BR0115616A - Preparação de inibidores de permutadores sódio-hidrogênio do tipo 1 - Google Patents
Preparação de inibidores de permutadores sódio-hidrogênio do tipo 1Info
- Publication number
- BR0115616A BR0115616A BR0115616-0A BR0115616A BR0115616A BR 0115616 A BR0115616 A BR 0115616A BR 0115616 A BR0115616 A BR 0115616A BR 0115616 A BR0115616 A BR 0115616A
- Authority
- BR
- Brazil
- Prior art keywords
- type
- preparation
- sodium hydrogen
- inhibitors
- hydrogen exchanger
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
- C07C243/10—Hydrazines
- C07C243/22—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"PREPARAçãO DE INIBIDORES DE PERMUTADORES SóDIO-HIDROGêNIO DO TIPO 1". A presente invenção refere-se a métodos para preparar inibidores de permutadores de sódio-hidrogênio do tipo 1 (NHE-1) de fórmula I' intermediários dos inibidores de NHE-1 e uma forma quase sem cor do inibidor NHE-1, N-(5-ciclopropil-1-quinolin-5-il-1H-pirazol-4-carbonil)-guanidina.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25335300P | 2000-11-28 | 2000-11-28 | |
PCT/IB2001/002052 WO2002044133A1 (en) | 2000-11-28 | 2001-10-31 | Preparation of sodium-hydrogen exchanger type-1 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0115616A true BR0115616A (pt) | 2003-09-16 |
Family
ID=22959914
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0115616-0A BR0115616A (pt) | 2000-11-28 | 2001-10-31 | Preparação de inibidores de permutadores sódio-hidrogênio do tipo 1 |
Country Status (9)
Country | Link |
---|---|
US (1) | US6753334B2 (pt) |
EP (1) | EP1337508A1 (pt) |
JP (1) | JP2004514706A (pt) |
AR (1) | AR035601A1 (pt) |
AU (1) | AU2002210839A1 (pt) |
BR (1) | BR0115616A (pt) |
CA (1) | CA2430061A1 (pt) |
MX (1) | MXPA03004783A (pt) |
WO (1) | WO2002044133A1 (pt) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003051845A1 (en) * | 2001-12-19 | 2003-06-26 | Pfizer Products Inc. | Methods for preparing sodium-hydrogen exchanger type-1 inhibitors |
JP4880671B2 (ja) | 2005-04-05 | 2012-02-22 | エフ.ホフマン−ラ ロシュ アーゲー | 1H−ピラゾール4−カルボキシルアミドその製造方法および11β−ヒドロキシステロイドデヒドロゲナーゼとしてのその使用 |
US20100162956A1 (en) * | 2005-08-05 | 2010-07-01 | Seishi Murakami | Substrate Processing Apparatus and Substrate Mount Table Used in the Apparatus |
KR20110007258A (ko) | 2006-03-22 | 2011-01-21 | 에프. 호프만-라 로슈 아게 | 11-베타-hsd-1로서의 피라졸 |
WO2007114315A1 (ja) * | 2006-03-30 | 2007-10-11 | Santen Pharmaceutical Co., Ltd. | 角結膜障害治療剤 |
JP2011522828A (ja) | 2008-06-04 | 2011-08-04 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
CN103772282B (zh) * | 2014-02-26 | 2015-09-23 | 上海毕得医药科技有限公司 | 一种3-叔丁基-1h-吡唑-4-甲醛的制备方法 |
EP3584241B1 (en) | 2017-02-14 | 2023-04-26 | FUJIFILM Corporation | Method for producing indazole compound, and indazole compound |
WO2019224138A1 (de) | 2018-05-24 | 2019-11-28 | Bayer Aktiengesellschaft | Verfahren zur herstellung von substituierten n-arylpyrazolen |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH652389A5 (en) * | 1982-02-03 | 1985-11-15 | Sandoz Ag | Process for the preparation of o,o'-disubstituted phenylhydrazines |
US4599403A (en) * | 1985-10-07 | 1986-07-08 | Harold Levy | Method for recovery of stevioside |
EA003603B1 (ru) * | 1998-02-27 | 2003-06-26 | Пфайзер Продактс Инк. | N-[(замещенное пятичленное ди- или триазадиненасыщенное кольцо) карбонил] гуанидиновые производные для лечения ишемии |
-
2001
- 2001-10-31 EP EP01978750A patent/EP1337508A1/en not_active Withdrawn
- 2001-10-31 MX MXPA03004783A patent/MXPA03004783A/es unknown
- 2001-10-31 JP JP2002546503A patent/JP2004514706A/ja active Pending
- 2001-10-31 WO PCT/IB2001/002052 patent/WO2002044133A1/en not_active Application Discontinuation
- 2001-10-31 CA CA002430061A patent/CA2430061A1/en not_active Abandoned
- 2001-10-31 AU AU2002210839A patent/AU2002210839A1/en not_active Abandoned
- 2001-10-31 BR BR0115616-0A patent/BR0115616A/pt not_active IP Right Cessation
- 2001-11-26 AR ARP010105485A patent/AR035601A1/es unknown
- 2001-11-27 US US09/995,133 patent/US6753334B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2002044133A1 (en) | 2002-06-06 |
AU2002210839A1 (en) | 2002-06-11 |
US20020082274A1 (en) | 2002-06-27 |
AR035601A1 (es) | 2004-06-16 |
MXPA03004783A (es) | 2003-09-10 |
EP1337508A1 (en) | 2003-08-27 |
CA2430061A1 (en) | 2002-06-06 |
JP2004514706A (ja) | 2004-05-20 |
US6753334B2 (en) | 2004-06-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 1964 DE 26/08/2008 E CONSIDERANDO A AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS. |