PE20011086A1 - Linezolid-forma cristalina ii - Google Patents
Linezolid-forma cristalina iiInfo
- Publication number
- PE20011086A1 PE20011086A1 PE2001000080A PE2001000080A PE20011086A1 PE 20011086 A1 PE20011086 A1 PE 20011086A1 PE 2001000080 A PE2001000080 A PE 2001000080A PE 2001000080 A PE2001000080 A PE 2001000080A PE 20011086 A1 PE20011086 A1 PE 20011086A1
- Authority
- PE
- Peru
- Prior art keywords
- linezolid
- morpholinyl
- acetamide
- oxo
- fluoro
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 4
- TYZROVQLWOKYKF-ZDUSSCGKSA-N linezolid Chemical compound O=C1O[C@@H](CNC(=O)C)CN1C(C=C1F)=CC=C1N1CCOCC1 TYZROVQLWOKYKF-ZDUSSCGKSA-N 0.000 abstract 6
- 239000002904 solvent Substances 0.000 abstract 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- -1 4-MORPHOLINYL Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-PWCQTSIFSA-N Tritiated water Chemical compound [3H]O[3H] XLYOFNOQVPJJNP-PWCQTSIFSA-N 0.000 abstract 1
- 238000002441 X-ray diffraction Methods 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 238000002329 infrared spectrum Methods 0.000 abstract 1
- 229960003907 linezolid Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
- YXFVVABEGXRONW-CNRUNOGKSA-N tritiomethylbenzene Chemical compound [3H]CC1=CC=CC=C1 YXFVVABEGXRONW-CNRUNOGKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/22—Oxygen atoms attached in position 2 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17983700P | 2000-02-02 | 2000-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20011086A1 true PE20011086A1 (es) | 2001-10-04 |
Family
ID=22658183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000080A PE20011086A1 (es) | 2000-02-02 | 2001-01-25 | Linezolid-forma cristalina ii |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP1255754B1 (https=) |
| JP (1) | JP5235256B2 (https=) |
| KR (3) | KR100864745B1 (https=) |
| CN (1) | CN1221547C (https=) |
| AR (1) | AR027261A1 (https=) |
| AT (1) | ATE297920T1 (https=) |
| AU (1) | AU782138B2 (https=) |
| BR (1) | BR0107667A (https=) |
| CA (1) | CA2395603C (https=) |
| CO (1) | CO5261555A1 (https=) |
| CZ (1) | CZ302292B6 (https=) |
| DE (1) | DE60111497T2 (https=) |
| DK (1) | DK1255754T3 (https=) |
| EA (1) | EA004434B1 (https=) |
| EE (1) | EE05197B1 (https=) |
| ES (1) | ES2242728T3 (https=) |
| HU (1) | HUP0301076A3 (https=) |
| IL (1) | IL151010A0 (https=) |
| MX (1) | MXPA02007471A (https=) |
| MY (1) | MY122829A (https=) |
| NO (2) | NO323459B1 (https=) |
| NZ (1) | NZ520541A (https=) |
| PE (1) | PE20011086A1 (https=) |
| PL (1) | PL356433A1 (https=) |
| PT (1) | PT1255754E (https=) |
| SI (1) | SI1255754T1 (https=) |
| SK (1) | SK287025B6 (https=) |
| TW (1) | TWI297687B (https=) |
| WO (1) | WO2001057035A1 (https=) |
| ZA (1) | ZA200205162B (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100490643B1 (ko) * | 2002-10-29 | 2005-05-19 | 한국과학기술연구원 | 새로운 메틸리덴 피페리딘일 옥사졸리딘온 유도체 및이들의 제조방법 |
| PT1673370E (pt) | 2003-10-16 | 2009-11-05 | Symed Labs Ltd | Forma cristalina de linezolida |
| WO2005099353A2 (en) | 2004-04-19 | 2005-10-27 | Symed Labs Limited | A novel process for the preparation of linezolid and related compounds |
| CA2572207A1 (en) * | 2004-06-29 | 2006-10-19 | Teva Pharmaceutical Industries Ltd. | Solid forms of linezolid and processes for preparation thereof |
| US20060142283A1 (en) * | 2004-06-29 | 2006-06-29 | Judith Aronhime | Crystalline form IV of linezolid |
| WO2006091731A2 (en) * | 2005-02-24 | 2006-08-31 | Teva Pharmaceutical Industries Ltd. | Processes for the preparation of linezolid intermediate |
| MX2007002113A (es) * | 2005-06-22 | 2007-04-27 | Teva Pharma | Formas polimorfas de maleato de tegaserod. |
| AU2006277017A1 (en) * | 2005-07-20 | 2007-02-15 | Teva Pharmaceutical Industries Ltd. | Stable pharmaceutical composition comprising linezolid form IV |
| WO2007102082A1 (en) * | 2006-03-09 | 2007-09-13 | Glenmark Pharmaceuticals Limited | High oxazolidinone content solid dosage forms |
| EP2099299A4 (en) * | 2006-10-23 | 2011-11-30 | Concert Pharmaceuticals Inc | OXAZOLIDINONE DERIVATIVES AND METHOD FOR THEIR USE |
| WO2011050826A1 (en) | 2009-10-28 | 2011-05-05 | Synthon B.V. | Process for making crystalline form a of linezolid |
| MX2012012627A (es) | 2010-04-30 | 2013-05-09 | Univ Indiana Res & Tech Corp | Proceso para preparar linezolid. |
| EP2603505A1 (en) | 2010-08-11 | 2013-06-19 | Synthon BV | Process for making linezolid |
