PT1117669E - Derivados de purina antivirais - Google Patents
Derivados de purina antiviraisInfo
- Publication number
- PT1117669E PT1117669E PT99949151T PT99949151T PT1117669E PT 1117669 E PT1117669 E PT 1117669E PT 99949151 T PT99949151 T PT 99949151T PT 99949151 T PT99949151 T PT 99949151T PT 1117669 E PT1117669 E PT 1117669E
- Authority
- PT
- Portugal
- Prior art keywords
- purina
- antiviral derivatives
- antiviral
- derivatives
- purina antiviral
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9821058.6A GB9821058D0 (en) | 1998-09-28 | 1998-09-28 | Chemical compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1117669E true PT1117669E (pt) | 2003-06-30 |
Family
ID=10839578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99949151T PT1117669E (pt) | 1998-09-28 | 1999-09-27 | Derivados de purina antivirais |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6638919B2 (pt) |
| EP (1) | EP1117669B1 (pt) |
| JP (1) | JP2002525374A (pt) |
| KR (1) | KR20010085855A (pt) |
| CN (1) | CN1328565A (pt) |
| AR (1) | AR042368A1 (pt) |
| AT (1) | ATE231874T1 (pt) |
| AU (1) | AU762757B2 (pt) |
| BR (1) | BR9914097A (pt) |
| CA (1) | CA2345672A1 (pt) |
| DE (1) | DE69905181T2 (pt) |
| DK (1) | DK1117669T3 (pt) |
| ES (1) | ES2192081T3 (pt) |
| GB (1) | GB9821058D0 (pt) |
| GC (1) | GC0000174A (pt) |
| GT (1) | GT199900166A (pt) |
| HK (1) | HK1036455A1 (pt) |
| HU (1) | HUP0103641A3 (pt) |
| IL (1) | IL141959A0 (pt) |
| MA (1) | MA26694A1 (pt) |
| MY (1) | MY121839A (pt) |
| NO (1) | NO20011198L (pt) |
| NZ (1) | NZ510506A (pt) |
| PA (1) | PA8483101A1 (pt) |
| PE (1) | PE20001072A1 (pt) |
| PL (1) | PL346905A1 (pt) |
| PT (1) | PT1117669E (pt) |
| TN (1) | TNSN99183A1 (pt) |
| TR (1) | TR200100864T2 (pt) |
| TW (1) | TWI243176B (pt) |
| WO (1) | WO2000018775A1 (pt) |
| ZA (1) | ZA200102170B (pt) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL144647A0 (en) * | 1999-02-12 | 2002-05-23 | Glaxo Group Ltd | Phosphoramidate, and mono-, di-, and tri-phosphate esters of (ir, cis)-4-(6-amino-9h-purin-9-yl) 2-cyclopentene-1-methanol as antiviral agents |
| MXPA02000762A (es) | 1999-07-22 | 2002-08-20 | Newbiotics Inc | Metodos para tratar tumores resistentes a terapia. |
| PE20010915A1 (es) * | 1999-12-10 | 2001-09-29 | Glaxo Group Ltd | Analogos de (1s, cis)-4-(2-amino-9h-purin-9-il)-2-ciclopenten-1-metanol para uso en el tratamiento de infecciones virales |
| AU2576001A (en) * | 1999-12-10 | 2001-06-18 | Glaxo Group Limited | (1r,cis)-4-(4-amino-7h-pyrrolo'2,3-i(d) pyrimidine-7-yl)-2-cyclopentene-1-methanol derivatives as antiviral |
| NZ536942A (en) | 2000-07-21 | 2006-03-31 | Gilead Sciences Inc | Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same |
| US20030158532A1 (en) | 2002-02-20 | 2003-08-21 | Magee Luke R. | Disposable absorbent article designed to facilitate an easy intuitive change |
| US8716548B2 (en) | 2002-02-20 | 2014-05-06 | The Procter & Gamble Company | Disposable absorbent article designed to facilitate an easy change |
| CA2499253A1 (en) | 2002-09-30 | 2004-04-08 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis c virus infection |
| US7094768B2 (en) | 2002-09-30 | 2006-08-22 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis C virus infection |
| CN1849142A (zh) | 2002-11-15 | 2006-10-18 | 埃迪尼克斯(开曼)有限公司 | 2′－支链核苷和黄病毒突变 |
| GB0401088D0 (en) | 2004-01-19 | 2004-02-18 | Univ Cardiff | Phosphoramidate derivatives |
| EP1773355B1 (en) * | 2004-06-24 | 2014-06-25 | Merck Sharp & Dohme Corp. | Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection |
| MXPA06015112A (es) * | 2004-06-30 | 2007-02-08 | Lilly Co Eli | D-tartrato de 1-(indol-6-carbonil-d-fenilglicinil)-4-(1-metilpiperidin-4-il) piperazina. |
| GB0505781D0 (en) * | 2005-03-21 | 2005-04-27 | Univ Cardiff | Chemical compounds |
| GB0623493D0 (en) * | 2006-11-24 | 2007-01-03 | Univ Cardiff | Chemical compounds |
| US20080261913A1 (en) | 2006-12-28 | 2008-10-23 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of liver disorders |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| TWI576352B (zh) | 2009-05-20 | 2017-04-01 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| PL217694B1 (pl) | 2010-10-19 | 2014-08-29 | Inst Chemii Bioorg Polskiej Akademii Nauk | Analog nukleotydu, sposób otrzymywania analogu nukleotydu, zastosowanie analogu nukleotydu, pro-nukleotyd antywirusowy, kompozycja farmaceutyczna |
| CN103842369A (zh) | 2011-03-31 | 2014-06-04 | 埃迪尼克斯医药公司 | 用于治疗病毒感染的化合物和药物组合物 |
| TW201329096A (zh) | 2011-09-12 | 2013-07-16 | Idenix Pharmaceuticals Inc | 經取代羰氧基甲基磷酸醯胺化合物及用於治療病毒感染之藥學組成物 |
| DE202012013074U1 (de) | 2011-09-16 | 2014-10-29 | Gilead Pharmasset Lcc | Zusammensetzungen zur Behandlung von HCV |
| EP2768838A1 (en) | 2011-10-14 | 2014-08-27 | IDENIX Pharmaceuticals, Inc. | Substituted 3',5'-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections |
| WO2013177188A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphoramidate prodrugs for hcv infection |
| NZ702744A (en) | 2012-05-22 | 2016-12-23 | Idenix Pharmaceuticals Llc | D-amino acid compounds for liver disease |
| WO2013177195A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphate prodrugs for hcv infection |
| WO2013174962A1 (en) | 2012-05-25 | 2013-11-28 | Janssen R&D Ireland | Uracyl spirooxetane nucleosides |
| CN107312039B (zh) | 2012-08-30 | 2019-06-25 | 江苏豪森药业集团有限公司 | 一种替诺福韦前药的制备方法 |
| EP2900682A1 (en) | 2012-09-27 | 2015-08-05 | IDENIX Pharmaceuticals, Inc. | Esters and malonates of sate prodrugs |
| KR102001280B1 (ko) | 2012-10-08 | 2019-07-17 | 아이데닉스 파마슈티칼스 엘엘씨 | Hcv 감염에 대한 2'-클로로 뉴클레오시드 유사체 |
| US10723754B2 (en) | 2012-10-22 | 2020-07-28 | Idenix Pharmaceuticals Llc | 2′,4′-bridged nucleosides for HCV infection |
| US9211300B2 (en) | 2012-12-19 | 2015-12-15 | Idenix Pharmaceuticals Llc | 4′-fluoro nucleosides for the treatment of HCV |
| CN104144682A (zh) | 2013-01-31 | 2014-11-12 | 吉利德法莫赛特有限责任公司 | 两个抗病毒化合物的联用制剂 |
| US9339541B2 (en) | 2013-03-04 | 2016-05-17 | Merck Sharp & Dohme Corp. | Thiophosphate nucleosides for the treatment of HCV |
| US9309275B2 (en) | 2013-03-04 | 2016-04-12 | Idenix Pharmaceuticals Llc | 3′-deoxy nucleosides for the treatment of HCV |
| WO2014160484A1 (en) | 2013-03-13 | 2014-10-02 | Idenix Pharmaceuticals, Inc. | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
| US9187515B2 (en) | 2013-04-01 | 2015-11-17 | Idenix Pharmaceuticals Llc | 2′,4′-fluoro nucleosides for the treatment of HCV |
| US10005779B2 (en) | 2013-06-05 | 2018-06-26 | Idenix Pharmaceuticals Llc | 1′,4′-thio nucleosides for the treatment of HCV |
| WO2015017713A1 (en) | 2013-08-01 | 2015-02-05 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
| EP3131914B1 (en) | 2014-04-16 | 2023-05-10 | Idenix Pharmaceuticals LLC | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
| WO2016134058A1 (en) | 2015-02-18 | 2016-08-25 | Abbvie Inc. | Combinations useful to treat hepatitis c virus |
| CN107641121B (zh) * | 2016-07-20 | 2021-02-19 | 上海高驰资产管理有限公司 | 一种荧光探针及其制备方法和用途 |
| CN109843900A (zh) * | 2016-08-19 | 2019-06-04 | 桑多斯股份公司 | 治疗丙型肝炎的索非布韦衍生物 |
