PE20000935A1 - Una membrana o matriz para controlar la velocidad de penetracion de farmacos - Google Patents

Una membrana o matriz para controlar la velocidad de penetracion de farmacos

Info

Publication number
PE20000935A1
PE20000935A1 PE1999000584A PE00058499A PE20000935A1 PE 20000935 A1 PE20000935 A1 PE 20000935A1 PE 1999000584 A PE1999000584 A PE 1999000584A PE 00058499 A PE00058499 A PE 00058499A PE 20000935 A1 PE20000935 A1 PE 20000935A1
Authority
PE
Peru
Prior art keywords
elastomer
membrane
poly
matrix
polysyloxane
Prior art date
Application number
PE1999000584A
Other languages
English (en)
Inventor
Jarkko Ruohonen
Matti Lehtinen
Harri Jukarainen
Tommi Markkula
Juha Ala-Sorvari
Original Assignee
Leiras Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiras Oy filed Critical Leiras Oy
Publication of PE20000935A1 publication Critical patent/PE20000935A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
    • C08L83/10—Block- or graft-copolymers containing polysiloxane sequences
    • C08L83/12—Block- or graft-copolymers containing polysiloxane sequences containing polyether sequences
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0039—Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Polymers & Plastics (AREA)
  • Silicon Polymers (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Wrappers (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)

Abstract

SE REFIERE A UNA MEMBRANA O MATRIZ DE UN ELASTOMERO DE SILOXANOS A TRAVES DE LA CUAL SE VA A CONTROLAR LA VELOCIDAD DE PENETRACION O PERMEACION DE UN FARMACO CON ACCION HORMONAL DONDE LA MEMBRANA COMPRENDE: a)ELASTOMERO Y b)UN POLIMERO NO RETICULADO Y SE CARACTERIZA PORQUE COMPRENDE; c)GRUPOS POLI(OXIDO DE ALQUILENO) DE PREFERENCIA POLI(OXIDO DE ETILENO)(PEO), LOS CUALES ESTAN PRESENTES EN EL ELASTOMERO Y EN EL POLIMERO COMO INJERTOS O BLOQUES REMATADOS POR ALCOXI DE UNIDADES DE POLISILOXANO; LOS INJERTOS Y LOS BLOQUES ESTAN ENLAZADOS A LAS UNIDADES DE POLISILOXANO POR ENLACES DE SILICIO CON CARBONO. EL POLISILOXANO ES DE PREFERENCIA -(SiR`R''O)qSiR'R''-; R' Y R'' SON ALQUILO, FENILO, POLI(OXIDO DE ALQUILENO) REMATADOS POR ALCOXI DE FORMULA -R3-O-(CHR-CH2-O)m-alk, q ES 1-3000; alk ES ALQUILO; R ES H, ALQUILO; R3 ES ALQUILO C2-C6; m ES 1-30. TAMBIEN SE REFIERE A UN METODO PARA LA PREPARACION DE UN ELASTOMERO Y A UNA MEMBRANA O MATRIZ QUE ESTA CONSTITUIDA POR DOS ELASTOMEROS ENTRELAZADOS UNO DENTRO DEL OTRO, EL PRIMER ELASTOMERO ESTA FORMADO POR GRUPOS POLI(OXIDO DE ALQUILENO), Y EL SEGUNDO ELASTOMERO ES DE SILOXANO DE PREFERENCIA POLI(DIMETILSILOXANO) Y A UNA MEMBRANA CONSTITUIDA POR UNA MEZCLA DE UN ELASTOMERO BASADO EN SILOXANO Y UN COPOLIMERO DE POLISILOXANO DE CADENA LINEAL
PE1999000584A 1998-06-30 1999-06-25 Una membrana o matriz para controlar la velocidad de penetracion de farmacos PE20000935A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI981506A FI107339B (fi) 1998-06-30 1998-06-30 Lääkeaineiden läpäisynopeutta säätävä kalvo tai matriisi

Publications (1)

Publication Number Publication Date
PE20000935A1 true PE20000935A1 (es) 2000-09-18

Family

ID=8552104

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000584A PE20000935A1 (es) 1998-06-30 1999-06-25 Una membrana o matriz para controlar la velocidad de penetracion de farmacos

Country Status (28)

