ATE167854T1 - Indoloylguanidinderivate als inhibitoren des natrium-protonen austauschs - Google Patents
Indoloylguanidinderivate als inhibitoren des natrium-protonen austauschsInfo
- Publication number
- ATE167854T1 ATE167854T1 AT94303101T AT94303101T ATE167854T1 AT E167854 T1 ATE167854 T1 AT E167854T1 AT 94303101 T AT94303101 T AT 94303101T AT 94303101 T AT94303101 T AT 94303101T AT E167854 T1 ATE167854 T1 AT E167854T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- alkyl group
- formula
- substituted alkyl
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP12508593 | 1993-04-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE167854T1 true ATE167854T1 (de) | 1998-07-15 |
Family
ID=14901466
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT94303101T ATE167854T1 (de) | 1993-04-28 | 1994-04-28 | Indoloylguanidinderivate als inhibitoren des natrium-protonen austauschs |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0622356B1 (de) |
KR (1) | KR100295128B1 (de) |
CN (1) | CN1051301C (de) |
AT (1) | ATE167854T1 (de) |
CA (1) | CA2121391A1 (de) |
DE (1) | DE69411317T2 (de) |
DK (1) | DK0622356T3 (de) |
ES (1) | ES2117759T3 (de) |
GR (1) | GR3027733T3 (de) |
TW (1) | TW402600B (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6169107B1 (en) | 1993-04-28 | 2001-01-02 | Sumitomo Pharmaceutical Co., Ltd. | Indoloylguanidine derivatives |
US5852046A (en) * | 1993-08-03 | 1998-12-22 | Hoechst Aktiengesellschaft | Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them |
DE4412334A1 (de) * | 1994-04-11 | 1995-10-19 | Hoechst Ag | Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
CA2160600A1 (en) * | 1994-10-18 | 1996-04-19 | Masahumi Kitano | Indoloylguanidine derivatives |
US5627193A (en) * | 1995-02-09 | 1997-05-06 | Mitsui Toatsu Chemicals, Inc. | Quinoline-4-carbonylguanidine derivatives, process for producing the same and pharmaceutical preparations containing the compounds |
US6063806A (en) | 1995-10-05 | 2000-05-16 | Kyoto Pharmaceutical Industries, Ltd. | Indolyl or indolinyl derivatives and medicinal use thereof as ACAT or lipid peroxidation inhibitors |
DE19548708A1 (de) * | 1995-12-23 | 1997-06-26 | Merck Patent Gmbh | Cyclische Sulfone |
NZ314105A (en) | 1996-02-02 | 1997-12-19 | Sumitomo Pharma | Guanidine derivative substituted with a substituted indole which is peri condensed with a heterocyclic ring |
JPH09291076A (ja) * | 1996-04-24 | 1997-11-11 | Sumitomo Pharmaceut Co Ltd | 置換グアニジン誘導体およびその製法 |
AU3255697A (en) * | 1996-06-12 | 1998-01-07 | F. Hoffmann-La Roche Ag | A process for the manufacture of 1-(amino-alkyl)-indoles |
CA2260499A1 (en) * | 1998-01-29 | 1999-07-29 | Sumitomo Pharmaceuticals Company Limited | Pharmaceutical compositions for the treatment of ischemic brain damage |
NZ504769A (en) | 1998-02-27 | 2005-04-29 | Pfizer Prod Inc | N-[(substituted five-membered di- or triaza diunsaturated ring) carbonyl] guanidine derivatives for the treatment of ischemia |
CA2370607A1 (en) | 1999-04-23 | 2000-11-02 | Bristol-Myers Squibb Company | Bicyclic acyl guanidine sodium/proton exchange inhibitors and method |
AUPQ223999A0 (en) * | 1999-08-16 | 1999-09-09 | University Of Sydney, The | Intracellular feedback controls in the diagnosis and treatment of human disease |
EP1238971A4 (de) * | 1999-12-16 | 2003-02-26 | Sumitomo Pharma | Substituierte guanidin-derivate |
FR2842525B1 (fr) * | 2002-07-16 | 2005-05-13 | Aventis Pharma Sa | Derives de 3-guanidinocarbonyl-1-heteroaryl-indole, procede de preparation a titre de medicaments et compositions pharmaceutiques les renfermant |
FR2842526B1 (fr) | 2002-07-16 | 2007-07-13 | Aventis Pharma Sa | Compositions pharmaceutiques contenant un derive de 3-guanidinocarbonyl-1-heteroaryl-indole, procede de preparation a titre de medicaments |
WO2004007450A1 (ja) | 2002-07-17 | 2004-01-22 | Kyoto Pharmaceutical Industries, Ltd. | 新規インドリン化合物およびその医薬用途 |
FR2856062B1 (fr) * | 2003-06-12 | 2005-11-11 | Aventis Pharma Sa | Derives 3-guanidinocarbonyl-heterocycle, procede de preparation et intermediaires de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant |
US7230007B2 (en) | 2003-06-12 | 2007-06-12 | Sanofi-Aventis Deutschland Gmbh | Derivatives of 3-(Guanidinocarbonyl) heterocycle, methods of preparation and intermediates thereof, their use as medicaments, and pharmaceutical compositions therefrom |
US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
CA2573185A1 (en) | 2004-07-14 | 2006-02-23 | Ptc Therapeutics, Inc. | Methods for treating hepatitis c |
US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
MX2007000762A (es) | 2004-07-22 | 2007-04-02 | Ptc Therapeutics Inc | Tienopiridinas para tratamientode hepatitis c. |
JP5094394B2 (ja) | 2005-04-20 | 2012-12-12 | 武田薬品工業株式会社 | 縮合複素環化合物 |
US8076348B2 (en) | 2005-08-08 | 2011-12-13 | Astellas Pharma Inc. | Acylguanidine derivative or salt thereof |
KR20080105092A (ko) | 2006-02-20 | 2008-12-03 | 아스텔라스세이야쿠 가부시키가이샤 | 피롤 유도체 또는 그의 염 |
KR20080094962A (ko) * | 2006-02-20 | 2008-10-27 | 아스텔라스세이야쿠 가부시키가이샤 | 아미드 유도체 또는 그의 염 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3304019A1 (de) * | 1983-02-07 | 1984-08-09 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 3-acyloxy-1-phenyl-2-aminocarbonylindol-verbindungen sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
DE4127026A1 (de) * | 1991-08-16 | 1993-02-18 | Boehringer Ingelheim Kg | Neue pyrazinderivate, ihre herstellung und verwendung |
EP0639573A1 (de) * | 1993-08-03 | 1995-02-22 | Hoechst Aktiengesellschaft | Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament |
-
1994
- 1994-04-15 CA CA002121391A patent/CA2121391A1/en not_active Abandoned
- 1994-04-20 TW TW083103505A patent/TW402600B/zh not_active IP Right Cessation
- 1994-04-27 KR KR1019940009048A patent/KR100295128B1/ko not_active IP Right Cessation
- 1994-04-28 DE DE69411317T patent/DE69411317T2/de not_active Expired - Fee Related
- 1994-04-28 ES ES94303101T patent/ES2117759T3/es not_active Expired - Lifetime
- 1994-04-28 EP EP94303101A patent/EP0622356B1/de not_active Expired - Lifetime
- 1994-04-28 AT AT94303101T patent/ATE167854T1/de not_active IP Right Cessation
- 1994-04-28 CN CN94105367A patent/CN1051301C/zh not_active Expired - Fee Related
- 1994-04-28 DK DK94303101T patent/DK0622356T3/da active
-
1998
- 1998-08-26 GR GR980401914T patent/GR3027733T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2121391A1 (en) | 1994-10-29 |
DE69411317D1 (de) | 1998-08-06 |
KR100295128B1 (ko) | 2001-09-17 |
CN1106800A (zh) | 1995-08-16 |
GR3027733T3 (en) | 1998-11-30 |
ES2117759T3 (es) | 1998-08-16 |
DK0622356T3 (da) | 1998-10-26 |
CN1051301C (zh) | 2000-04-12 |
DE69411317T2 (de) | 1999-02-18 |
EP0622356A1 (de) | 1994-11-02 |
EP0622356B1 (de) | 1998-07-01 |
TW402600B (en) | 2000-08-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE167854T1 (de) | Indoloylguanidinderivate als inhibitoren des natrium-protonen austauschs | |
BRPI0014526C1 (pt) | compostos cíclicos de seis elementos contendo nitrogênio aromático, composição farmacêutica e uso do mesmo | |
NO942452L (no) | Amid- og ureaderivater med antihyperkolesteremisk aktivitet, deres fremstilling og terapeutiske anvendelser | |
NO972666L (no) | Anilinderivater med nitrogenmonoksyd-synteseinhiberende aktivitet | |
ATE170519T1 (de) | Stickstoff enthaltende kondensierte heterocylen | |
DK1113011T3 (da) | Aminotetrazol-derivater, der er anvendelige som nitrogenoxidsynthaseinhibitorer | |
NO940245L (no) | Quinolin eller quinazolinderivater, deres fremstilling og anvendelse | |
ES2081747B1 (es) | Amidas derivadas de tienopirroles, su preparacion y su aplicacion como medicamentos. | |
DK0572635T3 (da) | Hidtil ukendte forbindelser med guanidinstruktur og farmaceutisk komposition indeholdende forbindelserne | |
ATE194982T1 (de) | Benzoxazepin-derivate als cholinesterase- inhibitoren | |
DE69702419D1 (de) | Substituierte Guanidin Derivate und ihre Verwendung als Na+/H+ Austausch Inhibitoren | |
GR3015047T3 (en) | Heterocyclic acyl aminodiol beta-amino acid derivatives. | |
ES2061868T3 (es) | Derivados ariloxi-, ariltio-, heteroariloxi-, heteroariltio-alquenilen-aminas. | |
PT92147A (pt) | Processo para a preparacao de derivados de pirrolidina | |
GB1475586A (en) | N-hydroxyamidine compounds | |
TH15125EX (th) | อนุพันธ์อินดอลชนิดใหม่ | |
TH13791A (th) | อนุพันธ์ต่างๆของกรดบิวไทริค | |
MX9603735A (es) | Compuestos fungicidas. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |