DE69411317T2 - Indoloylguanidinderivate als Inhibitoren des Natrium-Protonen Austauschs - Google Patents

Indoloylguanidinderivate als Inhibitoren des Natrium-Protonen Austauschs

Info

Publication number
DE69411317T2
DE69411317T2 DE69411317T DE69411317T DE69411317T2 DE 69411317 T2 DE69411317 T2 DE 69411317T2 DE 69411317 T DE69411317 T DE 69411317T DE 69411317 T DE69411317 T DE 69411317T DE 69411317 T2 DE69411317 T2 DE 69411317T2
Authority
DE
Germany
Prior art keywords
group
alkyl group
formula
substituted alkyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69411317T
Other languages
English (en)
Other versions
DE69411317D1 (de
Inventor
Atsuyuki Kojima
Masahumi Kitano
Akira Miyagishi
Tsuyoshi Noguchi
Hideki Yagi
Kazuhiro Nakano
Naohito Ohashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharmaceuticals Co Ltd
Original Assignee
Sumitomo Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharmaceuticals Co Ltd filed Critical Sumitomo Pharmaceuticals Co Ltd
Publication of DE69411317D1 publication Critical patent/DE69411317D1/de
Application granted granted Critical
Publication of DE69411317T2 publication Critical patent/DE69411317T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69411317T 1993-04-28 1994-04-28 Indoloylguanidinderivate als Inhibitoren des Natrium-Protonen Austauschs Expired - Fee Related DE69411317T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12508593 1993-04-28

Publications (2)

Publication Number Publication Date
DE69411317D1 DE69411317D1 (de) 1998-08-06
DE69411317T2 true DE69411317T2 (de) 1999-02-18

Family

ID=14901466

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69411317T Expired - Fee Related DE69411317T2 (de) 1993-04-28 1994-04-28 Indoloylguanidinderivate als Inhibitoren des Natrium-Protonen Austauschs

Country Status (10)