Country Link
EP (1) EP1124902B1 (es)
JP (1) JP2002519467A (es)
KR (1) KR100599868B1 (es)
CN (2) CN1269909C (es)
AR (1) AR018952A1 (es)
AT (1) ATE290049T1 (es)
AU (1) AU752895B2 (es)
BG (1) BG65148B1 (es)
BR (1) BR9911140B1 (es)
CA (1) CA2336149C (es)
CO (1) CO5060523A1 (es)
CZ (1) CZ299613B6 (es)
DE (1) DE69923992T2 (es)
EE (1) EE04685B1 (es)
ES (1) ES2237120T3 (es)
FI (1) FI107339B (es)
HU (1) HU229159B1 (es)
NO (1) NO327955B1 (es)
NZ (1) NZ508275A (es)
PE (1) PE20000935A1 (es)
PL (1) PL193485B1 (es)
PT (1) PT1124902E (es)
RU (1) RU2201794C2 (es)
SK (1) SK285325B6 (es)
TW (1) TWI237571B (es)
UA (1) UA71566C2 (es)
WO (1) WO2000000550A1 (es)
ZA (1) ZA200006986B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6476079B1 (en) * 1999-12-23 2002-11-05 Leiras Oy Devices for the delivery of drugs having antiprogestinic properties
WO2002032433A1 (en) * 2000-10-20 2002-04-25 Leiras Oy Drug delivery system
EP1438942A1 (en) * 2003-01-17 2004-07-21 Schering Oy An otorhinological drug delivery device
ES2300048T3 (es) * 2004-08-25 2008-06-01 UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION Pelicula polimerica.
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
KR101484509B1 (ko) 2007-03-12 2015-01-21 베이어 오와이 토코페롤을 사용하는 방법
EP2140860A1 (en) 2008-07-03 2010-01-06 Bayer Schering Pharma Oy An improved method of contraception
CN102159162B (zh) 2008-09-17 2013-04-24 拜耳公司 插入器
FI20080523A0 (fi) 2008-09-17 2008-09-17 Bayer Schering Pharma Oy Insertteri
FI20080524A0 (fi) 2008-09-17 2008-09-17 Bayer Schering Pharma Oy Insertteri
US11992431B2 (en) 2008-09-17 2024-05-28 Bayer Oy Inserter
FI122579B (fi) 2010-10-29 2012-03-30 Bayer Oy Insertteri
CN102008909B (zh) * 2010-12-13 2012-10-10 大连欧科膜技术工程有限公司 一种气体分离复合膜的制备方法
CN102068914B (zh) * 2010-12-13 2012-10-10 大连欧科膜技术工程有限公司 一种气体分离复合膜的制备方法
MA37443A1 (fr) 2012-04-23 2016-05-31 Bayer Pharma AG Utilisation de 18-méthyl-15 bêta, 16-bêta-méthylène-19-nor-20-spirox-4-en-3-ones pour le traitement des ménorragies, ainsi que système intra-utérin contenant du 18-méthyl-15 bêta, 16-bêta-méthylène-19-nor-20-spirox-4-en-3-ones pour le traitement des hémorragies utérines
TW201350122A (zh) 2012-04-23 2013-12-16 Bayer Pharma AG １８－甲基－１５β，１６β－亞甲基－１９－降－２０－螺氧－４－烯－３－酮的子宮內用途，包含１８－甲基－１５β，１６β－亞甲基－１９－降－２０－螺氧－４－烯－３－酮的子宮內系統，及其於避孕及婦科治療之用途
JP2016539088A (ja) * 2013-10-18 2016-12-15 バイエル・オサケユキテュアＢａｙｅｒ Ｏｙ 子宮内送達システム
CN108135910B (zh) 2015-05-13 2022-12-02 拜耳股份有限公司 长效药物递送装置及其在避孕中的用途
WO2018202574A1 (en) 2017-05-04 2018-11-08 Bayer Oy Intravaginal drug delivery system, method for manufacturing such system and its use in gynecological therapies and contraception
CN111770750B (zh) 2017-12-22 2024-05-10 阿利拉生物科技有限公司 痛经有关的疼痛和/或疼痛相关症状的治疗
ES2834450T3 (es) * 2018-03-05 2021-06-17 Evonik Operations Gmbh Copolímeros en bloques de poliéter-siloxano reticulados, así como su empleo para la producción de espumas de poliuretano
WO2020237325A1 (en) 2019-05-31 2020-12-03 Alyra Biotech Pty Ltd Methods, compositions and devices for treating neuroinflammatory conditions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5889108A (en) * 1997-06-02 1999-03-30 Dow Corning Corporation Thickening solvents with elastomeric silicone polyethers

Also Published As

Publication number Publication date
CN1269909C (zh) 2006-08-16
ES2237120T3 (es) 2005-07-16
WO2000000550A1 (en) 2000-01-06
SK285325B6 (sk) 2006-11-03
FI107339B (fi) 2001-07-13
HUP0102600A3 (en) 2004-04-28
HU229159B1 (hu) 2013-09-30
EE200000788A (et) 2002-04-15
ATE290049T1 (de) 2005-03-15
CN1176999C (zh) 2004-11-24
KR100599868B1 (ko) 2006-07-12
HUP0102600A2 (hu) 2001-11-28
BR9911140A (pt) 2001-03-06
CN1308653A (zh) 2001-08-15
EP1124902A1 (en) 2001-08-22
NZ508275A (en) 2002-09-27
CA2336149C (en) 2007-01-02
AU752895B2 (en) 2002-10-03
KR20010053346A (ko) 2001-06-25
DE69923992T2 (de) 2006-04-13
BR9911140B1 (pt) 2009-08-11
BG65148B1 (bg) 2007-04-30
CN1488678A (zh) 2004-04-14
EP1124902B1 (en) 2005-03-02
EE04685B1 (et) 2006-08-15
HK1038939A1 (en) 2002-04-04
NO20006581D0 (no) 2000-12-21
AU4783999A (en) 2000-01-17
UA71566C2 (uk) 2004-12-15
JP2002519467A (ja) 2002-07-02
FI981506L (fi) 1999-12-31
SK18942000A3 (sk) 2001-07-10
NO327955B1 (no) 2009-10-26
AR018952A1 (es) 2001-12-12
FI981506A0 (fi) 1998-06-30
TWI237571B (en) 2005-08-11
CZ20004749A3 (cs) 2001-10-17
PL345103A1 (en) 2001-12-03
BG105081A (en) 2001-09-28
PL193485B1 (pl) 2007-02-28
DE69923992D1 (de) 2005-04-07
CO5060523A1 (es) 2001-07-30
CZ299613B6 (cs) 2008-09-17
CA2336149A1 (en) 2000-01-06
PT1124902E (pt) 2005-07-29
ZA200006986B (en) 2001-05-23
NO20006581L (no) 2000-12-29
RU2201794C2 (ru) 2003-04-10

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Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed