PE20010764A1 - Cristales de inhibidor del intercambiador de sodio-hidrogeno tipo 1 - Google Patents
Cristales de inhibidor del intercambiador de sodio-hidrogeno tipo 1Info
- Publication number
- PE20010764A1 PE20010764A1 PE2000001145A PE0011452000A PE20010764A1 PE 20010764 A1 PE20010764 A1 PE 20010764A1 PE 2000001145 A PE2000001145 A PE 2000001145A PE 0011452000 A PE0011452000 A PE 0011452000A PE 20010764 A1 PE20010764 A1 PE 20010764A1
- Authority
- PE
- Peru
- Prior art keywords
- hydrogen exchanger
- quinolin
- guanidine
- cyclopropyl
- refers
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Treatment Of Water By Ion Exchange (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A INHIBIDORES DEL INTERCAMBIADOR DE SODIO-HIDROGENO TIPO 1 TAL COMO SAL MONOMESILATO DE N-(5-CICLOPROPIL-1-QUINOLIN-5-IL-1H-PIRAZOL-4-CARBONIL)-GUANIDINA DE FORMULA I EN FORMA CRISTALINA, ANHIDRA FORMA D, A, HEMIHIDRATADA; QUE TIENE UN PATRON DE DIFRACCION DE RAYOS X. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA PREPARAR EL CRISTAL QUE COMPRENDE COMBINAR UNA SOLUCION EN ACETONA DE N-(5-CICLOPROPIL-1-QUINOLIN-5-IL-1H-PIRAZOL-4-CARBONIL)-GUANIDINA Y N-METILPIRROLIDONA CON ACIDO METANOSULFONICO A UNA TEMPERATURA DE 30°C A 60°C SEGUIDO POR EL ENFRIAMIENTO HASTA LA TEMPERATURA AMBIENTE A 35°C; UTILIZANDOSE DE 0,01 mg/Kg/DIA A 10 mg/Kg/DIA UTILES PARA REDUCIR LESIONES ORIGINADAS POR ISQUEMIA O HIPOXIA EN LOS TEJIDOS CARDIACO, CEREBRAL, HEPATICO, RENAL, PULMONAR, ESTOMACAL, MUSCULO ESQUELETICO, BAZO PANCREATICO, NERVIOSO, MEDULA ESPINAL, INTESTINAL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16237499P | 1999-10-29 | 1999-10-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20010764A1 true PE20010764A1 (es) | 2001-07-23 |
Family
ID=22585355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000001145A PE20010764A1 (es) | 1999-10-29 | 2000-10-26 | Cristales de inhibidor del intercambiador de sodio-hidrogeno tipo 1 |
Country Status (44)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6441176B1 (en) | 1999-10-29 | 2002-08-27 | Pfizer Inc. | Method for preparing sodium-hydrogen exchanger type 1 inhibitor |
| IL156220A0 (en) * | 2001-01-31 | 2003-12-23 | Pfizer Prod Inc | Ethanolates of sodium-hydrogen exchanger type-1 inhibitor |
| BR0307195A (pt) * | 2002-01-30 | 2004-11-03 | Pfizer Prod Inc | Composições farmacêuticas de mesilato de zoniporide e processos para melhorar a solubilidade do zoniporide |
| CA2483927A1 (en) * | 2002-05-02 | 2003-11-13 | Pfizer Products Inc. | Treatment of diabetes and diabetic complications with nhe-1 inhibitors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA003603B1 (ru) * | 1998-02-27 | 2003-06-26 | Пфайзер Продактс Инк. | N-[(замещенное пятичленное ди- или триазадиненасыщенное кольцо) карбонил] гуанидиновые производные для лечения ишемии |
-
2000
- 2000-09-10 UA UA2002043503A patent/UA72002C2/uk unknown
- 2000-10-09 GE GEAP20006430A patent/GEP20043222B/en unknown