Country Link
EP (1) EP0622356B1 (de)
KR (1) KR100295128B1 (de)
CN (1) CN1051301C (de)
AT (1) ATE167854T1 (de)
CA (1) CA2121391A1 (de)
DE (1) DE69411317T2 (de)
DK (1) DK0622356T3 (de)
ES (1) ES2117759T3 (de)
GR (1) GR3027733T3 (de)
TW (1) TW402600B (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6169107B1 (en) 1993-04-28 2001-01-02 Sumitomo Pharmaceutical Co., Ltd. Indoloylguanidine derivatives
US5852046A (en) * 1993-08-03 1998-12-22 Hoechst Aktiengesellschaft Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them
DE4412334A1 (de) * 1994-04-11 1995-10-19 Hoechst Ag Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
CA2160600A1 (en) * 1994-10-18 1996-04-19 Masahumi Kitano Indoloylguanidine derivatives
US5627193A (en) * 1995-02-09 1997-05-06 Mitsui Toatsu Chemicals, Inc. Quinoline-4-carbonylguanidine derivatives, process for producing the same and pharmaceutical preparations containing the compounds
US6063806A (en) 1995-10-05 2000-05-16 Kyoto Pharmaceutical Industries, Ltd. Indolyl or indolinyl derivatives and medicinal use thereof as ACAT or lipid peroxidation inhibitors
DE19548708A1 (de) * 1995-12-23 1997-06-26 Merck Patent Gmbh Cyclische Sulfone
NZ314105A (en) 1996-02-02 1997-12-19 Sumitomo Pharma Guanidine derivative substituted with a substituted indole which is peri condensed with a heterocyclic ring
JPH09291076A (ja) * 1996-04-24 1997-11-11 Sumitomo Pharmaceut Co Ltd 置換グアニジン誘導体およびその製法
AU3255697A (en) * 1996-06-12 1998-01-07 F. Hoffmann-La Roche Ag A process for the manufacture of 1-(amino-alkyl)-indoles
CA2260499A1 (en) * 1998-01-29 1999-07-29 Sumitomo Pharmaceuticals Company Limited Pharmaceutical compositions for the treatment of ischemic brain damage
NZ504769A (en) 1998-02-27 2005-04-29 Pfizer Prod Inc N-[(substituted five-membered di- or triaza diunsaturated ring) carbonyl] guanidine derivatives for the treatment of ischemia
CA2370607A1 (en) 1999-04-23 2000-11-02 Bristol-Myers Squibb Company Bicyclic acyl guanidine sodium/proton exchange inhibitors and method
AUPQ223999A0 (en) * 1999-08-16 1999-09-09 University Of Sydney, The Intracellular feedback controls in the diagnosis and treatment of human disease
EP1238971A4 (de) * 1999-12-16 2003-02-26 Sumitomo Pharma Substituierte guanidin-derivate
FR2842525B1 (fr) * 2002-07-16 2005-05-13 Aventis Pharma Sa Derives de 3-guanidinocarbonyl-1-heteroaryl-indole, procede de preparation a titre de medicaments et compositions pharmaceutiques les renfermant
FR2842526B1 (fr) 2002-07-16 2007-07-13 Aventis Pharma Sa Compositions pharmaceutiques contenant un derive de 3-guanidinocarbonyl-1-heteroaryl-indole, procede de preparation a titre de medicaments
WO2004007450A1 (ja) 2002-07-17 2004-01-22 Kyoto Pharmaceutical Industries, Ltd. 新規インドリン化合物およびその医薬用途
FR2856062B1 (fr) * 2003-06-12 2005-11-11 Aventis Pharma Sa Derives 3-guanidinocarbonyl-heterocycle, procede de preparation et intermediaires de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant
US7230007B2 (en) 2003-06-12 2007-06-12 Sanofi-Aventis Deutschland Gmbh Derivatives of 3-(Guanidinocarbonyl) heterocycle, methods of preparation and intermediates thereof, their use as medicaments, and pharmaceutical compositions therefrom
US7772271B2 (en) 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
CA2573185A1 (en) 2004-07-14 2006-02-23 Ptc Therapeutics, Inc. Methods for treating hepatitis c
US7868037B2 (en) 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
MX2007000762A (es) 2004-07-22 2007-04-02 Ptc Therapeutics Inc Tienopiridinas para tratamientode hepatitis c.
JP5094394B2 (ja) 2005-04-20 2012-12-12 武田薬品工業株式会社 縮合複素環化合物
US8076348B2 (en) 2005-08-08 2011-12-13 Astellas Pharma Inc. Acylguanidine derivative or salt thereof
KR20080105092A (ko) 2006-02-20 2008-12-03 아스텔라스세이야쿠 가부시키가이샤 피롤 유도체 또는 그의 염
KR20080094962A (ko) * 2006-02-20 2008-10-27 아스텔라스세이야쿠 가부시키가이샤 아미드 유도체 또는 그의 염

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3304019A1 (de) * 1983-02-07 1984-08-09 Kali-Chemie Pharma Gmbh, 3000 Hannover 3-acyloxy-1-phenyl-2-aminocarbonylindol-verbindungen sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3929582A1 (de) * 1989-09-06 1991-03-07 Hoechst Ag Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
DE4127026A1 (de) * 1991-08-16 1993-02-18 Boehringer Ingelheim Kg Neue pyrazinderivate, ihre herstellung und verwendung
EP0639573A1 (de) * 1993-08-03 1995-02-22 Hoechst Aktiengesellschaft Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
CA2121391A1 (en) 1994-10-29
DE69411317D1 (de) 1998-08-06
ATE167854T1 (de) 1998-07-15
KR100295128B1 (ko) 2001-09-17
CN1106800A (zh) 1995-08-16
GR3027733T3 (en) 1998-11-30
ES2117759T3 (es) 1998-08-16
DK0622356T3 (da) 1998-10-26
CN1051301C (zh) 2000-04-12
EP0622356A1 (de) 1994-11-02
EP0622356B1 (de) 1998-07-01
TW402600B (en) 2000-08-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee