OA13247A - Phenyl or pyridyl amide coumpounds as prostaglandin E2 antagonists. - Google Patents

Phenyl or pyridyl amide coumpounds as prostaglandin E2 antagonists. Download PDF

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Publication number
OA13247A
OA13247A OA1200600068A OA1200600068A OA13247A OA 13247 A OA13247 A OA 13247A OA 1200600068 A OA1200600068 A OA 1200600068A OA 1200600068 A OA1200600068 A OA 1200600068A OA 13247 A OA13247 A OA 13247A
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OA
OAPI
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groups
carbon atoms
chloro
amino
group
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OA1200600068A
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English (en)
Inventor
Kanzunari Nakao
Yoshiyuki Okumura
Seiji Nukui
Tatsuya Yamagishi
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Pfizer
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Publication of OA13247A publication Critical patent/OA13247A/en

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101160290B (zh) 2004-12-02 2011-01-19 第一三共株式会社 7-元环化合物、其制备方法和药物用途
UY30121A1 (es) 2006-02-03 2007-08-31 Glaxo Group Ltd Nuevos compuestos
CA2648729A1 (fr) * 2006-04-24 2007-11-01 Merck Frosst Canada Ltd. Derives d'indolamide comme antagonistes du recepteur ep4
WO2007139230A1 (fr) * 2006-05-31 2007-12-06 Asubio Pharma Co., Ltd. Anneau hétérocycliques à 7 éléments, son procédé de production et ses utilisations pharmaceutiques
CA2654811A1 (fr) * 2006-06-12 2007-12-21 Merck Frosst Canada Ltd. Derives amide de l'indoline en tant que ligands du recepteur ep4
ITMI20061368A1 (it) * 2006-07-14 2008-01-15 Acraf Composto 2-arilindolico sostituito in posizione 5, composizione farmaceutica che lo comprende nonche' composti intermedi e procedimento per prepararlo
CA2660133C (fr) * 2006-08-11 2015-10-27 Merck Frosst Canada Ltd. Derives de thiophenecarboxamide en tant que ligands du recepteur ep4
KR20090089868A (ko) 2006-12-15 2009-08-24 글락소 그룹 리미티드 Ｅｐ４ 수용체 작동제로서 벤즈아미드 유도체
US8158671B2 (en) * 2007-02-26 2012-04-17 Merck Canada Inc. Indole and indoline cyclopropyl amide derivatives as EP4 receptor antagonists
EP2460787A1 (fr) 2007-07-03 2012-06-06 Astellas Pharma Inc. Composés d'amide et leur utilidsation comme anagonistes de la PGE2.
EP2185534A1 (fr) * 2007-08-09 2010-05-19 Merck Sharp & Dohme Corp. Procédé pour fabriquer un dérivé de carboxamide de thiophène
GB0721611D0 (en) * 2007-11-02 2007-12-12 Glaxo Group Ltd Novel compounds
NZ585085A (en) * 2007-11-16 2012-08-31 Abbott Lab Method of treating arthritis using arylsulfonamide compounds
PT2565191E (pt) * 2008-05-14 2014-12-04 Astellas Pharma Inc Derivados do ácido 4-(indol-7- ilcarbonilaminometil)ciclo-hexanocarboxílico como antagonistas de receptores ep4, úteis no tratamento de insuficiência renal crónica ou de nefropatia diabética
TW200951139A (en) * 2008-05-27 2009-12-16 Astrazeneca Ab Chemical compounds 293
GB0810313D0 (en) * 2008-06-05 2008-07-09 Glaxo Group Ltd Novel compounds
JP5536773B2 (ja) 2008-08-14 2014-07-02 ベータ・ファーマ・カナダ・インコーポレイテッド Ｅｐ４受容体アンタゴニストとしてのヘテロ環式アミド誘導体
ME02642B (me) * 2008-12-05 2017-06-20 Abbvie Inc Sulfonamid derivati i kao BCL- 2 selektivni agensi za induciranje apoptoze namijenjeni liječenju raka i imunih bolesti
WO2010087425A1 (fr) 2009-01-30 2010-08-05 国立大学法人京都大学 Inhibiteur de la progression du cancer de la prostate et procédé d'inhibition de la progression
ES2960438T3 (es) * 2009-04-22 2024-03-04 Askat Inc Sustancia antagonista del receptor EP4 selectivo para el tratamiento del cáncer
CA2789665C (fr) * 2010-02-22 2020-06-16 Raqualia Pharma Inc. Utilisation d'antagonistes de recepteur ep4 dans le traitement de maladies mediees par il-23
BR112013002484B1 (pt) * 2010-09-21 2021-10-13 Eisai R&D Management Co. , Ltd. Composto, composição farmacêutica, e, usos de um composto
US8828987B2 (en) 2010-12-10 2014-09-09 Rottapharm Biotech S.R.L. Pyridine amide derivatives as EP4 receptor antagonists
IN2014CN00719A (fr) 2011-07-04 2015-04-03 Rottapharm Spa
KR101412794B1 (ko) 2011-07-27 2014-07-01 보령제약 주식회사 혈관생성억제 작용을 갖는 신규한 화합물, 이의 제조방법 및 이를 포함하는 약학적 조성물
WO2013032971A1 (fr) 2011-08-29 2013-03-07 Ticona Llc Substrat extrudé à l'état fondu destiné être utilisé dans des articles thermoformés
JP2014525499A (ja) 2011-08-29 2014-09-29 ティコナ・エルエルシー 低い融解温度をもつ耐熱性液晶ポリマー組成物
US9045685B2 (en) 2011-08-29 2015-06-02 Ticona Llc Cast molded parts formed from a liquid crystalline polymer
TW201313884A (zh) 2011-08-29 2013-04-01 Ticona Llc 液晶聚合物之固態聚合
JP2014529627A (ja) 2011-08-29 2014-11-13 ティコナ・エルエルシー 芳香族アミド化合物
CN103764793B (zh) 2011-08-29 2016-09-14 提克纳有限责任公司 高流动液晶聚合物组合物
JP2014525498A (ja) 2011-08-29 2014-09-29 ティコナ・エルエルシー 高流動性液晶ポリマー組成物
WO2013032975A1 (fr) 2011-08-29 2013-03-07 Ticona Llc Polymère cristallin liquide thermotrope à viscosité à faible cisaillement améliorée
JP2014525500A (ja) 2011-08-29 2014-09-29 ティコナ・エルエルシー 低溶融粘度液晶ポリマーの溶融重合
AR091429A1 (es) 2012-06-29 2015-02-04 Lilly Co Eli Compuestos de fenoxietil piperidina
UA115576C2 (uk) 2012-12-06 2017-11-27 Байєр Фарма Акцієнгезелльшафт Похідні бензимідазолу як антагоністи ер4
PT3239134T (pt) * 2013-01-31 2021-01-28 Vertex Pharma Piridona amidas como moduladores dos canais de sódio
TW201443004A (zh) 2013-02-15 2014-11-16 Lilly Co Eli 苯氧基乙氧基化合物
WO2014130275A2 (fr) 2013-02-22 2014-08-28 Ticona Llc Composition de polymères haute performance présentant des propriétés d'écoulement améliorées
KR102239641B1 (ko) 2013-03-19 2021-04-13 에스크엣 인크. 연골질환 치료에서의 ep4 수용체 길항제의 용도
US10391086B2 (en) 2013-03-19 2019-08-27 Askat Inc. Use of EP4 receptor antagonists in the treatment of cartilage disease
TWI636046B (zh) 2013-05-17 2018-09-21 美國禮來大藥廠 苯氧基乙基二氫－１ｈ－異喹啉化合物
US9206300B2 (en) 2013-06-07 2015-12-08 Ticona Llc High strength thermotropic liquid crystalline polymer
NO3009426T3 (fr) 2013-06-12 2018-09-29
CA2916653C (fr) 2013-06-27 2017-07-18 Pfizer Inc. Composes hetero-aromatiques et leur utilisation en tant que ligands d1 de la dopamine
WO2015048553A1 (fr) * 2013-09-27 2015-04-02 Allergan, Inc. Composés et méthodes de réparation cutanée
ES2727329T3 (es) * 2013-12-17 2019-10-15 Lilly Co Eli Compuestos de ácido dimetilbenzoico
CA2928593A1 (fr) * 2013-12-17 2015-06-25 Eli Lilly And Company Derives d'amine cyclique de phenoxyethyle et leur activite en tant que modulateurs du recepteur ep4
TW201607943A (zh) 2013-12-19 2016-03-01 拜耳製藥公司 作為ｅｐ４配體之新穎苯并咪唑衍生物
WO2016021742A1 (fr) * 2014-08-07 2016-02-11 Takeda Pharmaceutical Company Limited Composés hétérocycliques utilisés en tant qu'antagonistes des récepteurs ccr4
WO2016088903A1 (fr) * 2014-12-05 2016-06-09 Takeda Pharmaceutical Company Limited Composés hétérocycliques
KR102369674B1 (ko) 2015-02-17 2022-03-04 삼성디스플레이 주식회사 디스플레이 장치, 및 이를 포함하는 전자 기기
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
CN109563053B (zh) * 2016-06-28 2023-02-28 肯塔基大学研究基金会 前列腺素e合成酶抑制剂及使用其的方法
US10342785B2 (en) 2016-11-04 2019-07-09 Askat Inc. Use of EP4 receptor antagonists for the treatment of NASH-associated liver cancer
CA3060394A1 (fr) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Derives de pyrimidine utilises en tant que modulateurs des recepteurs des pge2
EP3625224B1 (fr) 2017-05-18 2021-08-04 Idorsia Pharmaceuticals Ltd Dérivés d'indole n-substitués
US11446298B2 (en) 2017-05-18 2022-09-20 Idorsia Pharmaceuticals Ltd Pyrimidine derivatives
WO2018210987A1 (fr) 2017-05-18 2018-11-22 Idorsia Pharmaceuticals Ltd Dérivés de benzofurane et de benzothiophène utilisés en tant que modulateurs du récepteur pge2
HUE056080T2 (hu) 2017-05-18 2022-01-28 Idorsia Pharmaceuticals Ltd Fenilszármazékok mint PGE2 receptor modulátorok
WO2019121143A1 (fr) 2017-12-20 2019-06-27 Basf Se Dérivés de cyclopropyle substitués
WO2019186297A1 (fr) * 2018-03-29 2019-10-03 Zietchick Research Institute, Llc Méthodes pour le traitement d'une glycémie élevée
US10973834B2 (en) 2018-04-16 2021-04-13 Arrys Therapeutics, Inc. EP4 inhibitors and use thereof
WO2020014445A1 (fr) * 2018-07-11 2020-01-16 Arrys Therapeutics, Inc. Inhibiteurs ep4 et synthèse de ceux-ci
EP3693359A1 (fr) * 2019-02-08 2020-08-12 Medibiofarma, S.L. Nouveaux dérivés de n-benzyl-2-phénoxybenzamide en tant que modulateurs des récepteurs de la prostaglandine e2 (pge2)
WO2021226162A1 (fr) 2020-05-05 2021-11-11 Arrys Therapeutics, Inc. Antagonistes de l'ep4 et leur utilisation dans le traitement des maladies prolifératives"
GB2594931A (en) * 2020-05-06 2021-11-17 Syngenta Crop Protection Ag Improvements in or relating to organic compounds
JPWO2022102731A1 (fr) 2020-11-13 2022-05-19
JPWO2022138792A1 (fr) * 2020-12-24 2022-06-30
TW202246217A (zh) * 2021-01-28 2022-12-01 大陸商深圳晶泰科技有限公司 咪唑醯胺衍生物及其製備方法和應用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2500157C2 (de) 1975-01-03 1983-09-15 Hoechst Ag, 6230 Frankfurt N-Acyl-4-(2-aminoäthyl)-benzoesäuren, deren Salze und Ester, Verfahren zu deren Herstellung und deren Verwendung
DE2706977A1 (de) 1977-02-18 1978-08-24 Hoechst Ag Benzoesaeuren und deren derivate sowie verfahren zu ihrer herstellung
DE19655143A1 (de) * 1996-12-13 2000-06-08 Doht Gmbh Pfeil für eine Armbrust
TW523506B (en) * 1996-12-18 2003-03-11 Ono Pharmaceutical Co Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients
JP2000510481A (ja) * 1997-04-04 2000-08-15 ファイザー・プロダクツ・インク ニコチンアミド誘導体
ES2261202T3 (es) 1999-04-28 2006-11-16 Sanofi-Aventis Deutschland Gmbh Derivados de acido de triarilo como ligandos para el receptor ppar.
KR20020076330A (ko) * 2000-02-22 2002-10-09 오노 야꾸힝 고교 가부시키가이샤 안식향산 유도체, 이들의 제조 방법 및 이들을 유효성분으로서 함유하는 약제
EP1229034B1 (fr) * 2001-01-31 2005-04-13 Pfizer Products Inc. Derivés du nicotinamide et leur mimetiques actifs comme ihibiteurs de PDE4 isozymes
JP4529119B2 (ja) * 2001-08-09 2010-08-25 小野薬品工業株式会社 カルボン酸誘導体化合物およびその化合物を有効成分として含有する薬剤
CA2492019A1 (fr) * 2002-08-13 2004-02-19 Warner-Lambert Company Llc Derives d'isoquinoleine utilises comme inhibiteurs de metalloprotease de matrice

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AP2006003534A0 (en) 2006-04-30
ECSP066405A (es) 2006-09-18
PE20050349A1 (es) 2005-05-17
RS20060143A (en) 2008-06-05
EP1663979A1 (fr) 2006-06-07
JP2008273936A (ja) 2008-11-13
CA2536870C (fr) 2009-10-27
MXPA06002551A (es) 2006-06-20
BRPI0414130B8 (pt) 2021-05-25
AU2004268839A1 (en) 2005-03-10
EA200600358A1 (ru) 2006-08-25
CN1867551B (zh) 2013-09-11
IL173735A0 (en) 2006-07-05
ES2441206T3 (es) 2014-02-03
CA2536870A1 (fr) 2005-03-10
JP2012140435A (ja) 2012-07-26
EA009201B1 (ru) 2007-12-28
WO2005021508A1 (fr) 2005-03-10
BRPI0414130B1 (pt) 2020-08-11
NO20061251L (no) 2006-03-17
BRPI0414130A (pt) 2006-10-31
CR8268A (es) 2007-10-23
JP2008044949A (ja) 2008-02-28
PA8610801A1 (es) 2005-03-28
NL1026958C2 (nl) 2005-06-29
AR045551A1 (es) 2005-11-02
US20050065188A1 (en) 2005-03-24
EP1663979B1 (fr) 2013-10-09
NL1026958A1 (nl) 2005-03-07
MA28020A1 (fr) 2006-07-03
KR20070026302A (ko) 2007-03-08
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IS8307A (is) 2006-02-16
CN1867551A (zh) 2006-11-22
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