- 2000-10-09 IL IL14858100A patent/IL148581A0/xx unknown
- 2000-10-09 EP EP00962776A patent/EP1224179B1/en not_active Expired - Lifetime
- 2000-10-09 CZ CZ20021332A patent/CZ20021332A3/cs unknown
- 2000-10-09 OA OA1200200128A patent/OA12080A/en unknown
- 2000-10-09 CN CNB008146748A patent/CN1205205C/zh not_active Expired - Fee Related
- 2000-10-09 SI SI200030449T patent/SI1224179T1/xx unknown
- 2000-10-09 KR KR10-2002-7005366A patent/KR100464526B1/ko not_active IP Right Cessation
- 2000-10-09 PL PL00354869A patent/PL354869A1/xx not_active Application Discontinuation
- 2000-10-09 WO PCT/IB2000/001460 patent/WO2001030759A2/en active IP Right Grant
- 2000-10-09 SK SK531-2002A patent/SK5312002A3/sk unknown
- 2000-10-09 TR TR2002/01167T patent/TR200201167T2/xx unknown
- 2000-10-09 JP JP2001533113A patent/JP2003512455A/ja active Pending
- 2000-10-09 AT AT00962776T patent/ATE271047T1/de not_active IP Right Cessation
- 2000-10-09 MX MXPA02004358A patent/MXPA02004358A/es active IP Right Grant
- 2000-10-09 CN CNA200410094665XA patent/CN1636991A/zh active Pending
- 2000-10-09 DK DK00962776T patent/DK1224179T3/da active
- 2000-10-09 PT PT00962776T patent/PT1224179E/pt unknown
- 2000-10-09 NZ NZ517738A patent/NZ517738A/en unknown
- 2000-10-09 DE DE60012208T patent/DE60012208T2/de not_active Expired - Fee Related
- 2000-10-09 BR BR0015275-7A patent/BR0015275A/pt not_active IP Right Cessation
- 2000-10-09 DZ DZ003463A patent/DZ3463A1/fr active
- 2000-10-09 AP APAP/P/2002/002493A patent/AP2002002493A0/en unknown
- 2000-10-09 EA EA200200416A patent/EA004937B1/ru not_active IP Right Cessation
- 2000-10-09 AU AU74415/00A patent/AU778573B2/en not_active Ceased
- 2000-10-09 HU HU0204009A patent/HUP0204009A3/hu unknown
- 2000-10-09 YU YU31502A patent/YU31502A/sh unknown
- 2000-10-09 EE EEP200200227A patent/EE200200227A/xx unknown
- 2000-10-09 ES ES00962776T patent/ES2222923T3/es not_active Expired - Lifetime
- 2000-10-09 CA CA002389020A patent/CA2389020A1/en not_active Abandoned
- 2000-10-18 GT GT200000180A patent/GT200000180A/es unknown
- 2000-10-20 PA PA20008505501A patent/PA8505501A1/es unknown
- 2000-10-25 CO CO00081375A patent/CO5271714A1/es not_active Application Discontinuation
- 2000-10-26 PE PE2000001145A patent/PE20010764A1/es not_active Application Discontinuation
- 2000-10-27 SV SV2000000209A patent/SV2002000209A/es unknown
- 2000-10-27 AR ARP000105700A patent/AR029402A1/es unknown
- 2000-10-27 TN TNTNSN00210A patent/TNSN00210A1/fr unknown
-
2002
- 2002-03-15 IS IS6302A patent/IS6302A/is unknown
- 2002-04-18 NO NO20021821A patent/NO20021821L/no not_active Application Discontinuation
- 2002-04-22 MA MA26615A patent/MA26840A1/fr unknown
- 2002-04-25 ZA ZA200203295A patent/ZA200203295B/xx unknown
- 2002-04-25 HR HR20020366A patent/HRP20020366B1/xx not_active IP Right Cessation
- 2002-05-20 BG BG106729A patent/BG106729A/bg unknown
-
2003
- 2003-01-21 HK HK03100504.6A patent/HK1048472B/zh not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |