand Pharmaceuticals Inc. | Aminopyridopyrazinone derivatives for treating neurodegenerative diseases |
GB201214106D0 (en) * | 2012-08-07 | 2012-09-19 | Univ Strathclyde | Immunomodulatory compounds |
CA3014943A1 (en) | 2016-03-31 | 2017-10-05 | Versi Group, Llc | Delta opioid agonist, mu opioid antagonist compositions and methods for treating parkinson's disease |
CN106866582A (zh) * | 2017-01-10 | 2017-06-20 | 广州隽沐生物科技有限公司 | 一种氟班色林中间体的制备方法 |
WO2020002968A1 (en) * | 2018-06-26 | 2020-01-02 | Zhejiang Vimgreen Pharmaceuticals, Ltd | Triazolotriazine derivatives as a2a receptor antagonists |
US20220235056A1 (en) * | 2019-05-03 | 2022-07-28 | Nektar Therapeutics | Adenosine 2 receptor antagonists |
BR112023021918A2 (pt) * | 2021-04-23 | 2023-12-19 | Chong Kun Dang Pharmaceutical Corp | Composto como antagonista do receptor de adenosina a2a e composição farmacêutica compreendendo o mesmo |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1264901B1 (it) | 1993-06-29 | 1996-10-17 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina |
AU7237294A (en) * | 1993-07-27 | 1995-02-28 | Kyowa Hakko Kogyo Co. Ltd. | Remedy for parkinson's disease |
IT1277392B1 (it) | 1995-07-28 | 1997-11-10 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina |
ATE257156T1 (de) * | 1997-03-24 | 2004-01-15 | Kyowa Hakko Kogyo Kk | (1,2,4)triazolo(1,5-c)pyrimidin-derivate |
IT1291372B1 (it) | 1997-05-21 | 1999-01-07 | Schering Plough S P A | Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie |
WO1999043678A1 (fr) * | 1998-02-24 | 1999-09-02 | Kyowa Hakko Kogyo Co., Ltd. | Medicaments et prophylaxie contre la maladie de parkinson |
CN1328560A (zh) * | 1998-09-22 | 2001-12-26 | 协和发酵工业株式会社 | [1,2,4]三唑并[1,5-c]嘧啶衍生物 |
US6355653B1 (en) | 1999-09-06 | 2002-03-12 | Hoffmann-La Roche Inc. | Amino-triazolopyridine derivatives |
JP2002037787A (ja) * | 2000-05-16 | 2002-02-06 | Kyowa Hakko Kogyo Co Ltd | [1,2,4]トリアゾロ[1,5−c]ピリミジン誘導体の製造法 |
MY132006A (en) | 2000-05-26 | 2007-09-28 | Schering Corp | ADENOSINE A2a RECEPTOR ANTAGONISTS |
PE20030477A1 (es) | 2001-10-15 | 2003-06-06 | Schering Corp | ANTAGONISTAS DEL RECEPTOR DE ADENOSINA A2a |
ES2283625T3 (es) * | 2001-11-30 | 2007-11-01 | Schering Corporation | Antagonistas del receptopr a2a de adenosina de (1,2,4)-triazol biciclicos. |
-
2002
- 2002-11-26 ES ES02789893T patent/ES2283625T3/es not_active Expired - Lifetime
- 2002-11-26 AU AU2002352933A patent/AU2002352933A1/en not_active Abandoned
- 2002-11-26 HU HU0402324A patent/HUP0402324A3/hu unknown
- 2002-11-26 US US10/304,939 patent/US6875772B2/en not_active Expired - Lifetime
- 2002-11-26 EP EP02789893A patent/EP1453836B1/en not_active Expired - Lifetime
- 2002-11-26 WO PCT/US2002/037915 patent/WO2003048163A1/en active IP Right Grant
- 2002-11-26 DE DE60219196T patent/DE60219196T2/de not_active Expired - Lifetime
- 2002-11-26 CA CA002468658A patent/CA2468658C/en not_active Expired - Fee Related
- 2002-11-26 MX MXPA04005158A patent/MXPA04005158A/es active IP Right Grant
- 2002-11-26 KR KR1020047007953A patent/KR20050044600A/ko not_active Application Discontinuation
- 2002-11-26 JP JP2003549353A patent/JP4429724B2/ja not_active Expired - Fee Related
- 2002-11-26 AT AT02789893T patent/ATE358130T1/de not_active IP Right Cessation
- 2002-11-26 IL IL16157302A patent/IL161573A0/xx unknown
- 2002-11-26 CN CNA028239679A patent/CN1688581A/zh active Pending
- 2002-11-27 AR ARP020104562A patent/AR037681A1/es unknown
- 2002-11-27 TW TW091134487A patent/TW200300689A/zh unknown
- 2002-11-28 PE PE2002001149A patent/PE20030653A1/es not_active Application Discontinuation
-
2004
- 2004-05-27 ZA ZA200404168A patent/ZA200404168B/en unknown
- 2004-09-10 HK HK04106857A patent/HK1064097A1/xx not_active IP Right Cessation
- 2004-10-26 US US10/973,642 patent/US7078408B2/en not_active Expired - Lifetime
-
2009
- 2009-10-26 JP JP2009245977A patent/JP2010018634A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
MXPA04005158A (es) | 2004-08-11 |
PE20030653A1 (es) | 2003-08-04 |
US6875772B2 (en) | 2005-04-05 |
US7078408B2 (en) | 2006-07-18 |
CA2468658C (en) | 2009-04-14 |
HUP0402324A3 (en) | 2008-09-29 |
US20030191130A1 (en) | 2003-10-09 |
EP1453836B1 (en) | 2007-03-28 |
US20050113380A1 (en) | 2005-05-26 |
ATE358130T1 (de) | 2007-04-15 |
AU2002352933A1 (en) | 2003-06-17 |
CA2468658A1 (en) | 2003-06-12 |
AR037681A1 (es) | 2004-12-01 |
EP1453836A1 (en) | 2004-09-08 |
TW200300689A (en) | 2003-06-16 |
WO2003048163A1 (en) | 2003-06-12 |
JP2005511697A (ja) | 2005-04-28 |
ZA200404168B (en) | 2005-09-02 |
JP4429724B2 (ja) | 2010-03-10 |
DE60219196T2 (de) | 2008-01-03 |
ES2283625T3 (es) | 2007-11-01 |
DE60219196D1 (de) | 2007-05-10 |
CN1688581A (zh) | 2005-10-26 |
HK1064097A1 (en) | 2005-01-21 |
KR20050044600A (ko) | 2005-05-12 |
HUP0402324A2 (hu) | 2005-02-28 |
JP2010018634A (ja) | 2010-01-28 |
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