GT200200055A - Inhibidores de la pcp del tipo de acidos 3-heterociclilpropanohidroxamicos - Google Patents

Inhibidores de la pcp del tipo de acidos 3-heterociclilpropanohidroxamicos

Info

Publication number
GT200200055A
GT200200055A GT200200055A GT200200055A GT200200055A GT 200200055 A GT200200055 A GT 200200055A GT 200200055 A GT200200055 A GT 200200055A GT 200200055 A GT200200055 A GT 200200055A GT 200200055 A GT200200055 A GT 200200055A
Authority
GT
Guatemala
Prior art keywords
pcp
type
heterociclilpropanohidroxamicos
acids
formation
Prior art date
Application number
GT200200055A
Other languages
English (en)
Inventor
Paul Vincent Fish
Jackie Diane Kendall
Gavin Alistair Whitlock
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200200055A publication Critical patent/GT200200055A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A COMPUESTOS QUE INHIBEN LA PROCOLAGENO C PROTEINASA (PCP) DEL TIPO DE ACIDOS 3HETEROCICLILPROPANOHIDROXAMICOS DE FORMULA GENERAL (I) EN DONDE R, X, X1,Y1, R,W, SON GRUPOS FUNCIONALES DESCRITOS EN EL EXPEDIENTE. ESTOS COMPUESTOS REDUCEN LA FORMACION Y DEPOSICION DE COLAGENO POR LA INHIBICION DE LA PCP REDUCIENDO CON ELLO LA FORMACION DE TEJIDO DE ESCARAS POR LO QUE SON DE INTERES COMO ANTIESCARIFICANTE DE HERIDAS Y OTROS TRASTORNOS MEDIADOS POR PCP.
GT200200055A 2001-03-30 2002-03-21 Inhibidores de la pcp del tipo de acidos 3-heterociclilpropanohidroxamicos GT200200055A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0108097.7A GB0108097D0 (en) 2001-03-30 2001-03-30 Compounds

Publications (1)

Publication Number Publication Date
GT200200055A true GT200200055A (es) 2002-11-21

Family

ID=9911979

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200200055A GT200200055A (es) 2001-03-30 2002-03-21 Inhibidores de la pcp del tipo de acidos 3-heterociclilpropanohidroxamicos

Country Status (16)

Country Link
EP (1) EP1373231B1 (es)
JP (1) JP2004524364A (es)
AP (1) AP2002002464A0 (es)
AT (1) ATE297382T1 (es)
BR (1) BR0208500A (es)
CA (1) CA2442483C (es)
DE (1) DE60204552T2 (es)
ES (1) ES2240703T3 (es)
GB (1) GB0108097D0 (es)
GT (1) GT200200055A (es)
MX (1) MXPA03008849A (es)
PA (1) PA8542301A1 (es)
PE (1) PE20021104A1 (es)
TN (1) TNSN02035A1 (es)
UY (1) UY27231A1 (es)
WO (1) WO2002079175A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009097893A1 (en) * 2008-02-04 2009-08-13 Proyecto De Biomedicina Cima, S.L. Methods for the treatment of cardiac disease associated to myocardial fibrosis using an inhibitor of pcp
KR20160106684A (ko) 2014-01-10 2016-09-12 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 히드록시포름아미드 유도체 및 그의 용도

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200101868T2 (tr) * 1998-12-22 2001-11-21 F. Hoffmann-La Roche Ag Sülfonamit hidroksamatlar.
CZ20013155A3 (cs) * 1999-03-03 2002-01-16 The Procter & Gamble Company Inhibitory metaloproteas
GB9930570D0 (en) * 1999-12-23 2000-02-16 Pfizer Ltd Therapy

Also Published As

Publication number Publication date
DE60204552D1 (en) 2005-07-14
JP2004524364A (ja) 2004-08-12
UY27231A1 (es) 2002-11-29
EP1373231B1 (en) 2005-06-08
ES2240703T3 (es) 2005-10-16
BR0208500A (pt) 2004-04-20
CA2442483A1 (en) 2002-10-10
EP1373231A1 (en) 2004-01-02
WO2002079175A1 (en) 2002-10-10
TNSN02035A1 (fr) 2005-12-23
ATE297382T1 (de) 2005-06-15
GB0108097D0 (en) 2001-05-23
AP2002002464A0 (en) 2002-06-30
PA8542301A1 (es) 2002-10-28
DE60204552T2 (de) 2006-05-11
PE20021104A1 (es) 2002-12-07
MXPA03008849A (es) 2003-12-11
CA2442483C (en) 2007-11-13

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