BR0208500A - ácidos 3-heterociclilpropano-hidroxâmicos inibidores de pcp - Google Patents

ácidos 3-heterociclilpropano-hidroxâmicos inibidores de pcp

Info

Publication number
BR0208500A
BR0208500A BR0208500-3A BR0208500A BR0208500A BR 0208500 A BR0208500 A BR 0208500A BR 0208500 A BR0208500 A BR 0208500A BR 0208500 A BR0208500 A BR 0208500A
Authority
BR
Brazil
Prior art keywords
heterocyclylpropane
pcp
hydroxamic acids
inhibitor
pcp inhibitor
Prior art date
Application number
BR0208500-3A
Other languages
English (en)
Inventor
Paul Vincent Fish
Jackie Diane Kendall
Gavin Alistair Whitlock
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BR0208500A publication Critical patent/BR0208500A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)

Abstract

"áCIDOS 3-HETEROCICLILPROPANO-HIDROXâMICOS INIBIDORES DE PCP". Compostos de fórmula (I): e seus sais, solvatos, pró-drogas, etc., onde os substituintes. têm os valores aqui mencionados, são inibidores da Procolagênio C-Proteinase (PCP) e têm utilidade em doenças mediadas pela PCP.
BR0208500-3A 2001-03-30 2002-03-18 ácidos 3-heterociclilpropano-hidroxâmicos inibidores de pcp BR0208500A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0108097.7A GB0108097D0 (en) 2001-03-30 2001-03-30 Compounds
PCT/IB2002/000817 WO2002079175A1 (en) 2001-03-30 2002-03-18 3-heterocyclylpropanohydroxamic acid pcp inhibitors

Publications (1)

Publication Number Publication Date
BR0208500A true BR0208500A (pt) 2004-04-20

Family

ID=9911979

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0208500-3A BR0208500A (pt) 2001-03-30 2002-03-18 ácidos 3-heterociclilpropano-hidroxâmicos inibidores de pcp

Country Status (16)

Country Link
EP (1) EP1373231B1 (pt)
JP (1) JP2004524364A (pt)
AP (1) AP2002002464A0 (pt)
AT (1) ATE297382T1 (pt)
BR (1) BR0208500A (pt)
CA (1) CA2442483C (pt)
DE (1) DE60204552T2 (pt)
ES (1) ES2240703T3 (pt)
GB (1) GB0108097D0 (pt)
GT (1) GT200200055A (pt)
MX (1) MXPA03008849A (pt)
PA (1) PA8542301A1 (pt)
PE (1) PE20021104A1 (pt)
TN (1) TNSN02035A1 (pt)
UY (1) UY27231A1 (pt)
WO (1) WO2002079175A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009097893A1 (en) * 2008-02-04 2009-08-13 Proyecto De Biomedicina Cima, S.L. Methods for the treatment of cardiac disease associated to myocardial fibrosis using an inhibitor of pcp
CR20160316A (es) 2014-01-10 2016-09-19 Glaxosmithkline Intellectual Property (No 2) Ltd Compuestos derivados de hidroxiformamida y usos del mismo

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0104658A3 (en) * 1998-12-22 2005-12-28 Hoffmann La Roche Sulfonamide hydroxamates
NZ513830A (en) * 1999-03-03 2001-09-28 Procter & Gamble Dihetero-substituted metalloprotease inhibitors
GB9930570D0 (en) * 1999-12-23 2000-02-16 Pfizer Ltd Therapy

Also Published As

Publication number Publication date
MXPA03008849A (es) 2003-12-11
GT200200055A (es) 2002-11-21
ATE297382T1 (de) 2005-06-15
PE20021104A1 (es) 2002-12-07
CA2442483A1 (en) 2002-10-10
AP2002002464A0 (en) 2002-06-30
JP2004524364A (ja) 2004-08-12
PA8542301A1 (es) 2002-10-28
CA2442483C (en) 2007-11-13
EP1373231A1 (en) 2004-01-02
DE60204552D1 (en) 2005-07-14
ES2240703T3 (es) 2005-10-16
WO2002079175A1 (en) 2002-10-10
TNSN02035A1 (fr) 2005-12-23
EP1373231B1 (en) 2005-06-08
GB0108097D0 (en) 2001-05-23
DE60204552T2 (de) 2006-05-11
UY27231A1 (es) 2002-11-29

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A(S) 8A E 9A ANUIDADE(S)

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2103 DE 26/04/2011.