BR0115616A - Preparação de inibidores de permutadores sódio-hidrogênio do tipo 1 - Google Patents

Preparação de inibidores de permutadores sódio-hidrogênio do tipo 1

Info

Publication number
BR0115616A
BR0115616A BR0115616-0A BR0115616A BR0115616A BR 0115616 A BR0115616 A BR 0115616A BR 0115616 A BR0115616 A BR 0115616A BR 0115616 A BR0115616 A BR 0115616A
Authority
BR
Brazil
Prior art keywords
type
preparation
sodium hydrogen
inhibitors
hydrogen exchanger
Prior art date
Application number
BR0115616-0A
Other languages
English (en)
Inventor
John Francis Lambert
Timothy Norris
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0115616A publication Critical patent/BR0115616A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/22—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"PREPARAçãO DE INIBIDORES DE PERMUTADORES SóDIO-HIDROGêNIO DO TIPO 1". A presente invenção refere-se a métodos para preparar inibidores de permutadores de sódio-hidrogênio do tipo 1 (NHE-1) de fórmula I' intermediários dos inibidores de NHE-1 e uma forma quase sem cor do inibidor NHE-1, N-(5-ciclopropil-1-quinolin-5-il-1H-pirazol-4-carbonil)-guanidina.
BR0115616-0A 2000-11-28 2001-10-31 Preparação de inibidores de permutadores sódio-hidrogênio do tipo 1 BR0115616A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25335300P 2000-11-28 2000-11-28
PCT/IB2001/002052 WO2002044133A1 (en) 2000-11-28 2001-10-31 Preparation of sodium-hydrogen exchanger type-1 inhibitors

Publications (1)

Publication Number Publication Date
BR0115616A true BR0115616A (pt) 2003-09-16

Family

ID=22959914

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0115616-0A BR0115616A (pt) 2000-11-28 2001-10-31 Preparação de inibidores de permutadores sódio-hidrogênio do tipo 1

Country Status (9)

Country Link
US (1) US6753334B2 (pt)
EP (1) EP1337508A1 (pt)
JP (1) JP2004514706A (pt)
AR (1) AR035601A1 (pt)
AU (1) AU2002210839A1 (pt)
BR (1) BR0115616A (pt)
CA (1) CA2430061A1 (pt)
MX (1) MXPA03004783A (pt)
WO (1) WO2002044133A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003051845A1 (en) * 2001-12-19 2003-06-26 Pfizer Products Inc. Methods for preparing sodium-hydrogen exchanger type-1 inhibitors
JP4880671B2 (ja) 2005-04-05 2012-02-22 エフ．ホフマン−ラ ロシュ アーゲー １Ｈ−ピラゾール４−カルボキシルアミドその製造方法および１１β−ヒドロキシステロイドデヒドロゲナーゼとしてのその使用
US20100162956A1 (en) * 2005-08-05 2010-07-01 Seishi Murakami Substrate Processing Apparatus and Substrate Mount Table Used in the Apparatus
KR20110007258A (ko) 2006-03-22 2011-01-21 에프. 호프만-라 로슈 아게 11-베타-ｈｓｄ-1로서의 피라졸
WO2007114315A1 (ja) * 2006-03-30 2007-10-11 Santen Pharmaceutical Co., Ltd. 角結膜障害治療剤
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
CN103772282B (zh) * 2014-02-26 2015-09-23 上海毕得医药科技有限公司 一种3-叔丁基-1h-吡唑-4-甲醛的制备方法
EP3584241B1 (en) 2017-02-14 2023-04-26 FUJIFILM Corporation Method for producing indazole compound, and indazole compound
WO2019224138A1 (de) 2018-05-24 2019-11-28 Bayer Aktiengesellschaft Verfahren zur herstellung von substituierten n-arylpyrazolen

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH652389A5 (en) * 1982-02-03 1985-11-15 Sandoz Ag Process for the preparation of o,o'-disubstituted phenylhydrazines
US4599403A (en) * 1985-10-07 1986-07-08 Harold Levy Method for recovery of stevioside
EA003603B1 (ru) * 1998-02-27 2003-06-26 Пфайзер Продактс Инк. N-[(замещенное пятичленное ди- или триазадиненасыщенное кольцо) карбонил] гуанидиновые производные для лечения ишемии

Also Published As

Publication number Publication date
WO2002044133A1 (en) 2002-06-06
AU2002210839A1 (en) 2002-06-11
US20020082274A1 (en) 2002-06-27
AR035601A1 (es) 2004-06-16
MXPA03004783A (es) 2003-09-10
EP1337508A1 (en) 2003-08-27
CA2430061A1 (en) 2002-06-06
JP2004514706A (ja) 2004-05-20
US6753334B2 (en) 2004-06-22

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 1964 DE 26/08/2008 E CONSIDERANDO A AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS.