PE20001072A1 - Antivirales derivados de purinas - Google Patents
Antivirales derivados de purinasInfo
- Publication number
- PE20001072A1 PE20001072A1 PE1999000978A PE00097899A PE20001072A1 PE 20001072 A1 PE20001072 A1 PE 20001072A1 PE 1999000978 A PE1999000978 A PE 1999000978A PE 00097899 A PE00097899 A PE 00097899A PE 20001072 A1 PE20001072 A1 PE 20001072A1
- Authority
- PE
- Peru
- Prior art keywords
- purin
- aryl
- amino
- alkyl
- cyclopropylamine
- Prior art date
Links
- 239000003443 antiviral agent Substances 0.000 title 1
- 229940121357 antivirals Drugs 0.000 title 1
- HTJDQJBWANPRPF-UHFFFAOYSA-N Cyclopropylamine Chemical compound NC1CC1 HTJDQJBWANPRPF-UHFFFAOYSA-N 0.000 abstract 4
- 229910019142 PO4 Inorganic materials 0.000 abstract 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 3
- 239000010452 phosphate Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002777 nucleoside Substances 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- -1 NUCLEOSIDE PHOSPHORAMIDATE COMPOUNDS Chemical class 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Substances OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- JDFADOFJMLEJSU-MRVPVSSYSA-N phosphono (2R)-2-(phenylmethoxyamino)propanoate Chemical compound OP(=O)(O)OC(=O)[C@@H](C)NOCC1=CC=CC=C1 JDFADOFJMLEJSU-MRVPVSSYSA-N 0.000 abstract 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pulmonology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS FOSFORAMIDATOS DE NUCLEOSIDOS DE FORMULA I, DONDE Ar ES ARILO; R1 Y R2 SON H, ARILO, ALQUILO; X ES O, NH, NR4, S; R4 ES ALQUILO, ARILO; R5 ES H, ALQUILO, ARILO; CUANDO R1 Y R5 SON ALQUILO PUEDEN FORMAR UN ANILLO DE 5 o 6 MIEMBROS; R3 ES H, ALQUILO, ARILO, HETEROCICLO, POLICICLO; EL CARBONO UNIDO A R1 Y R2 ES QUIRAL. SON COMPUESTOS PREFERIDOS (1S,4R)-4-[2-AMINO-6-(CICLOPROPILAMINO)-9H-PURIN-9-IL]-2-CICLOPENTENO-1-METILENO-[FENILMETOXI-L-ALANINIL]FOSFATO, (1S,4R)-4-[2-AMINO-6-(CICLOPROPILAMINO)-9H-PURIN-9-IL]-2-CICLOPENTENO-1-METILENO[FENILBENCILOXI-L-ALANINIL]FOSFATO, (1S,4R)-4-[2-AMINO-6-(CICLOPROPILAMINO)-9H-PURIN-9-IL]-2-CICLOPENTENO-1-METILENO[FENILMETOXI-D-ALANINIL]FOSFATO, (1S,4R)-4-[2-AMINO-(6-CICLOPROPILAMINO)-9H-PURIN-9-IL]-2-CICLOPENTENO-1-METILENO[FENILMETOXI-a,a-DIMETILGLICINIL]FOSFATO, 5`-[FENIL-(METOXI-L-ALANIL)]-FOSFORAMIDATO DE (1S,4R)-4-[2-AMINO-6-(CICLOPROPILAMINO)-9H-PURIN-9-IL]-2-CICLOPENTANO-1-METANOL, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO DE FORMULA I ES UN FOSFORAMIDATO DE NUCLEOSIDO POR LO QUE PUEDE SER UTIL PARA EL TRATAMIENTO, PROFILAXIS DE UNA INFECCION VIRAL COMO VIH O HEPATITIS B (HBV)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9821058.6A GB9821058D0 (en) | 1998-09-28 | 1998-09-28 | Chemical compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001072A1 true PE20001072A1 (es) | 2000-11-20 |
Family
ID=10839578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999000978A PE20001072A1 (es) | 1998-09-28 | 1999-09-27 | Antivirales derivados de purinas |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6638919B2 (es) |
| EP (1) | EP1117669B1 (es) |
| JP (1) | JP2002525374A (es) |
| KR (1) | KR20010085855A (es) |
| CN (1) | CN1328565A (es) |
| AR (1) | AR042368A1 (es) |
| AT (1) | ATE231874T1 (es) |
| AU (1) | AU762757B2 (es) |
| BR (1) | BR9914097A (es) |
| CA (1) | CA2345672A1 (es) |
| DE (1) | DE69905181T2 (es) |
| DK (1) | DK1117669T3 (es) |
| ES (1) | ES2192081T3 (es) |
| GB (1) | GB9821058D0 (es) |
| GC (1) | GC0000174A (es) |
| GT (1) | GT199900166A (es) |
| HK (1) | HK1036455A1 (es) |
| HU (1) | HUP0103641A3 (es) |
| IL (1) | IL141959A0 (es) |
| MA (1) | MA26694A1 (es) |
| MY (1) | MY121839A (es) |
| NO (1) | NO20011198L (es) |
| NZ (1) | NZ510506A (es) |
| PA (1) | PA8483101A1 (es) |
| PE (1) | PE20001072A1 (es) |
| PL (1) | PL346905A1 (es) |
| PT (1) | PT1117669E (es) |
| TN (1) | TNSN99183A1 (es) |
| TR (1) | TR200100864T2 (es) |
| TW (1) | TWI243176B (es) |
| WO (1) | WO2000018775A1 (es) |
| ZA (1) | ZA200102170B (es) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE241633T1 (de) * | 1999-02-12 | 2003-06-15 | Glaxo Group Ltd | Phosphoramidat-, mono-, di-, und triphosphatester von (1r, cis)-4-(6-amino-9h-purin-9-yl)-2- cyclopentene-1-methanol als antivirale mittel |
| WO2001007088A2 (en) | 1999-07-22 | 2001-02-01 | Newbiotics, Inc. | Methods for treating therapy-resistant tumors |
| WO2001042255A1 (en) * | 1999-12-10 | 2001-06-14 | Glaxo Group Limited | (1R,CIS)-4-(4-AMINO-7H-PYRROLO'2,3-I(D) ! PYRIMIDINE-7-YL)-2-CYCLOPENTENE-1-METHANOL DERIVATIVES AS ANTIVIRAL |
| PE20010915A1 (es) * | 1999-12-10 | 2001-09-29 | Glaxo Group Ltd | Analogos de (1s, cis)-4-(2-amino-9h-purin-9-il)-2-ciclopenten-1-metanol para uso en el tratamiento de infecciones virales |
| KR100767432B1 (ko) | 2000-07-21 | 2007-10-17 | 길리애드 사이언시즈, 인코포레이티드 | 포스포네이트 뉴클레오티드 유사체의 전구 약물과 그것의 선택 및 제조 방법 |
| US8716548B2 (en) | 2002-02-20 | 2014-05-06 | The Procter & Gamble Company | Disposable absorbent article designed to facilitate an easy change |
| US20030158532A1 (en) | 2002-02-20 | 2003-08-21 | Magee Luke R. | Disposable absorbent article designed to facilitate an easy intuitive change |
| KR20050059199A (ko) | 2002-09-30 | 2005-06-17 | 제네랩스 테크놀로지스, 인코포레이티드 | Ｃ형 간염 바이러스 감염 치료용의 뉴클레오시드 유도체 |
| US7094768B2 (en) | 2002-09-30 | 2006-08-22 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis C virus infection |
| HUE033832T2 (en) | 2002-11-15 | 2018-01-29 | Idenix Pharmaceuticals Llc | 2'-methyl nucleosides in combination with interferon and Flaviviridae mutation |
| GB0401088D0 (en) | 2004-01-19 | 2004-02-18 | Univ Cardiff | Phosphoramidate derivatives |
| US20070265222A1 (en) * | 2004-06-24 | 2007-11-15 | Maccoss Malcolm | Nucleoside Aryl Phosphoramidates for the Treatment of Rna-Dependent Rna Viral Infection |
| MXPA06015112A (es) * | 2004-06-30 | 2007-02-08 | Lilly Co Eli | D-tartrato de 1-(indol-6-carbonil-d-fenilglicinil)-4-(1-metilpiperidin-4-il) piperazina. |
| GB0505781D0 (en) * | 2005-03-21 | 2005-04-27 | Univ Cardiff | Chemical compounds |
| GB0623493D0 (en) * | 2006-11-24 | 2007-01-03 | Univ Cardiff | Chemical compounds |
| US7951789B2 (en) | 2006-12-28 | 2011-05-31 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
| TWI576352B (zh) | 2009-05-20 | 2017-04-01 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| PL217694B1 (pl) * | 2010-10-19 | 2014-08-29 | Inst Chemii Bioorg Polskiej Akademii Nauk | Analog nukleotydu, sposób otrzymywania analogu nukleotydu, zastosowanie analogu nukleotydu, pro-nukleotyd antywirusowy, kompozycja farmaceutyczna |
| US9243025B2 (en) | 2011-03-31 | 2016-01-26 | Idenix Pharmaceuticals, Llc | Compounds and pharmaceutical compositions for the treatment of viral infections |
| WO2013039920A1 (en) | 2011-09-12 | 2013-03-21 | Idenix Pharmaceuticals, Inc. | Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections |
| NZ623396A (en) | 2011-09-16 | 2016-07-29 | Gilead Pharmasset Llc | Methods for treating hcv |
| TW201331221A (zh) | 2011-10-14 | 2013-08-01 | Idenix Pharmaceuticals Inc | 嘌呤核苷酸化合物類之經取代的３’，５’－環磷酸酯及用於治療病毒感染之醫藥組成物 |
| EP2852605B1 (en) | 2012-05-22 | 2018-01-31 | Idenix Pharmaceuticals LLC | 3',5'-cyclic phosphate prodrugs for hcv infection |
| AU2013266393B2 (en) | 2012-05-22 | 2017-09-28 | Idenix Pharmaceuticals Llc | D-amino acid compounds for liver disease |
| WO2013177188A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphoramidate prodrugs for hcv infection |
| SG11201407336PA (en) | 2012-05-25 | 2015-03-30 | Janssen Sciences Ireland Uc | Uracyl spirooxetane nucleosides |
| CN103665043B (zh) | 2012-08-30 | 2017-11-10 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药及其在医药上的应用 |
| US9192621B2 (en) | 2012-09-27 | 2015-11-24 | Idenix Pharmaceuticals Llc | Esters and malonates of SATE prodrugs |
| GEP201706723B (en) | 2012-10-08 | 2017-08-25 | Idenix Pharmaceuticals Llk | 2'-chloro nucleoside analogs for hcv infection |
| WO2014066239A1 (en) | 2012-10-22 | 2014-05-01 | Idenix Pharmaceuticals, Inc. | 2',4'-bridged nucleosides for hcv infection |
| WO2014099941A1 (en) | 2012-12-19 | 2014-06-26 | Idenix Pharmaceuticals, Inc. | 4'-fluoro nucleosides for the treatment of hcv |
| LT2950786T (lt) | 2013-01-31 | 2020-03-10 | Gilead Pharmasset Llc | Dviejų antivirusinių junginių preparatų kompozicija |
| US9339541B2 (en) | 2013-03-04 | 2016-05-17 | Merck Sharp & Dohme Corp. | Thiophosphate nucleosides for the treatment of HCV |
| WO2014137926A1 (en) | 2013-03-04 | 2014-09-12 | Idenix Pharmaceuticals, Inc. | 3'-deoxy nucleosides for the treatment of hcv |
| WO2014160484A1 (en) | 2013-03-13 | 2014-10-02 | Idenix Pharmaceuticals, Inc. | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
| WO2014165542A1 (en) | 2013-04-01 | 2014-10-09 | Idenix Pharmaceuticals, Inc. | 2',4'-fluoro nucleosides for the treatment of hcv |
| EP3004130B1 (en) | 2013-06-05 | 2019-08-07 | Idenix Pharmaceuticals LLC. | 1',4'-thio nucleosides for the treatment of hcv |
| WO2015017713A1 (en) | 2013-08-01 | 2015-02-05 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
| US10202411B2 (en) | 2014-04-16 | 2019-02-12 | Idenix Pharmaceuticals Llc | 3′-substituted methyl or alkynyl nucleosides nucleotides for the treatment of HCV |
| WO2016134058A1 (en) | 2015-02-18 | 2016-08-25 | Abbvie Inc. | Combinations useful to treat hepatitis c virus |
| CN113444094B (zh) * | 2016-07-20 | 2023-12-22 | 纳莹(上海)生物科技有限公司 | 一种荧光探针及其制备方法和用途 |
| MX2019002017A (es) * | 2016-08-19 | 2019-06-06 | Sandoz Ag | Derivados de sofosbuvir para el tratamiento de la hepatitis c. |
| RU2659388C1 (ru) * | 2017-02-28 | 2018-07-02 | Васильевич Иващенко Александр | Нуклеотиды, включающие N-[(S)-1-циклобутоксикарбонил]фосфорамидатный фрагмент, их аналоги и их применение |
| CN112512529A (zh) * | 2018-07-27 | 2021-03-16 | 富士胶片株式会社 | 环戊烯嘌呤衍生物或其盐 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT89098B (pt) | 1987-11-30 | 1993-03-31 | Beecham Group Plc | Processo para a preparacao de derivados de guanina |
| CA2001715C (en) * | 1988-11-14 | 1999-12-28 | Muzammil M. Mansuri | Carbocyclic nucleosides and nucleotides |
| MY104575A (en) * | 1989-12-22 | 1994-04-30 | The Wellcome Foundation Ltd | Therapeutic nucleosides. |
| EP0468119A1 (en) * | 1990-07-24 | 1992-01-29 | Merrell Dow Pharmaceuticals Inc. | Novel carbocyclic analogs of certain nucleosides |
| SE9003151D0 (sv) * | 1990-10-02 | 1990-10-02 | Medivir Ab | Nucleoside derivatives |
| EP0618214A1 (en) | 1993-04-01 | 1994-10-05 | Merrell Dow Pharmaceuticals Inc. | Unsaturated phosphonate derivatives of purines and pyrimidines |
| JP4086314B2 (ja) | 1993-09-17 | 2008-05-14 | ギリアード サイエンシーズ， インコーポレイテッド | ヌクレオチドアナログ |
| GB9505025D0 (en) * | 1995-03-13 | 1995-05-03 | Medical Res Council | Chemical compounds |
| ATE271063T1 (de) | 1996-10-16 | 2004-07-15 | Icn Pharmaceuticals | Purin-l-nukleoside, deren analoga und verwendungen |
-
1998
- 1998-09-28 GB GBGB9821058.6A patent/GB9821058D0/en not_active Ceased
-
1999
- 1999-09-22 TW TW088116280A patent/TWI243176B/zh active
- 1999-09-24 MA MA25787A patent/MA26694A1/fr unknown
- 1999-09-27 KR KR1020017003894A patent/KR20010085855A/ko not_active Application Discontinuation
- 1999-09-27 DK DK99949151T patent/DK1117669T3/da active
- 1999-09-27 CA CA002345672A patent/CA2345672A1/en not_active Abandoned
- 1999-09-27 PA PA19998483101A patent/PA8483101A1/es unknown
- 1999-09-27 ES ES99949151T patent/ES2192081T3/es not_active Expired - Lifetime
- 1999-09-27 HU HU0103641A patent/HUP0103641A3/hu unknown
- 1999-09-27 WO PCT/GB1999/003207 patent/WO2000018775A1/en not_active Application Discontinuation
- 1999-09-27 EP EP99949151A patent/EP1117669B1/en not_active Expired - Lifetime
- 1999-09-27 NZ NZ510506A patent/NZ510506A/en unknown
- 1999-09-27 AT AT99949151T patent/ATE231874T1/de not_active IP Right Cessation
- 1999-09-27 PE PE1999000978A patent/PE20001072A1/es not_active Application Discontinuation
- 1999-09-27 TR TR2001/00864T patent/TR200100864T2/xx unknown
- 1999-09-27 BR BR9914097-7A patent/BR9914097A/pt not_active IP Right Cessation
- 1999-09-27 CN CN99813577A patent/CN1328565A/zh active Pending
- 1999-09-27 PT PT99949151T patent/PT1117669E/pt unknown
- 1999-09-27 IL IL14195999A patent/IL141959A0/xx unknown
- 1999-09-27 JP JP2000572234A patent/JP2002525374A/ja not_active Withdrawn
- 1999-09-27 AU AU62138/99A patent/AU762757B2/en not_active Ceased
- 1999-09-27 ZA ZA200102170A patent/ZA200102170B/en unknown
- 1999-09-27 MY MYPI99004169A patent/MY121839A/en unknown
- 1999-09-27 DE DE69905181T patent/DE69905181T2/de not_active Expired - Fee Related
- 1999-09-27 TN TNTNSN99183A patent/TNSN99183A1/fr unknown
- 1999-09-27 PL PL99346905A patent/PL346905A1/xx unknown
- 1999-09-28 AR ARP990104876A patent/AR042368A1/es not_active Application Discontinuation
- 1999-09-28 GT GT199900166A patent/GT199900166A/es unknown
- 1999-09-28 GC GCP1999302 patent/GC0000174A/en active
-
2001
- 2001-03-08 NO NO20011198A patent/NO20011198L/no unknown
- 2001-03-27 US US09/825,554 patent/US6638919B2/en not_active Expired - Fee Related
- 2001-10-12 HK HK01107186A patent/HK1036455A1/xx not_active IP Right Cessation
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