| RU2659388C1 (ru) * | 2017-02-28 | 2018-07-02 | Васильевич Иващенко Александр | Нуклеотиды, включающие N-[(S)-1-циклобутоксикарбонил]фосфорамидатный фрагмент, их аналоги и их применение |
| CN112512529A (zh) * | 2018-07-27 | 2021-03-16 | 富士胶片株式会社 | 环戊烯嘌呤衍生物或其盐 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ227104A (en) | 1987-11-30 | 1991-11-26 | Beecham Group Plc | Phosphorus-substituted purine derivatives and pharmaceutical compositions |
| CA2001715C (en) * | 1988-11-14 | 1999-12-28 | Muzammil M. Mansuri | Carbocyclic nucleosides and nucleotides |
| MY104575A (en) * | 1989-12-22 | 1994-04-30 | The Wellcome Foundation Ltd | Therapeutic nucleosides. |
| EP0468119A1 (en) * | 1990-07-24 | 1992-01-29 | Merrell Dow Pharmaceuticals Inc. | Novel carbocyclic analogs of certain nucleosides |
| SE9003151D0 (sv) * | 1990-10-02 | 1990-10-02 | Medivir Ab | Nucleoside derivatives |
| EP0618214A1 (en) | 1993-04-01 | 1994-10-05 | Merrell Dow Pharmaceuticals Inc. | Unsaturated phosphonate derivatives of purines and pyrimidines |
| DE69435319D1 (de) | 1993-09-17 | 2010-12-16 | Gilead Sciences Inc | Nukleotidanaloge |
| GB9505025D0 (en) * | 1995-03-13 | 1995-05-03 | Medical Res Council | Chemical compounds |
| CA2266889A1 (en) | 1996-10-16 | 1998-04-23 | Guangyi Wang | Purine l-nucleosides, analogs and uses thereof |
-
1998
- 1998-09-28 GB GBGB9821058.6A patent/GB9821058D0/en not_active Ceased
-
1999
- 1999-09-22 TW TW088116280A patent/TWI243176B/zh active
- 1999-09-24 MA MA25787A patent/MA26694A1/fr unknown
- 1999-09-27 PE PE1999000978A patent/PE20001072A1/es not_active Application Discontinuation
- 1999-09-27 JP JP2000572234A patent/JP2002525374A/ja not_active Withdrawn
- 1999-09-27 TN TNTNSN99183A patent/TNSN99183A1/fr unknown
- 1999-09-27 ES ES99949151T patent/ES2192081T3/es not_active Expired - Lifetime
- 1999-09-27 WO PCT/GB1999/003207 patent/WO2000018775A1/en not_active Application Discontinuation
- 1999-09-27 KR KR1020017003894A patent/KR20010085855A/ko not_active Application Discontinuation
- 1999-09-27 PL PL99346905A patent/PL346905A1/xx unknown
- 1999-09-27 CA CA002345672A patent/CA2345672A1/en not_active Abandoned
- 1999-09-27 IL IL14195999A patent/IL141959A0/xx unknown
- 1999-09-27 TR TR2001/00864T patent/TR200100864T2/xx unknown
- 1999-09-27 EP EP99949151A patent/EP1117669B1/en not_active Expired - Lifetime
- 1999-09-27 BR BR9914097-7A patent/BR9914097A/pt not_active IP Right Cessation
- 1999-09-27 MY MYPI99004169A patent/MY121839A/en unknown
- 1999-09-27 ZA ZA200102170A patent/ZA200102170B/en unknown
- 1999-09-27 HU HU0103641A patent/HUP0103641A3/hu unknown
- 1999-09-27 DE DE69905181T patent/DE69905181T2/de not_active Expired - Fee Related
- 1999-09-27 DK DK99949151T patent/DK1117669T3/da active
- 1999-09-27 NZ NZ510506A patent/NZ510506A/en unknown
- 1999-09-27 PT PT99949151T patent/PT1117669E/pt unknown
- 1999-09-27 CN CN99813577A patent/CN1328565A/zh active Pending
- 1999-09-27 AU AU62138/99A patent/AU762757B2/en not_active Ceased
- 1999-09-27 AT AT99949151T patent/ATE231874T1/de not_active IP Right Cessation
- 1999-09-27 PA PA19998483101A patent/PA8483101A1/es unknown
- 1999-09-28 GT GT199900166A patent/GT199900166A/es unknown
- 1999-09-28 AR ARP990104876A patent/AR042368A1/es not_active Application Discontinuation
- 1999-09-28 GC GCP1999302 patent/GC0000174A/en active
-
2001
- 2001-03-08 NO NO20011198A patent/NO20011198L/no unknown
- 2001-03-27 US US09/825,554 patent/US6638919B2/en not_active Expired - Fee Related
- 2001-10-12 HK HK01107186A patent/HK1036455A1/xx not_active IP Right Cessation
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