| EP2603506A1 (en) | 2010-08-11 | 2013-06-19 | Synthon BV | Process for making linezolid |
| WO2012114354A1 (en) * | 2011-02-24 | 2012-08-30 | Lee Pharma Limited | Anhydrous linezolid crystalline form-ii |
| EP2683696A1 (en) | 2011-03-09 | 2014-01-15 | Synthon BV | Process for making crystalline form a of linezolid |
| CN102731341A (zh) * | 2011-04-13 | 2012-10-17 | 上海医药工业研究院 | 用于制备利奈唑胺的中间体及其制备方法 |
| CN102766106A (zh) * | 2011-05-03 | 2012-11-07 | 江苏豪森医药集团有限公司 | 利奈唑胺的新晶型及其制备方法 |
| CN102399200B (zh) * | 2011-12-14 | 2013-12-04 | 浙江新东港药业股份有限公司 | 一种利用悬浮结晶法制备利奈唑胺晶型ⅰ的方法 |
| IN2014DN06213A (https=) | 2012-01-24 | 2015-10-23 | Jubilant Life Sciences Ltd | |
| WO2013120496A1 (en) | 2012-02-14 | 2013-08-22 | Pharmathen S.A. | Process for the preparation of linezolid in crystalline form and salts thereof |
| CN102643245A (zh) * | 2012-04-10 | 2012-08-22 | 杭州华东医药集团生物工程研究所有限公司 | 一种利奈唑胺晶型及其制备方法 |
| EP2917189B1 (en) | 2012-11-09 | 2016-08-17 | Synthon BV | Process for making linezolid |
| DK3541442T3 (da) | 2016-11-16 | 2022-03-14 | Persica Pharmaceuticals Ltd | Antibiotiske formuleringer mod lændesmerter |
| DK3709970T3 (da) * | 2017-11-16 | 2025-07-07 | Persica Pharmaceuticals Ltd | Linezolidformuleringer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
| MY115155A (en) * | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| US5688792A (en) * | 1994-08-16 | 1997-11-18 | Pharmacia & Upjohn Company | Substituted oxazine and thiazine oxazolidinone antimicrobials |
| DK1114819T3 (da) * | 1996-04-11 | 2008-04-14 | Pharmacia & Upjohn Co Llc | Fremgangsmåde til fremstilling af oxazolidinoner |
| EP1772453A1 (en) * | 1997-11-07 | 2007-04-11 | Pharmacia & Upjohn Company LLC | Process to produce Oxazolidinones |
-
2001
- 2001-01-22 AR ARP010100269A patent/AR027261A1/es not_active Application Discontinuation
- 2001-01-25 PE PE2001000080A patent/PE20011086A1/es not_active Application Discontinuation
- 2001-01-26 CO CO01005901A patent/CO5261555A1/es not_active Application Discontinuation
- 2001-01-29 SK SK994-2002A patent/SK287025B6/sk not_active IP Right Cessation
- 2001-01-29 EA EA200200819A patent/EA004434B1/ru not_active IP Right Cessation
- 2001-01-29 WO PCT/US2001/000657 patent/WO2001057035A1/en not_active Ceased
- 2001-01-29 AT AT01904805T patent/ATE297920T1/de active
- 2001-01-29 BR BR0107667-1A patent/BR0107667A/pt not_active Application Discontinuation
- 2001-01-29 SI SI200130405T patent/SI1255754T1/sl unknown
- 2001-01-29 HU HU0301076A patent/HUP0301076A3/hu unknown
- 2001-01-29 KR KR1020077016678A patent/KR100864745B1/ko not_active Expired - Fee Related
- 2001-01-29 KR KR1020087010742A patent/KR20080044358A/ko not_active Ceased
- 2001-01-29 EP EP01904805A patent/EP1255754B1/en not_active Expired - Lifetime
- 2001-01-29 AU AU32755/01A patent/AU782138B2/en not_active Ceased
- 2001-01-29 PL PL01356433A patent/PL356433A1/xx unknown
- 2001-01-29 PT PT01904805T patent/PT1255754E/pt unknown
- 2001-01-29 CA CA2395603A patent/CA2395603C/en not_active Expired - Lifetime
- 2001-01-29 MX MXPA02007471A patent/MXPA02007471A/es active IP Right Grant
- 2001-01-29 EE EEP200200420A patent/EE05197B1/xx not_active IP Right Cessation
- 2001-01-29 ES ES01904805T patent/ES2242728T3/es not_active Expired - Lifetime
- 2001-01-29 DE DE60111497T patent/DE60111497T2/de not_active Expired - Lifetime
- 2001-01-29 DK DK01904805T patent/DK1255754T3/da active
- 2001-01-29 MY MYPI20010371A patent/MY122829A/en unknown
- 2001-01-29 CN CNB018034489A patent/CN1221547C/zh not_active Expired - Fee Related
- 2001-01-29 CZ CZ20022635A patent/CZ302292B6/cs not_active IP Right Cessation
- 2001-01-29 JP JP2001557867A patent/JP5235256B2/ja not_active Expired - Lifetime
- 2001-01-29 IL IL15101001A patent/IL151010A0/xx active IP Right Grant
- 2001-01-29 NZ NZ520541A patent/NZ520541A/en not_active IP Right Cessation
- 2001-01-29 KR KR1020027009923A patent/KR100781815B1/ko not_active Expired - Fee Related
- 2001-02-02 TW TW090102231A patent/TWI297687B/zh not_active IP Right Cessation
-
2002
- 2002-06-27 ZA ZA200205162A patent/ZA200205162B/en unknown
- 2002-08-01 NO NO20023654A patent/NO323459B1/no not_active IP Right Cessation
-
2006
- 2006-12-15 NO NO20065836A patent/NO20065836L/no not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal | ||
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |